Nonlinear PAPR reducers, such as clipping and companding techniques, are some simple methods used to reduce the Peak-to-Average Power Ratio (PAPR). In this paper, assuming that the baseband OFDM signal is characterize...Nonlinear PAPR reducers, such as clipping and companding techniques, are some simple methods used to reduce the Peak-to-Average Power Ratio (PAPR). In this paper, assuming that the baseband OFDM signal is characterized as a band-limited complex Gaussian process, we investigate the PAPR distribution of an OFDM signal when it is passed through a nonlinear PAPR reducer. The obtained PAPR distribution depends on the nonlinear function which characterizes the PAPR reducer. Later in this paper, we apply the obtained PAPR distribution in the clipping case. The comparisons made between the proposed distribution and that obtained thanks to computer simulations show good agreement.展开更多
A geometrical parameters optimization and reducers selection method was proposed for robotic manipulators design. The Lagrangian approach was employed in deriving the dynamic model of a two-DOF manipulator. The flexib...A geometrical parameters optimization and reducers selection method was proposed for robotic manipulators design. The Lagrangian approach was employed in deriving the dynamic model of a two-DOF manipulator. The flexibility of links and joints was taken into account in the mechanical structure dimensions optimization and reducers selection, in which Timoshenko model was used to discretize the hollow links. Two criteria, i.e. maximization of fundamental frequency and minimization of self-mass/load ratio, were utilized to optimize the manipulators. The NSGA-II (fast elitist nondominated sorting genetic algorithms) was employed to solve the multi-objective optimization problem. How the joints flexibility affects the manipulators design was analyzed and shown in the numerical analysis example. The results indicate that simultaneous consideration of the joints and the links flexibility is very necessary for manipulators optimal design. Finally, several optimal combinations were provided. The effectiveness of the optimization method was proved by comparing with ADAMS simulation results. The self-mass/load ratio error of the two methods is within 10%. The maximum error of the natural frequency by the two methods is 23.74%. The method proposed in this work provides a fast and effective pathway for manipulator design and reducers selection.展开更多
Owing to some excellent properties(such as large transmission ratio, high reliability, high precision,large stiffness, small volume and long service life), filtering reducers are suitable for occasions with high requi...Owing to some excellent properties(such as large transmission ratio, high reliability, high precision,large stiffness, small volume and long service life), filtering reducers are suitable for occasions with high requirements(e.g. space equipment). However, the tough working condition in space(including frequent changes of temperature, and large temperature difference combined with shock loads) may significantly affect the reliability.In this paper, the expressions of the minimal and maximal instantaneous transmission ratios(ITRs) considering temperature correction are developed. The minimal and maximal ITRs from simulation are used to verify the accuracy. Moreover, the reliability of a filtering reducer under different temperatures and the shock load are calculated, respectively. The research is beneficial to the design of spacecraft mechanism.展开更多
In the article titled“Inhibiting SHP2 reduces glycolysis,promotes microglial M1 polarization,and alleviates secondary inflammation following spinal cord injury in a mouse model,”published in Neural Regeneration Rese...In the article titled“Inhibiting SHP2 reduces glycolysis,promotes microglial M1 polarization,and alleviates secondary inflammation following spinal cord injury in a mouse model,”published in Neural Regeneration Research(Ding et al.,2025),the title was incorrectly presented due to an error during the language polishing process.展开更多
Type 2 diabetes mellitus has central complications:Diabetes,a metabolic disorder primarily characterized by hyperglycemia due to insufficient insulin secretion,or impaired insulin signaling,has significant central com...Type 2 diabetes mellitus has central complications:Diabetes,a metabolic disorder primarily characterized by hyperglycemia due to insufficient insulin secretion,or impaired insulin signaling,has significant central complications.Type 2 diabetes mellitus(T2DM),the most prevalent type of diabetes,affects more than 38 million individuals in the United States(approximately 1 in 10)and is defined by chronic hyperglycemia and insulin resistance,which refers to a reduced cellular response to insulin.展开更多
BACKGROUND Ulcerative colitis(UC)is a chronic and debilitating inflammatory bowel disease.Cumulative evidence indicates that excess hydrogen peroxide,a potent neutrophilic chemotactic agent,produced by colonic epithel...BACKGROUND Ulcerative colitis(UC)is a chronic and debilitating inflammatory bowel disease.Cumulative evidence indicates that excess hydrogen peroxide,a potent neutrophilic chemotactic agent,produced by colonic epithelial cells has a causal role leading to infiltration of neutrophils into the colonic mucosa and subsequent development of UC.This evidence-based mechanism identifies hydrogen peroxide as a therapeutic target for reducing agents in the treatment of UC.CASE SUMMARY Presented is a 41-year-old female with a 26-year history of refractory UC.Having developed steroid dependence and never achieving complete remission on treatment by conventional and advanced therapies,she began treatment with oral R-dihydrolipoic acid(RDLA),a lipid-soluble reducing agent with intracellular site of action.Within a week,rectal bleeding ceased.She was asymptomatic for three years until a highly stressful experience,when she noticed blood in her stool.RDLA was discontinued,and she began treatment with oral sodium thiosulfate pentahydrate(STS),a reducing agent with extracellular site of action.After a week,rectal bleeding ceased,and she resumed oral RDLA and discontinued STS.To date,she remains asymptomatic with normal stool calprotectin while on RDLA.CONCLUSION STS and RDLA are reducing agents that serve as highly effective and safe therapy for the induction and maintenance of remission in UC,even in patients refractory or poorly controlled by conventional and advanced therapies.Should preliminary findings be validated by subsequent clinical trials,the use of reducing agents could potentially prevent thousands of colectomies and represent a paradigm shift in the treatment of UC.展开更多
