The dynamics of complex gene regulation systems can be simulated by the Gillespie algorithm. The classic Gillespie algorithm is appropriate to simulate a stochastic
This paper sets Chaihu Town, Zhongxiang City of Hubei Province as an example, analyzing the ecological and hydrological conditions of Chaihu Town, applying LID （low impact development） mode and putting forward the e...This paper sets Chaihu Town, Zhongxiang City of Hubei Province as an example, analyzing the ecological and hydrological conditions of Chaihu Town, applying LID （low impact development） mode and putting forward the ecological stormwater regulation system planning strategy which adapts to the development of small towns. The main conclusions are as follows： （1） The ＂three-low＂ development mode is put forward, which means low impact, low cost and low carbon, using this construction mode to minimize the ecological impact, relying on natural green space and water to achieve the function of rainstorm regulation; （2） Through the analysis and calculation of the local amount of precipitation, this paper scientifically calculates the required area of storage water and green space, taking the roads as trunks, green spaces as stems, water as veins, and building the green infrastructure system; （3） The author has been repairing and integrating the original drainage ditches of the planning area, replacing traditional rain drainage pipes, establishing ＂two-loop＂ water network system which aims at the detention and purification of rainwater, maximizing ecological benefit, economic benefit and landscape benefit.展开更多
After the new round of restructuring of Chinese telecom sector,it's pressing to formulate and implement asymmetric regulation policies so as to shape an effectively competitive market structure in a relatively sho...After the new round of restructuring of Chinese telecom sector,it's pressing to formulate and implement asymmetric regulation policies so as to shape an effectively competitive market structure in a relatively short term.This paper reviewed the asymmetric regulation policies and practices carried out in foreign telecom market,and then according to the specific situations of Chinese telecom market,proposed the principles and corresponding policies for establishing an asymmetric regulation system fit for Chinese telecom market.展开更多
This paper presents the solution of regulating the wind rate automatically by means of fuzzy control technology and implementing it with PLC (programmable logical controller) under the circumstance of many influence f...This paper presents the solution of regulating the wind rate automatically by means of fuzzy control technology and implementing it with PLC (programmable logical controller) under the circumstance of many influence factors, which exists in the axial flow fans wind rate regulation system during the process of mine ventilation, and has difficulty in modifying the mathematic model to obtain the satisfied result by normal control ways. According to this analysis, the intelligent and analytic treatment of fuzzy controller has been made and fuzzy control scheme involving self regulation divisor and intelligent integral has been deeply proposed. Test result shows that this system based on the scheme above is obviously prior to others in its responsibility such as high speed, overshoot, control precision and robustness. The system furnishes the great reliability of mine working safety and fans running efficiency.展开更多
Outlined the South African mine health and safety regulatory framework,in- cluding the roles of government,tripartite council,service agencies,mine enterprises, rescue stations and workers unions,analyzed the institut...Outlined the South African mine health and safety regulatory framework,in- cluding the roles of government,tripartite council,service agencies,mine enterprises, rescue stations and workers unions,analyzed the institutional structures of South African mine health and safety standardization,including the South African standard and specifi- cation systems and standard development processes,and characterized the South African mine health and safety standardization and regulation systems.Intended to provide some suggestions for the transformation and improvement of mine health and safety standardi- zation and regulation systems in China or in similar situations.展开更多
During electric vehicle(EV)-assisted grid frequency modulation,inconsistent state of charge(SOC)among EVs can result in overcharging and discharging of the batteries,affecting the stability of the electrical system.As...During electric vehicle(EV)-assisted grid frequency modulation,inconsistent state of charge(SOC)among EVs can result in overcharging and discharging of the batteries,affecting the stability of the electrical system.As a solution,this paper proposes a priority-based frequency regulation strategy for EVs.Firstly,models for the primary and secondary frequency regulation of EV-assisted power grids are established.Secondly,a consensus algorithm is used to construct a distributed com-munication system for EVs.Target SOC values are used to obtain a local frequency regulation priori-ty list.The list is used in an optimal control plan allowing individual EVs to participate in frequency regulation.Finally,a simulation of this strategy under several scenarios is conducted.The results indicate that the strategy ensures uniform SOC among the participating group of EVs,thereby avoi-ding overcharging and discharging of their batteries.It also reduces frequency fluctuations in the electrical system,making the system more robust compared with the frequency regulation strategy that is not priority-based.展开更多
