Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with ca...Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with cardiac neurosis were selected for treatment through acupuncture at PC 6 in combination with respiratory reinforcing and reducing method. With twice per day, treated for 6 days per week, and 4 weeks as one course, the therapeutic effect was assessed after one course. Results Twenty-one cases were cured, 15 cases were remarkably improved, and 2 cases were failed. The total effective rate was 94.7%. Conclusion Acupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis.展开更多
Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision...Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision process is formulated as a Markov decision process(MDP)model to maximize the modularity.Corresponding key partitioning constraints on parallel restoration are considered.Second,based on the partitioning objective and constraints,the reward function of the partitioning MDP model is set by adopting a relative deviation normalization scheme to reduce mutual interference between the reward and penalty in the reward function.The soft bonus scaling mechanism is introduced to mitigate overestimation caused by abrupt jumps in the reward.Then,the deep Q network method is applied to solve the partitioning MDP model and generate partitioning schemes.Two experience replay buffers are employed to speed up the training process of the method.Finally,case studies on the IEEE 39-bus test system demonstrate that the proposed method can generate a high-modularity partitioning result that meets all key partitioning constraints,thereby improving the parallelism and reliability of the restoration process.Moreover,simulation results demonstrate that an appropriate discount factor is crucial for ensuring both the convergence speed and the stability of the partitioning training.展开更多
To study the uncertainty quantification of resonant states in open quantum systems,we developed a Bayesian framework by integrating a reduced basis method(RBM)emulator with the Gamow coupled-channel(GCC)approach.The R...To study the uncertainty quantification of resonant states in open quantum systems,we developed a Bayesian framework by integrating a reduced basis method(RBM)emulator with the Gamow coupled-channel(GCC)approach.The RBM,constructed via eigenvector continuation and trained on both bound and resonant configurations,enables the fast and accurate emulation of resonance properties across the parameter space.To identify the physical resonant states from the emulator’s output,we introduce an overlap-based selection technique that effectively isolates true solutions from background artifacts.By applying this framework to unbound nucleus ^(6)Be,we quantified the model uncertainty in the predicted complex energies.The results demonstrate relative errors of 17.48%in the real part and 8.24%in the imaginary part,while achieving a speedup of four orders of magnitude compared with the full GCC calculations.To further investigate the asymptotic behavior of the resonant-state wavefunctions within the RBM framework,we employed a Lippmann–Schwinger(L–S)-based correction scheme.This approach not only improves the consistency between eigenvalues and wavefunctions but also enables a seamless extension from real-space training data to the complex energy plane.By bridging the gap between bound-state and continuum regimes,the L–S correction significantly enhances the emulator’s capability to accurately capture continuum structures in open quantum systems.展开更多
OBJECTIVE:To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM)might be the central mechanism underlying the action.METHODS:In the study,^(18)F-2-fluo...OBJECTIVE:To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM)might be the central mechanism underlying the action.METHODS:In the study,^(18)F-2-fluoro-deoxy-D-glucose positron emission tomography(18 F-FDG-PET)was employed.Fifity-six spontaneous hypertensive rats(SHRs)were randomly divided into a model group,a single-needle acupuncture(SNA)group,a twirling reinforcing group(SNA+TRF)and a twirling reducing(SNA+TRD)group.Fourteen Wistar rats were assigned to the control group.The acupuncture intervention at Taichong(LR 3)acupoint was administered once daily in the SNA,SNA+TRF and SNA+TRD groups for 14 days,with 1 d interval between the two weeks.The blood pressure(BP)of all rats was measured repeatedly and18 F-FDG-PET scans were conducted on the 14 th day.PET images were processed with Statistical Parametric Mapping 8.0.RESULTS:After the intervention,systolic BP showed a significant decrease in the SNA,SNA+TRF and SNA+TRD versus the model groups(all P<0.01)and in the SNA+TRF and SNA+TRD versus the SNA groups(both P<0.01),with the SNA+TRD group exhibited the best antihypertensive effect(P<0.01).The key brain regions activated by TRRM were mainly concentrated in the cerebellum,hippocampus,hypothalamus,medulla oblongata,insular cortex,midbrain,thalamus and visual cortex.CONCLUTION:TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission.展开更多
To observe the effects of different acupuncture manipulations on blood pressure and target organ damage in spontaneously hypertensive rats（SHRs）, this study used the reinforcing twirling method（1.5–2-mm depth; rot...To observe the effects of different acupuncture manipulations on blood pressure and target organ damage in spontaneously hypertensive rats（SHRs）, this study used the reinforcing twirling method（1.5–2-mm depth; rotating needle clockwise for 360° and then counter clockwise for 360°, with the thumb moving heavily forward and gently backward, 60 times per minute for 1 minute, and retaining needle for 9 minutes）, the reducing twirling method（1.5–2-mm depth; rotating needle counter clockwise for 360° and then clockwise for 360°, with the thumb moving heavily backward and gently forward, 60 times per minute for 1 minute, and retaining needle for 9 minutes）, and the needle retaining method（1.5–2-mm depth and retaining the needle for 10 minutes）. Bilateral Taichong（LR3） was treated by acupuncture using different manipulations and manual stimulation. Reinforcing twirling, reducing twirling, and needle retaining resulted in a decreased number of apoptotic cells, reduced Bax m RNA and protein expression, and an increased Bcl-2/Bax ratio in the hippocampus compared with the SHR group. Among these groups, the Bcl-2/Bax protein ratio was highest in the reducing twirling group, and the Bcl-2/Bax m RNA ratio was highest in the needle retaining group. These results suggest that reinforcing twirling, reducing twirling, and needle retaining methods all improve blood pressure and prevent target organ damage by increasing the hippocampal Bcl-2/Bax ratio and inhibiting cell apoptosis in the hippocampus in SHR.展开更多
