A slurry-phase carbonation technique was utilized,employing argon oxygen decarburization slag(AOD slag)as a source of calcium and MgCl_(2) as a regulator for the crystal morphology of acicular aragonite.Subsequently,t...A slurry-phase carbonation technique was utilized,employing argon oxygen decarburization slag(AOD slag)as a source of calcium and MgCl_(2) as a regulator for the crystal morphology of acicular aragonite.Subsequently,the carbonated AOD slag,enriched with acicular aragonite,was employed in fabricating composite cementitious materials,followed by an analysis of their evolution in hydration heat,hydration products,and microscopic morphology.Additionally,it delved into the mechanism through which acicular aragonite enhances the stength of composite cementitious materials.Moreover,advanced simulation software for engineering and sciences(ABAQUS)was utilized to simulate the compressive performance of composite mortar with varying dosages of acicular aragonite.The findings demonstrate that the carbonated AOD slag,containing 83.4%acicular aragonite(with an average aspect ratio of 21.31),exhibited commendable compatibility with cement.Moderate integration of carbonated AOD slag facilitated the formation of calcium sulfoaluminate hydrate(AFt)phases.The acicular aragonite within the cementitious matrix showcased remarkable filling effects.As the dosage of carbonated AOD slag increased,flexural and compressive strengths of cement mortar initially rose before declining.Upon reaching a 6%cement inclusion of carbonated AOD slag,the various constituents of the cementitious material displayed optimal synergy.The numerical simulation results confirmed the experimental findings,demonstrating a favorable increase in compressive strength and flexural strength with the addition of acicular aragonite.The acicular aragonite strengthened the matrix by serving bridging and pull-out functions.展开更多
The crevice corrosion of the reinforcing steel in the carbonated simulated concrete pore solutions(SCPSs)containing 0.04 mol/L chloride was investigated.In comparison,the steel without crevice covered on its surface w...The crevice corrosion of the reinforcing steel in the carbonated simulated concrete pore solutions(SCPSs)containing 0.04 mol/L chloride was investigated.In comparison,the steel without crevice covered on its surface was also studied.Results showed that the crevice corrosion in the uncarbonated SCPS was not triggered and the steel remained passivity by suppressing the anodic dissolution in the crevice interior.As SCPS was carbonated to have pH values of 10.5 and 11.5,the crevice corrosion was easier to be activated than the widely reported pitting corrosion owing to the rapid oxygen depletion within the crevice,but the crevice corrosion damage might be alleviated to a certain extent due to the relative compact surface film formed inside the crevice.The further carbonation led to the activation dissolution of both the crevice interior and exterior,causing the more serious corrosion damage.Corrosion process of the crevice corrosion was systematically analyzed by combining the electrochemical measurement results and Evens polarization diagram.展开更多
BACKGROUND Anastomotic leakage(AL)is a challenging complication following rectal cancer surgery,often leading to increased morbidity and healthcare costs.The use of reinforcement sutures is expected to reduce the rate...BACKGROUND Anastomotic leakage(AL)is a challenging complication following rectal cancer surgery,often leading to increased morbidity and healthcare costs.The use of reinforcement sutures is expected to reduce the rate of AL,their preventive effects are controversial.AIM To determine the efficacy of reinforcing sutures in preventing AL in rectal cancer.METHODS A systematic search of major medical databases was conducted to identify studies up to June 2024.Intraoperative and postoperative outcomes were assessed;the primary outcome assessed was the incidence of AL.Pooled odds ratios(ORs)and mean differences(MDs)with a 95%confidence interval(CI)were calculated using fixed-effect or random-effect models under heterogeneity.RESULTS This meta-analysis incorporated 20 studies involving 3726 patients.Pooled results demonstrated a statistically significant reduction AL incidence in the reinforced suture group(OR:0.26,95%CI:0.19-0.35,P<0.001)than the unreinforced suture group.The reinforced suture group also exhibited a shorter hospital stay(MD:-1.17,95%CI:-1.78 to-0.57,P<0.001),earlier anal exhaust(MD:-0.13,95%CI:-0.22 to-0.05,P=0.002),longer operative time(MD:15.25,95%CI:10.71-19.80,P<0.001),lower infection rate(OR:0.54,95%CI:0.29-1.00,P=0.05)and lower reoperation rate(OR:0.19,95%CI:0.08-0.45,P<0.001).CONCLUSION The results substantiate the clinical value of anastomotic reinforcement sutures in reducing AL incidence postrectal cancer surgery.Nevertheless,these conclusions warrant verification through additional high-quality randomized controlled trials.展开更多
Objective To evaluate the effectiveness and safety of the tonifying spleen and reinforcing Qi(TSRQ)therapy combined with thyroid hormone replacement therapy(THRT)for treating Hashimoto’s hypothyroidism.Methods From d...Objective To evaluate the effectiveness and safety of the tonifying spleen and reinforcing Qi(TSRQ)therapy combined with thyroid hormone replacement therapy(THRT)for treating Hashimoto’s hypothyroidism.Methods From database foundation to January 14,2025,PubMed,Web of Science,Cochrane,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data,China Science and Technology Journal Database(VIP),and China Biomedical Literature Database(CBM)were searched for relevant information.Randomized clinical trials(RCTs)evaluating the efficacy and safety of TSRQ therapy combined with THRT for Hashimoto’s hypothyroidism were eligible for inclusion.Following quality assessment,data were analyzed using Stata 15.1 to conduct a meta-analysis and systematic review.Subgroup analysis was used to identify the sources of heterogeneity.The Grading of Recommendations Assessment,Development and Evaluation(GRADE)system was adopted to evaluate the certainty of the evidence.Results This study included 30 RCTs,comprising 2687 patients with Hashimoto’s hypothyroidism.Overall methodological quality was acceptable,with no studies exhibiting a high risk of bias.Meta-analysis demonstrated that TSRQ therapy combined with THRT significantly enhanced serum free triiodothyronine(fT3)levels[standardized mean difference(SMD)=0.76,95%confidence interval(CI):0.57 to 0.94,P<0.001]and free thyroxine(fT4)levels(SMD=0.86,95%CI:0.61 to 1.11,P<0.001),while reducing thyroid-stimulating hormone(TSH)levels(SMD=–0.99,95%CI:–1.20 to–0.78,P<0.001)compared with THRT alone.Furthermore,the combination therapy significantly decreased anti-thyroid peroxidase antibody(TPOAb)levels(SMD=–1.46,95%CI:–1.79 to–1.13,P<0.001)and anti-thyroglobulin antibody(TgAb)levels(SMD=–1.46,95%CI:–1.80 to–1.11,P<0.001).TSRQ therapy did not adversely impact the safety profile of THRT.However,while some sources of heterogeneity have been identified(e.g.,specific detection methodologies,I²=0.0%,P=0.938),there remains a portion of unexplained heterogeneity(e.g.,publication year,I²=93.4%,P<0.001),which has undermined confidence in these pooled estimates.The evidence ratings for fT3,fT4,and TSH were limited,and those for TPOAb and TgAb were even more limited.Conclusion TSRQ therapy combined with THRT may strengthen thyroid function and modulate immune dysregulation in patients with Hashimoto’s hypothyroidism without increasing adverse event incidence.展开更多
