The relative response factors（RRFs） for noble gas（Ng） were determined on a pulsed discharge helium photoionization detector. Using ab initio method, the atomic orbitals of noble gas were calculated and used to det...The relative response factors（RRFs） for noble gas（Ng） were determined on a pulsed discharge helium photoionization detector. Using ab initio method, the atomic orbitals of noble gas were calculated and used to determine the number of ionizable electrons on the basis of the continuous emission of He2. The molar responses of noble gases is well correlated with the number of ionizable electrons.展开更多
AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was me...AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods.展开更多
Our recently proposed three-step method showed the promising potential to improve the accuracy of relative wavelength response(RWR) characterization in the wavelength-modulation spectroscopy(WMS) over the commonly use...Our recently proposed three-step method showed the promising potential to improve the accuracy of relative wavelength response(RWR) characterization in the wavelength-modulation spectroscopy(WMS) over the commonly used summation method.A detailed comparison of the three-step method and the summation method,for the wavelength-scanned WMS gas-sensing,was performed with different laser parameters(modulation indexes and scan indexes) and gas properties(pressures and concentrations).Simulation results show that the accuracy of the predicted gas parameters is strongly limited by the RWR characterization with large modulation index and high gas pressure conditions.Both fitting residuals of RWR and errors of predicted gas parameters from the recently proposed three-step method are nearly 2 orders of magnitude smaller than those from the summation method.In addition,the three-step method is further improved by introducing a coupling term for the 2^(nd) harmonic amplitude.Experiments with CO_(2) absorption transition at 6976.2026 cm^(-1) were conducted and validated the simulation analysis.The modified-three-step method presents an improved accuracy in RWR description with at least 5% smaller fitting residual for all conditions compared with the three-step method,although the deviation of the deduced CO_(2) concentrations between these two methods does not exceed 0.2%.展开更多
This work introduces the branching ratio(BR) method for determining relative spectral responses,which are needed routinely in laser induced breakdown spectroscopy(LIBS). Neutral and singly ionized Ti lines in the 250...This work introduces the branching ratio(BR) method for determining relative spectral responses,which are needed routinely in laser induced breakdown spectroscopy(LIBS). Neutral and singly ionized Ti lines in the 250–498 nm spectral range are investigated by measuring laser-induced micro plasma near a Ti plate and used to calculate the relative spectral response of an entire LIBS detection system. The results are compared with those of the conventional relative spectral response calibration method using a tungsten halogen lamp, and certain lines available for the BR method are selected. The study supports the common manner of using BRs to calibrate the detection system in LIBS setups.展开更多
The intestinal and intratumoral microbiota are closely associated with tumor progression and response to antitumor treatments.The antibacterial or tumor microenvironment(TME)-modulating approaches have been shown to m...The intestinal and intratumoral microbiota are closely associated with tumor progression and response to antitumor treatments.The antibacterial or tumor microenvironment(TME)-modulating approaches have been shown to markedly improve antitumor efficacy,strategies focused on normalizing the microbial environment are rarely reported.Here,we reported the development of an orally administered inulin-based hydrogel with colon-targeting and retention effects,containing hollow MnO^(2) nanocarrier loaded with the chemotherapeutic drug Oxa(Oxa@HMI).On the one hand,beneficial bacteria in the colon specifically metabolized Oxa@HMI,resulting in the degradation of inulin and the generation of short-chain fatty acids(SCFAs).These SCFAs play a crucial role in modulating microbiota and stimulating immune responses.On the other hand,the hydrogel matrix underwent colon microbiota-specific degradation,enabling the targeted release of Oxa and production of reactive oxygen species in the acidic TME.In this study,we have established,for the first time,a microbiota-targeted drug delivery system Oxa@HMI that exhibited high efficiency in colorectal cancer targeting and colon retention.Oxa@HMI promoted chemotherapy efficiency and activated antitumor immune responses by intervening in the microbial environment within the tumor tissue,providing a crucial clinical approach for the treatment of colorectal cancer that susceptible to microbial invasion.展开更多