Main Exhauster is one of the main equipment of sintering production. It needs to consume a lot of electricity. Therefore, the system＇ s reconstruction for energy-saving will effectively reduce electricity for the pro...Main Exhauster is one of the main equipment of sintering production. It needs to consume a lot of electricity. Therefore, the system＇ s reconstruction for energy-saving will effectively reduce electricity for the production. The paper takes an iron and steel enterprise that had successfully transformed the synchronous motors of main exhauster of sintering as an example, which describes the application of high-voltage variable frequency speed regulation system in main exhauster of Sintering, so as to provide a reference for other iron and steel enterprises.展开更多
In order to scientifically deal with the problems of less water and more sediment in the Yellow River and the uncoordinated relationship between water and sediment,it is necessary to establish a perfect water and sedi...In order to scientifically deal with the problems of less water and more sediment in the Yellow River and the uncoordinated relationship between water and sediment,it is necessary to establish a perfect water and sediment regulation system.Through the calculation of the sediment transport capacity of the Yellow River and the application of the water and sediment regulation system,it is found that the sediment transport efficiency of the Yellow River will increase with the increase of water flow,and there will be an obvious inflection point near the flat discharge.The joint regulation of the backbone reservoir group can discharge the large discharge close to the minimum flat discharge of the downstream river,which improves the sediment transport capacity of the river and alleviates the problem of sediment deposition.In this paper,through the introduction of the Yellow River water and sediment regulation project system,regulation indicators and mechanisms,the author discusses in detail the Yellow River water and sediment regulation scheme and its operation effect,hoping to provide help promote the improvement of the Yellow River governance effect.展开更多
Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluct...Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluctuation caused by new energy units,this paper proposes a new energy power system frequency regulation strategy with multiple units including the doubly-fed pumped storage unit(DFPSU).Firstly,based on the model predictive control(MPC)theory,the state space equations are established by considering the operating characteristics of the units and the dynamic behavior of the system;secondly,the proportional-differential control link is introduced to minimize the frequency deviation to further optimize the frequency modulation(FM)output of the DFPSU and inhibit the rapid fluctuation of the frequency;lastly,it is verified on theMatlab/Simulink simulation platform,and the results show that the model predictive control with proportional-differential control link can further release the FM potential of the DFPSU,increase the depth of its FM,effectively reduce the frequency deviation of the system and its rate of change,realize the optimization of the active output of the DFPSU and that of other units,and improve the frequency response capability of the system.展开更多
Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica...Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.展开更多
Amid ongoing global environmental change and the critical pursuit of sustainable development,human-environment systems are exhibiting increasingly complex dynamic evolutions and spatial relationships,underscoring an u...Amid ongoing global environmental change and the critical pursuit of sustainable development,human-environment systems are exhibiting increasingly complex dynamic evolutions and spatial relationships,underscoring an urgent need for innovative research frameworks.Integrated geography synthesizes physical geography,human geography,and geographic information science,providing key frameworks for understanding complex human-environment systems.This editorial proposes an emerging research framework for integrated geography—“Composite driving-System evolution-Coupling mechanism-Synergistic regulation(CSCS)”—based on key issues such as climate change,biodiversity loss,resource scarcity,and social-ecological interactions,which have been highlighted in both recent critical literature on human-environment systems and UN assessment reports.The framework starts with diverse composite driving forces,extends to the evolution of human-environment system structures,processes,and functions that these drivers induce,explores couplings within human-environment systems,and calls for regulation aimed at sustainable development in synergies.Major research frontiers include understanding the cascading“evolution-coupling”effects of shocks;measuring system resilience,thresholds,and safe and just operating space boundaries;clarifying linkage mechanisms across scales;and achieving synergistic outcomes for multi-objective sustainability.This framework will help promote the interdisciplinary integration and development of integrated geography,and provide geographical solutions for the global sustainable development agenda.展开更多
Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the p...Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the production line,the manufacturing layer and the workshop layer.The dynamics of re-entrant production lines are governed by hyperbolic partial differential equations(PDEs)based on the law of mass conservation.展开更多