High porosity and high brittleness are the main reasons that limit the long-term service life of the alumina-titanium oxide composite coating.Herein,a metastable nanostructured aluminatitanium oxide composite coating ...High porosity and high brittleness are the main reasons that limit the long-term service life of the alumina-titanium oxide composite coating.Herein,a metastable nanostructured aluminatitanium oxide composite coating with high density and high properties was synthesized by plasma spraying of TiO_(2)-Al composite powder.The main phases of the metastable nanostructured alumina-titanium oxide wereγ-Al_(2)O_(3),TiO and AlTiO_(2).The coating,as prepared,contains various metastable microstructures,such as fine-grained,intra-/inter-granular,and"self-locking"microstructures.These metastable microstruc-tures are important for the improvement of hardness and toughness of the coating.Compared with other alumina-based composite coatings,the metastable nanostructured aluminatitanium oxide composite coating showed the most impressive overall performance.The reinforcing and toughening mechanism of the metastable alumina-titanium oxide composite coating included fine grain strengthening and self-toughening of the metastable microstructure.展开更多
The mineralization process of microbial-induced calcium carbonate precipitation(MICP)is influenced by many factors,and the uniformity of the calcium carbonate precipitation has become the main focus and challenge for ...The mineralization process of microbial-induced calcium carbonate precipitation(MICP)is influenced by many factors,and the uniformity of the calcium carbonate precipitation has become the main focus and challenge for MICP technology.In this study,the uniformity of the saturated calcareous sand treated with MICP was in-vestigated through one-dimensional calcareous sand column tests and model tests.The coefficient of variation was employed in one-dimensional sand column tests to investigate the impact of injection rate,cementation solution concentration,and number of injection cycles on the uniformity of the MICP treatment.Additionally,model tests were conducted to investigate the impact of injection pressure and methods on the treatment range and uniformity under three-dimensional seepage conditions.Test results demonstrate that the reinforcement strength and uniformity are significantly influenced by the injection rate of the cementation solution,with a rate of 3 mL/min,yielding a favorable treatment effect.Excessive concentration of the cementation solution can lead to significant non-uniformity and a reduction in the compressive strength of MICP-treated samples.Conversely,excessively low concentrations may result in decreased bonding efficiency.Among the four considered con-centrations,0.5 mol/L and 1 mol/L exhibit superior reinforcing effects.The morphological development of calcareous sandy foundation reinforcement is associated with the spatial distribution pattern of the bacterial solution,exhibiting a relatively larger reinforcement area in proximity to the lower region of the model and a gradually decreasing range towards the upper part.Under three-dimensional seepage conditions,in addition to the non-uniform radial cementation along the injection pipe,there is also vertical heterogeneity of cementation along the length of the injection pipe due to gravitational effects,resulting in preferential deposition of calcium carbonate at the lower section,The application of injection pressure and a double-pipe circulation injection method can mitigate the accumulation of bacterial solution and cementation solution at the bottom,thereby improving the reinforcement range and uniformity.展开更多
Most researches associated with target encircling control are focused on moving along a circular orbit under an ideal environment free from external disturbances.However,elliptical encirclement with a time-varying obs...Most researches associated with target encircling control are focused on moving along a circular orbit under an ideal environment free from external disturbances.However,elliptical encirclement with a time-varying observation radius,may permit a more flexible and high-efficacy enclosing solution,whilst the non-orthogonal property between axial and tangential speed components,non-ignorable environmental perturbations,and strict assignment requirements empower elliptical encircling control to be more challenging,and the relevant investigations are still open.Following this line,an appointed-time elliptical encircling control rule capable of reinforcing circumnavigation performances is developed to enable Unmanned Aerial Vehicles(UAVs)to move along a specified elliptical path within a predetermined reaching time.The remarkable merits of the designed strategy are that the relative distance controlling error can be guaranteed to evolve within specified regions with a designer-specified convergence behavior.Meanwhile,wind perturbations can be online counteracted based on an unknown system dynamics estimator(USDE)with only one regulating parameter and high computational efficiency.Lyapunov tool demonstrates that all involved error variables are ultimately limited,and simulations are implemented to confirm the usability of the suggested control algorithm.展开更多
OBJECTIVE:To compare the efficacy of modified treatments based on "kidney reinforcing" in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and e...OBJECTIVE:To compare the efficacy of modified treatments based on "kidney reinforcing" in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),"kidney reinforcing and Qi tonifying"(KQ),and "kidney reinforcing and blood circulation invigorating"(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery.展开更多
Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with ca...Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with cardiac neurosis were selected for treatment through acupuncture at PC 6 in combination with respiratory reinforcing and reducing method. With twice per day, treated for 6 days per week, and 4 weeks as one course, the therapeutic effect was assessed after one course. Results Twenty-one cases were cured, 15 cases were remarkably improved, and 2 cases were failed. The total effective rate was 94.7%. Conclusion Acupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis.展开更多
For preventing and curing the rupture disaster of shaft lining effectively, according to the additional force theory of shaft lining fracture, more than forty tests were carried out on the large scale test rig on the ...For preventing and curing the rupture disaster of shaft lining effectively, according to the additional force theory of shaft lining fracture, more than forty tests were carried out on the large scale test rig on the basis of simulating theory. The influence of the position of aquifer, the reinforcing scope of aquifer, reinforcing distance and the strength of grouting cemented mixture on the value and variation law of the axial additional force on shaft lining is studied. The relationships between the reinforcing parameters and the axial additional force on shaft lining are obtained, which provides the theoretic foundation and construction design parameters for the method of reinforcing strata by grouting to prevent and cure tbe rupture disaster of shart lining.展开更多
