With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challe...With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challenge of improving the frequency regulation performance of a thermal-storage primary frequency regulation system while reducing its associated losses,this paper proposes a multi-dimensional cooperative optimization strategy for the control parameters of a combined thermal-storage system,considering regulation losses.First,the frequency regulation losses of various components within the thermal power unit are quantified,and a calculation method for energy storage regulation loss is proposed,based on Depth of Discharge(DOD)and C-rate.Second,a thermal-storage cooperative control method based on series compensation is developed to improve the system’s frequency regulation performance.Third,targeting system regulation loss cost and regulation output,and considering constraints on output overshoot and system parameters,an improved Particle Swarm Optimization(PSO)algorithm is employed to tune the parameters of the low-pass filter and the series compensator,thereby reducing regulation losses while enhancing performance.Finally,simulation results demonstrate that the total loss cost of the proposed control strategy is comparable to that of a system with only thermal power participation.However,the thermal power loss cost is reduced by 42.16%compared to the thermal-only case,while simultaneously improving system frequency stability.Thus,the proposed strategy effectively balances system frequency stability and economic efficiency.展开更多
Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica...Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.展开更多
Excessive unbalanced vibrations of rotor-bearing systems significantly affect the stability and safety of high-end rotating machinery,such as aero engines,turbo-generators,and high-end machine tools.To realize the on-...Excessive unbalanced vibrations of rotor-bearing systems significantly affect the stability and safety of high-end rotating machinery,such as aero engines,turbo-generators,and high-end machine tools.To realize the on-line self-recovery of unbalanced vibration faults in a rotor system,a self-recovery regulation method based on the grey wolf optimization-adaptive linear quadratic regulator(GWO-ALQR)is proposed.First,a self-recovery regulation system for unbalanced vibrations was constructed,with the state-space equation of the control system obtained and discretized based on the dynamic equation of the rotor-bearing system.Subsequently,a self-recovery regulation method for unbalanced vi-brations based on GWO-ALQR was designed based on the state-space equation.In this method,the parameters of the control system are optimized using grey wolf optimization(GwO),with the working conditions identified on-line.The optimization parameters were selected independently,while the control commands were generated through a linear quadratic regulator(LQR)to control the action of the actuator to achieve self-recovery of the unbalanced vibration.The experimental results indicate that the unbalanced vibration of the rotor system can be restrained below the expected vibration threshold by the self-recovery regulation system based on GWO-ALQR and the final vibration suppression effect can exceed 70%.展开更多
Nanofiltration(NF) technology,with its capacity for nanoscale filtration and controllable selectivity,holds significant promise in diverse applications.However,the current upper bound of permeance and selectivity of N...Nanofiltration(NF) technology,with its capacity for nanoscale filtration and controllable selectivity,holds significant promise in diverse applications.However,the current upper bound of permeance and selectivity of NF membranes is intrinsically constrained by the morphology and structure of the polyamide(PA) selective layer.This issue arises because NF membranes typically exhibit relatively smooth nodular structures,which theoretically impede efficient water transport.In this study,we enhanced the formation of nanobubbles by synergistically regulating with surfactant and low temperatures,resulting in the fabrication of PA NF membranes with a crumpled morphology.We observed that lower temperatures promote enhanced gas solubility in the aqueous phase,facilitating increased nanobubble formation through the foaming effect of surfactant sodium dodecylbenzene sulfonate(SDBS).Consequently,this resulted in the creation of PA NF membranes with more crumpled structures and superior performance,with pure water permeance reaching 36.25 ± 0.42 L m^(-2)h^(-1)bar^(-1),representing an improvement of 14.47 L m^(-2)h^(-1)bar^(-1)compared to the control group.Additionally,it maintains a high Na_(2)SO_(4) rejection rate of97.00 % ± 0.58 %.The PA NF membranes produced by eliminating nanobubbles and free interfaces exhibited a smooth structure,whereas introducing nanobubbles(through Na HCO_(3) addition,N_(2) pressurization,and ultrasonication) resulted in the formation of crumpled membranes.This emphasized that the large amount of nanobubbles generated by SDBS and low temperature in the interfacial process played a critical role in shaping crumpled PA NF membranes and enhancing membrane performance.This approach has the potential to provide valuable insights into customizing the structural design of TFC PA NF membranes,contributing to further advancements in this field.展开更多
BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this ...BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.展开更多
Sleep is a fundamental biological process essential for maintaining brain function,cognitive performance,and overall health.Despite over a century of research,the mechanisms underlying sleep homeostasis-the process by...Sleep is a fundamental biological process essential for maintaining brain function,cognitive performance,and overall health.Despite over a century of research,the mechanisms underlying sleep homeostasis-the process by which the need for sleep accumulates during wakefulness and dissipates during sleep-remain incompletely understood.This article explores the latest advancements in sleep research,focusing on the role of synaptic plasticity in sleep homeostasis,as illuminated by Sawada et al.(2024).展开更多
Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditio...Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditions)faces significant challenges,including accelerated electrolyte decomposition,interfacial instability,and potential thermal runaway risks.To address these challenges,we present a solvation-interphase synergistic regulation strategy using 2-fluorobenzenesulfonamide(2-FBS)as a multifunctional electrolyte additive.The 2-FBS molecule effectively modulates the Li^(+)solvation structure by reducing the coordination of ethylene carbonate(EC)solvent.This transformation suppresses EC-induced parasitic reactions while scavenging superoxide radicals,thereby mitigating gas evolution at electrode interfaces.Upon preferential decomposition,2-FBS further promotes the formation of a robust LiF-Li_(3)N-Li_(2)S-rich interphase with exceptional mechanical strength(Young’s modulus:39.4 GPa).This inorganic-rich hybrid interphase simultaneously enables dendrite-free lithium plating and enhances cathode thermal stability.Consequently,2-FBS-modified electrolyte empowers LiCoO_(2)//Li cells to deliver 82.8%capacity retention after 800 cycles at 55°C and sustain 81.2%capacity retention after 1500 cycles at 4 C.Moreover,practical validation through nail penetration tests confirms the effectiveness of the electrolyte in preventing thermal propagation in fully charged pouch cells.This work establishes a paradigm for enabling reliable battery operation under extreme conditions through synergistic solvation and interphase engineering.展开更多
Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigeneti...Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigenetic modifications have been indicated to significantly influence anthocyanin accumulation and response to various environmental cues.Recently,epigenetic regulation at the population level has become an increasingly important research focus.Here,we briefly describe the recent studies on epigenetic regulation of anthocyanin biosynthesis in horticultural crops,including the repressive role of DNA methylation,the dynamic gene expression control by histone modifications,and gene silencing or regulation mediated by non-coding RNAs.Furthermore,we also discuss recent technological breakthroughs in epigenetic editing and their potential applications in plant breeding.The review aims to provide new,more flexible research perspectives to enhance fruit quality in horticultural crops and to understand the molecular regulation of color formation.展开更多
Diabetes mellitus is an escalating global health issue,with 463 million adults affected in 2019.Without intervention,this number is projected to increase to 578 million by 2030 and 700 million by 2045[1].Diabetic woun...Diabetes mellitus is an escalating global health issue,with 463 million adults affected in 2019.Without intervention,this number is projected to increase to 578 million by 2030 and 700 million by 2045[1].Diabetic wound,a significant complication,is characterized by delayed healing,high disability rates,and elevated mortality[2].The challenges of wound healing in diabetic patients,compounded by their high morbidity and mortality rates,have drawn growing attention in biomedical research.展开更多
Layered oxides have attracted significant attention as cathodes for sodium-ion batteries(SIBs)due to their compositional versatility and tuneable electrochemical performance.However,these materials still face challeng...Layered oxides have attracted significant attention as cathodes for sodium-ion batteries(SIBs)due to their compositional versatility and tuneable electrochemical performance.However,these materials still face challenges such as structural phase transitions,Na^(+)/vacancy ordering,and Jahn–Teller distortion effect,resulting in severe capacity decay and sluggish ion kinetics.We develop a novel Cu/Y dual-doping strategy that leads to the formation of"Na–Y"interlayer aggregates,which act as structural pillars within alkali metal layers,enhancing structural stability and disrupting the ordered arrangement of Na^(+)/vacancies.This disruption leads to a unique coexistence of ordered and disordered Na^(+)/vacancy states with near-zero strain,which significantly improves Na^(+)diffusion kinetics.This structural innovation not only mitigates the unfavorable P2–O2 phase transition but also facilitates rapid ion transport.As a result,the doped material demonstrates exceptional electrochemical performance,including an ultra-long cycle life of 3000 cycles at 10 C and an outstanding high-rate capability of~70 mAh g^(−1)at 50 C.The discovery of this novel interlayer pillar,along with its role in modulating Na^(+)/vacancy arrangements,provides a fresh perspective on engineering layered oxides.It opens up promising new pathways for the structural design of advanced cathode materials toward efficient,stable,and high-rate SIBs.展开更多
Nekemias megalophylla is a popular folk tea consumed by people in the Western Hubei(China)of which ampelopsin(AMP)is the main active ingredient.In this study,we investigated the effect of AMP on cervical cancer and ex...Nekemias megalophylla is a popular folk tea consumed by people in the Western Hubei(China)of which ampelopsin(AMP)is the main active ingredient.In this study,we investigated the effect of AMP on cervical cancer and explored its mechanism of action,focusing on apoptosis and autophagy.Firstly,we verified that AMP strongly inhibited the growth of C-33A cells and observed apoptosis and autophagy phenomenon in vivo,and found that AMP induces C-33A cell apoptosis via death receptor or mitochondrial pathways.The results also indicated that AMP-induced autophagy occurs via the PI3K/Akt/m TOR pathway.Secondly,when autophagy was inhibited,the AMP-induced apoptosis of C-33A cells was strengthened,when apoptosis was inhibited,the AMP-induced autophagy of C-33A cells was strengthened.PI3K/Akt/m TOR pathway activation enhances AMP-induced apoptosis in C-33A cells,while its inhibition strengthens AMP-induced autophagy.Finally,we confirmed that AMP inhibited cell growth and induced apoptosis and autophagy of C-33A cells in an in vivo nude mouse model of C-33A tumor xenografts.These results elucidate that AMP bidirectionally regulates apoptosis and autophagy in human cervical cancer C-33A cells by mediating the PI3K/Akt/m TOR pathway.展开更多
Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespr...Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespread attention for CO_(2)RR due to their high catalytic activity,selectivity,excellent stability,and low cost.However,they still need to be further improved to meet the needs of industrial applications.This review article comprehensively summarizes the recent advances in regulation strategies of Bi-based catalysts and can be divided into six categories:(1)defect engineering,(2)atomic doping engineering,(3)organic framework engineering,(4)inorganic heterojunction engineering,(5)crystal face engineering,and(6)alloying and polarization engineering.Meanwhile,the corresponding catalytic mechanisms of each regulation strategy will also be discussed in detail,aiming to enable researchers to understand the structure-property relationship of the improved Bibased catalysts fundamentally.Finally,the challenges and future opportunities of the Bi-based catalysts in the photoelectrocatalytic CO_(2)RR application field will also be featured from the perspectives of the(1)combination or synergy of multiple regulatory strategies,(2)revealing formation mechanism and realizing controllable synthesis,and(3)in situ multiscale investigation of activation pathways and uncovering the catalytic mechanisms.On the one hand,through the comparative analysis and mechanism explanation of the six major regulatory strategies,a multidimensional knowledge framework of the structure-activity relationship of Bi-based catalysts can be constructed for researchers,which not only deepens the atomic-level understanding of catalytic active sites,charge transport paths,and the adsorption behavior of intermediate products,but also provides theoretical guiding principles for the controllable design of new catalysts;on the other hand,the promising collaborative regulation strategies,controllable synthetic paths,and the in situ multiscale characterization techniques presented in this work provides a paradigm reference for shortening the research and development cycle of high-performance catalysts,conducive to facilitating the transition of photoelectrocatalytic CO_(2)RR technology from the laboratory routes to industrial application.展开更多