In order to study the calculation methods of bending behavior of Chinese reinforced concrete beams from 1912 to 1949, tests on the mechanical performance of 66 rebars from different modem Chinese concrete buildings, t...In order to study the calculation methods of bending behavior of Chinese reinforced concrete beams from 1912 to 1949, tests on the mechanical performance of 66 rebars from different modem Chinese concrete buildings, the concrete compressive strength of 12 modem Chinese concrete buildings, and the concrete cover thickness of 9 modem Chinese concrete buildings are carried out; and the actual material properties and structural conformations of modem Chinese concrete buildings are obtained. Then, the comparison on calculation methods of bending behavior including the original Chinese calculation method, the present Chinese calculation method, the present American calculation method and the present European calculation method is studied. The results show that the original Chinese calculation method of bending behavior is based on the allowable stress calculation method, and the design safety factors are 3.55 to 4. 0. In term of the calculation area of longitudinal rebars of reinforced concrete beams, without considering earthquake action, the original Chinese structural calculation method is safer than the present Chinese structural calculation method, the present European structural calculation method, and the present American structural calculation method. The results can provide support for the structural safety assessments of modem Chinese reinforced concrete buildings.展开更多
Ce^(3+)as the active site on the CeO_(2)abrasive surface is the key to enhancing the material removal rate(MRR).The CeO_(2)abrasives with high chemical activity were prepared by the molten salt method under a reducing...Ce^(3+)as the active site on the CeO_(2)abrasive surface is the key to enhancing the material removal rate(MRR).The CeO_(2)abrasives with high chemical activity were prepared by the molten salt method under a reducing atmosphere.The crystal structure and morphology of CeO_(2)abrasive s were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FT-IR),ultraviolet—visible diffuse reflectance spectroscopy(UV-Vis DRS),and X-ray photoelectron spectroscopy(XPS).The CeO_(2)abrasives were obtained under different atmospheres(Air,Ar,and Ar/H_(2)).With the enhancement of the reducing atmosphere,the morphology of the abrasives transforms from spherical to octahedral,while more oxygen vacancies and Ce^(3+)are generated on the surface of CeO_(2)abrasives.The CMP experiments show that the MRRs of the CeO_(2)-Air,CeO_(2)-Ar,and CeO_(2)-Ar/H_(2)abrasives on SiO_(2)substrates are 337.60,578.74,and 691.28 nm/min,respectively.Moreover,as confirmed by atomic force microscopy(AFM),the substrate surfaces exhibit low roughness(20.5 nm)after being polished using all of the prepared samples.Especially,the MRR of CeO_(2)-Ar/H_(2)abrasives is increased by 104.76%compared with CeO_(2)-air abrasives.The improved CMP performance is attributed to the increased Ce^(3+)concentration and the octahedral morphology of the abrasives enhancing the chemical reaction and mechanical removal at the abrasive-substrate interface.展开更多
In order to study the calculation methods of shear behavior of reinforced concrete beams of Chinese modern reinforced concrete buildings,this paper carried out tests on the concrete compressive strength of 12 Chinese ...In order to study the calculation methods of shear behavior of reinforced concrete beams of Chinese modern reinforced concrete buildings,this paper carried out tests on the concrete compressive strength of 12 Chinese modern concrete buildings,the mechanical properties of 66 rebars from different Chinese modern concrete buildings,and the concrete cover thickness of 9 Chinese modern concrete buildings,and the actual material properties and structural configurations have been obtained. Then,the comparison on calculation methods include the Chinese original calculation method,the Chinese present calculation method,the American present calculation method and the European present calculation method is studied with case analysis method.The results show that the Chinese original calculation method of shear behavior of reinforced concrete beams is based on the allowable stress calculation method,and the design safety factors are 3. 55- 4. 00. The standard value of the compressive strength of concrete cubes is 8. 48 MPa,the standard value of the concrete tensile strength is 1.20 MPa,the standard value of the yield strength of rectangular rebars is 229. 56 MPa,and the standard value of the yield strength of round rebars is 276. 82 MPa. The average value of the concrete cover thickness of beams and columns is 35.96 mm. In term of calculation area of hoop rebars of reinforced concrete beams,without considering earthquake loads,the Chinese original structural calculation method is safer than the Chinese present structural calculation method,but is more unsafe than the American present structural calculation method and the European present structural calculation method. The results can provide the support for structural safety assessments and repair designs of Chinese modern reinforced concrete buildings.展开更多