Carbon fiber reinforced carbon composites(C/Cs),are the most promising high-temperature materials and could be widely applied in aerospace and nucleation fields,owing to their superior performances.However,C/Cs are ve...Carbon fiber reinforced carbon composites(C/Cs),are the most promising high-temperature materials and could be widely applied in aerospace and nucleation fields,owing to their superior performances.However,C/Cs are very susceptible to destructive oxidation and thus fail at elevated temperatures.Though matrix modification and coating technologies with Si-based and ultra-high temperature ceramics(UHTCs)are valid to enhance the oxidation/ablation resistance of C/Cs,it’s not sufficient to satisfy the increasing practical applications,due to the inherent brittleness of ceramics,mismatch issues between coatings and C/C substrates,and the fact that carbonaceous matrices are easily prone to high-temperature oxidation.To effectively solve the aforementioned problems,micro/nano multiscale reinforcing strategies have been developed for C/Cs and/or the coatings over the past two decades,to fabricate C/Cs with high strength and excellent high-temperature stability.This review is to systematically summarize the most recent major and important advancements in some micro/nano multiscale strategies,including nanoparticles,nanowires,carbon nanotubes/fibers,whiskers,graphene,ceramic fibers and hybrid micro/nano structures,for C/Cs and/or the coatings,to achieve high-temperature oxidation/ablation-resistant C/Cs.Finally,this review is concluded with an outlook of major unsolved problems,challenges to be met and future research advice for C/Cs with excellent comprehensive mechanical-thermal performance.It’s hoped that a better understanding of this review will be of high scientific and industrial interest,since it provides unusual and feasible new ideas to develop potential and practical C/Cs with improved high-temperature mechanical and oxidation/ablation-resistant properties.展开更多
Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we p...Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we performed acupuncture on 30 patients with hemiplegia due to acute ischemic stroke. All participants were pre-screened to ensure that they exhibited immediate responses to acupuncture. We used a twirling reinforcing acupuncture manipulation at the specific lines between the bilateral Baihui（GV20） and Taiyang（EX-HN5）. We collected neurologic deficit score, simplified Fugl-Meyer assessment score, muscle strength of the proximal and distal hemiplegic limbs, ratio of the maximal H-reflex to the maximal M-wave（Hmax/Mmax）, muscle tension at baseline and immediately after treatment, and the syndromes of traditional Chinese medicine at baseline. We then conducted data mining using an association algorithm and an artificial neural network backpropagation algorithm. We found that the twirling reinforcing manipulation had no obvious therapeutic difference in traditional Chinese medicine syndromes of ＂Deficiency and Excess＂. The change in the muscle strength of the upper distal and lower proximal limbs was one of the main factors affecting the immediate change in Fugl-Meyer scores. Additionally, we found a positive correlation between the muscle tension change of the upper limb and Hmax/Mmax immediate change, and both positive and negative correlations existed between the muscle tension change of the lower limb and immediate Hmax/Mmax change. Additionally, when the difference value of muscle tension for the upper and lower limbs was 〉 0 or 〈 0, the difference value of Hmax/Mmax was correspondingly positive or negative, indicating the scalp acupuncture has a bidirectional effect on muscle tension in hemiplegic limbs. Therefore, acupuncture with twirling reinforcing manipulation has distinct effects on acute ischemic stroke patients with different symptoms or stages of disease. Improved muscle tension in the upper and lower limbs, reflected by the variation in the Hmax/Mmax ratio, is crucial for recovery of motor function from hemiplegia.展开更多
Floor heave is the most common convergence in gob-side entry retaining.The paper analyzes the form,process and characteristics of gob-side entry retaining with the comprehensive methods of theoretical analysis,numeric...Floor heave is the most common convergence in gob-side entry retaining.The paper analyzes the form,process and characteristics of gob-side entry retaining with the comprehensive methods of theoretical analysis,numerical simulation and the field trial.Research results present that bending and folding floor heave is the main factor in the stage of the first panel mining;squeezing and fluidity floor heave plays a great role in the stable stage of gob-side entry retaining;the combination of the former two factors affects mainly the stage of the second mining ahead;abutment pressure is a fundamental contribution to the serious floor heave of gob-side entry retaining,and sides corners of solid coal body are key part in the case of floor heave controlling of gob-side entry retaining.Floor heave of gob-side entry retaining can be significantly controlled by reinforcing sides and corners of solid coal body,and influence rules on the floor heave of gob side entry retaining of sides supporting strength and the bottom bolt orientation in solid coal side are obtained.Research results have been successfully applied in gob-side entry retaining of G20-F23070 face haulage roadway in #2 coal mine of Pingmei Group,and the field observation shows that the proposed technique is an effective way in controlling the floor heave of gob-side entry retaining.展开更多
Objective:To observe reinforcing effect of calcium sulfate cement(CSC) bovine bone morphogenetic protein(bBMP) on vertebral in the rabbit model of osteoporosis.Methods:A total of 48 New Zealand white rabbits were rand...Objective:To observe reinforcing effect of calcium sulfate cement(CSC) bovine bone morphogenetic protein(bBMP) on vertebral in the rabbit model of osteoporosis.Methods:A total of 48 New Zealand white rabbits were randomly divided into group Ⅰ(blank control group),groupⅡ(CSC injection group),group Ⅲ(CSC/bBMP injection group) and control group.White rabbit osteoporosis model was established rapidly by using castration mcthod+methylprcdnisolone candidate.After modeling,groups Ⅱ.Ⅲ were given corresponding vertebral body injection material,and 4 animals were sacrificed respectively at 24 h,6 weeks,12 weeks after vertebral plasty.Tissue pathological status,vertebral mineral density and vertebral body bone mechanical strength were observed.Results:Vertebral body structure form was normal in the groups Ⅱand Ⅲ.Trabecular bone coarsens,connection and repair were observed in micro fracture and bone defects,bone trabecular connectivity was superior to group I significantly;vertebral body compression strength in the group I was on the decline,vertebral compression strength in the groups Ⅱ and Ⅲ was on the rise,the largest vertebra.Postoperative BMC and BMD in groups Ⅱand Ⅲ were incresed,and significantly higher than group I after 6 weeks(P<0.05),BMC and BMD in group Ⅲ after 12 weeks were higher than the other three groups.Conclusion:Compound bBMP CSC has good bone induction.It can improve the three-dimensional construction effect for osteoporosis vertebral trabecula,and can significantly improve the vertebral strength,as a vertebral packing material with good application prospect.展开更多