Hard carbon(HC)remains a leading anode candidate for sodium-ion storage,yet its application is hindered by low initial Coulombic efficiency(ICE)and limited plateau capacity due to uncontrolled defect density and open ...Hard carbon(HC)remains a leading anode candidate for sodium-ion storage,yet its application is hindered by low initial Coulombic efficiency(ICE)and limited plateau capacity due to uncontrolled defect density and open porosity.Here,we propose a scalable dual-regulation strategy that simultaneously tunes pore mouth size and defect chemistry to enhance sodium storage performance.Using phenol-formaldehyde resin as the carbon precursor and phosphorus pentoxide(P_(2)O_(5))as a bifunctional sacrificial template and dopant source,we synthesize phosphorus-functionalized hard carbon(PF-PHC)featuring a high density of closed pores with well-confined sub-nanometer pore entrances.The in-situ sublimation of P_(2)O_(5) during pyrolysis promotes the formation of closed-pore architectures,while residual phosphorus atoms effectively passivate vacancy-type defects,thereby reducing irreversible Na+adsorption and mitigating excessive solid electrolyte interphase(SEI)formation.As a result,PF-PHC achieves an ICE of 89.3%and a plateau capacity of 289 mAh g^(−1).In-situ characterizations reveal that regulating pore mouth dimensions decouples Na+and solvent access,enabling highly selective ion transport and stable interfacial chemistry.Sodium-ion hybrid capacitors(SIHCs)assembled based on PF-PHC deliver exceptional rate performance and outstanding long-term cycling stability,retaining 98.2%after 10,000 cycles at 2 A g^(−1).This study establishes pore mouth engineering as a robust and scalable design principle for advancing next-generation HC-based sodium storage materials.展开更多
Energy-saving buildings(ESBs)are an emerging green technology that can significantly reduce building-associated cooling and heating energy consumption,catering to the desire for carbon neutrality and sustainable devel...Energy-saving buildings(ESBs)are an emerging green technology that can significantly reduce building-associated cooling and heating energy consumption,catering to the desire for carbon neutrality and sustainable development of society.Smart photovoltaic windows(SPWs)offer a promising platform for designing ESBs because they present the capability to regulate and harness solar energy.With frequent outbreaks of extreme weather all over the world,the achievement of exceptional energy-saving effect under different weather conditions is an inevitable trend for the development of ESBs but is hardly achieved via existing SPWs.Here,we substantially reduce the driving voltage of polymerdispersed liquid crystals(PDLCs)by 28.1%via molecular engineering while maintaining their high solar transmittance(T_(sol)=83.8%,transparent state)and solar modulating ability(ΔT_(sol)=80.5%).By the assembly of perovskite solar cell and a broadband thermal-managing unit encompassing the electrical-responsive PDLCs,transparent high-emissivity SiO_(2) passive radiation-cooling,and Ag low-emissivity layers possesses,we present a tri-band regulation and split-type SPW possessing superb energy-saving effect in all-season.The perovskite solar cell can produce the electric power to stimulate the electrical-responsive behavior of the PDLCs,endowing the SPWs zero-energy input solar energy regulating characteristic,and compensate the daily energy consumption needed for ESBs.Moreover,the scalable manufacturing technology holds a great potential for the real-world applications.展开更多
Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of de...Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.展开更多
Cation disordering is a common issue in Ni-rich cathodes that significantly degrades cycle life and compromises safety.The cubic rock-salt phase formation and the slow oxidation kinetics of Ni^(2+)during solid-state s...Cation disordering is a common issue in Ni-rich cathodes that significantly degrades cycle life and compromises safety.The cubic rock-salt phase formation and the slow oxidation kinetics of Ni^(2+)during solid-state sintering are widely recognized as the principal causes of these structural defects.To solve this issue,a topotactic soft-chemical precursor engineering strategy is proposed for use in aqueous solution.By utilizing the layered structure of the precursor,this method allows for selective proton extraction and efficient Ni^(2+)oxidation,along with rapid Li+intercalation to form a layered lithiated intermediate.This intermediate crystallizes without further phase transitions during subsequent heat treatment,preventing structural defects caused by complex phase evolution and slow ion diffusion.The resulting cathode exhibits a long-range ordered layered structure and a uniform phase distribution,enabling efficient Li+insertion and extraction.Electrochemical tests reveal a high discharge capacity of 229.6 mAh g^(−1)and an initial coulombic efficiency of 95.77%at 0.1 C,greatly exceeding the performance of a conventionally synthesized cathode(210.3 mAh g^(−1),88.93%).Improved Li^(+)transport kinetics reduces phase-transition hysteresis and alleviates stress concentration,resulting in better cycling stability with a capacity retention of 85.3%after 300 cycles,compared to 61.5%for the conventional sample.This work presents a scalable and effective synthesis route for Ni-rich cathodes with reduced structural disorder and extended lifespan,providing valuable insights into how the regulation of intermediate phases influences electrochemical performance in high-performance Ni-rich cathodes.展开更多
Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a...Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.展开更多