The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can serio...The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral function, facial appearance, and mental health. As anterior crossbite tends to worsen with growth, early orthodontic treatment can harness growth potential to normalize maxillofacial development or reduce skeletal malformation severity, thereby reducing the difficulty and shortening the treatment cycle of later-stage treatment. This is beneficial for the physical and mental growth of children. Therefore,early orthodontic treatment for Class Ⅲ malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. Currently, standardized treatment guidelines for early orthodontic treatment of Class Ⅲ malocclusion are lacking. This review provides a comprehensive summary of the etiology, clinical manifestations, classification, and early orthodontic techniques for Class Ⅲ malocclusion, along with systematic discussions on selecting early treatment plans. The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class Ⅲ malocclusion through early orthodontic treatment.展开更多
Silicon-air batteries(SABs),a new type of semiconductor air battery,have a high energy density.However,some side reactions in SABs cause Si anodes to be covered by a passivation layer to prevent continuous discharge,a...Silicon-air batteries(SABs),a new type of semiconductor air battery,have a high energy density.However,some side reactions in SABs cause Si anodes to be covered by a passivation layer to prevent continuous discharge,and the anode utilization rate is low.In this work,reduced graphene oxide(RGO)fabricated via high-temperature annealing or L-ascorbic acid(L.AA)reduction was first used to obtain Si nanowires/RGO-1000(Si NWs/RGO-1000)and Si nanowires/RGO-L.AA(Si NWs/RGO-L.AA)composite anodes for SABs.It was found that RGO suppressed the passivation and self-corrosion reactions and that SABs using Si NWs/RGO-L.AA as the anode can discharge for more than 700 h,breaking the previous performance of SABs,and that the specific capacity was increased by 90.8%compared to bare Si.This work provides a new solution for the design of high specific capacity SABs with nanostructures and anode protective layers.展开更多
Macroalgae dominate nutrient dynamics and function as high-value foods for microbial,meio-and macrofaunal communities in coastal ecosystems.Because of this vital role,it is important to clarify the physiological infor...Macroalgae dominate nutrient dynamics and function as high-value foods for microbial,meio-and macrofaunal communities in coastal ecosystems.Because of this vital role,it is important to clarify the physiological information associated with environmental changes as it reflects their growth potential.To evaluate the effects of the changes in salinity and nutrients,the photosynthetic efficiency of a green macroalga Ulva fasciata from the Daya Bay was tested at a range of salinity(i.e.,31 to 10 psu)and nitrogen content(i.e.,5 to 60μmol L^(-1)).The results showed that cellular chlorophyll a(Chl a),carbohydrate and protein contents of U.fasciata were increased due to reduced salinity,and were decreased by interactive nitrogen enrichment.Within a short culture period(i.e.,18 h),the reduced salinity decreased the maximum photosynthetic efficiency(rETRmax and Pmax)derived from the rapid light response curve and photosynthetic oxygen evolution rate versus irradiance curve,respectively,as well as the saturation irradiance(E_(K)).This reducing effect diminished with enlonged cultivation time and reversed to a stimulating effect after 24 h of cultivation.The nitrogen enrichment stimulated the rETRmax and Pmax,as well as the E_(K),regardless of salinity,especially within short-term cultivation period(i.e.,<24 h).In addition,our results indicate that seawater freshening lowers the photosynthetic efficiency of U.fasciata in the short term,which is mitigated by nitrogen enrichment,but stimulates it in the long term,providing insight into how macroalgae thrive in coastal or estuarine waters where salinity and nutrients normally covary strongly.展开更多
To make agricultural systems sustainable in terms of their greenness and efficiency,optimizing the tillage and fertilization practices is essential.To assess the effects of tilling and fertilization practices in wheat...To make agricultural systems sustainable in terms of their greenness and efficiency,optimizing the tillage and fertilization practices is essential.To assess the effects of tilling and fertilization practices in wheat-maize cropping systems,a three-year field experiment was designed to quantify the carbon footprint(CF)and energy efficiency of the cropping systems in the North China Plain.The study parameters included four tillage practices(no tillage(NT),conventional tillage(CT),rotary tillage(RT),and subsoiling rotary tillage(SRT))and two fertilizer regimes(inorganic fertilizer(IF)and hybrid fertilizer with organic and inorganic components(HF)).The results indicated that the most prominent energy inputs and greenhouse gas(GHG)emissions could be ascribed to the use of fertilizers and fuel consumption.Under the same fertilization regime,ranking the tillage patterns with respect to the value of the crop yield,profit,CF,energy use efficiency(EUE)or energy productivity(EP)for either wheat or maize always gave the same sequence of SRT>RT>CT>NT.For the same tillage,the energy consumption associated with HF was higher than IF,but its GHG emissions and CF were lower while the yield and profit were higher.In terms of overall performance,tilling is more beneficial than NT,and reduced tillage practices(RT and SRT)are more beneficial than CT.The fertilization regime with the best overall performance was HF.Combining SRT with HF has significant potential for reducing CF and increasing EUE,thereby improving sustainability.Adopting measures that promote these optimizations can help to overcome the challenges posed by a lack of food security,energy crises and ecological stress.展开更多