Tunnel construction is susceptible to accidents such as loosening, deformation, collapse, and water inrush, especiallyunder complex geological conditions like dense fault areas. These accidents can cause instability a...Tunnel construction is susceptible to accidents such as loosening, deformation, collapse, and water inrush, especiallyunder complex geological conditions like dense fault areas. These accidents can cause instability and damageto the tunnel. As a result, it is essential to conduct research on tunnel construction and grouting reinforcementtechnology in fault fracture zones to address these issues and ensure the safety of tunnel excavation projects. Thisstudy utilized the Xianglushan cross-fault tunnel to conduct a comprehensive analysis on the construction, support,and reinforcement of a tunnel crossing a fault fracture zone using the three-dimensional finite element numericalmethod. The study yielded the following research conclusions: The excavation conditions of the cross-fault tunnelarray were analyzed to determine the optimal construction method for excavation while controlling deformationand stress in the surrounding rock. The middle partition method (CD method) was found to be the most suitable.Additionally, the effects of advanced reinforcement grouting on the cross-fault fracture zone tunnel were studied,and the optimal combination of grouting reinforcement range (140°) and grouting thickness (1m) was determined.The stress and deformation data obtained fromon-site monitoring of the surrounding rock was slightly lower thanthe numerical simulation results. However, the change trend of both sets of data was found to be consistent. Theseresearch findings provide technical analysis and data support for the construction and design of cross-fault tunnels.展开更多
The reduced basis methods (RBM) have been demonstrated as a promising numerical technique for statics problems and are extended to structural dynamic problems in this paper. Direct step-by-step integration and mode su...The reduced basis methods (RBM) have been demonstrated as a promising numerical technique for statics problems and are extended to structural dynamic problems in this paper. Direct step-by-step integration and mode superposition are the most widely used methods in the field of the finite element analysis of structural dynamic response and solid mechanics. Herein these two methods are both transformed into reduced forms according to the proposed reduced basis methods. To generate a reduced surrogate model with small size, a greedy algorithm is suggested to construct sample set and reduced basis space adaptively in a prescribed training parameter space. For mode superposition method, the reduced basis space comprises the truncated eigenvectors from generalized eigenvalue problem associated with selected sample parameters. The reduced generalized eigenvalue problem is obtained by the projection of original generalized eigenvalue problem onto the reduced basis space. In the situation of direct integration, the solutions of the original increment formulation corresponding to the sample set are extracted to construct the reduced basis space. The reduced increment formulation is formed by the same method as mode superposition method. Numerical example is given in Section 5 to validate the efficiency of the presented reduced basis methods for structural dynamic problems.展开更多
Current damage detection methods based on model updating and sensitivity Jacobian matrixes show a low convergence ratio and computational efficiency for online calculations.The aim of this paper is to construct a real...Current damage detection methods based on model updating and sensitivity Jacobian matrixes show a low convergence ratio and computational efficiency for online calculations.The aim of this paper is to construct a real-time automated damage detection method by developing a theory-assisted adaptive mutiagent twin delayed deep deterministic(TA2-MATD3)policy gradient algorithm.First,the theoretical framework of reinforcement-learning-driven damage detection is established.To address the disadvantages of traditional mutiagent twin delayed deep deterministic(MATD3)method,the theory-assisted mechanism and the adaptive experience playback mechanism are introduced.Moreover,a historical residential house built in 1889 was taken as an example,using its 12-month structural health monitoring data.TA2-MATD3 was compared with existing damage detection methods in terms of the convergence ratio,online computing efficiency,and damage detection accuracy.The results show that the computational efficiency of TA2-MATD3 is approximately 117–160 times that of the traditional methods.The convergence ratio of damage detection on the training set is approximately 97%,and that on the test set is in the range of 86.2%–91.9%.In addition,the main apparent damages found in the field survey were identified by TA2-MATD3.The results indicate that the proposed method can significantly improve the online computing efficiency and damage detection accuracy.This research can provide novel perspectives for the use of reinforcement learning methods to conduct damage detection in online structural health monitoring.展开更多
During fully mechanized caving mining of thick coal seams,a large amount of strain energy accumulates in the roof,especially when the roof is thick and hard,making it difficultfor the roof to collapse naturally.When t...During fully mechanized caving mining of thick coal seams,a large amount of strain energy accumulates in the roof,especially when the roof is thick and hard,making it difficultfor the roof to collapse naturally.When the roof eventually collapses,the accumulated energy is released instantaneously,exerting a strong impact on the roadway.To address this issue,we proposed the synergistic control method of directional comprehensive pressure relief and energy-absorbing support(PREA)for roadways with hard roofs.In this study,we developed a three-dimensional physical model test apparatus for roof cutting and pressure relief.The 122108 ventilation roadway at the Caojiatan Coal Mine,which has a thick and hard roof,was taken as the engineering example.We analyzed the evolution patterns of stress and displacement in both the stope and the roadway surrounding rocks under different schemes.The PREA reinforcement mechanism for the roadway was investigated through comparative model tests between the new and original methods.The results showed that,compared to the original method,the new method reduced surrounding rock stress by up to 60.4%,and the roadway convergence decreased by up to 52.1%.Based on these results,we proposed corresponding engineering recommendations,which can guide fieldreinforcement design and application.The results demonstrate that the PREA method effectively reduces stress and ensures the safety and stability of the roadway.展开更多