This study aims to develop an accurate calculation model of transmission torque and load-bearing capacity for hydro-viscous clutches(HVC)used in high-power vehicles,which is important to investigate the step-less spee...This study aims to develop an accurate calculation model of transmission torque and load-bearing capacity for hydro-viscous clutches(HVC)used in high-power vehicles,which is important to investigate the step-less speed regulation characteristics in a fan drive system.However,most of the existing models ignore the distribution differences of groove area along the radial direction,which may lead to significant deviations in calculating the mechanical property of friction pairs related to operating conditions and the engagement process.To fill this gap,a new calculation model for bearing capacity and frictional torque of friction pairs with different oil grooves is proposed,in which the traditional fixed contact area ratio coefficient for oil groove measurement is replaced by a more precise discrete micro-ring area ratio(DMAR)integration method.Then,a 32-degree-of-freedoms dynamic model of HVC at a fan drive system is established for the prediction of dynamic responses during speed regulation.Results show that friction pairs with different oil grooves have a direct influence on frictional torque and bearing capacity through the change of DMAR along the radial direction.The friction pairs with different groove structures have oscillation phenomena at the engagement steady-state boundary.Furthermore,a step-less speed regulation experimental setup is established to verify the correctness of the proposed model.It is demonstrated that the axial engagement force and the speed regulation curve predicted by the proposed method are in good agreement with the experimental data.The results could effectively predict the engagement dynamic characteristics.The numerical relationship among the structure parameters,the mechanical properties of friction pairs,and the speed regulation characteristics of the system are established through the proposed model,which lays a theoretical foundation for the structure design of friction plates and optimization of step-less speed regulation performance.展开更多
This paper investigates the issue of load disturbances in DC motor speed regulation systems.In response to the limited disturbance rejection capability of traditional PID controllers,a PID controller with feedforward ...This paper investigates the issue of load disturbances in DC motor speed regulation systems.In response to the limited disturbance rejection capability of traditional PID controllers,a PID controller with feedforward compensation is designed.The study first analyzes the dynamic impact mechanism of sudden load changes on motor speed,and then achieves precise control of the DC motor using PWM technology.Through comparative analysis of simulation and experimental results,the proposed feedforward-compens ated PID control demonstrates significant improvements in dynamic response speed,overshoot,and steady-state accuracy compared to traditional PID control.The findings indicate that the proposed control strategy effectively supp resses load disturbances,e nhances system stability and robustness,and offers valuable insights for practical engineering applications.展开更多
BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this ...BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.展开更多
Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespr...Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespread attention for CO_(2)RR due to their high catalytic activity,selectivity,excellent stability,and low cost.However,they still need to be further improved to meet the needs of industrial applications.This review article comprehensively summarizes the recent advances in regulation strategies of Bi-based catalysts and can be divided into six categories:(1)defect engineering,(2)atomic doping engineering,(3)organic framework engineering,(4)inorganic heterojunction engineering,(5)crystal face engineering,and(6)alloying and polarization engineering.Meanwhile,the corresponding catalytic mechanisms of each regulation strategy will also be discussed in detail,aiming to enable researchers to understand the structure-property relationship of the improved Bibased catalysts fundamentally.Finally,the challenges and future opportunities of the Bi-based catalysts in the photoelectrocatalytic CO_(2)RR application field will also be featured from the perspectives of the(1)combination or synergy of multiple regulatory strategies,(2)revealing formation mechanism and realizing controllable synthesis,and(3)in situ multiscale investigation of activation pathways and uncovering the catalytic mechanisms.On the one hand,through the comparative analysis and mechanism explanation of the six major regulatory strategies,a multidimensional knowledge framework of the structure-activity relationship of Bi-based catalysts can be constructed for researchers,which not only deepens the atomic-level understanding of catalytic active sites,charge transport paths,and the adsorption behavior of intermediate products,but also provides theoretical guiding principles for the controllable design of new catalysts;on the other hand,the promising collaborative regulation strategies,controllable synthetic paths,and the in situ multiscale characterization techniques presented in this work provides a paradigm reference for shortening the research and development cycle of high-performance catalysts,conducive to facilitating the transition of photoelectrocatalytic CO_(2)RR technology from the laboratory routes to industrial application.展开更多
Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of de...Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.展开更多
Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a...Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.展开更多