The metal ion batteries have gained widespread attention for wearable electronics due to their competitive energy density and long cycling life.Exploring the advanced anode materials is significant for next generation...The metal ion batteries have gained widespread attention for wearable electronics due to their competitive energy density and long cycling life.Exploring the advanced anode materials is significant for next generation energy storage systems.However,severe electrode volume changes and sluggish redox kinetics are the critical problems for lithium/potassium ion batteries(LIBs/PIBs)towards large-scale applications.Herein,we prepare a novel anode material,which consists of reduced graphene oxide wrapping one-dimensional(1D)N-doped porous carbon nanotube with cobalt phosphoselenide(CoPSe)nanoparticles embedded inside them(r GO@Co PSe/NC).Benefited from the dual carbon decorations and ultrafine nanoparticles structure,it achieves a reversible capacity of 245 mAh/g at 5 A/g after 2000 cycles for LIBs and 215 mAh/g at 1 A/g after 500 cycles for PIBs.The pseudocapacitance and GITT measurements are used to investigate the electrochemical kinetics of r GO@Co PSe/NC for LIBs.In addition,the lithium ion full cell also shows good electrochemical performance when paired with high capacity LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode.This work provides a feasible electrode design strategy for high-efficiency metal ion batteries based on multidimensional nanoarchitecture engineering and composition tailoring.展开更多
Carbon-based foams with a three-dimensional structure can serve as a lightweight template for the rational design and control-lable preparation of metal oxide/carbon-based composite microwave absorption materials.In t...Carbon-based foams with a three-dimensional structure can serve as a lightweight template for the rational design and control-lable preparation of metal oxide/carbon-based composite microwave absorption materials.In this study,a flake-like nickel cobaltate/re-duced graphene oxide/melamine-derived carbon foam(FNC/RGO/MDCF)was successfully fabricated through a combination of solvo-thermal treatment and high-temperature pyrolysis.Results indicated that RGO was evenly distributed in the MDCF skeleton,providing ef-fective support for the load growth of FNC on its surface.Sample S3,the FNC/RGO/MDCF composite prepared by solvothermal method for 16 h,exhibited a minimum reflection loss(RL_(min))of-66.44 dB at a thickness of 2.29 mm.When the thickness was reduced to 1.50 mm,the optimal effective absorption bandwidth was 3.84 GHz.Analysis of the absorption mechanism of FNC/RGO/MDCF revealed that its excellent absorption performance was primarily attributed to the combined effects of conduction loss,multiple reflection,scattering,in-terface polarization,and dipole polarization.展开更多
The iron and steel industry,standing as a quintessential manufacture example with high consumption,pollution and emissions,faces significant environmental and sustainable development challenges.Electric arc furnace(EA...The iron and steel industry,standing as a quintessential manufacture example with high consumption,pollution and emissions,faces significant environmental and sustainable development challenges.Electric arc furnace(EAF)steelmaking process mainly uses scrap as raw material and is characterized by environmentally friendly and recyclable process.However,the further development of EAF route in China is limited by the reserve,supply,availability and quality of scrap resource.Direct reduced iron(DRI)is one of typical low-carbon and clean charges,which can effectively make up for the adverse effects caused by the lack of scrap.The physical and chemical properties,classifications,and production technologies of DRI are firstly reviewed.In particular,the reducing gas types,reduction temperature,and reduction mechanism of the DRI production with gas-based shaft furnace(SF)technology are detailed.Considering the crucial role played by DRI application in EAF,the influences of DRI addition on EAF smelting rules and operations including the blending and charging process,heat transfer and melting in molten bath,slag formation operation,refractory corrosion,and slag system evolution are then further discussed.Finally,the comparative analysis and assessment of the consumption level of material and energy as well as the cleaner production both covering the clean chemical composition of molten steel and the clean environment impact in EAF steelmaking with DRI charged are conducted.From perspectives of metallurgical process engineering,a suitable route of hydrogen generation and application(from coke oven gas,methanol,and clean energy power),CO_(2) capture and utilization integrated with SF–EAF process is proposed.In view of the difficulties in large-scale DRI application in EAF,the follow-up work should focus on the investigation of DRI charging and melting,slag system evolution and molten pool reaction rules,as well as the developments of the DRI standardized use technology and intelligent batching and control models.展开更多
This paper proposes a lightweight traffic sign detection system based on you only look once(YOLO).Firstly,the classification to fusion(C2f)structure is integrated into the backbone network,employing deformable convolu...This paper proposes a lightweight traffic sign detection system based on you only look once(YOLO).Firstly,the classification to fusion(C2f)structure is integrated into the backbone network,employing deformable convolution and bi-directional feature pyramid network(BiFPN)_Concat to improve the adaptability of the network.Secondly,the simple attention module(SimAm)is embedded to prioritize key features and reduce the complexity of the model after the C2f layer at the end of the backbone network.Next,the focal efficient intersection over union(EloU)is introduced to adjust the weights of challenging samples.Finally,we accomplish the design and deployment for the mobile app.The results demonstrate improvements,with the F1 score of 0.8987,mean average precision(mAP)@0.5 of 98.8%,mAP@0.5:0.95 of 75.6%,and the detection speed of 50 frames per second(FPS).展开更多
Dear Editor,As an important energy storage device,lithium-ion battery plays a vital role in electric aircrafts,which are new and promising equipment of transportation in the future with low carbon emissions.Accurate p...Dear Editor,As an important energy storage device,lithium-ion battery plays a vital role in electric aircrafts,which are new and promising equipment of transportation in the future with low carbon emissions.Accurate prediction of the state of charge(SOC)of lithium-ion batteries is of great importance in reducing the probability of abnormal accidents and ensuring flight safety.展开更多
Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better under...Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms.Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss.Our study uses the prematurely aged PolgD257A/D257A(PolgA)mouse model to scrutinize age-and sex-related alterations in musculoskeletal health parameters(frailty,grip strength,gait data),bone and particularly the osteocyte lacuno-canalicular network(LCN).Moreover,a new quantitative in silico image analysis pipeline is used to evaluate the alterations in the osteocyte network with aging.Our findings underscore the pronounced degenerative changes in the musculoskeletal health parameters,bone,and osteocyte LCN in PolgA mice as early as 40 weeks,with more prominent alterations evident in aged males.Our findings suggest that the PolgA mouse model serves as a valuable model for studying the cellular mechanisms underlying age-related bone loss,given the comparable aging signs and age-related degeneration of the bone and the osteocyte network observed in naturally aging mice and elderly humans.展开更多
In this manuscript,we propose an analytical equivalent linear viscoelastic constitutive model for fiber-reinforced composites,bypassing general computational homogenization.The method is based on the reduced-order hom...In this manuscript,we propose an analytical equivalent linear viscoelastic constitutive model for fiber-reinforced composites,bypassing general computational homogenization.The method is based on the reduced-order homogenization(ROH)approach.The ROH method typically involves solving multiple finite element problems under periodic conditions to evaluate elastic strain and eigenstrain influence functions in an‘off-line’stage,which offers substantial cost savings compared to direct computational homogenization methods.Due to the unique structure of the fibrous unit cell,“off-line”stage calculation can be eliminated by influence functions obtained analytically.Introducing the standard solid model to the ROH method enables the creation of a comprehensive analytical homogeneous viscoelastic constitutive model.This method treats fibrous composite materials as homogeneous,anisotropic viscoelastic materials,significantly reducing computational time due to its analytical nature.This approach also enables precise determination of a homogenized anisotropic relaxation modulus and accurate capture of various viscoelastic responses under different loading conditions.Three sets of numerical examples,including unit cell tests,three-point beam bending tests,and torsion tests,are given to demonstrate the predictive performance of the homogenized viscoelastic model.Furthermore,the model is validated against experimental measurements,confirming its accuracy and reliability.展开更多
Silicon-based materials have attracted considerable attention as potential anodes in lithium-ion energy storage systems,primarily due to their having a theoretical capacity greater than conventional graphite anodes.De...Silicon-based materials have attracted considerable attention as potential anodes in lithium-ion energy storage systems,primarily due to their having a theoretical capacity greater than conventional graphite anodes.Despite this advantage,the inherent problem of substantial volume changes during lithiation/delithiation severely hinders their practical implementation in commercial battery configurations.We report the synthesis of a material by an electrostatic self-assembly method in which citric acid(CA)serves as a crosslinker to anchor cetyltrimethylammonium bromide-modified positively charged silicon nanoparticles between graphene oxide(GO)layers.After freeze-drying and thermal treatment under a nitrogen atmosphere,silicon particle core layers sandwiched between reduced graphene oxide(rGO)layers were obtained.Control samples with Si/rGO mass ratios of 0.5,1 and 2 were prepared for evaluation.The continuous conductive rGO network significantly increased the electronic conductivity of the material and the incorporation of CA acted as a binding agent between the Si and the rGO which increased the structural stability.By anchoring the silicon particles between adjacent rGO layers,the abundant void spaces and favorable mechanical flexibility of rGO were harnessed to effectively alleviate the volume expansion of silicon during charge-discharge cycles.The material with the Si/rGO mass ratio of 1 gave the highest specific capacity of 946.6 mAh g^(−1)after 200 cycles at a current density of 0.5 A g^(−1).It also had a good rate performance,with a good reversible capacity of 1005.1 mAh g^(−1)at a high current density of 2 A g^(−1).展开更多
In order to meet the demands of new-generation electric vehicles that require high power output(over 15 kW/kg),it is crucial to increase the energy density of car-bon-based supercapacitors to a level comparable to tha...In order to meet the demands of new-generation electric vehicles that require high power output(over 15 kW/kg),it is crucial to increase the energy density of car-bon-based supercapacitors to a level comparable to that of batteries,while maintaining a high power density.We re-port a porous carbon material produced by immersing pop-lar wood(PW)sawdust in a solution of KOH and graphene oxide(GO),followed by carbonization.The resulting mater-ial has exceptional properties as an electrode for high-en-ergy supercapacitors.Compared to the material prepared by the direct carbonization of PW,its electrical conductivity was in-creased from 0.36 to 26.3 S/cm.Because of this and a high microporosity of over 80%,which provides fast electron channels and a large ion storage surface,when used as the electrodes for a symmetric supercapacitor,it gave a high energy density of 27.9 Wh/kg@0.95 kW/kg in an aqueous electrolyte of 1.0 mol/L Na_(2)SO_(4).The device also had battery-level energy storage with maximum energy densities of 73.9 Wh/kg@2.0 kW/kg and 67.6 Wh/kg@40 kW/kg,an ultrahigh power density,in an organic electrolyte of 1.0 mol/L TEABF4/AN.These values are comparable to those of 30−45 Wh/kg for Pb-acid batteries and 30−55 Wh/kg for aqueous lithium batteries.This work indicates a way to prepare carbon materials that can be used in supercapacit-ors with ultrahigh energy and power densities.展开更多
文摘Nonlinear PAPR reducers, such as clipping and companding techniques, are some simple methods used to reduce the Peak-to-Average Power Ratio (PAPR). In this paper, assuming that the baseband OFDM signal is characterized as a band-limited complex Gaussian process, we investigate the PAPR distribution of an OFDM signal when it is passed through a nonlinear PAPR reducer. The obtained PAPR distribution depends on the nonlinear function which characterizes the PAPR reducer. Later in this paper, we apply the obtained PAPR distribution in the clipping case. The comparisons made between the proposed distribution and that obtained thanks to computer simulations show good agreement.