OBJECTIVE:To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM)might be the central mechanism underlying the action.METHODS:In the study,^(18)F-2-fluo...OBJECTIVE:To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM)might be the central mechanism underlying the action.METHODS:In the study,^(18)F-2-fluoro-deoxy-D-glucose positron emission tomography(18 F-FDG-PET)was employed.Fifity-six spontaneous hypertensive rats(SHRs)were randomly divided into a model group,a single-needle acupuncture(SNA)group,a twirling reinforcing group(SNA+TRF)and a twirling reducing(SNA+TRD)group.Fourteen Wistar rats were assigned to the control group.The acupuncture intervention at Taichong(LR 3)acupoint was administered once daily in the SNA,SNA+TRF and SNA+TRD groups for 14 days,with 1 d interval between the two weeks.The blood pressure(BP)of all rats was measured repeatedly and18 F-FDG-PET scans were conducted on the 14 th day.PET images were processed with Statistical Parametric Mapping 8.0.RESULTS:After the intervention,systolic BP showed a significant decrease in the SNA,SNA+TRF and SNA+TRD versus the model groups(all P<0.01)and in the SNA+TRF and SNA+TRD versus the SNA groups(both P<0.01),with the SNA+TRD group exhibited the best antihypertensive effect(P<0.01).The key brain regions activated by TRRM were mainly concentrated in the cerebellum,hippocampus,hypothalamus,medulla oblongata,insular cortex,midbrain,thalamus and visual cortex.CONCLUTION:TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission.展开更多
To observe the effects of different acupuncture manipulations on blood pressure and target organ damage in spontaneously hypertensive rats（SHRs）, this study used the reinforcing twirling method（1.5–2-mm depth; rot...To observe the effects of different acupuncture manipulations on blood pressure and target organ damage in spontaneously hypertensive rats（SHRs）, this study used the reinforcing twirling method（1.5–2-mm depth; rotating needle clockwise for 360° and then counter clockwise for 360°, with the thumb moving heavily forward and gently backward, 60 times per minute for 1 minute, and retaining needle for 9 minutes）, the reducing twirling method（1.5–2-mm depth; rotating needle counter clockwise for 360° and then clockwise for 360°, with the thumb moving heavily backward and gently forward, 60 times per minute for 1 minute, and retaining needle for 9 minutes）, and the needle retaining method（1.5–2-mm depth and retaining the needle for 10 minutes）. Bilateral Taichong（LR3） was treated by acupuncture using different manipulations and manual stimulation. Reinforcing twirling, reducing twirling, and needle retaining resulted in a decreased number of apoptotic cells, reduced Bax m RNA and protein expression, and an increased Bcl-2/Bax ratio in the hippocampus compared with the SHR group. Among these groups, the Bcl-2/Bax protein ratio was highest in the reducing twirling group, and the Bcl-2/Bax m RNA ratio was highest in the needle retaining group. These results suggest that reinforcing twirling, reducing twirling, and needle retaining methods all improve blood pressure and prevent target organ damage by increasing the hippocampal Bcl-2/Bax ratio and inhibiting cell apoptosis in the hippocampus in SHR.展开更多
OBJECTIVE: To explore the mechanism of reinforcing kidney-essence, removing phlegm, and promoting mental therapy in treating Alzheimer's disease (AD). METHODS: Sixty patients with AD in Wuhan No.1 Hospital of Trad...OBJECTIVE: To explore the mechanism of reinforcing kidney-essence, removing phlegm, and promoting mental therapy in treating Alzheimer's disease (AD). METHODS: Sixty patients with AD in Wuhan No.1 Hospital of Traditional Chinese Medicine for Geriatrics from May 2009 to April 2011 were randomly divided into two groups, with 30 in each group. Patients in Bushenhuatanyizhi group (BHY group) took BHY instant granules (6 g, twice per day). Patients in the control group took piracetam (0.8 g, 3 times per day). There were twelve weeks in a course. Changes in the mini-mental state examination (MMSE) score and Activity of Daily Living Scale (ADL) score were analyzed before and after treatment. RESULTS: MMSE scores in the two groups in-creased and ADL scores decreased after treatment, compared with those before treatment (both P< 0.05).The total effective rate was 86.67% in the BHY group (10 very effective, 13 effective, 7 non-responsive). The control group was 57.69% (5 very effective, 16 effective, 9 non-responsive) (P<0.05). Superoxide dismutase levels were increased, lipid peroxide and triglyceride levels decreased after treatment in the BHY group as compared with the control group. CONCLUSION: Reinforcing kidney-essence, removing phlegm, and promoting mental therapy can improve cognitive function and daily life of AD patients. The mechanism of the therapy might be related to improving blood fat, scavenging free radicals, and inhibiting lipid peroxides.展开更多
An experiment of producing high density polyethylene (HDPE) nano-composite filled with 4wt.% talc was presented. Acting as filler and a reinforcing agent in the HDPE, talc powder, sized at around 5 μm, was surface-tr...An experiment of producing high density polyethylene (HDPE) nano-composite filled with 4wt.% talc was presented. Acting as filler and a reinforcing agent in the HDPE, talc powder, sized at around 5 μm, was surface-treated with aluminum diethylene glycol dinitrate coupling agent before adding to the HDPE. Analyses of the reinforced HDPE nano-composite show significant improvement in its mechanical properties including, tensile strength (>26 MPa), break elongation (<1.1%), flexural strength (>22 MPa), and friction coefficients<0.11. The results demonstrate that, after surface-treated, talc can be used as a promising filling material and a reinforcing agent in making HDPE nano-composite.展开更多
The movement principle of sidewalls and floor of extraction opening is analyzed, it is found that floor heave not only has something to do with the floor strata, but sidewalls. The effect of sidewall anchor and corner...The movement principle of sidewalls and floor of extraction opening is analyzed, it is found that floor heave not only has something to do with the floor strata, but sidewalls. The effect of sidewall anchor and corner anchor is studied, the mechanical principle of reinforcing sidewalls and corners is put forward and applied in engineering practice.展开更多
基金the financial support from Innovative Research Group Project of Natural Science Foundation of Hebei Province(No.E2022209093)Central Guidance Local Science and Technology Development Fund Project of Hebei Province(No.236Z3803G)+1 种基金Scientific and Technological Project of Tangshan(No.23130205E)Youth Teacher Pre Research Fund Project of the School of Metallurgy and Energy(No.YJY20244373).