It has been well established that the recovery ability of central nervous system （CNS） is very poor in adult mammals. As a result, CNS trauma generally leads to severe and persistent functional deficits. Thus, the i...It has been well established that the recovery ability of central nervous system （CNS） is very poor in adult mammals. As a result, CNS trauma generally leads to severe and persistent functional deficits. Thus, the investigation in this field becomes a ＂hot spot＂. Up to date, accumulating evidence supports the hypothesis that the failure of CNS neurons to regenerate is not due to their intrinsic inability to grow new axons, but due to their growth state and due to lack of a permissive growth environment. Therefore, any successful approaches to facilitate the regeneration of injured CNS axons will likely include multiple steps： keeping neurons alive in a certain growth-state, preventing the formation of a glial scar, overcoming inhibitory molecules present in the myelin debris, and giving direction to the growing axons. This brief review focused on the recent progress in the neuron regeneration of CNS in adult mammals.展开更多
Northern blot analysis was conducted with mitochondrial RNA from seedling leaves, floral buds, and developing seeds of NCa CMS, maintainer line and fertile F1 using ten mitochondrial genes as probes. The results revea...Northern blot analysis was conducted with mitochondrial RNA from seedling leaves, floral buds, and developing seeds of NCa CMS, maintainer line and fertile F1 using ten mitochondrial genes as probes. The results revealed that 9 out of the 10 mitochondrial genes, except for atp6, showed no difference in different tissues of the corresponding materials of NCα CMS system and that they might be constitutively expressed genes. Eight genes, such as orf139, orf222, atpl, cox1, cox2, cob, rm5S, and rm26S, showed no difference among the three tissues of all the materials detected. So the expression of these eight genes was not regulated by nuclear genes and was not tissue-specific. The transcripts of atp9 were identical among different tissues, but diverse among different materials, indicating that transcription of atp9 was neither controlled by nuclear gene nor tissue-specific. Gene atp6 displayed similar transcripts with the same size among different tissues of all the materials but differed in abundance among tissues of corresponding materials and its expression might be tissue-specific under regulation of nuclear gene. Moreover, three transcripts of orf222 were detected in the floral buds of NCa cms and fertile F1, but no transcript was detected in floral buds of the maintainer line.The transcription of orf139 was similar to that of orf222 but only two transcripts of 0.8 kb and 0.6 kb were produced. The atp9 probe detected a single transcript of 0.6 kb in NCa cms and in maintainer line and an additional transcript of 1.2 kb in fertile F1. The relationship of expression of orf222, orf139, and atp9 with NCa sterility was discussed.展开更多
文摘The dynamics of complex gene regulation systems can be simulated by the Gillespie algorithm. The classic Gillespie algorithm is appropriate to simulate a stochastic
文摘This paper sets Chaihu Town, Zhongxiang City of Hubei Province as an example, analyzing the ecological and hydrological conditions of Chaihu Town, applying LID （low impact development） mode and putting forward the ecological stormwater regulation system planning strategy which adapts to the development of small towns. The main conclusions are as follows： （1） The ＂three-low＂ development mode is put forward, which means low impact, low cost and low carbon, using this construction mode to minimize the ecological impact, relying on natural green space and water to achieve the function of rainstorm regulation; （2） Through the analysis and calculation of the local amount of precipitation, this paper scientifically calculates the required area of storage water and green space, taking the roads as trunks, green spaces as stems, water as veins, and building the green infrastructure system; （3） The author has been repairing and integrating the original drainage ditches of the planning area, replacing traditional rain drainage pipes, establishing ＂two-loop＂ water network system which aims at the detention and purification of rainwater, maximizing ecological benefit, economic benefit and landscape benefit.
文摘After the new round of restructuring of Chinese telecom sector,it's pressing to formulate and implement asymmetric regulation policies so as to shape an effectively competitive market structure in a relatively short term.This paper reviewed the asymmetric regulation policies and practices carried out in foreign telecom market,and then according to the specific situations of Chinese telecom market,proposed the principles and corresponding policies for establishing an asymmetric regulation system fit for Chinese telecom market.
文摘This paper presents the solution of regulating the wind rate automatically by means of fuzzy control technology and implementing it with PLC (programmable logical controller) under the circumstance of many influence factors, which exists in the axial flow fans wind rate regulation system during the process of mine ventilation, and has difficulty in modifying the mathematic model to obtain the satisfied result by normal control ways. According to this analysis, the intelligent and analytic treatment of fuzzy controller has been made and fuzzy control scheme involving self regulation divisor and intelligent integral has been deeply proposed. Test result shows that this system based on the scheme above is obviously prior to others in its responsibility such as high speed, overshoot, control precision and robustness. The system furnishes the great reliability of mine working safety and fans running efficiency.