基金Project(2009AA04Z216) supported by the National High-Tech Research and Development Program (863 Program) of ChinaProject(2009ZX04013-011) supported by the National Science and Technology Major Project of ChinaProject supported by the HIT Oversea Talents Introduction Program,China
文摘A geometrical parameters optimization and reducers selection method was proposed for robotic manipulators design. The Lagrangian approach was employed in deriving the dynamic model of a two-DOF manipulator. The flexibility of links and joints was taken into account in the mechanical structure dimensions optimization and reducers selection, in which Timoshenko model was used to discretize the hollow links. Two criteria, i.e. maximization of fundamental frequency and minimization of self-mass/load ratio, were utilized to optimize the manipulators. The NSGA-II (fast elitist nondominated sorting genetic algorithms) was employed to solve the multi-objective optimization problem. How the joints flexibility affects the manipulators design was analyzed and shown in the numerical analysis example. The results indicate that simultaneous consideration of the joints and the links flexibility is very necessary for manipulators optimal design. Finally, several optimal combinations were provided. The effectiveness of the optimization method was proved by comparing with ADAMS simulation results. The self-mass/load ratio error of the two methods is within 10%. The maximum error of the natural frequency by the two methods is 23.74%. The method proposed in this work provides a fast and effective pathway for manipulator design and reducers selection.
基金the Open Foundation of the State Key Laboratory of Mechanical Transmissions of Chongqing University(No.SKLMT-KFKT-201601)
文摘Owing to some excellent properties(such as large transmission ratio, high reliability, high precision,large stiffness, small volume and long service life), filtering reducers are suitable for occasions with high requirements(e.g. space equipment). However, the tough working condition in space(including frequent changes of temperature, and large temperature difference combined with shock loads) may significantly affect the reliability.In this paper, the expressions of the minimal and maximal instantaneous transmission ratios(ITRs) considering temperature correction are developed. The minimal and maximal ITRs from simulation are used to verify the accuracy. Moreover, the reliability of a filtering reducer under different temperatures and the shock load are calculated, respectively. The research is beneficial to the design of spacecraft mechanism.
文摘In the article titled“Inhibiting SHP2 reduces glycolysis,promotes microglial M1 polarization,and alleviates secondary inflammation following spinal cord injury in a mouse model,”published in Neural Regeneration Research(Ding et al.,2025),the title was incorrectly presented due to an error during the language polishing process.
基金supported by grants from NIH T32(DK007260,to WC)the Steno North American Fellowship awarded by the Novo Nordisk Foundation(NNF23OC0087108,to WC)+6 种基金STI2030-Major Projects(2021ZD0202700,to HY)the National Natural Science Foundation of China(32241004,to HY)the Natural Science Foundation of Zhejiang Province of China(LR24C090001,to HY)Key R&D Program of Zhejiang Province(2024SSYS0017,to HY)CAMS Innovation Fund for Medical Sciences(2019-12M-5-057,to HY)Fundamental Research Funds for the Central Universities(226-2022-00193,to HY)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2023-PT310-01,to HY)。
文摘Type 2 diabetes mellitus has central complications:Diabetes,a metabolic disorder primarily characterized by hyperglycemia due to insufficient insulin secretion,or impaired insulin signaling,has significant central complications.Type 2 diabetes mellitus(T2DM),the most prevalent type of diabetes,affects more than 38 million individuals in the United States(approximately 1 in 10)and is defined by chronic hyperglycemia and insulin resistance,which refers to a reduced cellular response to insulin.
文摘BACKGROUND Ulcerative colitis(UC)is a chronic and debilitating inflammatory bowel disease.Cumulative evidence indicates that excess hydrogen peroxide,a potent neutrophilic chemotactic agent,produced by colonic epithelial cells has a causal role leading to infiltration of neutrophils into the colonic mucosa and subsequent development of UC.This evidence-based mechanism identifies hydrogen peroxide as a therapeutic target for reducing agents in the treatment of UC.CASE SUMMARY Presented is a 41-year-old female with a 26-year history of refractory UC.Having developed steroid dependence and never achieving complete remission on treatment by conventional and advanced therapies,she began treatment with oral R-dihydrolipoic acid(RDLA),a lipid-soluble reducing agent with intracellular site of action.Within a week,rectal bleeding ceased.She was asymptomatic for three years until a highly stressful experience,when she noticed blood in her stool.RDLA was discontinued,and she began treatment with oral sodium thiosulfate pentahydrate(STS),a reducing agent with extracellular site of action.After a week,rectal bleeding ceased,and she resumed oral RDLA and discontinued STS.To date,she remains asymptomatic with normal stool calprotectin while on RDLA.CONCLUSION STS and RDLA are reducing agents that serve as highly effective and safe therapy for the induction and maintenance of remission in UC,even in patients refractory or poorly controlled by conventional and advanced therapies.Should preliminary findings be validated by subsequent clinical trials,the use of reducing agents could potentially prevent thousands of colectomies and represent a paradigm shift in the treatment of UC.
