The study objectives were to investigate the relationship between early exposure to genistein and obesity in young adulthood and to evaluate changes in reproductive health during puberty and adulthood following in ute...The study objectives were to investigate the relationship between early exposure to genistein and obesity in young adulthood and to evaluate changes in reproductive health during puberty and adulthood following in utero exposure to genistein.展开更多
Initial fluid resuscitation remains a cornerstone in the management of septic shock,where hypovolemia is consistently present and,if uncorrected,leads to organ hypoperfusion and dysfunction via reduced cardiac output....Initial fluid resuscitation remains a cornerstone in the management of septic shock,where hypovolemia is consistently present and,if uncorrected,leads to organ hypoperfusion and dysfunction via reduced cardiac output.This hypovolemia is both absolute and relative in nature.Absolute hypovolemia arises from frequent reduced oral intake in the hours preceding hospital admission and is often compounded by external fluid losses(e.g.,vomiting,diarrhea)or internal redistribution(e.g.,third-spacing into the gastrointestinal tract).In addition,increased capillary permeability—partly due to the degradation of the endothelial glycocalyx[1]—may contribute to fluid extravasation into the interstitial space.Relative hypovolemia results from sepsis-induced vasodilation and an increase in venous capacitance,particularly within the splanchnic circulation.展开更多
基金supported by Natural Science Foundation of China(81202190)Bureau of Health Foundation,Heilongjiang Province(2012-768)the Innovative Foundation of the Harbin Medical University in China(HCXS2008006)
文摘The study objectives were to investigate the relationship between early exposure to genistein and obesity in young adulthood and to evaluate changes in reproductive health during puberty and adulthood following in utero exposure to genistein.
文摘Initial fluid resuscitation remains a cornerstone in the management of septic shock,where hypovolemia is consistently present and,if uncorrected,leads to organ hypoperfusion and dysfunction via reduced cardiac output.This hypovolemia is both absolute and relative in nature.Absolute hypovolemia arises from frequent reduced oral intake in the hours preceding hospital admission and is often compounded by external fluid losses(e.g.,vomiting,diarrhea)or internal redistribution(e.g.,third-spacing into the gastrointestinal tract).In addition,increased capillary permeability—partly due to the degradation of the endothelial glycocalyx[1]—may contribute to fluid extravasation into the interstitial space.Relative hypovolemia results from sepsis-induced vasodilation and an increase in venous capacitance,particularly within the splanchnic circulation.