Facing the economic challenges of significant frequency regulation wear and tear on thermal power units and short energy storage lifespan in thermal-energy storage combined systems participating in grid primary freque...Facing the economic challenges of significant frequency regulation wear and tear on thermal power units and short energy storage lifespan in thermal-energy storage combined systems participating in grid primary frequency regulation(PFR),this paper proposes a novel hybrid energy storage system(HESS)control strategy based on Newton-Raphson optimization algorithm(NRBO)-VMD and a fuzzy neural network(FNN)for PFR.In the primary power allocation stage,the high inertia and slow response of thermal power units prevent them from promptly responding to the high-frequency components of PFR signals,leading to increased mechanical stress.To address the distinct response characteristics of thermal units and HESS,an NRBO-VMD based decomposition method for PFR signals is proposed,enabling a flexible system response to grid frequency deviations.Within the HESS,an adaptive coordinated control strategy and a State of Charge(SOC)self-recovery strategy are introduced.These strategies autonomously adjust the virtual inertia and droop coefficients based on the depth of frequency regulation and the real-time SOC.Furthermore,a FNN is constructed to perform secondary refinement of the internal power distribution within the HESS.Finally,simulations under various operational conditions demonstrate that the proposed strategy effectively mitigates frequent power adjustments of the thermal unit during PFR,adaptively achieves optimal power decomposition and distribution,maintains the flywheel energy storage’s SOC within an optimal range,and ensures the long-term stable operation of the HESS.展开更多
Low-cost and high-safety aqueous Zn-I_(2) batteries attract extensive attention for large-scale energy storage systems.However,polyiodide shuttling and sluggish iodine conversion reactions lead to inferior rate capabi...Low-cost and high-safety aqueous Zn-I_(2) batteries attract extensive attention for large-scale energy storage systems.However,polyiodide shuttling and sluggish iodine conversion reactions lead to inferior rate capability and severe capacity decay.Herein,a three-dimensional polyaniline is wrapped by carboxylcarbon nanotubes(denoted as C-PANI)which is designed as a catalytic cathode to effectively boost iodine conversion with suppressed polyiodide shuttling,thereby improving Zn-I_(2) batteries.Specifically,carboxyl-carbon nanotubes serve as a proton reservoir for more protonated-NH+=sites in PANI chains,achieving a direct I0/I−reaction for suppressed polyiodide generation and Zn corrosion.Attributing to this“proton-iodine”regulation,catalytic protonated C-PANI strongly fixes electrolytic iodine species and stores proton ions simultaneously through reversible-N=/-NH^(+)-reaction.Therefore,the electrolytic Zn-I_(2) battery with C-PANI cathode exhibits an impressive capacity of 420 mAh g^(−1) and ultra-long lifespan over 40,000 cycles.Additionally,a 60 mAh pouch cell was assembled with excellent cycling stability after 100 cycles,providing new insights into exploring effective organocatalysts for superb Zn-halogen batteries.展开更多
The adult subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal dentate gyrus(DG)are the two brain regions where neurogenesis occurs throughout life in the adult mammalian brain(Min...The adult subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal dentate gyrus(DG)are the two brain regions where neurogenesis occurs throughout life in the adult mammalian brain(Ming and Song,2011).Adult quiescent hippocampal neural stem cells(NSCs)are bona fide stem cells and,when activated,give rise to newborn granule neurons in the adult brain,which play vital roles in learning,memory,mood,and affective cognition(Bonaguidi et al.,2011;Ming and Song,2011).展开更多
基金supported by the Science and Technology Development Project of Jilin Province(Project No.YDZJ202301ZYTS284).
文摘With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challenge of improving the frequency regulation performance of a thermal-storage primary frequency regulation system while reducing its associated losses,this paper proposes a multi-dimensional cooperative optimization strategy for the control parameters of a combined thermal-storage system,considering regulation losses.First,the frequency regulation losses of various components within the thermal power unit are quantified,and a calculation method for energy storage regulation loss is proposed,based on Depth of Discharge(DOD)and C-rate.Second,a thermal-storage cooperative control method based on series compensation is developed to improve the system’s frequency regulation performance.Third,targeting system regulation loss cost and regulation output,and considering constraints on output overshoot and system parameters,an improved Particle Swarm Optimization(PSO)algorithm is employed to tune the parameters of the low-pass filter and the series compensator,thereby reducing regulation losses while enhancing performance.Finally,simulation results demonstrate that the total loss cost of the proposed control strategy is comparable to that of a system with only thermal power participation.However,the thermal power loss cost is reduced by 42.16%compared to the thermal-only case,while simultaneously improving system frequency stability.Thus,the proposed strategy effectively balances system frequency stability and economic efficiency.
文摘Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.
基金Supported by National Natural Science Foundation of China(Grant No.51875031)Beijing Municipal Natural Science Foundation of China(Grant No.3212010).
文摘Excessive unbalanced vibrations of rotor-bearing systems significantly affect the stability and safety of high-end rotating machinery,such as aero engines,turbo-generators,and high-end machine tools.To realize the on-line self-recovery of unbalanced vibration faults in a rotor system,a self-recovery regulation method based on the grey wolf optimization-adaptive linear quadratic regulator(GWO-ALQR)is proposed.First,a self-recovery regulation system for unbalanced vibrations was constructed,with the state-space equation of the control system obtained and discretized based on the dynamic equation of the rotor-bearing system.Subsequently,a self-recovery regulation method for unbalanced vi-brations based on GWO-ALQR was designed based on the state-space equation.In this method,the parameters of the control system are optimized using grey wolf optimization(GwO),with the working conditions identified on-line.The optimization parameters were selected independently,while the control commands were generated through a linear quadratic regulator(LQR)to control the action of the actuator to achieve self-recovery of the unbalanced vibration.The experimental results indicate that the unbalanced vibration of the rotor system can be restrained below the expected vibration threshold by the self-recovery regulation system based on GWO-ALQR and the final vibration suppression effect can exceed 70%.