文摘Outlined the South African mine health and safety regulatory framework,in- cluding the roles of government,tripartite council,service agencies,mine enterprises, rescue stations and workers unions,analyzed the institutional structures of South African mine health and safety standardization,including the South African standard and specifi- cation systems and standard development processes,and characterized the South African mine health and safety standardization and regulation systems.Intended to provide some suggestions for the transformation and improvement of mine health and safety standardi- zation and regulation systems in China or in similar situations.
基金Supported by the China Postdoctoral Science Foundation(No.2022M710039).
文摘During electric vehicle(EV)-assisted grid frequency modulation,inconsistent state of charge(SOC)among EVs can result in overcharging and discharging of the batteries,affecting the stability of the electrical system.As a solution,this paper proposes a priority-based frequency regulation strategy for EVs.Firstly,models for the primary and secondary frequency regulation of EV-assisted power grids are established.Secondly,a consensus algorithm is used to construct a distributed com-munication system for EVs.Target SOC values are used to obtain a local frequency regulation priori-ty list.The list is used in an optimal control plan allowing individual EVs to participate in frequency regulation.Finally,a simulation of this strategy under several scenarios is conducted.The results indicate that the strategy ensures uniform SOC among the participating group of EVs,thereby avoi-ding overcharging and discharging of their batteries.It also reduces frequency fluctuations in the electrical system,making the system more robust compared with the frequency regulation strategy that is not priority-based.
文摘Main Exhauster is one of the main equipment of sintering production. It needs to consume a lot of electricity. Therefore, the system＇ s reconstruction for energy-saving will effectively reduce electricity for the production. The paper takes an iron and steel enterprise that had successfully transformed the synchronous motors of main exhauster of sintering as an example, which describes the application of high-voltage variable frequency speed regulation system in main exhauster of Sintering, so as to provide a reference for other iron and steel enterprises.
文摘In order to scientifically deal with the problems of less water and more sediment in the Yellow River and the uncoordinated relationship between water and sediment,it is necessary to establish a perfect water and sediment regulation system.Through the calculation of the sediment transport capacity of the Yellow River and the application of the water and sediment regulation system,it is found that the sediment transport efficiency of the Yellow River will increase with the increase of water flow,and there will be an obvious inflection point near the flat discharge.The joint regulation of the backbone reservoir group can discharge the large discharge close to the minimum flat discharge of the downstream river,which improves the sediment transport capacity of the river and alleviates the problem of sediment deposition.In this paper,through the introduction of the Yellow River water and sediment regulation project system,regulation indicators and mechanisms,the author discusses in detail the Yellow River water and sediment regulation scheme and its operation effect,hoping to provide help promote the improvement of the Yellow River governance effect.
基金supported by the National Natural Science Foundation of China(Project No.52377082)the Scientific Research Program of Jilin Provincial Department of Education(Project No.JJKH20230123KJ).
文摘Large-scale new energy grid connection leads to the weakening of the system frequency regulation capability,and the system frequency stability is facing unprecedented challenges.In order to solve rapid frequency fluctuation caused by new energy units,this paper proposes a new energy power system frequency regulation strategy with multiple units including the doubly-fed pumped storage unit(DFPSU).Firstly,based on the model predictive control(MPC)theory,the state space equations are established by considering the operating characteristics of the units and the dynamic behavior of the system;secondly,the proportional-differential control link is introduced to minimize the frequency deviation to further optimize the frequency modulation(FM)output of the DFPSU and inhibit the rapid fluctuation of the frequency;lastly,it is verified on theMatlab/Simulink simulation platform,and the results show that the model predictive control with proportional-differential control link can further release the FM potential of the DFPSU,increase the depth of its FM,effectively reduce the frequency deviation of the system and its rate of change,realize the optimization of the active output of the DFPSU and that of other units,and improve the frequency response capability of the system.
文摘Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.
基金supported by the National Natural Science Foundation of China(Grants No.W2412144,42271292)the 111 project,and the Fundamental Research Funds for the Central Universities of China.
