To observe the effect of Fufang Jisheng Liujin Gao （复方寄生流浸膏 Compound Mistletoe Fluidextract） on blood pressure in the spontaneous hypertensive rats （SHR） and the renal hypertensive dogs （RHD）. Methods： T...To observe the effect of Fufang Jisheng Liujin Gao （复方寄生流浸膏 Compound Mistletoe Fluidextract） on blood pressure in the spontaneous hypertensive rats （SHR） and the renal hypertensive dogs （RHD）. Methods： The blood pressure-decreasing effects of single administration and 14-day consecutive administration of Compound Mistletoe Fluidextract （CMF） in SHR and RHD were investigated and compared with that of Niuhuang Jiangya Wan （牛黄降压丸 Bezoar Hypertension-relieving Pills）. Results： Both single administration and 14-day consecutive administration of CMF had significant hypotensive effects in SHR and RHD. Conclusion： The hypotensive action of CMF is gradual, but lasts for a longer period, with a dose-effect relationship in a range of doses.展开更多
Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough v...Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups.One group was the reference group(40 cases)treated with procaterol hydrochloride tablets and montelukast sodium,and the other group was the research group(40 cases)・The method of eliminating wind,eliminating lung and relieving cough was combined with procaterol hydrochloride tablets and montelukast sodium to observe and compare the curative effects of the two groups.Results:There was no significant difference in TCM symptom score and eosinophil(EOS)count between the two groups before treatment(P>0.05);After treatment,the TCM symptom scores of coughs,pharyngeal itching,expectoration,nasal congestion and nasal itching in the research group were lower than those in the reference group,and the EOS count was lower than that in the reference group(P<0.05);The effective rate of research group was higher than that of reference group(P<0.05).Conclusions:For children with cough variant asthma,Qufeng Sufei cough relieving method combined with procaterol hydrochloride and montelukast sodium can improve children's symptoms and reduce eosinophil count.展开更多
Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research a...Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.展开更多
Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and m...Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and may be manifested as cough withoutsputum,cough with watery thin sputum orwith yellow thick sputum,cough withdyspnea due to affection by exopathogens,or cough with dyspnea due to consumptivediseases.Appropriate drugs should be chos-en with regard to the different syndromes,展开更多
Based on the geological condition of Zhangxiaolou deep mine in Xuzhou mining area, under 986 m in depth, 20.6-31.6 MPa in maximum horizontal principal stress, and friable and fractured surrounding rock, test researche...Based on the geological condition of Zhangxiaolou deep mine in Xuzhou mining area, under 986 m in depth, 20.6-31.6 MPa in maximum horizontal principal stress, and friable and fractured surrounding rock, test researches on partial relieving pressure were completed for the entry with U-steel arched yielding support. The relieving pressure parameters, technology process and results of springing blasting by boreholes and excavating pockets in the two sides of entry were introduced. It is demonstrated that springing will not be shaped under the condition of single borehole arrangement after exploded, the arrangement by a group, it will make borehole bottom form springing in 0.6-0.8 m in diameter, that convergence of two sides and roof to floor have some increments by using springing blasting for reliving pressure. This kind of method for reliving pressure is not suitable to use in the deep mine, and that the convergence of two sides obviously declined by excavating pocket in two sides, it can be still used in the entry with metal support, while maintenance of entry in deep mines is difficult, and can not be supported by bolt or bolt with wire mesh.展开更多
The anti-wrinkle,relieving effect and safety of a group of hexapeptide compounds(HCs)were evaluated by in vitro antioxidant test,hyaluronidase inhibition test and human clinical test.The results showed that HCs posses...The anti-wrinkle,relieving effect and safety of a group of hexapeptide compounds(HCs)were evaluated by in vitro antioxidant test,hyaluronidase inhibition test and human clinical test.The results showed that HCs possess+high overall antioxidant activity,and the scavenging activity of ABTS•radical and DPPH radical by 4 mg/mL HCs solution were(92.23±1.15)%and(90.24±1.25)%.The scavenging activity of PTIO radical by 80 mg/mL HCs solution was(80.29±2.41)%.The inhibition rate of 80 mg/mL HCs on hyaluronidase was(75.00±6.13)%.The test of clinical results showed that the HCs have good anti-wrinkle and relieving effect,and no case of grade 1 or above skin adverse reactions occurred,indicating that HCs have good safety.展开更多
文摘To observe the effect of Fufang Jisheng Liujin Gao （复方寄生流浸膏 Compound Mistletoe Fluidextract） on blood pressure in the spontaneous hypertensive rats （SHR） and the renal hypertensive dogs （RHD）. Methods： The blood pressure-decreasing effects of single administration and 14-day consecutive administration of Compound Mistletoe Fluidextract （CMF） in SHR and RHD were investigated and compared with that of Niuhuang Jiangya Wan （牛黄降压丸 Bezoar Hypertension-relieving Pills）. Results： Both single administration and 14-day consecutive administration of CMF had significant hypotensive effects in SHR and RHD. Conclusion： The hypotensive action of CMF is gradual, but lasts for a longer period, with a dose-effect relationship in a range of doses.