文摘A slurry-phase carbonation technique was utilized,employing argon oxygen decarburization slag(AOD slag)as a source of calcium and MgCl_(2) as a regulator for the crystal morphology of acicular aragonite.Subsequently,the carbonated AOD slag,enriched with acicular aragonite,was employed in fabricating composite cementitious materials,followed by an analysis of their evolution in hydration heat,hydration products,and microscopic morphology.Additionally,it delved into the mechanism through which acicular aragonite enhances the stength of composite cementitious materials.Moreover,advanced simulation software for engineering and sciences(ABAQUS)was utilized to simulate the compressive performance of composite mortar with varying dosages of acicular aragonite.The findings demonstrate that the carbonated AOD slag,containing 83.4%acicular aragonite(with an average aspect ratio of 21.31),exhibited commendable compatibility with cement.Moderate integration of carbonated AOD slag facilitated the formation of calcium sulfoaluminate hydrate(AFt)phases.The acicular aragonite within the cementitious matrix showcased remarkable filling effects.As the dosage of carbonated AOD slag increased,flexural and compressive strengths of cement mortar initially rose before declining.Upon reaching a 6%cement inclusion of carbonated AOD slag,the various constituents of the cementitious material displayed optimal synergy.The numerical simulation results confirmed the experimental findings,demonstrating a favorable increase in compressive strength and flexural strength with the addition of acicular aragonite.The acicular aragonite strengthened the matrix by serving bridging and pull-out functions.
基金supported by the Fundamental Research Program of Shanxi Province(Grant Nos.202203021222188 and 202303021211166)Scientific Research Fund of Taiyuan University of Science and Technology(Grant No.20222073)+1 种基金Award Fund for Outstanding Doctors in Shanxi Province(Grant No.20232047)Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(Grant No.2022L280).
文摘The crevice corrosion of the reinforcing steel in the carbonated simulated concrete pore solutions(SCPSs)containing 0.04 mol/L chloride was investigated.In comparison,the steel without crevice covered on its surface was also studied.Results showed that the crevice corrosion in the uncarbonated SCPS was not triggered and the steel remained passivity by suppressing the anodic dissolution in the crevice interior.As SCPS was carbonated to have pH values of 10.5 and 11.5,the crevice corrosion was easier to be activated than the widely reported pitting corrosion owing to the rapid oxygen depletion within the crevice,but the crevice corrosion damage might be alleviated to a certain extent due to the relative compact surface film formed inside the crevice.The further carbonation led to the activation dissolution of both the crevice interior and exterior,causing the more serious corrosion damage.Corrosion process of the crevice corrosion was systematically analyzed by combining the electrochemical measurement results and Evens polarization diagram.
文摘BACKGROUND Anastomotic leakage(AL)is a challenging complication following rectal cancer surgery,often leading to increased morbidity and healthcare costs.The use of reinforcement sutures is expected to reduce the rate of AL,their preventive effects are controversial.AIM To determine the efficacy of reinforcing sutures in preventing AL in rectal cancer.METHODS A systematic search of major medical databases was conducted to identify studies up to June 2024.Intraoperative and postoperative outcomes were assessed;the primary outcome assessed was the incidence of AL.Pooled odds ratios(ORs)and mean differences(MDs)with a 95%confidence interval(CI)were calculated using fixed-effect or random-effect models under heterogeneity.RESULTS This meta-analysis incorporated 20 studies involving 3726 patients.Pooled results demonstrated a statistically significant reduction AL incidence in the reinforced suture group(OR:0.26,95%CI:0.19-0.35,P<0.001)than the unreinforced suture group.The reinforced suture group also exhibited a shorter hospital stay(MD:-1.17,95%CI:-1.78 to-0.57,P<0.001),earlier anal exhaust(MD:-0.13,95%CI:-0.22 to-0.05,P=0.002),longer operative time(MD:15.25,95%CI:10.71-19.80,P<0.001),lower infection rate(OR:0.54,95%CI:0.29-1.00,P=0.05)and lower reoperation rate(OR:0.19,95%CI:0.08-0.45,P<0.001).CONCLUSION The results substantiate the clinical value of anastomotic reinforcement sutures in reducing AL incidence postrectal cancer surgery.Nevertheless,these conclusions warrant verification through additional high-quality randomized controlled trials.
基金National Natural Science Foundation of China(82305090)Shanghai Municipal Health Commission(20234Y0168)National Key Research and Development Program of China(2017YFC1703301)。
文摘Objective To evaluate the effectiveness and safety of the tonifying spleen and reinforcing Qi(TSRQ)therapy combined with thyroid hormone replacement therapy(THRT)for treating Hashimoto’s hypothyroidism.Methods From database foundation to January 14,2025,PubMed,Web of Science,Cochrane,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data,China Science and Technology Journal Database(VIP),and China Biomedical Literature Database(CBM)were searched for relevant information.Randomized clinical trials(RCTs)evaluating the efficacy and safety of TSRQ therapy combined with THRT for Hashimoto’s hypothyroidism were eligible for inclusion.Following quality assessment,data were analyzed using Stata 15.1 to conduct a meta-analysis and systematic review.Subgroup analysis was used to identify the sources of heterogeneity.The Grading of Recommendations Assessment,Development and Evaluation(GRADE)system was adopted to evaluate the certainty of the evidence.Results This study included 30 RCTs,comprising 2687 patients with Hashimoto’s hypothyroidism.Overall methodological quality was acceptable,with no studies exhibiting a high risk of bias.Meta-analysis demonstrated that TSRQ therapy combined with THRT significantly enhanced serum free triiodothyronine(fT3)levels[standardized mean difference(SMD)=0.76,95%confidence interval(CI):0.57 to 0.94,P<0.001]and free thyroxine(fT4)levels(SMD=0.86,95%CI:0.61 to 1.11,P<0.001),while reducing thyroid-stimulating hormone(TSH)levels(SMD=–0.99,95%CI:–1.20 to–0.78,P<0.001)compared with THRT alone.Furthermore,the combination therapy significantly decreased anti-thyroid peroxidase antibody(TPOAb)levels(SMD=–1.46,95%CI:–1.79 to–1.13,P<0.001)and anti-thyroglobulin antibody(TgAb)levels(SMD=–1.46,95%CI:–1.80 to–1.11,P<0.001).TSRQ therapy did not adversely impact the safety profile of THRT.However,while some sources of heterogeneity have been identified(e.g.,specific detection methodologies,I²=0.0%,P=0.938),there remains a portion of unexplained heterogeneity(e.g.,publication year,I²=93.4%,P<0.001),which has undermined confidence in these pooled estimates.The evidence ratings for fT3,fT4,and TSH were limited,and those for TPOAb and TgAb were even more limited.Conclusion TSRQ therapy combined with THRT may strengthen thyroid function and modulate immune dysregulation in patients with Hashimoto’s hypothyroidism without increasing adverse event incidence.
基金supported by the National Natural Science Foundation of China(Nos.52371063 and 52072110)the Natural Science Foundation of Hebei Province(No.E2018202034)+1 种基金the Central Funds Guiding the Local Science and Technology Development of Hebei Province(No.236Z7610G)the Graduate Innovation Project of Hebei Province(No.CXZZBS2022035).