文摘The prevalence of Class Ⅲ malocclusion varies among different countries and regions. The populations from Southeast Asian countries (Chinese and Malaysian) showed the highest prevalence rate of 15.8%, which can seriously affect oral function, facial appearance, and mental health. As anterior crossbite tends to worsen with growth, early orthodontic treatment can harness growth potential to normalize maxillofacial development or reduce skeletal malformation severity, thereby reducing the difficulty and shortening the treatment cycle of later-stage treatment. This is beneficial for the physical and mental growth of children. Therefore,early orthodontic treatment for Class Ⅲ malocclusion is particularly important. Determining the optimal timing for early orthodontic treatment requires a comprehensive assessment of clinical manifestations, dental age, and skeletal age, and can lead to better results with less effort. Currently, standardized treatment guidelines for early orthodontic treatment of Class Ⅲ malocclusion are lacking. This review provides a comprehensive summary of the etiology, clinical manifestations, classification, and early orthodontic techniques for Class Ⅲ malocclusion, along with systematic discussions on selecting early treatment plans. The purpose of this expert consensus is to standardize clinical practices and improve the treatment outcomes of Class Ⅲ malocclusion through early orthodontic treatment.
基金supported by the National Natural Science Foundation of China(No.61904073)Spring City Plan-Special Program for Young Talents(No.K202005007)+4 种基金Yunnan Talents Support Plan for Yong Talents(No.XDYC-QNRC-20220482)Yunnan Local Colleges Applied Basic Research Projects(No.202101BA070001-138)Scientific Research Fund of Yunnan Education Department(No.2023Y0883)Frontier Research Team of Kunming University 2023Key Laboratory of Artificial Microstructures in Yunnan Higher Education。
文摘Silicon-air batteries(SABs),a new type of semiconductor air battery,have a high energy density.However,some side reactions in SABs cause Si anodes to be covered by a passivation layer to prevent continuous discharge,and the anode utilization rate is low.In this work,reduced graphene oxide(RGO)fabricated via high-temperature annealing or L-ascorbic acid(L.AA)reduction was first used to obtain Si nanowires/RGO-1000(Si NWs/RGO-1000)and Si nanowires/RGO-L.AA(Si NWs/RGO-L.AA)composite anodes for SABs.It was found that RGO suppressed the passivation and self-corrosion reactions and that SABs using Si NWs/RGO-L.AA as the anode can discharge for more than 700 h,breaking the previous performance of SABs,and that the specific capacity was increased by 90.8%compared to bare Si.This work provides a new solution for the design of high specific capacity SABs with nanostructures and anode protective layers.
基金funded by the National Key Research and Development Program of China(No.20022YFC3102405)the National Natural Science Foundation of China(Nos.42425004,32371665)the Natural Science Foundation of Guangdong Province(Nos.2022A1515011461,2022A1515011831)。
文摘Macroalgae dominate nutrient dynamics and function as high-value foods for microbial,meio-and macrofaunal communities in coastal ecosystems.Because of this vital role,it is important to clarify the physiological information associated with environmental changes as it reflects their growth potential.To evaluate the effects of the changes in salinity and nutrients,the photosynthetic efficiency of a green macroalga Ulva fasciata from the Daya Bay was tested at a range of salinity(i.e.,31 to 10 psu)and nitrogen content(i.e.,5 to 60μmol L^(-1)).The results showed that cellular chlorophyll a(Chl a),carbohydrate and protein contents of U.fasciata were increased due to reduced salinity,and were decreased by interactive nitrogen enrichment.Within a short culture period(i.e.,18 h),the reduced salinity decreased the maximum photosynthetic efficiency(rETRmax and Pmax)derived from the rapid light response curve and photosynthetic oxygen evolution rate versus irradiance curve,respectively,as well as the saturation irradiance(E_(K)).This reducing effect diminished with enlonged cultivation time and reversed to a stimulating effect after 24 h of cultivation.The nitrogen enrichment stimulated the rETRmax and Pmax,as well as the E_(K),regardless of salinity,especially within short-term cultivation period(i.e.,<24 h).In addition,our results indicate that seawater freshening lowers the photosynthetic efficiency of U.fasciata in the short term,which is mitigated by nitrogen enrichment,but stimulates it in the long term,providing insight into how macroalgae thrive in coastal or estuarine waters where salinity and nutrients normally covary strongly.
基金supported by research grants from the Natural Science Foundation of Shandong Province,China(ZR2020MC092)the Key Research and Development Project of Shandong Province,China(2019TSCYCX-33)the Key Research and Development Project of Shandong Province,China(LJNY202025).
文摘To make agricultural systems sustainable in terms of their greenness and efficiency,optimizing the tillage and fertilization practices is essential.To assess the effects of tilling and fertilization practices in wheat-maize cropping systems,a three-year field experiment was designed to quantify the carbon footprint(CF)and energy efficiency of the cropping systems in the North China Plain.The study parameters included four tillage practices(no tillage(NT),conventional tillage(CT),rotary tillage(RT),and subsoiling rotary tillage(SRT))and two fertilizer regimes(inorganic fertilizer(IF)and hybrid fertilizer with organic and inorganic components(HF)).The results indicated that the most prominent energy inputs and greenhouse gas(GHG)emissions could be ascribed to the use of fertilizers and fuel consumption.Under the same fertilization regime,ranking the tillage patterns with respect to the value of the crop yield,profit,CF,energy use efficiency(EUE)or energy productivity(EP)for either wheat or maize always gave the same sequence of SRT>RT>CT>NT.For the same tillage,the energy consumption associated with HF was higher than IF,but its GHG emissions and CF were lower while the yield and profit were higher.In terms of overall performance,tilling is more beneficial than NT,and reduced tillage practices(RT and SRT)are more beneficial than CT.The fertilization regime with the best overall performance was HF.Combining SRT with HF has significant potential for reducing CF and increasing EUE,thereby improving sustainability.Adopting measures that promote these optimizations can help to overcome the challenges posed by a lack of food security,energy crises and ecological stress.
