人类大脑皮层发育过程中,大量神经细胞从靠近脑室的增殖区产生并向软脑膜方向迁移,最终形成与人类许多高级功能相关的6层大脑新皮质结构,Reelin-Dab1信号通路在神经细胞迁移中起到了关键的作用。Reelin结合于迁移细胞膜上的极低密度脂...人类大脑皮层发育过程中,大量神经细胞从靠近脑室的增殖区产生并向软脑膜方向迁移,最终形成与人类许多高级功能相关的6层大脑新皮质结构,Reelin-Dab1信号通路在神经细胞迁移中起到了关键的作用。Reelin结合于迁移细胞膜上的极低密度脂蛋白受体(very lowlipoprotein recep-tor,VLDLR)和载脂蛋白E受体2(apolipoprotein E receptor2,ApoER2),磷酸化胞浆内的衔接蛋白disabled1(Dab1),继而与下游信号分子如细胞骨架蛋白等相互作用,指导皮层神经元的正确迁移和定位。本篇综述讨论了Reelin-Dab1信号通路在人类新皮质形成过程中的作用及近几年的研究新进展。展开更多
The development of the 6-layered cerebral neocortex is one of the most important events during nervous system development, and disturbances could result in various malformations, causing clinically intractable disease...The development of the 6-layered cerebral neocortex is one of the most important events during nervous system development, and disturbances could result in various malformations, causing clinically intractable diseases, such as epilepsy and cerebral palsy. Pre-plate splitting is the first developmental step of the cortical plate formation. Without correct pre-plate splitting, normal cerebral cortex structures are disturbed. The Reelin-Dabl molecular pathway plays a critical role during cerebral cortex development, and deficiencies in this pathway result in failed pre-plate splitting and an inverted cortical plate. This paper summarizes findings involving Reelin and pre-plate splitting and further explores the precise role of Reelin during pre-plate splitting.展开更多
基金supported by the National Natural Science Foundation of China(No.31070952)the Joint Fund for Fostering Talents of the National Natural Science Foundation of China and Henan Province+2 种基金China(No.U1204311)the Program of Excellent Thesis for Master’s Degree of Henan UniversityChina(No.Y1319001)
文摘人类大脑皮层发育过程中,大量神经细胞从靠近脑室的增殖区产生并向软脑膜方向迁移,最终形成与人类许多高级功能相关的6层大脑新皮质结构,Reelin-Dab1信号通路在神经细胞迁移中起到了关键的作用。Reelin结合于迁移细胞膜上的极低密度脂蛋白受体(very lowlipoprotein recep-tor,VLDLR)和载脂蛋白E受体2(apolipoprotein E receptor2,ApoER2),磷酸化胞浆内的衔接蛋白disabled1(Dab1),继而与下游信号分子如细胞骨架蛋白等相互作用,指导皮层神经元的正确迁移和定位。本篇综述讨论了Reelin-Dab1信号通路在人类新皮质形成过程中的作用及近几年的研究新进展。
基金the Project of Abroad Researcher Foundation of Heilongjiang Province,No.LC07C17
文摘The development of the 6-layered cerebral neocortex is one of the most important events during nervous system development, and disturbances could result in various malformations, causing clinically intractable diseases, such as epilepsy and cerebral palsy. Pre-plate splitting is the first developmental step of the cortical plate formation. Without correct pre-plate splitting, normal cerebral cortex structures are disturbed. The Reelin-Dabl molecular pathway plays a critical role during cerebral cortex development, and deficiencies in this pathway result in failed pre-plate splitting and an inverted cortical plate. This paper summarizes findings involving Reelin and pre-plate splitting and further explores the precise role of Reelin during pre-plate splitting.