Because the main failure type of a dangerous rock mass is collapse, the treatment of such a mass should focus on controlling collapse failure. When treating dangerous rock masses, disturbing the mass （e. g. by blast...Because the main failure type of a dangerous rock mass is collapse, the treatment of such a mass should focus on controlling collapse failure. When treating dangerous rock masses, disturbing the mass （e. g. by blasting） needs to be avoided, as this new damage could cause collapse. So the self-bearing capacity of the mountain mass must be used to treat the dangerous rock mass. This article is based on a practical example of the control of a dangerous rock mass at Banyan Mountain, Huangshi, Hubei Province. On the basis of an analysis of damage mechanism and the stability of the dangerous rock mass, a flexible network reinforcement method was designed to prevent the collapse of the rock mass. The deformations of section Ⅱ w of the dangerous rock mass before and after the flexible network reinforcement were calculated using the two-dimensional finite element method. The results show that the maximum deformation reduced by 55 % after the application of the flexible network reinforcement, from 45.99 to 20.75 ram, which demonstrates that the flexible network method is effective, and can provide some scientific basis for the treatment of dangerous rock masses.展开更多
The fracture toughness (KIC) values determined by indentation microfracture method (IM ) for SiC whisker reinforced Al2O3 and ZrO2 based composites were calculated with different IM equations and compared with those o...The fracture toughness (KIC) values determined by indentation microfracture method (IM ) for SiC whisker reinforced Al2O3 and ZrO2 based composites were calculated with different IM equations and compared with those obtained by singte edge notched beam (SENB) technique. Experimental results show that the KIC (IM) values calculated with different equations are quite different one from another. For composites without phase transformable components the KIC (IM) and KIC (SENB) values are practically on the same level, but for composites with phase transformable components (partially stabilized zirconia) the KIC (SENB) values are always higher than KIC (IM). This is because that the IM method can not reveal sensitively the toughening effect due to dynamic t-m transformation of ZrO2 as the SENB method does. The accuracy of the IM method depends on the Suitability of the IM equations and was evaluated for the materials used in this investigation. Two new IM equations are suggested with which the KIC (IM ) values can be obtained very close to KIC (SENB) values for composites having phase transformable components.展开更多
In this experiment, the contents of serum total cholesterol (TC), triglyceride(TG),low-density lipoprotein(LDL), high-density lipoprotein(HDL) were used as indexes to observe the effects of warming-reinforcing method ...In this experiment, the contents of serum total cholesterol (TC), triglyceride(TG),low-density lipoprotein(LDL), high-density lipoprotein(HDL) were used as indexes to observe the effects of warming-reinforcing method on rabbit’s lipide, liopoprotein. The results indicated that in the warming-reinforcing group, TC decreased markedly and HDL increased obviously with significant difference as compared with the twirling-reinforcing group:TC and LDL also decreased, but no significant differencte as compared with the twirling-reinforcing group. Warming-reinforcing method can decrease lipids more effectively than twirling-reinforcing method.展开更多
The Trefftz-type boundary solution methods([1]) are applied in analysing moderately thick plate bending problems. A new type of locking problem caused by the overflow of Trefftz functions has been found and a so-calle...The Trefftz-type boundary solution methods([1]) are applied in analysing moderately thick plate bending problems. A new type of locking problem caused by the overflow of Trefftz functions has been found and a so-called variable-reducing procedure for eliminating such a phenomenon is also proposed.展开更多
Based on the hybrid numerical method (HNM) combining with a reduced-basis method (RBM), the real-time transient response of a functionally graded material (FGM) plates is obtained. The large eigenvalue problem in wave...Based on the hybrid numerical method (HNM) combining with a reduced-basis method (RBM), the real-time transient response of a functionally graded material (FGM) plates is obtained. The large eigenvalue problem in wavenumber domain has been solved through real-time off-line/on-line calculation. At off-line stage, a reduced-basis space is constructed in sample wavenumbers according to the solved eigenvalue problems. The matrices independent of parameters are projected onto the reduced-basis spaces. At on-line stage, the reduced eigenvalue problems of the arbitrary wavenumbers are built. Subsequently, the responses in wavenumber domain are obtained by the approximated eigen-pairs. Because of the application of RBM, the computational cost of transient displacement analysis of FGM plate is decreased significantly, while the accuracy of the solution and the physics of the structure are still retained. The efficiency and validity of the proposed method are demonstrated through a numerical example.展开更多
文摘Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with cardiac neurosis were selected for treatment through acupuncture at PC 6 in combination with respiratory reinforcing and reducing method. With twice per day, treated for 6 days per week, and 4 weeks as one course, the therapeutic effect was assessed after one course. Results Twenty-one cases were cured, 15 cases were remarkably improved, and 2 cases were failed. The total effective rate was 94.7%. Conclusion Acupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis.