基金the National Natural Science Foundation of China (Nos.52430001,52470091,52200108) for the financial support。
文摘Nanofiltration(NF) technology,with its capacity for nanoscale filtration and controllable selectivity,holds significant promise in diverse applications.However,the current upper bound of permeance and selectivity of NF membranes is intrinsically constrained by the morphology and structure of the polyamide(PA) selective layer.This issue arises because NF membranes typically exhibit relatively smooth nodular structures,which theoretically impede efficient water transport.In this study,we enhanced the formation of nanobubbles by synergistically regulating with surfactant and low temperatures,resulting in the fabrication of PA NF membranes with a crumpled morphology.We observed that lower temperatures promote enhanced gas solubility in the aqueous phase,facilitating increased nanobubble formation through the foaming effect of surfactant sodium dodecylbenzene sulfonate(SDBS).Consequently,this resulted in the creation of PA NF membranes with more crumpled structures and superior performance,with pure water permeance reaching 36.25 ± 0.42 L m^(-2)h^(-1)bar^(-1),representing an improvement of 14.47 L m^(-2)h^(-1)bar^(-1)compared to the control group.Additionally,it maintains a high Na_(2)SO_(4) rejection rate of97.00 % ± 0.58 %.The PA NF membranes produced by eliminating nanobubbles and free interfaces exhibited a smooth structure,whereas introducing nanobubbles(through Na HCO_(3) addition,N_(2) pressurization,and ultrasonication) resulted in the formation of crumpled membranes.This emphasized that the large amount of nanobubbles generated by SDBS and low temperature in the interfacial process played a critical role in shaping crumpled PA NF membranes and enhancing membrane performance.This approach has the potential to provide valuable insights into customizing the structural design of TFC PA NF membranes,contributing to further advancements in this field.
文摘BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.
基金supported by Japan Society forthe Promotion of Science(JSPS)Grants-in-Aidfor Scientific Research(KAKENHI)(20H05894,20H05903,21K15136,22K21351,23H02518A,23H02663,and 23K18147 to SS),JST-CREST(JPMJCR24T4 to SS),the World PremierInternational Research Center Initiative(WPI)fromthe Ministry of Education,Culture,Sports,Scienceand Technology(MEXT)to SS(WPI-IIIS),the TopRunners in Strategy of Transborder AdvancedResearches(TRiSTAR)by the MEXT to SSJapanAgency for Medical Research and Development(AMED)(JP21zf0127005 to SS),Cell ScienceResearch Foundation Grant to YI,38th Brain ScienceFoundation Research Grant to YI,Research Granton Biogenic Amines and Neurological Diseases(Sumitomo pharma)to YI.
文摘Sleep is a fundamental biological process essential for maintaining brain function,cognitive performance,and overall health.Despite over a century of research,the mechanisms underlying sleep homeostasis-the process by which the need for sleep accumulates during wakefulness and dissipates during sleep-remain incompletely understood.This article explores the latest advancements in sleep research,focusing on the role of synaptic plasticity in sleep homeostasis,as illuminated by Sawada et al.(2024).
基金supported by the Key Laboratory of Sichuan Province for Lithium Resources Comprehensive Utilization and New Lithium Based Materials for Advanced Battery Technology(LRMKF202405)the National Natural Science Foundation of China(52402226)the Sichuan Provincial Natural Science Foundation (2024NSFSC1016)
文摘Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditions)faces significant challenges,including accelerated electrolyte decomposition,interfacial instability,and potential thermal runaway risks.To address these challenges,we present a solvation-interphase synergistic regulation strategy using 2-fluorobenzenesulfonamide(2-FBS)as a multifunctional electrolyte additive.The 2-FBS molecule effectively modulates the Li^(+)solvation structure by reducing the coordination of ethylene carbonate(EC)solvent.This transformation suppresses EC-induced parasitic reactions while scavenging superoxide radicals,thereby mitigating gas evolution at electrode interfaces.Upon preferential decomposition,2-FBS further promotes the formation of a robust LiF-Li_(3)N-Li_(2)S-rich interphase with exceptional mechanical strength(Young’s modulus:39.4 GPa).This inorganic-rich hybrid interphase simultaneously enables dendrite-free lithium plating and enhances cathode thermal stability.Consequently,2-FBS-modified electrolyte empowers LiCoO_(2)//Li cells to deliver 82.8%capacity retention after 800 cycles at 55°C and sustain 81.2%capacity retention after 1500 cycles at 4 C.Moreover,practical validation through nail penetration tests confirms the effectiveness of the electrolyte in preventing thermal propagation in fully charged pouch cells.This work establishes a paradigm for enabling reliable battery operation under extreme conditions through synergistic solvation and interphase engineering.
基金funded by grants from the sub-project of Liaoning Province Germplasm Innovation Grain Storage and Technology Special Program(Grant No.2023JH1/10200003)National Natural Science Foundation of China(Grant Nos.32102350,32130092)+1 种基金Liaoning Provincial Department of Education Project(Grant No.LJKZ0635)funded by Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Vegetables),Ministry of Agriculture and Rural Affairs.