The soil environment plays a crucial role in agricultural production,safeguarding water resources,and maintaining ecological balance.Additionally,the soil environment can regulate climate through carbon cycling and se...The soil environment plays a crucial role in agricultural production,safeguarding water resources,and maintaining ecological balance.Additionally,the soil environment can regulate climate through carbon cycling and serves as an essential habitat for the survival of animals and humans.Therefore,a green and healthy soil environment forms the bedrock of sustainable development of biological systems and serves as the basic support for socio-economic progress,thereby affecting the survival of every organism.However,with the advancement of human society and technology,numerous emerging pollutants have gradually been identified.Among these pollutants,perfluorinated compounds(PFASs)are known for their high thermal stability,bioaccumulation potential,and strong biological toxicity.PFASs are complex persistent pollutants that infiltrate soil ecosystems through industrial emissions,agricultural practices,and household waste,posing a significant threat to soil environments as well as human health and receiving considerable attention.However,current research mainly focuses on PFASs pollution in water media,with few reports on its interaction with soil environments.Moreover,due to the diversity and heterogeneity of soil environmental factors,the species diversity of PFASs may affect the different responses between different PFASs(short and long chain types)and soil factors.Elucidating these complex relationships is crucial for developing future treatment technologies to remediate PFASs pollution.Therefore,this paper reviews the impacts of PFASs pollution on soil properties and preliminarily compares the response and effect of various environmental factors,such as pH,organic matter,and microbial communities,to PFASs stress.Furthermore,the paper provides a scientific basis and theoretical insights into the processes,transformation mechanisms,and remediation methods related to soil PFASs pollution.展开更多
This paper examines the response of the bandpass filter with Gaussian weighting function to arbitrary two-dimensional fields and proposes a new concept of relative response function.Based on the properties of relative...This paper examines the response of the bandpass filter with Gaussian weighting function to arbitrary two-dimensional fields and proposes a new concept of relative response function.Based on the properties of relative re- sponse function,satisfactory weighting parameters C_1 and C_2 are obtained.By studying two cases,the procedure of us- ing structure function curves to choose the maximum response wavelength is formulated.It is shown that bandpass fil- tering offers some improvements to the analysis and forecast of mesoscale weather processes.展开更多
基金the National Natural Science Foundation of China(No.20503010)
文摘The relative response factors（RRFs） for noble gas（Ng） were determined on a pulsed discharge helium photoionization detector. Using ab initio method, the atomic orbitals of noble gas were calculated and used to determine the number of ionizable electrons on the basis of the continuous emission of He2. The molar responses of noble gases is well correlated with the number of ionizable electrons.
文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51906120 and 11972213)China Postdoctoral Science Foundation(Grant Nos.2018M640125 and 2019T120088)the National Basic Research Program of China(Grant No.2016YFC0201104)。
文摘Our recently proposed three-step method showed the promising potential to improve the accuracy of relative wavelength response(RWR) characterization in the wavelength-modulation spectroscopy(WMS) over the commonly used summation method.A detailed comparison of the three-step method and the summation method,for the wavelength-scanned WMS gas-sensing,was performed with different laser parameters(modulation indexes and scan indexes) and gas properties(pressures and concentrations).Simulation results show that the accuracy of the predicted gas parameters is strongly limited by the RWR characterization with large modulation index and high gas pressure conditions.Both fitting residuals of RWR and errors of predicted gas parameters from the recently proposed three-step method are nearly 2 orders of magnitude smaller than those from the summation method.In addition,the three-step method is further improved by introducing a coupling term for the 2^(nd) harmonic amplitude.Experiments with CO_(2) absorption transition at 6976.2026 cm^(-1) were conducted and validated the simulation analysis.The modified-three-step method presents an improved accuracy in RWR description with at least 5% smaller fitting residual for all conditions compared with the three-step method,although the deviation of the deduced CO_(2) concentrations between these two methods does not exceed 0.2%.