基金funded by the Beijing Engineering Research Center of Electric Rail Transportation.
文摘Effective partitioning is crucial for enabling parallel restoration of power systems after blackouts.This paper proposes a novel partitioning method based on deep reinforcement learning.First,the partitioning decision process is formulated as a Markov decision process(MDP)model to maximize the modularity.Corresponding key partitioning constraints on parallel restoration are considered.Second,based on the partitioning objective and constraints,the reward function of the partitioning MDP model is set by adopting a relative deviation normalization scheme to reduce mutual interference between the reward and penalty in the reward function.The soft bonus scaling mechanism is introduced to mitigate overestimation caused by abrupt jumps in the reward.Then,the deep Q network method is applied to solve the partitioning MDP model and generate partitioning schemes.Two experience replay buffers are employed to speed up the training process of the method.Finally,case studies on the IEEE 39-bus test system demonstrate that the proposed method can generate a high-modularity partitioning result that meets all key partitioning constraints,thereby improving the parallelism and reliability of the restoration process.Moreover,simulation results demonstrate that an appropriate discount factor is crucial for ensuring both the convergence speed and the stability of the partitioning training.
基金supported by the National Key Research and Development Program(MOST 2023YFA1606404 and MOST 2022YFA1602303)the National Natural Science Foundation of China(Nos.12347106,12147101,and 12447122)the China Postdoctoral Science Foundation(No.2024M760489).
文摘To study the uncertainty quantification of resonant states in open quantum systems,we developed a Bayesian framework by integrating a reduced basis method(RBM)emulator with the Gamow coupled-channel(GCC)approach.The RBM,constructed via eigenvector continuation and trained on both bound and resonant configurations,enables the fast and accurate emulation of resonance properties across the parameter space.To identify the physical resonant states from the emulator’s output,we introduce an overlap-based selection technique that effectively isolates true solutions from background artifacts.By applying this framework to unbound nucleus ^(6)Be,we quantified the model uncertainty in the predicted complex energies.The results demonstrate relative errors of 17.48%in the real part and 8.24%in the imaginary part,while achieving a speedup of four orders of magnitude compared with the full GCC calculations.To further investigate the asymptotic behavior of the resonant-state wavefunctions within the RBM framework,we employed a Lippmann–Schwinger(L–S)-based correction scheme.This approach not only improves the consistency between eigenvalues and wavefunctions but also enables a seamless extension from real-space training data to the complex energy plane.By bridging the gap between bound-state and continuum regimes,the L–S correction significantly enhances the emulator’s capability to accurately capture continuum structures in open quantum systems.
基金Supported by the National Natural Science Foundation of China(Use PET Brain Imaging Technology to Study the Acupuncture Manipulation of Twirling Reinforcing-Reducing Regulation in Spontaneously Hypertensive Rats by Central Integration Signaling Network Construction,No.8157150840)
文摘OBJECTIVE:To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM)might be the central mechanism underlying the action.METHODS:In the study,^(18)F-2-fluoro-deoxy-D-glucose positron emission tomography(18 F-FDG-PET)was employed.Fifity-six spontaneous hypertensive rats(SHRs)were randomly divided into a model group,a single-needle acupuncture(SNA)group,a twirling reinforcing group(SNA+TRF)and a twirling reducing(SNA+TRD)group.Fourteen Wistar rats were assigned to the control group.The acupuncture intervention at Taichong(LR 3)acupoint was administered once daily in the SNA,SNA+TRF and SNA+TRD groups for 14 days,with 1 d interval between the two weeks.The blood pressure(BP)of all rats was measured repeatedly and18 F-FDG-PET scans were conducted on the 14 th day.PET images were processed with Statistical Parametric Mapping 8.0.RESULTS:After the intervention,systolic BP showed a significant decrease in the SNA,SNA+TRF and SNA+TRD versus the model groups(all P<0.01)and in the SNA+TRF and SNA+TRD versus the SNA groups(both P<0.01),with the SNA+TRD group exhibited the best antihypertensive effect(P<0.01).The key brain regions activated by TRRM were mainly concentrated in the cerebellum,hippocampus,hypothalamus,medulla oblongata,insular cortex,midbrain,thalamus and visual cortex.CONCLUTION:TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission.