文摘Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigenetic modifications have been indicated to significantly influence anthocyanin accumulation and response to various environmental cues.Recently,epigenetic regulation at the population level has become an increasingly important research focus.Here,we briefly describe the recent studies on epigenetic regulation of anthocyanin biosynthesis in horticultural crops,including the repressive role of DNA methylation,the dynamic gene expression control by histone modifications,and gene silencing or regulation mediated by non-coding RNAs.Furthermore,we also discuss recent technological breakthroughs in epigenetic editing and their potential applications in plant breeding.The review aims to provide new,more flexible research perspectives to enhance fruit quality in horticultural crops and to understand the molecular regulation of color formation.
基金supported by a grant from General Scientific Research Project of Zhejiang Provincial Department of Education(No.Y202455614).
文摘Diabetes mellitus is an escalating global health issue,with 463 million adults affected in 2019.Without intervention,this number is projected to increase to 578 million by 2030 and 700 million by 2045[1].Diabetic wound,a significant complication,is characterized by delayed healing,high disability rates,and elevated mortality[2].The challenges of wound healing in diabetic patients,compounded by their high morbidity and mortality rates,have drawn growing attention in biomedical research.
基金supported by the “Pioneer” and “Leading Goose” R&D Program of Zhejiang Province of China (No. 2024C01056)the support from London South Bank University
文摘Layered oxides have attracted significant attention as cathodes for sodium-ion batteries(SIBs)due to their compositional versatility and tuneable electrochemical performance.However,these materials still face challenges such as structural phase transitions,Na^(+)/vacancy ordering,and Jahn–Teller distortion effect,resulting in severe capacity decay and sluggish ion kinetics.We develop a novel Cu/Y dual-doping strategy that leads to the formation of"Na–Y"interlayer aggregates,which act as structural pillars within alkali metal layers,enhancing structural stability and disrupting the ordered arrangement of Na^(+)/vacancies.This disruption leads to a unique coexistence of ordered and disordered Na^(+)/vacancy states with near-zero strain,which significantly improves Na^(+)diffusion kinetics.This structural innovation not only mitigates the unfavorable P2–O2 phase transition but also facilitates rapid ion transport.As a result,the doped material demonstrates exceptional electrochemical performance,including an ultra-long cycle life of 3000 cycles at 10 C and an outstanding high-rate capability of~70 mAh g^(−1)at 50 C.The discovery of this novel interlayer pillar,along with its role in modulating Na^(+)/vacancy arrangements,provides a fresh perspective on engineering layered oxides.It opens up promising new pathways for the structural design of advanced cathode materials toward efficient,stable,and high-rate SIBs.
基金supported by the Major Science and Technology Project of Hubei Province(2020ACA007)the Scientific and Technological Bureau of Wuhan(2018060401011308).
文摘Nekemias megalophylla is a popular folk tea consumed by people in the Western Hubei(China)of which ampelopsin(AMP)is the main active ingredient.In this study,we investigated the effect of AMP on cervical cancer and explored its mechanism of action,focusing on apoptosis and autophagy.Firstly,we verified that AMP strongly inhibited the growth of C-33A cells and observed apoptosis and autophagy phenomenon in vivo,and found that AMP induces C-33A cell apoptosis via death receptor or mitochondrial pathways.The results also indicated that AMP-induced autophagy occurs via the PI3K/Akt/m TOR pathway.Secondly,when autophagy was inhibited,the AMP-induced apoptosis of C-33A cells was strengthened,when apoptosis was inhibited,the AMP-induced autophagy of C-33A cells was strengthened.PI3K/Akt/m TOR pathway activation enhances AMP-induced apoptosis in C-33A cells,while its inhibition strengthens AMP-induced autophagy.Finally,we confirmed that AMP inhibited cell growth and induced apoptosis and autophagy of C-33A cells in an in vivo nude mouse model of C-33A tumor xenografts.These results elucidate that AMP bidirectionally regulates apoptosis and autophagy in human cervical cancer C-33A cells by mediating the PI3K/Akt/m TOR pathway.
基金supports from the National Natural Science Foundation of China(Grant Nos.12305372 and 22376217)the National Key Research&Development Program of China(Grant Nos.2022YFA1603802 and 2022YFB3504100)+1 种基金the projects of the key laboratory of advanced energy materials chemistry,ministry of education(Nankai University)key laboratory of Jiangxi Province for persistent pollutants prevention control and resource reuse(2023SSY02061)are gratefully acknowledged.
文摘Using photoelectrocatalytic CO_(2) reduction reaction(CO_(2)RR)to produce valuable fuels is a fascinating way to alleviate environmental issues and energy crises.Bismuth-based(Bi-based)catalysts have attracted widespread attention for CO_(2)RR due to their high catalytic activity,selectivity,excellent stability,and low cost.However,they still need to be further improved to meet the needs of industrial applications.This review article comprehensively summarizes the recent advances in regulation strategies of Bi-based catalysts and can be divided into six categories:(1)defect engineering,(2)atomic doping engineering,(3)organic framework engineering,(4)inorganic heterojunction engineering,(5)crystal face engineering,and(6)alloying and polarization engineering.Meanwhile,the corresponding catalytic mechanisms of each regulation strategy will also be discussed in detail,aiming to enable researchers to understand the structure-property relationship of the improved Bibased catalysts fundamentally.Finally,the challenges and future opportunities of the Bi-based catalysts in the photoelectrocatalytic CO_(2)RR application field will also be featured from the perspectives of the(1)combination or synergy of multiple regulatory strategies,(2)revealing formation mechanism and realizing controllable synthesis,and(3)in situ multiscale investigation of activation pathways and uncovering the catalytic mechanisms.On the one hand,through the comparative analysis and mechanism explanation of the six major regulatory strategies,a multidimensional knowledge framework of the structure-activity relationship of Bi-based catalysts can be constructed for researchers,which not only deepens the atomic-level understanding of catalytic active sites,charge transport paths,and the adsorption behavior of intermediate products,but also provides theoretical guiding principles for the controllable design of new catalysts;on the other hand,the promising collaborative regulation strategies,controllable synthetic paths,and the in situ multiscale characterization techniques presented in this work provides a paradigm reference for shortening the research and development cycle of high-performance catalysts,conducive to facilitating the transition of photoelectrocatalytic CO_(2)RR technology from the laboratory routes to industrial application.