文摘High porosity and high brittleness are the main reasons that limit the long-term service life of the alumina-titanium oxide composite coating.Herein,a metastable nanostructured aluminatitanium oxide composite coating with high density and high properties was synthesized by plasma spraying of TiO_(2)-Al composite powder.The main phases of the metastable nanostructured alumina-titanium oxide wereγ-Al_(2)O_(3),TiO and AlTiO_(2).The coating,as prepared,contains various metastable microstructures,such as fine-grained,intra-/inter-granular,and"self-locking"microstructures.These metastable microstruc-tures are important for the improvement of hardness and toughness of the coating.Compared with other alumina-based composite coatings,the metastable nanostructured aluminatitanium oxide composite coating showed the most impressive overall performance.The reinforcing and toughening mechanism of the metastable alumina-titanium oxide composite coating included fine grain strengthening and self-toughening of the metastable microstructure.
基金support of Natural Science Foundation of China(Grant No.52108324,No.52008207,and No.52108298)for conducting this study.
文摘The mineralization process of microbial-induced calcium carbonate precipitation(MICP)is influenced by many factors,and the uniformity of the calcium carbonate precipitation has become the main focus and challenge for MICP technology.In this study,the uniformity of the saturated calcareous sand treated with MICP was in-vestigated through one-dimensional calcareous sand column tests and model tests.The coefficient of variation was employed in one-dimensional sand column tests to investigate the impact of injection rate,cementation solution concentration,and number of injection cycles on the uniformity of the MICP treatment.Additionally,model tests were conducted to investigate the impact of injection pressure and methods on the treatment range and uniformity under three-dimensional seepage conditions.Test results demonstrate that the reinforcement strength and uniformity are significantly influenced by the injection rate of the cementation solution,with a rate of 3 mL/min,yielding a favorable treatment effect.Excessive concentration of the cementation solution can lead to significant non-uniformity and a reduction in the compressive strength of MICP-treated samples.Conversely,excessively low concentrations may result in decreased bonding efficiency.Among the four considered con-centrations,0.5 mol/L and 1 mol/L exhibit superior reinforcing effects.The morphological development of calcareous sandy foundation reinforcement is associated with the spatial distribution pattern of the bacterial solution,exhibiting a relatively larger reinforcement area in proximity to the lower region of the model and a gradually decreasing range towards the upper part.Under three-dimensional seepage conditions,in addition to the non-uniform radial cementation along the injection pipe,there is also vertical heterogeneity of cementation along the length of the injection pipe due to gravitational effects,resulting in preferential deposition of calcium carbonate at the lower section,The application of injection pressure and a double-pipe circulation injection method can mitigate the accumulation of bacterial solution and cementation solution at the bottom,thereby improving the reinforcement range and uniformity.
基金National Natural Science Foundation of China(Grant Nos.61803348,62173312,51922009)Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement(Grant No.201905D121001).
文摘Most researches associated with target encircling control are focused on moving along a circular orbit under an ideal environment free from external disturbances.However,elliptical encirclement with a time-varying observation radius,may permit a more flexible and high-efficacy enclosing solution,whilst the non-orthogonal property between axial and tangential speed components,non-ignorable environmental perturbations,and strict assignment requirements empower elliptical encircling control to be more challenging,and the relevant investigations are still open.Following this line,an appointed-time elliptical encircling control rule capable of reinforcing circumnavigation performances is developed to enable Unmanned Aerial Vehicles(UAVs)to move along a specified elliptical path within a predetermined reaching time.The remarkable merits of the designed strategy are that the relative distance controlling error can be guaranteed to evolve within specified regions with a designer-specified convergence behavior.Meanwhile,wind perturbations can be online counteracted based on an unknown system dynamics estimator(USDE)with only one regulating parameter and high computational efficiency.Lyapunov tool demonstrates that all involved error variables are ultimately limited,and simulations are implemented to confirm the usability of the suggested control algorithm.
基金Supported by Special Item of Important Disease of Zhejiang Province Traditional Chinese Medicine Sic-Tech Innovation Platform(Effect and Mechanism of Traditional Chinese Medicine on the Treatment of Aplastic Anemia and the Funding of Traditional Chinese Medicine Assessment Criterion,No.2009ZDJB01)Subject of Key Sic-Tech Innovation Team of Zhejiang Province(Clinical Study on Treatment of Chronic Aplastic Anemia by Tonifying Kidney and Promoting Blood Circulation,No.2011R09042-02)+2 种基金Special Research Funds for Traditional Chinese Medicine Industry(Effect of Traditional Chinese Medicine on the Treatment of Risk Factors of Chronic Aplastic Anemia,No.201107001)Special Research Funds for Traditional Chinese Medicine Industry(Clinical Study on the Diagnosis and Treatment of Aplastic Anemia Based on the Syndrome And Stage Differentiation,No.201407001)Zhejiang Provincial Traditional Chinese Medicine Administration Bureau Program(Establishment of Traditional Chinese Medicine Clinical Pathway on Aplastic Anemia,No.2010ZA039)
文摘OBJECTIVE:To compare the efficacy of modified treatments based on "kidney reinforcing" in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),"kidney reinforcing and Qi tonifying"(KQ),and "kidney reinforcing and blood circulation invigorating"(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery.
文摘Objective To observe the clinical effect of acupuncture at Neiguan （内关 PC 6） in combination with respiratory reinforcing and reducing method for treatment of cardiac neurosis. Methods Thirty-eight patients with cardiac neurosis were selected for treatment through acupuncture at PC 6 in combination with respiratory reinforcing and reducing method. With twice per day, treated for 6 days per week, and 4 weeks as one course, the therapeutic effect was assessed after one course. Results Twenty-one cases were cured, 15 cases were remarkably improved, and 2 cases were failed. The total effective rate was 94.7%. Conclusion Acupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis.
文摘For preventing and curing the rupture disaster of shaft lining effectively, according to the additional force theory of shaft lining fracture, more than forty tests were carried out on the large scale test rig on the basis of simulating theory. The influence of the position of aquifer, the reinforcing scope of aquifer, reinforcing distance and the strength of grouting cemented mixture on the value and variation law of the axial additional force on shaft lining is studied. The relationships between the reinforcing parameters and the axial additional force on shaft lining are obtained, which provides the theoretic foundation and construction design parameters for the method of reinforcing strata by grouting to prevent and cure tbe rupture disaster of shart lining.