基金supported by the National Natural Science Foundation of China,No.81072861,81373727
文摘To observe the effects of different acupuncture manipulations on blood pressure and target organ damage in spontaneously hypertensive rats（SHRs）, this study used the reinforcing twirling method（1.5–2-mm depth; rotating needle clockwise for 360° and then counter clockwise for 360°, with the thumb moving heavily forward and gently backward, 60 times per minute for 1 minute, and retaining needle for 9 minutes）, the reducing twirling method（1.5–2-mm depth; rotating needle counter clockwise for 360° and then clockwise for 360°, with the thumb moving heavily backward and gently forward, 60 times per minute for 1 minute, and retaining needle for 9 minutes）, and the needle retaining method（1.5–2-mm depth and retaining the needle for 10 minutes）. Bilateral Taichong（LR3） was treated by acupuncture using different manipulations and manual stimulation. Reinforcing twirling, reducing twirling, and needle retaining resulted in a decreased number of apoptotic cells, reduced Bax m RNA and protein expression, and an increased Bcl-2/Bax ratio in the hippocampus compared with the SHR group. Among these groups, the Bcl-2/Bax protein ratio was highest in the reducing twirling group, and the Bcl-2/Bax m RNA ratio was highest in the needle retaining group. These results suggest that reinforcing twirling, reducing twirling, and needle retaining methods all improve blood pressure and prevent target organ damage by increasing the hippocampal Bcl-2/Bax ratio and inhibiting cell apoptosis in the hippocampus in SHR.
基金The National Natural Science Foundation of China(No.51138002)the Foundation for the Author of National Excellent Doctoral Dissertation of PR China(No.201452)the Open Fund of Shanghai Key Laboratory of Engineering Structure Safety(No.2015-KF06)
文摘In order to study the calculation methods of bending behavior of Chinese reinforced concrete beams from 1912 to 1949, tests on the mechanical performance of 66 rebars from different modem Chinese concrete buildings, the concrete compressive strength of 12 modem Chinese concrete buildings, and the concrete cover thickness of 9 modem Chinese concrete buildings are carried out; and the actual material properties and structural conformations of modem Chinese concrete buildings are obtained. Then, the comparison on calculation methods of bending behavior including the original Chinese calculation method, the present Chinese calculation method, the present American calculation method and the present European calculation method is studied. The results show that the original Chinese calculation method of bending behavior is based on the allowable stress calculation method, and the design safety factors are 3.55 to 4. 0. In term of the calculation area of longitudinal rebars of reinforced concrete beams, without considering earthquake action, the original Chinese structural calculation method is safer than the present Chinese structural calculation method, the present European structural calculation method, and the present American structural calculation method. The results can provide support for the structural safety assessments of modem Chinese reinforced concrete buildings.
基金the National Natural Science Foundation of China(51905324)the Scientific Research Program Funded by Shaanxi Provincial Education Department(20JK0545)the Doctoral Scientific Research Startup Foundation of Shaanxi University of Science and Technology(2018BJ-14)。
文摘Ce^(3+)as the active site on the CeO_(2)abrasive surface is the key to enhancing the material removal rate(MRR).The CeO_(2)abrasives with high chemical activity were prepared by the molten salt method under a reducing atmosphere.The crystal structure and morphology of CeO_(2)abrasive s were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FT-IR),ultraviolet—visible diffuse reflectance spectroscopy(UV-Vis DRS),and X-ray photoelectron spectroscopy(XPS).The CeO_(2)abrasives were obtained under different atmospheres(Air,Ar,and Ar/H_(2)).With the enhancement of the reducing atmosphere,the morphology of the abrasives transforms from spherical to octahedral,while more oxygen vacancies and Ce^(3+)are generated on the surface of CeO_(2)abrasives.The CMP experiments show that the MRRs of the CeO_(2)-Air,CeO_(2)-Ar,and CeO_(2)-Ar/H_(2)abrasives on SiO_(2)substrates are 337.60,578.74,and 691.28 nm/min,respectively.Moreover,as confirmed by atomic force microscopy(AFM),the substrate surfaces exhibit low roughness(20.5 nm)after being polished using all of the prepared samples.Especially,the MRR of CeO_(2)-Ar/H_(2)abrasives is increased by 104.76%compared with CeO_(2)-air abrasives.The improved CMP performance is attributed to the increased Ce^(3+)concentration and the octahedral morphology of the abrasives enhancing the chemical reaction and mechanical removal at the abrasive-substrate interface.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51138002)a Foundation for the Author of National Excellent Doctoral Dissertation of PR China(Grant No.201452)
文摘In order to study the calculation methods of shear behavior of reinforced concrete beams of Chinese modern reinforced concrete buildings,this paper carried out tests on the concrete compressive strength of 12 Chinese modern concrete buildings,the mechanical properties of 66 rebars from different Chinese modern concrete buildings,and the concrete cover thickness of 9 Chinese modern concrete buildings,and the actual material properties and structural configurations have been obtained. Then,the comparison on calculation methods include the Chinese original calculation method,the Chinese present calculation method,the American present calculation method and the European present calculation method is studied with case analysis method.The results show that the Chinese original calculation method of shear behavior of reinforced concrete beams is based on the allowable stress calculation method,and the design safety factors are 3. 55- 4. 00. The standard value of the compressive strength of concrete cubes is 8. 48 MPa,the standard value of the concrete tensile strength is 1.20 MPa,the standard value of the yield strength of rectangular rebars is 229. 56 MPa,and the standard value of the yield strength of round rebars is 276. 82 MPa. The average value of the concrete cover thickness of beams and columns is 35.96 mm. In term of calculation area of hoop rebars of reinforced concrete beams,without considering earthquake loads,the Chinese original structural calculation method is safer than the Chinese present structural calculation method,but is more unsafe than the American present structural calculation method and the European present structural calculation method. The results can provide the support for structural safety assessments and repair designs of Chinese modern reinforced concrete buildings.