文摘Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups.One group was the reference group(40 cases)treated with procaterol hydrochloride tablets and montelukast sodium,and the other group was the research group(40 cases)・The method of eliminating wind,eliminating lung and relieving cough was combined with procaterol hydrochloride tablets and montelukast sodium to observe and compare the curative effects of the two groups.Results:There was no significant difference in TCM symptom score and eosinophil(EOS)count between the two groups before treatment(P>0.05);After treatment,the TCM symptom scores of coughs,pharyngeal itching,expectoration,nasal congestion and nasal itching in the research group were lower than those in the reference group,and the EOS count was lower than that in the reference group(P<0.05);The effective rate of research group was higher than that of reference group(P<0.05).Conclusions:For children with cough variant asthma,Qufeng Sufei cough relieving method combined with procaterol hydrochloride and montelukast sodium can improve children's symptoms and reduce eosinophil count.
基金Poly U(G-YBGQ G-SB81+3 种基金 G-YZ95)the Research Grant Council of Hong Kong(15101014)ITSP-Guangdong-Hong Kong Technology Cooperation Funding Scheme(GHP/012/16GD)Shenzhen Basic Research Program(JCYJ20160331141459373)
文摘Alzheimer disease(AD) has now become the most common brain disorder among the older population. In addition, the currently existing therapeutics only offer temporary symptomatic relieves. Therefore, further research and development of more efficacious and disease-modifying agents for the prevention, treatment and restoration of AD will have tremendous value from both scientific, and economic standpoints. Over the past few years, our series of studies have identified several highly promising anti-AD dimeric leads, with disease-modifying potentials. In this presentation, the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.
文摘Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and may be manifested as cough withoutsputum,cough with watery thin sputum orwith yellow thick sputum,cough withdyspnea due to affection by exopathogens,or cough with dyspnea due to consumptivediseases.Appropriate drugs should be chos-en with regard to the different syndromes,
基金Supported by the Key Project of the National Natural Science Foundation （50490273）
文摘Based on the geological condition of Zhangxiaolou deep mine in Xuzhou mining area, under 986 m in depth, 20.6-31.6 MPa in maximum horizontal principal stress, and friable and fractured surrounding rock, test researches on partial relieving pressure were completed for the entry with U-steel arched yielding support. The relieving pressure parameters, technology process and results of springing blasting by boreholes and excavating pockets in the two sides of entry were introduced. It is demonstrated that springing will not be shaped under the condition of single borehole arrangement after exploded, the arrangement by a group, it will make borehole bottom form springing in 0.6-0.8 m in diameter, that convergence of two sides and roof to floor have some increments by using springing blasting for reliving pressure. This kind of method for reliving pressure is not suitable to use in the deep mine, and that the convergence of two sides obviously declined by excavating pocket in two sides, it can be still used in the entry with metal support, while maintenance of entry in deep mines is difficult, and can not be supported by bolt or bolt with wire mesh.
文摘The anti-wrinkle,relieving effect and safety of a group of hexapeptide compounds(HCs)were evaluated by in vitro antioxidant test,hyaluronidase inhibition test and human clinical test.The results showed that HCs possess+high overall antioxidant activity,and the scavenging activity of ABTS•radical and DPPH radical by 4 mg/mL HCs solution were(92.23±1.15)%and(90.24±1.25)%.The scavenging activity of PTIO radical by 80 mg/mL HCs solution was(80.29±2.41)%.The inhibition rate of 80 mg/mL HCs on hyaluronidase was(75.00±6.13)%.The test of clinical results showed that the HCs have good anti-wrinkle and relieving effect,and no case of grade 1 or above skin adverse reactions occurred,indicating that HCs have good safety.