基金supported by the National Key Scientific Instrument and Equipment Development Projects of China (2014YQ120351)National Natural Science Foundation of China (11704372)Anhui Provincial Natural Science Foundation (1708085QF130)
文摘This work introduces the branching ratio(BR) method for determining relative spectral responses,which are needed routinely in laser induced breakdown spectroscopy(LIBS). Neutral and singly ionized Ti lines in the 250–498 nm spectral range are investigated by measuring laser-induced micro plasma near a Ti plate and used to calculate the relative spectral response of an entire LIBS detection system. The results are compared with those of the conventional relative spectral response calibration method using a tungsten halogen lamp, and certain lines available for the BR method are selected. The study supports the common manner of using BRs to calibrate the detection system in LIBS setups.
基金supported by the Natural Science Foundation of Guangdong Province(2023A1515030291)Science and Technology Program of Guangzhou(202201011130280065)Dongguan Science and Technology of Social Development Program(20211800905282).
文摘The intestinal and intratumoral microbiota are closely associated with tumor progression and response to antitumor treatments.The antibacterial or tumor microenvironment(TME)-modulating approaches have been shown to markedly improve antitumor efficacy,strategies focused on normalizing the microbial environment are rarely reported.Here,we reported the development of an orally administered inulin-based hydrogel with colon-targeting and retention effects,containing hollow MnO^(2) nanocarrier loaded with the chemotherapeutic drug Oxa(Oxa@HMI).On the one hand,beneficial bacteria in the colon specifically metabolized Oxa@HMI,resulting in the degradation of inulin and the generation of short-chain fatty acids(SCFAs).These SCFAs play a crucial role in modulating microbiota and stimulating immune responses.On the other hand,the hydrogel matrix underwent colon microbiota-specific degradation,enabling the targeted release of Oxa and production of reactive oxygen species in the acidic TME.In this study,we have established,for the first time,a microbiota-targeted drug delivery system Oxa@HMI that exhibited high efficiency in colorectal cancer targeting and colon retention.Oxa@HMI promoted chemotherapy efficiency and activated antitumor immune responses by intervening in the microbial environment within the tumor tissue,providing a crucial clinical approach for the treatment of colorectal cancer that susceptible to microbial invasion.
基金supported by the China Postdoctoral Science Foundation(No.2024T170869)the National Natural Science Foundation of China(No.22308342)the Fundamental Research Funds for the Central Public-interest Scientific Institution(No.2023YSKY-28).
文摘The soil environment plays a crucial role in agricultural production,safeguarding water resources,and maintaining ecological balance.Additionally,the soil environment can regulate climate through carbon cycling and serves as an essential habitat for the survival of animals and humans.Therefore,a green and healthy soil environment forms the bedrock of sustainable development of biological systems and serves as the basic support for socio-economic progress,thereby affecting the survival of every organism.However,with the advancement of human society and technology,numerous emerging pollutants have gradually been identified.Among these pollutants,perfluorinated compounds(PFASs)are known for their high thermal stability,bioaccumulation potential,and strong biological toxicity.PFASs are complex persistent pollutants that infiltrate soil ecosystems through industrial emissions,agricultural practices,and household waste,posing a significant threat to soil environments as well as human health and receiving considerable attention.However,current research mainly focuses on PFASs pollution in water media,with few reports on its interaction with soil environments.Moreover,due to the diversity and heterogeneity of soil environmental factors,the species diversity of PFASs may affect the different responses between different PFASs(short and long chain types)and soil factors.Elucidating these complex relationships is crucial for developing future treatment technologies to remediate PFASs pollution.Therefore,this paper reviews the impacts of PFASs pollution on soil properties and preliminarily compares the response and effect of various environmental factors,such as pH,organic matter,and microbial communities,to PFASs stress.Furthermore,the paper provides a scientific basis and theoretical insights into the processes,transformation mechanisms,and remediation methods related to soil PFASs pollution.
文摘This paper examines the response of the bandpass filter with Gaussian weighting function to arbitrary two-dimensional fields and proposes a new concept of relative response function.Based on the properties of relative re- sponse function,satisfactory weighting parameters C_1 and C_2 are obtained.By studying two cases,the procedure of us- ing structure function curves to choose the maximum response wavelength is formulated.It is shown that bandpass fil- tering offers some improvements to the analysis and forecast of mesoscale weather processes.