基金supported by the National Natural Science Foundation of China(Nos.91860203,51821091,51872239,52002321 and 52061135102)the China Postdoctoral Science Foundation(No.2019M660265)+3 种基金the Fundamental Research Funds for the Central Universities(China,Nos.G2019KY05116,G2020KY05125)the Innovation Talent Promotion Plan of Shaanxi Province for Science and Technology Innovation Team(No.2020TD003)the Creative Research Foundation of Science and Technology on Thermostructural Composite Materials Laboratory(Nos.614291102010517,5050200015 and 5150200033)the Shaanxi Provincial Education Department of China(No.2020JQ-170)。
文摘Carbon fiber reinforced carbon composites(C/Cs),are the most promising high-temperature materials and could be widely applied in aerospace and nucleation fields,owing to their superior performances.However,C/Cs are very susceptible to destructive oxidation and thus fail at elevated temperatures.Though matrix modification and coating technologies with Si-based and ultra-high temperature ceramics(UHTCs)are valid to enhance the oxidation/ablation resistance of C/Cs,it’s not sufficient to satisfy the increasing practical applications,due to the inherent brittleness of ceramics,mismatch issues between coatings and C/C substrates,and the fact that carbonaceous matrices are easily prone to high-temperature oxidation.To effectively solve the aforementioned problems,micro/nano multiscale reinforcing strategies have been developed for C/Cs and/or the coatings over the past two decades,to fabricate C/Cs with high strength and excellent high-temperature stability.This review is to systematically summarize the most recent major and important advancements in some micro/nano multiscale strategies,including nanoparticles,nanowires,carbon nanotubes/fibers,whiskers,graphene,ceramic fibers and hybrid micro/nano structures,for C/Cs and/or the coatings,to achieve high-temperature oxidation/ablation-resistant C/Cs.Finally,this review is concluded with an outlook of major unsolved problems,challenges to be met and future research advice for C/Cs with excellent comprehensive mechanical-thermal performance.It’s hoped that a better understanding of this review will be of high scientific and industrial interest,since it provides unusual and feasible new ideas to develop potential and practical C/Cs with improved high-temperature mechanical and oxidation/ablation-resistant properties.
基金supported by a grant from the Supporting Program of the"Eleventh Five-year Plan"for Science&Technology Research of China,Ministry of Science and Technology of China,No.2006BAI12B02a grant from the Scientific Research Fund for Talent Introduction in the Gansu University of Chinese Medicine of China,No.2012-11
文摘Data mining has the potential to provide information for improving clinical acupuncture strategies by uncovering hidden rules between acupuncture manipulation and therapeutic effects in a data set. In this study, we performed acupuncture on 30 patients with hemiplegia due to acute ischemic stroke. All participants were pre-screened to ensure that they exhibited immediate responses to acupuncture. We used a twirling reinforcing acupuncture manipulation at the specific lines between the bilateral Baihui（GV20） and Taiyang（EX-HN5）. We collected neurologic deficit score, simplified Fugl-Meyer assessment score, muscle strength of the proximal and distal hemiplegic limbs, ratio of the maximal H-reflex to the maximal M-wave（Hmax/Mmax）, muscle tension at baseline and immediately after treatment, and the syndromes of traditional Chinese medicine at baseline. We then conducted data mining using an association algorithm and an artificial neural network backpropagation algorithm. We found that the twirling reinforcing manipulation had no obvious therapeutic difference in traditional Chinese medicine syndromes of ＂Deficiency and Excess＂. The change in the muscle strength of the upper distal and lower proximal limbs was one of the main factors affecting the immediate change in Fugl-Meyer scores. Additionally, we found a positive correlation between the muscle tension change of the upper limb and Hmax/Mmax immediate change, and both positive and negative correlations existed between the muscle tension change of the lower limb and immediate Hmax/Mmax change. Additionally, when the difference value of muscle tension for the upper and lower limbs was 〉 0 or 〈 0, the difference value of Hmax/Mmax was correspondingly positive or negative, indicating the scalp acupuncture has a bidirectional effect on muscle tension in hemiplegic limbs. Therefore, acupuncture with twirling reinforcing manipulation has distinct effects on acute ischemic stroke patients with different symptoms or stages of disease. Improved muscle tension in the upper and lower limbs, reflected by the variation in the Hmax/Mmax ratio, is crucial for recovery of motor function from hemiplegia.
基金provided by the National Natural Science Foundation of China(No.51174195)the State Key Laboratory of Coal Resources and Mine Safety of China University of Mining and Technology(No.SKLCRSM08X04)+1 种基金a foundation for the author of the National Excellent Doctoral Dissertation of China(No.200760)the Science Research Fund of China University of Mining and Technology(No.2008A002)
文摘Floor heave is the most common convergence in gob-side entry retaining.The paper analyzes the form,process and characteristics of gob-side entry retaining with the comprehensive methods of theoretical analysis,numerical simulation and the field trial.Research results present that bending and folding floor heave is the main factor in the stage of the first panel mining;squeezing and fluidity floor heave plays a great role in the stable stage of gob-side entry retaining;the combination of the former two factors affects mainly the stage of the second mining ahead;abutment pressure is a fundamental contribution to the serious floor heave of gob-side entry retaining,and sides corners of solid coal body are key part in the case of floor heave controlling of gob-side entry retaining.Floor heave of gob-side entry retaining can be significantly controlled by reinforcing sides and corners of solid coal body,and influence rules on the floor heave of gob side entry retaining of sides supporting strength and the bottom bolt orientation in solid coal side are obtained.Research results have been successfully applied in gob-side entry retaining of G20-F23070 face haulage roadway in #2 coal mine of Pingmei Group,and the field observation shows that the proposed technique is an effective way in controlling the floor heave of gob-side entry retaining.
基金supported by Scientific Research Project of People's Hospital number IN Xinjiang Uygur Autonomous Region(20130255)
文摘Objective:To observe reinforcing effect of calcium sulfate cement(CSC) bovine bone morphogenetic protein(bBMP) on vertebral in the rabbit model of osteoporosis.Methods:A total of 48 New Zealand white rabbits were randomly divided into group Ⅰ(blank control group),groupⅡ(CSC injection group),group Ⅲ(CSC/bBMP injection group) and control group.White rabbit osteoporosis model was established rapidly by using castration mcthod+methylprcdnisolone candidate.After modeling,groups Ⅱ.Ⅲ were given corresponding vertebral body injection material,and 4 animals were sacrificed respectively at 24 h,6 weeks,12 weeks after vertebral plasty.Tissue pathological status,vertebral mineral density and vertebral body bone mechanical strength were observed.Results:Vertebral body structure form was normal in the groups Ⅱand Ⅲ.Trabecular bone coarsens,connection and repair were observed in micro fracture and bone defects,bone trabecular connectivity was superior to group I significantly;vertebral body compression strength in the group I was on the decline,vertebral compression strength in the groups Ⅱ and Ⅲ was on the rise,the largest vertebra.Postoperative BMC and BMD in groups Ⅱand Ⅲ were incresed,and significantly higher than group I after 6 weeks(P<0.05),BMC and BMD in group Ⅲ after 12 weeks were higher than the other three groups.Conclusion:Compound bBMP CSC has good bone induction.It can improve the three-dimensional construction effect for osteoporosis vertebral trabecula,and can significantly improve the vertebral strength,as a vertebral packing material with good application prospect.