基金the Postgraduate Research and Practice Innovation Program of Jiangsu Province(Grant No.KYCX22_0621)the National Natural Science Foundation of China(Grant No.52209130)Jiangsu Funding Program for Excellent Postdoctoral Talent.
文摘Tunnel construction is susceptible to accidents such as loosening, deformation, collapse, and water inrush, especiallyunder complex geological conditions like dense fault areas. These accidents can cause instability and damageto the tunnel. As a result, it is essential to conduct research on tunnel construction and grouting reinforcementtechnology in fault fracture zones to address these issues and ensure the safety of tunnel excavation projects. Thisstudy utilized the Xianglushan cross-fault tunnel to conduct a comprehensive analysis on the construction, support,and reinforcement of a tunnel crossing a fault fracture zone using the three-dimensional finite element numericalmethod. The study yielded the following research conclusions: The excavation conditions of the cross-fault tunnelarray were analyzed to determine the optimal construction method for excavation while controlling deformationand stress in the surrounding rock. The middle partition method (CD method) was found to be the most suitable.Additionally, the effects of advanced reinforcement grouting on the cross-fault fracture zone tunnel were studied,and the optimal combination of grouting reinforcement range (140°) and grouting thickness (1m) was determined.The stress and deformation data obtained fromon-site monitoring of the surrounding rock was slightly lower thanthe numerical simulation results. However, the change trend of both sets of data was found to be consistent. Theseresearch findings provide technical analysis and data support for the construction and design of cross-fault tunnels.
文摘The reduced basis methods (RBM) have been demonstrated as a promising numerical technique for statics problems and are extended to structural dynamic problems in this paper. Direct step-by-step integration and mode superposition are the most widely used methods in the field of the finite element analysis of structural dynamic response and solid mechanics. Herein these two methods are both transformed into reduced forms according to the proposed reduced basis methods. To generate a reduced surrogate model with small size, a greedy algorithm is suggested to construct sample set and reduced basis space adaptively in a prescribed training parameter space. For mode superposition method, the reduced basis space comprises the truncated eigenvectors from generalized eigenvalue problem associated with selected sample parameters. The reduced generalized eigenvalue problem is obtained by the projection of original generalized eigenvalue problem onto the reduced basis space. In the situation of direct integration, the solutions of the original increment formulation corresponding to the sample set are extracted to construct the reduced basis space. The reduced increment formulation is formed by the same method as mode superposition method. Numerical example is given in Section 5 to validate the efficiency of the presented reduced basis methods for structural dynamic problems.
基金supported by National Key Research and Development Program of China(2023YFF0906100)National Natural Science Foundation of China(52408008)Key Research and Development Program of Jiangsu Province(BE2022833).
文摘Current damage detection methods based on model updating and sensitivity Jacobian matrixes show a low convergence ratio and computational efficiency for online calculations.The aim of this paper is to construct a real-time automated damage detection method by developing a theory-assisted adaptive mutiagent twin delayed deep deterministic(TA2-MATD3)policy gradient algorithm.First,the theoretical framework of reinforcement-learning-driven damage detection is established.To address the disadvantages of traditional mutiagent twin delayed deep deterministic(MATD3)method,the theory-assisted mechanism and the adaptive experience playback mechanism are introduced.Moreover,a historical residential house built in 1889 was taken as an example,using its 12-month structural health monitoring data.TA2-MATD3 was compared with existing damage detection methods in terms of the convergence ratio,online computing efficiency,and damage detection accuracy.The results show that the computational efficiency of TA2-MATD3 is approximately 117–160 times that of the traditional methods.The convergence ratio of damage detection on the training set is approximately 97%,and that on the test set is in the range of 86.2%–91.9%.In addition,the main apparent damages found in the field survey were identified by TA2-MATD3.The results indicate that the proposed method can significantly improve the online computing efficiency and damage detection accuracy.This research can provide novel perspectives for the use of reinforcement learning methods to conduct damage detection in online structural health monitoring.