基金financially supported by the National Natural Science Foundation of China(No.22204028)Young Talent Support Project of Guangzhou Association for Science and Technology(No.QT-2023-003)+3 种基金Guangdong Basic and Applied Basic Research Fund Project(No.2022A1515110451)Guangzhou University Graduate Student Innovation Ability Cultivation Funding Program(No.2022GDJC-M06)Science and Technology Projects in Guangzhou(Nos.202201010245,2023A03J0029)Double-Thousand Talents Plan of Jiangxi Province(No.jxsq2023102005)。
文摘The metal ion batteries have gained widespread attention for wearable electronics due to their competitive energy density and long cycling life.Exploring the advanced anode materials is significant for next generation energy storage systems.However,severe electrode volume changes and sluggish redox kinetics are the critical problems for lithium/potassium ion batteries(LIBs/PIBs)towards large-scale applications.Herein,we prepare a novel anode material,which consists of reduced graphene oxide wrapping one-dimensional(1D)N-doped porous carbon nanotube with cobalt phosphoselenide(CoPSe)nanoparticles embedded inside them(r GO@Co PSe/NC).Benefited from the dual carbon decorations and ultrafine nanoparticles structure,it achieves a reversible capacity of 245 mAh/g at 5 A/g after 2000 cycles for LIBs and 215 mAh/g at 1 A/g after 500 cycles for PIBs.The pseudocapacitance and GITT measurements are used to investigate the electrochemical kinetics of r GO@Co PSe/NC for LIBs.In addition,the lithium ion full cell also shows good electrochemical performance when paired with high capacity LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode.This work provides a feasible electrode design strategy for high-efficiency metal ion batteries based on multidimensional nanoarchitecture engineering and composition tailoring.
基金support of the Key Science Research Project in Colleges and Universities of Anhui Province,China(No.2022AH050813)the Medical Special Cultivation Project of Anhui University of Science and Technology,China(No.YZ2023H2A002).
文摘Carbon-based foams with a three-dimensional structure can serve as a lightweight template for the rational design and control-lable preparation of metal oxide/carbon-based composite microwave absorption materials.In this study,a flake-like nickel cobaltate/re-duced graphene oxide/melamine-derived carbon foam(FNC/RGO/MDCF)was successfully fabricated through a combination of solvo-thermal treatment and high-temperature pyrolysis.Results indicated that RGO was evenly distributed in the MDCF skeleton,providing ef-fective support for the load growth of FNC on its surface.Sample S3,the FNC/RGO/MDCF composite prepared by solvothermal method for 16 h,exhibited a minimum reflection loss(RL_(min))of-66.44 dB at a thickness of 2.29 mm.When the thickness was reduced to 1.50 mm,the optimal effective absorption bandwidth was 3.84 GHz.Analysis of the absorption mechanism of FNC/RGO/MDCF revealed that its excellent absorption performance was primarily attributed to the combined effects of conduction loss,multiple reflection,scattering,in-terface polarization,and dipole polarization.
基金financial support from the National Natural Science Foundation of China(No.52174328)the Fundamental Research Funds for the Central Universities of Central South University(No.2024ZZTS0062).
文摘The iron and steel industry,standing as a quintessential manufacture example with high consumption,pollution and emissions,faces significant environmental and sustainable development challenges.Electric arc furnace(EAF)steelmaking process mainly uses scrap as raw material and is characterized by environmentally friendly and recyclable process.However,the further development of EAF route in China is limited by the reserve,supply,availability and quality of scrap resource.Direct reduced iron(DRI)is one of typical low-carbon and clean charges,which can effectively make up for the adverse effects caused by the lack of scrap.The physical and chemical properties,classifications,and production technologies of DRI are firstly reviewed.In particular,the reducing gas types,reduction temperature,and reduction mechanism of the DRI production with gas-based shaft furnace(SF)technology are detailed.Considering the crucial role played by DRI application in EAF,the influences of DRI addition on EAF smelting rules and operations including the blending and charging process,heat transfer and melting in molten bath,slag formation operation,refractory corrosion,and slag system evolution are then further discussed.Finally,the comparative analysis and assessment of the consumption level of material and energy as well as the cleaner production both covering the clean chemical composition of molten steel and the clean environment impact in EAF steelmaking with DRI charged are conducted.From perspectives of metallurgical process engineering,a suitable route of hydrogen generation and application(from coke oven gas,methanol,and clean energy power),CO_(2) capture and utilization integrated with SF–EAF process is proposed.In view of the difficulties in large-scale DRI application in EAF,the follow-up work should focus on the investigation of DRI charging and melting,slag system evolution and molten pool reaction rules,as well as the developments of the DRI standardized use technology and intelligent batching and control models.
基金supported by the Shanxi Agricultural University Science and Technology Innovation Enhancement Project。
文摘This paper proposes a lightweight traffic sign detection system based on you only look once(YOLO).Firstly,the classification to fusion(C2f)structure is integrated into the backbone network,employing deformable convolution and bi-directional feature pyramid network(BiFPN)_Concat to improve the adaptability of the network.Secondly,the simple attention module(SimAm)is embedded to prioritize key features and reduce the complexity of the model after the C2f layer at the end of the backbone network.Next,the focal efficient intersection over union(EloU)is introduced to adjust the weights of challenging samples.Finally,we accomplish the design and deployment for the mobile app.The results demonstrate improvements,with the F1 score of 0.8987,mean average precision(mAP)@0.5 of 98.8%,mAP@0.5:0.95 of 75.6%,and the detection speed of 50 frames per second(FPS).