基金Supported by the National Natural Science Foundation of China(Use PET Brain Imaging Technology to Study the Acupuncture Manipulation of Twirling Reinforcing-Reducing Regulation in Spontaneously Hypertensive Rats by Central Integration Signaling Network Construction,No.8157150840)
文摘OBJECTIVE:To investigate antihypertensive effect in rats in order to confirm that twirling reinforcing-reducing manipulation(TRRM)might be the central mechanism underlying the action.METHODS:In the study,^(18)F-2-fluoro-deoxy-D-glucose positron emission tomography(18 F-FDG-PET)was employed.Fifity-six spontaneous hypertensive rats(SHRs)were randomly divided into a model group,a single-needle acupuncture(SNA)group,a twirling reinforcing group(SNA+TRF)and a twirling reducing(SNA+TRD)group.Fourteen Wistar rats were assigned to the control group.The acupuncture intervention at Taichong(LR 3)acupoint was administered once daily in the SNA,SNA+TRF and SNA+TRD groups for 14 days,with 1 d interval between the two weeks.The blood pressure(BP)of all rats was measured repeatedly and18 F-FDG-PET scans were conducted on the 14 th day.PET images were processed with Statistical Parametric Mapping 8.0.RESULTS:After the intervention,systolic BP showed a significant decrease in the SNA,SNA+TRF and SNA+TRD versus the model groups(all P<0.01)and in the SNA+TRF and SNA+TRD versus the SNA groups(both P<0.01),with the SNA+TRD group exhibited the best antihypertensive effect(P<0.01).The key brain regions activated by TRRM were mainly concentrated in the cerebellum,hippocampus,hypothalamus,medulla oblongata,insular cortex,midbrain,thalamus and visual cortex.CONCLUTION:TRRM could significantly lower the BP of SHRs by improving the cerebral glucose metabolism of the activated key brain regions and the underlying central mechanism may be related to the central rennin-angiotensin system and neurotransmission.
基金supported by the National Natural Science Foundation of China,No.81072861,81373727
文摘To observe the effects of different acupuncture manipulations on blood pressure and target organ damage in spontaneously hypertensive rats（SHRs）, this study used the reinforcing twirling method（1.5–2-mm depth; rotating needle clockwise for 360° and then counter clockwise for 360°, with the thumb moving heavily forward and gently backward, 60 times per minute for 1 minute, and retaining needle for 9 minutes）, the reducing twirling method（1.5–2-mm depth; rotating needle counter clockwise for 360° and then clockwise for 360°, with the thumb moving heavily backward and gently forward, 60 times per minute for 1 minute, and retaining needle for 9 minutes）, and the needle retaining method（1.5–2-mm depth and retaining the needle for 10 minutes）. Bilateral Taichong（LR3） was treated by acupuncture using different manipulations and manual stimulation. Reinforcing twirling, reducing twirling, and needle retaining resulted in a decreased number of apoptotic cells, reduced Bax m RNA and protein expression, and an increased Bcl-2/Bax ratio in the hippocampus compared with the SHR group. Among these groups, the Bcl-2/Bax protein ratio was highest in the reducing twirling group, and the Bcl-2/Bax m RNA ratio was highest in the needle retaining group. These results suggest that reinforcing twirling, reducing twirling, and needle retaining methods all improve blood pressure and prevent target organ damage by increasing the hippocampal Bcl-2/Bax ratio and inhibiting cell apoptosis in the hippocampus in SHR.
基金Supported by the State Key Program of National Natural Science of China(No.81130064)Doctoral Fund of Ministry of Education of China(No.20094230110001)National Natural Science Foundation of China(No.30901937)
文摘OBJECTIVE: To explore the mechanism of reinforcing kidney-essence, removing phlegm, and promoting mental therapy in treating Alzheimer's disease (AD). METHODS: Sixty patients with AD in Wuhan No.1 Hospital of Traditional Chinese Medicine for Geriatrics from May 2009 to April 2011 were randomly divided into two groups, with 30 in each group. Patients in Bushenhuatanyizhi group (BHY group) took BHY instant granules (6 g, twice per day). Patients in the control group took piracetam (0.8 g, 3 times per day). There were twelve weeks in a course. Changes in the mini-mental state examination (MMSE) score and Activity of Daily Living Scale (ADL) score were analyzed before and after treatment. RESULTS: MMSE scores in the two groups in-creased and ADL scores decreased after treatment, compared with those before treatment (both P< 0.05).The total effective rate was 86.67% in the BHY group (10 very effective, 13 effective, 7 non-responsive). The control group was 57.69% (5 very effective, 16 effective, 9 non-responsive) (P<0.05). Superoxide dismutase levels were increased, lipid peroxide and triglyceride levels decreased after treatment in the BHY group as compared with the control group. CONCLUSION: Reinforcing kidney-essence, removing phlegm, and promoting mental therapy can improve cognitive function and daily life of AD patients. The mechanism of the therapy might be related to improving blood fat, scavenging free radicals, and inhibiting lipid peroxides.
文摘An experiment of producing high density polyethylene (HDPE) nano-composite filled with 4wt.% talc was presented. Acting as filler and a reinforcing agent in the HDPE, talc powder, sized at around 5 μm, was surface-treated with aluminum diethylene glycol dinitrate coupling agent before adding to the HDPE. Analyses of the reinforced HDPE nano-composite show significant improvement in its mechanical properties including, tensile strength (>26 MPa), break elongation (<1.1%), flexural strength (>22 MPa), and friction coefficients<0.11. The results demonstrate that, after surface-treated, talc can be used as a promising filling material and a reinforcing agent in making HDPE nano-composite.
文摘The movement principle of sidewalls and floor of extraction opening is analyzed, it is found that floor heave not only has something to do with the floor strata, but sidewalls. The effect of sidewall anchor and corner anchor is studied, the mechanical principle of reinforcing sidewalls and corners is put forward and applied in engineering practice.
