[Objectives]To explore the anti-rheumatoid arthritis effect of Lignum Xanthocerais Sorbifoliae by network pharmacology method.[Methods]The chemical constituents and action targets of Lignum Xanthocerais Sorbifoliae we...[Objectives]To explore the anti-rheumatoid arthritis effect of Lignum Xanthocerais Sorbifoliae by network pharmacology method.[Methods]The chemical constituents and action targets of Lignum Xanthocerais Sorbifoliae were collected by Traditional Chinese Medicine Systems Pharmacology(TCMSP).Target genes of rheumatoid arthritis(RA)were obtained from TTD database.ClusterProfiler was used for gene ontology(GO)enrichment,and Cytoscape 3.7.2 software was used for Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment and screening of active component-target core network.[Results]There were 24 intersecting targets between active components and diseases.The analysis of GO enrichment and KEGG pathway enrichment indicated that the therapeutic effect of Lignum Xanthocerais Sorbifoliae on rheumatoid arthritis might be related to AGE-RAGE signaling pathway,IL-17 signaling pathway,rheumatoid arthritis pathway,C-type signaling pathway and Toll-like receptor signaling pathway.13 drug active components[flavanes,dihydroflavonoids,stigmasterol,oleanolic acid,kaempferol,ellagic acid,Terchebulin B,Copaene,(Z)-β-Caryophyllene,Aromadendrene,β-Elemene,emodin]and 12 core targets(TNF,IL6,ALOX5,MAPK14,PPARA,AKR1B1,CCR5,PLA2G1B,ADAM17,MMP1,PTGS1,SYK)constituted a core network.[Conclusions]This study could provide a theoretical basis for the treatment of RA with Lignum Xanthocerais Sorbifoliae preparation.展开更多
At present, the major drawback for mobile phones is the issue of power consumption. As one of the alternatives to decrease the power consumption of standard, power-hungry location-based services usually require the kn...At present, the major drawback for mobile phones is the issue of power consumption. As one of the alternatives to decrease the power consumption of standard, power-hungry location-based services usually require the knowledge of how individual phone features consume power. A typical phone feature is that the applications related to multimedia streaming utilize more power while receiving, processing, and displaying the multimedia contents, thus contributing to the increased power consumption. There is a growing concern that current battery modules have limited capability in fulfilling the long-term energy need for the progress on the mobile phone because of increasing power consumption during multimedia streaming processes. Considering this, in this paper, we provide an offline meaning sleep-mode method to compute the minimum power consumption comparing with the power-on solution to save power by implementing energy rate adaptation(RA) mechanism based on mobile excess energy level purpose to save battery power use. Our simulation results show that our RA method preserves efficient power while achieving better throughput compared with the mechanism without rate adaptation(WRA).展开更多
基金National Natural Science Foundation of China(81560702)Joint Research Project of Inner Mongolia Minzu University and Mongolian Academy of Sciences(NMDGJ0014)Graduate Research and Innovation Project in Inner Mongolia Autonomous Region(S20210280Z)。
文摘[Objectives]To explore the anti-rheumatoid arthritis effect of Lignum Xanthocerais Sorbifoliae by network pharmacology method.[Methods]The chemical constituents and action targets of Lignum Xanthocerais Sorbifoliae were collected by Traditional Chinese Medicine Systems Pharmacology(TCMSP).Target genes of rheumatoid arthritis(RA)were obtained from TTD database.ClusterProfiler was used for gene ontology(GO)enrichment,and Cytoscape 3.7.2 software was used for Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment and screening of active component-target core network.[Results]There were 24 intersecting targets between active components and diseases.The analysis of GO enrichment and KEGG pathway enrichment indicated that the therapeutic effect of Lignum Xanthocerais Sorbifoliae on rheumatoid arthritis might be related to AGE-RAGE signaling pathway,IL-17 signaling pathway,rheumatoid arthritis pathway,C-type signaling pathway and Toll-like receptor signaling pathway.13 drug active components[flavanes,dihydroflavonoids,stigmasterol,oleanolic acid,kaempferol,ellagic acid,Terchebulin B,Copaene,(Z)-β-Caryophyllene,Aromadendrene,β-Elemene,emodin]and 12 core targets(TNF,IL6,ALOX5,MAPK14,PPARA,AKR1B1,CCR5,PLA2G1B,ADAM17,MMP1,PTGS1,SYK)constituted a core network.[Conclusions]This study could provide a theoretical basis for the treatment of RA with Lignum Xanthocerais Sorbifoliae preparation.
基金supported by X-Project funded by the Ministry of Science,ICT&Future Planning under Grant No.NRF-2015R1A2A1A16074929
文摘At present, the major drawback for mobile phones is the issue of power consumption. As one of the alternatives to decrease the power consumption of standard, power-hungry location-based services usually require the knowledge of how individual phone features consume power. A typical phone feature is that the applications related to multimedia streaming utilize more power while receiving, processing, and displaying the multimedia contents, thus contributing to the increased power consumption. There is a growing concern that current battery modules have limited capability in fulfilling the long-term energy need for the progress on the mobile phone because of increasing power consumption during multimedia streaming processes. Considering this, in this paper, we provide an offline meaning sleep-mode method to compute the minimum power consumption comparing with the power-on solution to save power by implementing energy rate adaptation(RA) mechanism based on mobile excess energy level purpose to save battery power use. Our simulation results show that our RA method preserves efficient power while achieving better throughput compared with the mechanism without rate adaptation(WRA).