基金supported by the National Natural Science Foundation of China(22269020,U23A20582,42167068)the Gansu Province Higher Education Industry Support Plan Project(2023CYZC-17)+1 种基金2024 Major Cultivation Project for University Research and Innovation Platforms(2024CXPT-10)the Key Project of the Natural Science Foundation of Gansu Province(25JRRA004).
文摘Hard carbon(HC)remains a leading anode candidate for sodium-ion storage,yet its application is hindered by low initial Coulombic efficiency(ICE)and limited plateau capacity due to uncontrolled defect density and open porosity.Here,we propose a scalable dual-regulation strategy that simultaneously tunes pore mouth size and defect chemistry to enhance sodium storage performance.Using phenol-formaldehyde resin as the carbon precursor and phosphorus pentoxide(P_(2)O_(5))as a bifunctional sacrificial template and dopant source,we synthesize phosphorus-functionalized hard carbon(PF-PHC)featuring a high density of closed pores with well-confined sub-nanometer pore entrances.The in-situ sublimation of P_(2)O_(5) during pyrolysis promotes the formation of closed-pore architectures,while residual phosphorus atoms effectively passivate vacancy-type defects,thereby reducing irreversible Na+adsorption and mitigating excessive solid electrolyte interphase(SEI)formation.As a result,PF-PHC achieves an ICE of 89.3%and a plateau capacity of 289 mAh g^(−1).In-situ characterizations reveal that regulating pore mouth dimensions decouples Na+and solvent access,enabling highly selective ion transport and stable interfacial chemistry.Sodium-ion hybrid capacitors(SIHCs)assembled based on PF-PHC deliver exceptional rate performance and outstanding long-term cycling stability,retaining 98.2%after 10,000 cycles at 2 A g^(−1).This study establishes pore mouth engineering as a robust and scalable design principle for advancing next-generation HC-based sodium storage materials.
基金supported by Natural Science Foundation of China(Grant No.52372076,52073081,52203322,5252200843)Ministry of Science and Technology of the People’s Republic of China(2023YFB3812800)Fundamental Research Funds for the Central Universities(FRF-TP-25-073)。
文摘Energy-saving buildings(ESBs)are an emerging green technology that can significantly reduce building-associated cooling and heating energy consumption,catering to the desire for carbon neutrality and sustainable development of society.Smart photovoltaic windows(SPWs)offer a promising platform for designing ESBs because they present the capability to regulate and harness solar energy.With frequent outbreaks of extreme weather all over the world,the achievement of exceptional energy-saving effect under different weather conditions is an inevitable trend for the development of ESBs but is hardly achieved via existing SPWs.Here,we substantially reduce the driving voltage of polymerdispersed liquid crystals(PDLCs)by 28.1%via molecular engineering while maintaining their high solar transmittance(T_(sol)=83.8%,transparent state)and solar modulating ability(ΔT_(sol)=80.5%).By the assembly of perovskite solar cell and a broadband thermal-managing unit encompassing the electrical-responsive PDLCs,transparent high-emissivity SiO_(2) passive radiation-cooling,and Ag low-emissivity layers possesses,we present a tri-band regulation and split-type SPW possessing superb energy-saving effect in all-season.The perovskite solar cell can produce the electric power to stimulate the electrical-responsive behavior of the PDLCs,endowing the SPWs zero-energy input solar energy regulating characteristic,and compensate the daily energy consumption needed for ESBs.Moreover,the scalable manufacturing technology holds a great potential for the real-world applications.
基金funded by China Law Society 2025 Annual Legal Research,Project grant number:CLS(2025)Y04.
文摘Background:Medical artificial intelligence(MAI)is a synthesis of medical science and artificial intelligence development,serving as a crucial field in the current advancement and application of AI.In the process of developing medical AI,there may arise not only legal risks such as infringement of privacy rights and health rights but also ethical risks stemming from violations of the principles of beneficence and non-maleficence.Methods:To effectively address the damages caused by MAI in the future,it is necessary to establish a hierarchical governance system with MAI.This paper examines the systematic collection of local practices in China and the induction and integration of legal remedies for the damage of MAI.Results:To effectively address the ethical and legal challenges of medical artificial intelligence,a hierarchical regulatory system should be established,which based on the impact of intervention measures on natural rights and differences in intervention timing.This paper finally obtains a legal hierarchical governance system corresponding to the ethical risks and legal risks of MAI in China.Conclusion:The Chinese government has formed a multi-agent governance system based on the impact of risks on rights and the timing of legal intervention,which provides a reference for other countries to follow up on the research on MAI risk management.