文摘Amid ongoing global environmental change and the critical pursuit of sustainable development,human-environment systems are exhibiting increasingly complex dynamic evolutions and spatial relationships,underscoring an urgent need for innovative research frameworks.Integrated geography synthesizes physical geography,human geography,and geographic information science,providing key frameworks for understanding complex human-environment systems.This editorial proposes an emerging research framework for integrated geography—“Composite driving-System evolution-Coupling mechanism-Synergistic regulation(CSCS)”—based on key issues such as climate change,biodiversity loss,resource scarcity,and social-ecological interactions,which have been highlighted in both recent critical literature on human-environment systems and UN assessment reports.The framework starts with diverse composite driving forces,extends to the evolution of human-environment system structures,processes,and functions that these drivers induce,explores couplings within human-environment systems,and calls for regulation aimed at sustainable development in synergies.Major research frontiers include understanding the cascading“evolution-coupling”effects of shocks;measuring system resilience,thresholds,and safe and just operating space boundaries;clarifying linkage mechanisms across scales;and achieving synergistic outcomes for multi-objective sustainability.This framework will help promote the interdisciplinary integration and development of integrated geography,and provide geographical solutions for the global sustainable development agenda.
文摘Dear Editor,This letter focuses on the distributed cooperative regulation problem for a class of networked re-entrant manufacturing systems(RMSs).The networked system is structured with a three-tier architecture:the production line,the manufacturing layer and the workshop layer.The dynamics of re-entrant production lines are governed by hyperbolic partial differential equations(PDEs)based on the law of mass conservation.
基金Supported by the National Natural Science Foundation of China(Grant Nos.52475089,52035002)National Key Research and Development Program of China(Grant No.2021YFB2011400)the Chongqing Natural Science Foundation(Grant No.CSTB2022NSCQ-MSX1243).
文摘This study aims to develop an accurate calculation model of transmission torque and load-bearing capacity for hydro-viscous clutches(HVC)used in high-power vehicles,which is important to investigate the step-less speed regulation characteristics in a fan drive system.However,most of the existing models ignore the distribution differences of groove area along the radial direction,which may lead to significant deviations in calculating the mechanical property of friction pairs related to operating conditions and the engagement process.To fill this gap,a new calculation model for bearing capacity and frictional torque of friction pairs with different oil grooves is proposed,in which the traditional fixed contact area ratio coefficient for oil groove measurement is replaced by a more precise discrete micro-ring area ratio(DMAR)integration method.Then,a 32-degree-of-freedoms dynamic model of HVC at a fan drive system is established for the prediction of dynamic responses during speed regulation.Results show that friction pairs with different oil grooves have a direct influence on frictional torque and bearing capacity through the change of DMAR along the radial direction.The friction pairs with different groove structures have oscillation phenomena at the engagement steady-state boundary.Furthermore,a step-less speed regulation experimental setup is established to verify the correctness of the proposed model.It is demonstrated that the axial engagement force and the speed regulation curve predicted by the proposed method are in good agreement with the experimental data.The results could effectively predict the engagement dynamic characteristics.The numerical relationship among the structure parameters,the mechanical properties of friction pairs,and the speed regulation characteristics of the system are established through the proposed model,which lays a theoretical foundation for the structure design of friction plates and optimization of step-less speed regulation performance.
文摘This paper investigates the issue of load disturbances in DC motor speed regulation systems.In response to the limited disturbance rejection capability of traditional PID controllers,a PID controller with feedforward compensation is designed.The study first analyzes the dynamic impact mechanism of sudden load changes on motor speed,and then achieves precise control of the DC motor using PWM technology.Through comparative analysis of simulation and experimental results,the proposed feedforward-compens ated PID control demonstrates significant improvements in dynamic response speed,overshoot,and steady-state accuracy compared to traditional PID control.The findings indicate that the proposed control strategy effectively supp resses load disturbances,e nhances system stability and robustness,and offers valuable insights for practical engineering applications.
文摘BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.
基金supports from the National Natural Science Foundation of China(Grant Nos.12305372 and 22376217)the National Key Research&Development Program of China(Grant Nos.2022YFA1603802 and 2022YFB3504100)+1 种基金the projects of the key laboratory of advanced energy materials chemistry,ministry of education(Nankai University)key laboratory of Jiangxi Province for persistent pollutants prevention control and resource reuse(2023SSY02061)are gratefully acknowledged.