基金supported by the National Natural Science Foundation of China(Grant Nos.U24A2088 and 42277174)the Fundamental Research Funds for the Central Universities,China(Grant No.2024JCCXSB01).
文摘During fully mechanized caving mining of thick coal seams,a large amount of strain energy accumulates in the roof,especially when the roof is thick and hard,making it difficultfor the roof to collapse naturally.When the roof eventually collapses,the accumulated energy is released instantaneously,exerting a strong impact on the roadway.To address this issue,we proposed the synergistic control method of directional comprehensive pressure relief and energy-absorbing support(PREA)for roadways with hard roofs.In this study,we developed a three-dimensional physical model test apparatus for roof cutting and pressure relief.The 122108 ventilation roadway at the Caojiatan Coal Mine,which has a thick and hard roof,was taken as the engineering example.We analyzed the evolution patterns of stress and displacement in both the stope and the roadway surrounding rocks under different schemes.The PREA reinforcement mechanism for the roadway was investigated through comparative model tests between the new and original methods.The results showed that,compared to the original method,the new method reduced surrounding rock stress by up to 60.4%,and the roadway convergence decreased by up to 52.1%.Based on these results,we proposed corresponding engineering recommendations,which can guide fieldreinforcement design and application.The results demonstrate that the PREA method effectively reduces stress and ensures the safety and stability of the roadway.
文摘Because the main failure type of a dangerous rock mass is collapse, the treatment of such a mass should focus on controlling collapse failure. When treating dangerous rock masses, disturbing the mass （e. g. by blasting） needs to be avoided, as this new damage could cause collapse. So the self-bearing capacity of the mountain mass must be used to treat the dangerous rock mass. This article is based on a practical example of the control of a dangerous rock mass at Banyan Mountain, Huangshi, Hubei Province. On the basis of an analysis of damage mechanism and the stability of the dangerous rock mass, a flexible network reinforcement method was designed to prevent the collapse of the rock mass. The deformations of section Ⅱ w of the dangerous rock mass before and after the flexible network reinforcement were calculated using the two-dimensional finite element method. The results show that the maximum deformation reduced by 55 % after the application of the flexible network reinforcement, from 45.99 to 20.75 ram, which demonstrates that the flexible network method is effective, and can provide some scientific basis for the treatment of dangerous rock masses.
文摘The fracture toughness (KIC) values determined by indentation microfracture method (IM ) for SiC whisker reinforced Al2O3 and ZrO2 based composites were calculated with different IM equations and compared with those obtained by singte edge notched beam (SENB) technique. Experimental results show that the KIC (IM) values calculated with different equations are quite different one from another. For composites without phase transformable components the KIC (IM) and KIC (SENB) values are practically on the same level, but for composites with phase transformable components (partially stabilized zirconia) the KIC (SENB) values are always higher than KIC (IM). This is because that the IM method can not reveal sensitively the toughening effect due to dynamic t-m transformation of ZrO2 as the SENB method does. The accuracy of the IM method depends on the Suitability of the IM equations and was evaluated for the materials used in this investigation. Two new IM equations are suggested with which the KIC (IM ) values can be obtained very close to KIC (SENB) values for composites having phase transformable components.
文摘In this experiment, the contents of serum total cholesterol (TC), triglyceride(TG),low-density lipoprotein(LDL), high-density lipoprotein(HDL) were used as indexes to observe the effects of warming-reinforcing method on rabbit’s lipide, liopoprotein. The results indicated that in the warming-reinforcing group, TC decreased markedly and HDL increased obviously with significant difference as compared with the twirling-reinforcing group:TC and LDL also decreased, but no significant differencte as compared with the twirling-reinforcing group. Warming-reinforcing method can decrease lipids more effectively than twirling-reinforcing method.
基金National Natural Science Foundation of China(No.19872019)Solid Mechanics Open Research laboratory of Tongji University
文摘The Trefftz-type boundary solution methods([1]) are applied in analysing moderately thick plate bending problems. A new type of locking problem caused by the overflow of Trefftz functions has been found and a so-called variable-reducing procedure for eliminating such a phenomenon is also proposed.
文摘Based on the hybrid numerical method (HNM) combining with a reduced-basis method (RBM), the real-time transient response of a functionally graded material (FGM) plates is obtained. The large eigenvalue problem in wavenumber domain has been solved through real-time off-line/on-line calculation. At off-line stage, a reduced-basis space is constructed in sample wavenumbers according to the solved eigenvalue problems. The matrices independent of parameters are projected onto the reduced-basis spaces. At on-line stage, the reduced eigenvalue problems of the arbitrary wavenumbers are built. Subsequently, the responses in wavenumber domain are obtained by the approximated eigen-pairs. Because of the application of RBM, the computational cost of transient displacement analysis of FGM plate is decreased significantly, while the accuracy of the solution and the physics of the structure are still retained. The efficiency and validity of the proposed method are demonstrated through a numerical example.