基金supported in part by the Chunhui Project of the Ministry of Education of China(HZKY20220429)the Department of Science&Technology of Liaoning Province(2022-MS-300)the Educational Department of Liaoning Province(LJKMZ20220561)
文摘Dear Editor,As an important energy storage device,lithium-ion battery plays a vital role in electric aircrafts,which are new and promising equipment of transportation in the future with low carbon emissions.Accurate prediction of the state of charge(SOC)of lithium-ion batteries is of great importance in reducing the probability of abnormal accidents and ensuring flight safety.
基金the European Research Council(ERC Advanced MechAGE-ERC-2016-ADG-741883)the Swiss National Science Foundation(no.188522).
文摘Age-related osteoporosis poses a significant challenge in musculoskeletal health;a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms.Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets for age-related bone loss.Our study uses the prematurely aged PolgD257A/D257A(PolgA)mouse model to scrutinize age-and sex-related alterations in musculoskeletal health parameters(frailty,grip strength,gait data),bone and particularly the osteocyte lacuno-canalicular network(LCN).Moreover,a new quantitative in silico image analysis pipeline is used to evaluate the alterations in the osteocyte network with aging.Our findings underscore the pronounced degenerative changes in the musculoskeletal health parameters,bone,and osteocyte LCN in PolgA mice as early as 40 weeks,with more prominent alterations evident in aged males.Our findings suggest that the PolgA mouse model serves as a valuable model for studying the cellular mechanisms underlying age-related bone loss,given the comparable aging signs and age-related degeneration of the bone and the osteocyte network observed in naturally aging mice and elderly humans.
基金support by the National Key R&D Program of China(Grant No.2023YFA1008901)the National Natural Science Foundation of China(Grant Nos.11988102,12172009)is gratefully acknowledged.
文摘In this manuscript,we propose an analytical equivalent linear viscoelastic constitutive model for fiber-reinforced composites,bypassing general computational homogenization.The method is based on the reduced-order homogenization(ROH)approach.The ROH method typically involves solving multiple finite element problems under periodic conditions to evaluate elastic strain and eigenstrain influence functions in an‘off-line’stage,which offers substantial cost savings compared to direct computational homogenization methods.Due to the unique structure of the fibrous unit cell,“off-line”stage calculation can be eliminated by influence functions obtained analytically.Introducing the standard solid model to the ROH method enables the creation of a comprehensive analytical homogeneous viscoelastic constitutive model.This method treats fibrous composite materials as homogeneous,anisotropic viscoelastic materials,significantly reducing computational time due to its analytical nature.This approach also enables precise determination of a homogenized anisotropic relaxation modulus and accurate capture of various viscoelastic responses under different loading conditions.Three sets of numerical examples,including unit cell tests,three-point beam bending tests,and torsion tests,are given to demonstrate the predictive performance of the homogenized viscoelastic model.Furthermore,the model is validated against experimental measurements,confirming its accuracy and reliability.
文摘Silicon-based materials have attracted considerable attention as potential anodes in lithium-ion energy storage systems,primarily due to their having a theoretical capacity greater than conventional graphite anodes.Despite this advantage,the inherent problem of substantial volume changes during lithiation/delithiation severely hinders their practical implementation in commercial battery configurations.We report the synthesis of a material by an electrostatic self-assembly method in which citric acid(CA)serves as a crosslinker to anchor cetyltrimethylammonium bromide-modified positively charged silicon nanoparticles between graphene oxide(GO)layers.After freeze-drying and thermal treatment under a nitrogen atmosphere,silicon particle core layers sandwiched between reduced graphene oxide(rGO)layers were obtained.Control samples with Si/rGO mass ratios of 0.5,1 and 2 were prepared for evaluation.The continuous conductive rGO network significantly increased the electronic conductivity of the material and the incorporation of CA acted as a binding agent between the Si and the rGO which increased the structural stability.By anchoring the silicon particles between adjacent rGO layers,the abundant void spaces and favorable mechanical flexibility of rGO were harnessed to effectively alleviate the volume expansion of silicon during charge-discharge cycles.The material with the Si/rGO mass ratio of 1 gave the highest specific capacity of 946.6 mAh g^(−1)after 200 cycles at a current density of 0.5 A g^(−1).It also had a good rate performance,with a good reversible capacity of 1005.1 mAh g^(−1)at a high current density of 2 A g^(−1).
文摘In order to meet the demands of new-generation electric vehicles that require high power output(over 15 kW/kg),it is crucial to increase the energy density of car-bon-based supercapacitors to a level comparable to that of batteries,while maintaining a high power density.We re-port a porous carbon material produced by immersing pop-lar wood(PW)sawdust in a solution of KOH and graphene oxide(GO),followed by carbonization.The resulting mater-ial has exceptional properties as an electrode for high-en-ergy supercapacitors.Compared to the material prepared by the direct carbonization of PW,its electrical conductivity was in-creased from 0.36 to 26.3 S/cm.Because of this and a high microporosity of over 80%,which provides fast electron channels and a large ion storage surface,when used as the electrodes for a symmetric supercapacitor,it gave a high energy density of 27.9 Wh/kg@0.95 kW/kg in an aqueous electrolyte of 1.0 mol/L Na_(2)SO_(4).The device also had battery-level energy storage with maximum energy densities of 73.9 Wh/kg@2.0 kW/kg and 67.6 Wh/kg@40 kW/kg,an ultrahigh power density,in an organic electrolyte of 1.0 mol/L TEABF4/AN.These values are comparable to those of 30−45 Wh/kg for Pb-acid batteries and 30−55 Wh/kg for aqueous lithium batteries.This work indicates a way to prepare carbon materials that can be used in supercapacit-ors with ultrahigh energy and power densities.