文摘Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespread attention for CO_(2)RR due to their high catalytic activity,selectivity,excellent stability,and low cost.However,they still need to be further improved to meet the needs of industrial applications.This review article comprehensively summarizes the recent advances in regulation strategies of Bi-based catalysts and can be divided into six categories:(1)defect engineering,(2)atomic doping engineering,(3)organic framework engineering,(4)inorganic heterojunction engineering,(5)crystal face engineering,and(6)alloying and polarization engineering.Meanwhile,the corresponding catalytic mechanisms of each regulation strategy will also be discussed in detail,aiming to enable researchers to understand the structure-property relationship of the improved Bibased catalysts fundamentally.Finally,the challenges and future opportunities of the Bi-based catalysts in the photoelectrocatalytic CO_(2)RR application field will also be featured from the perspectives of the(1)combination or synergy of multiple regulatory strategies,(2)revealing formation mechanism and realizing controllable synthesis,and(3)in situ multiscale investigation of activation pathways and uncovering the catalytic mechanisms.On the one hand,through the comparative analysis and mechanism explanation of the six major regulatory strategies,a multidimensional knowledge framework of the structure-activity relationship of Bi-based catalysts can be constructed for researchers,which not only deepens the atomic-level understanding of catalytic active sites,charge transport paths,and the adsorption behavior of intermediate products,but also provides theoretical guiding principles for the controllable design of new catalysts;on the other hand,the promising collaborative regulation strategies,controllable synthetic paths,and the in situ multiscale characterization techniques presented in this work provides a paradigm reference for shortening the research and development cycle of high-performance catalysts,conducive to facilitating the transition of photoelectrocatalytic CO_(2)RR technology from the laboratory routes to industrial application.
基金funded by China Law Society 2025 Annual Legal Research,Project grant number:CLS(2025)Y04.
文摘Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.
基金supported by grants from the Deutsche Forschungsgemeinschaft(DFG)to MW.
文摘Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.
基金supported by the National Natural Science Foundation of China(No.30571909,No.30872666)the Youth Teacher Foundation of Jiangsu Pro-vince(No.BU134701)China,and the Medical Development Foundation of Soochow University(No.EE134615)
文摘It has been well established that the recovery ability of central nervous system （CNS） is very poor in adult mammals. As a result, CNS trauma generally leads to severe and persistent functional deficits. Thus, the investigation in this field becomes a ＂hot spot＂. Up to date, accumulating evidence supports the hypothesis that the failure of CNS neurons to regenerate is not due to their intrinsic inability to grow new axons, but due to their growth state and due to lack of a permissive growth environment. Therefore, any successful approaches to facilitate the regeneration of injured CNS axons will likely include multiple steps： keeping neurons alive in a certain growth-state, preventing the formation of a glial scar, overcoming inhibitory molecules present in the myelin debris, and giving direction to the growing axons. This brief review focused on the recent progress in the neuron regeneration of CNS in adult mammals.
基金This work was supported by the National High Technology R&D Project of China (No.2002AA207009) and Wuhan Dawn Project for Youth (No. 20035002016-36).
文摘Northern blot analysis was conducted with mitochondrial RNA from seedling leaves, floral buds, and developing seeds of NCa CMS, maintainer line and fertile F1 using ten mitochondrial genes as probes. The results revealed that 9 out of the 10 mitochondrial genes, except for atp6, showed no difference in different tissues of the corresponding materials of NCα CMS system and that they might be constitutively expressed genes. Eight genes, such as orf139, orf222, atpl, cox1, cox2, cob, rm5S, and rm26S, showed no difference among the three tissues of all the materials detected. So the expression of these eight genes was not regulated by nuclear genes and was not tissue-specific. The transcripts of atp9 were identical among different tissues, but diverse among different materials, indicating that transcription of atp9 was neither controlled by nuclear gene nor tissue-specific. Gene atp6 displayed similar transcripts with the same size among different tissues of all the materials but differed in abundance among tissues of corresponding materials and its expression might be tissue-specific under regulation of nuclear gene. Moreover, three transcripts of orf222 were detected in the floral buds of NCa cms and fertile F1, but no transcript was detected in floral buds of the maintainer line.The transcription of orf139 was similar to that of orf222 but only two transcripts of 0.8 kb and 0.6 kb were produced. The atp9 probe detected a single transcript of 0.6 kb in NCa cms and in maintainer line and an additional transcript of 1.2 kb in fertile F1. The relationship of expression of orf222, orf139, and atp9 with NCa sterility was discussed.