基金the financial support from the Central South University Fundamental Research Funds (Grant No.2025ZZTS0444)the Innovation-Driven Research Program(Grant No. 2023 CXQD053)+3 种基金the National Natural Science Foundation of China (Grant No. 52274310)the financial support (Project No.H202111040350002)the provision of the hydroxide precursors from Ningbo Ronbay New Energy Technology Co.,Ltdsupported in part by the High-Performance Computing Center of Central South University
文摘Cation disordering is a common issue in Ni-rich cathodes that significantly degrades cycle life and compromises safety.The cubic rock-salt phase formation and the slow oxidation kinetics of Ni^(2+)during solid-state sintering are widely recognized as the principal causes of these structural defects.To solve this issue,a topotactic soft-chemical precursor engineering strategy is proposed for use in aqueous solution.By utilizing the layered structure of the precursor,this method allows for selective proton extraction and efficient Ni^(2+)oxidation,along with rapid Li+intercalation to form a layered lithiated intermediate.This intermediate crystallizes without further phase transitions during subsequent heat treatment,preventing structural defects caused by complex phase evolution and slow ion diffusion.The resulting cathode exhibits a long-range ordered layered structure and a uniform phase distribution,enabling efficient Li+insertion and extraction.Electrochemical tests reveal a high discharge capacity of 229.6 mAh g^(−1)and an initial coulombic efficiency of 95.77%at 0.1 C,greatly exceeding the performance of a conventionally synthesized cathode(210.3 mAh g^(−1),88.93%).Improved Li^(+)transport kinetics reduces phase-transition hysteresis and alleviates stress concentration,resulting in better cycling stability with a capacity retention of 85.3%after 300 cycles,compared to 61.5%for the conventional sample.This work presents a scalable and effective synthesis route for Ni-rich cathodes with reduced structural disorder and extended lifespan,providing valuable insights into how the regulation of intermediate phases influences electrochemical performance in high-performance Ni-rich cathodes.
基金supported by grants from the Deutsche Forschungsgemeinschaft(DFG)to MW.
文摘Oligodendrocytes and their cell-intrinsic gene regulatory network:Oligodendrocytes(OLs)are the myelinating glial cells of the vertebrate central nervous system.They are responsible for insulating neuronal axons with a lipid-rich myelin sheath,which enables the saltatory conduction of action potentials.During development,oligodendrocyte progenitor cells(OPCs)emerge from neural stem cells in the ventricular zone.They then proliferate,increase their number,and migrate to their final destination where they encounter unmyelinated neuronal axons and differentiate in a stepwise fashion into myelinating oligodendrocytes(mOLs)under the influence of environmental stimuli.
基金supported by the Lanzhou Science and Technology Plan Project(XM1753694781389).
文摘Facing the economic challenges of significant frequency regulation wear and tear on thermal power units and short energy storage lifespan in thermal-energy storage combined systems participating in grid primary frequency regulation(PFR),this paper proposes a novel hybrid energy storage system(HESS)control strategy based on Newton-Raphson optimization algorithm(NRBO)-VMD and a fuzzy neural network(FNN)for PFR.In the primary power allocation stage,the high inertia and slow response of thermal power units prevent them from promptly responding to the high-frequency components of PFR signals,leading to increased mechanical stress.To address the distinct response characteristics of thermal units and HESS,an NRBO-VMD based decomposition method for PFR signals is proposed,enabling a flexible system response to grid frequency deviations.Within the HESS,an adaptive coordinated control strategy and a State of Charge(SOC)self-recovery strategy are introduced.These strategies autonomously adjust the virtual inertia and droop coefficients based on the depth of frequency regulation and the real-time SOC.Furthermore,a FNN is constructed to perform secondary refinement of the internal power distribution within the HESS.Finally,simulations under various operational conditions demonstrate that the proposed strategy effectively mitigates frequent power adjustments of the thermal unit during PFR,adaptively achieves optimal power decomposition and distribution,maintains the flywheel energy storage’s SOC within an optimal range,and ensures the long-term stable operation of the HESS.
基金supported by the National Natural Science Foundation of China(22209006,21935001)the Natural Science Foundation of Shandong Province(ZR2022QE009)+1 种基金Fundamental Research Funds for the Central Universities(buctrc202307)the Beijing Natural Science Foundation(Z210016).
文摘Low-cost and high-safety aqueous Zn-I_(2) batteries attract extensive attention for large-scale energy storage systems.However,polyiodide shuttling and sluggish iodine conversion reactions lead to inferior rate capability and severe capacity decay.Herein,a three-dimensional polyaniline is wrapped by carboxylcarbon nanotubes(denoted as C-PANI)which is designed as a catalytic cathode to effectively boost iodine conversion with suppressed polyiodide shuttling,thereby improving Zn-I_(2) batteries.Specifically,carboxyl-carbon nanotubes serve as a proton reservoir for more protonated-NH+=sites in PANI chains,achieving a direct I0/I−reaction for suppressed polyiodide generation and Zn corrosion.Attributing to this“proton-iodine”regulation,catalytic protonated C-PANI strongly fixes electrolytic iodine species and stores proton ions simultaneously through reversible-N=/-NH^(+)-reaction.Therefore,the electrolytic Zn-I_(2) battery with C-PANI cathode exhibits an impressive capacity of 420 mAh g^(−1) and ultra-long lifespan over 40,000 cycles.Additionally,a 60 mAh pouch cell was assembled with excellent cycling stability after 100 cycles,providing new insights into exploring effective organocatalysts for superb Zn-halogen batteries.
基金supported by National Institutes of Health(R35NS137480,R35NS116843,and RF1AG079557)by Dr.Miriam and Sheldon G.Adelson Medical Research Foundation.
文摘The adult subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal dentate gyrus(DG)are the two brain regions where neurogenesis occurs throughout life in the adult mammalian brain(Ming and Song,2011).Adult quiescent hippocampal neural stem cells(NSCs)are bona fide stem cells and,when activated,give rise to newborn granule neurons in the adult brain,which play vital roles in learning,memory,mood,and affective cognition(Bonaguidi et al.,2011;Ming and Song,2011).
