Background:Carbapenems are effective against severe Pseudomonas aeruginosa nosocomial infections.Therefore,carbapenem-resistant Pseudomonas aeruginosa is a serious public health threat.An understanding of the risk of ...Background:Carbapenems are effective against severe Pseudomonas aeruginosa nosocomial infections.Therefore,carbapenem-resistant Pseudomonas aeruginosa is a serious public health threat.An understanding of the risk of inappropriate exposure to different antimicrobials in resistant Pseudomonas aeruginosa infection could help in elucidating the effective approach towards using antimicrobials in vulnerable patients with CRPA infection.Object:To investigate the association between exposure ofβ-lactam antimicrobials and CRPA infection relative to control patients.Methods:The MEDLINE/PubMed and OVID/Embase databases were used to search case-control and cohort studies in English language which reported antimicrobial exposure as risk factors for CRPA infection.The pooled odds ratios(OR)were calculated using a random-effect and fixed-effect model,and forest plots from a cumulative meta-analysis method were used to better show how pooled OR changed as updated evidence accumulated.Results:A total of 24 studies comprising 7039 participants were included for cumulative meta-analysis.A positive correlation was found between development of CRPA infection and exposure of beta-lactam antimicrobials:carbapenems(OR=7.60,95%CI:3.95 to 14.62,P<0.0001),imipenem(OR=9.81,95%CI:5.56 to 17.33),ampicillin(OR=1.86,95%CI:1.14 to 2.41),piperacillin(OR=2.82,95%CI:1.46 to 2.43),penicillins(OR=1.42,95%CI:0.90 to 2.24),cephalosporins(OR=1.88,95%CI:1.46 to 2.43)andβlactamase inhibitors(OR=1.96,95%CI:1.44 to 2.67).Further,exposure of other antimicrobial agents like quinolone(OR=2.35,95%CI:1.78 to 3.10),ciprofloxacin(OR=2.35,95%CI:1.66 to 3.95),aminoglycoside(OR=2.17,95%CI:1.60 to 2.95),amikacin(OR=3.11,95%CI:2.10 to 4.61),glycopeptides(OR=3.02,95%CI:1.92 to 4.75)and vancomycin(OR=3.26,95%CI:1.48 to 7.18),were also found to be positively associated with development of CRPA infection.Conclusions:Exposure of all kinds ofβ-lactams is significantly associated with development of carbapenemresistant Pseudomonas aeruginosa infection.These findings provide an impetus to take a more active approach while usingβ-lactam antimicrobials in patients with resistant Pseudomonas aeruginosa infections.展开更多
Objective： To evaluate the effect of moxibustion on knee osteoarthritis patients with cumulative meta-analysis, and trial sequential analysis was applied to test the authenticity of results. Methods： We searched Pub...Objective： To evaluate the effect of moxibustion on knee osteoarthritis patients with cumulative meta-analysis, and trial sequential analysis was applied to test the authenticity of results. Methods： We searched PubMed, EMbase, The Cochrane Library, CNKI and CBM to collect RCTs about moxibustion on knee osteoarthritis patients. The selection of literature, data extraction and evaluation of eligible literature were carried out independently by two reviewers. Then Stata11.0 software was used for data analysis. Result： Totally 11 RCTs involved 1005 patients were recruited. The results of meta-analysis showed that no significant differences were found between the two groups in VAS, moxibustion is better than drug therapy in effective rate [OR = 0.40, 95%CI （0.27, 0.60）] and knee score [SMD = -0.70, 95%CI （-1.22, -0.19）]. The result of trial sequential analysis indicated that the sample size didn＇t reach the TSA Boundary on VAS, the sample size of effectiveness achieved Require Information Size. In the indicator of knee score has obtained certain re- sult before reaching the Require Information Size. Conclusion： moxibustion is superior to drug therapy on treatment knee osteoarthritis. However, large sample size and high-quality studies are still needed.展开更多
Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive...Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive access and electronic database search were carried out from inception to June 2020.Prospective randomized trials(TCHM plus TT vs.TT)were selected to assess the eradication rate of H.pylori(ER of H.pylori),clinical symptom relief rate(SRR),treatment-related adverse reactions(TRAR)and 95%confidence intervals(CI)in the meta-analysis and cumulative meta-analysis(CMA).Meta-regression analysis was used to analyze heterogeneity between studies and publication bias.Results:33 studies contained 3,226 participants were included.Compared with the TT group,TCHM plus TT group showed a significantly higher ER of H.pylori(OR=4.14,95%CI:3.21-5.35;P=0.000)and SRR(OR=4.50,95%CI:3.59-5.64).Meanwhile,the TRAR of TCHM plus TT remedy was significantly lower than TT monopoly(RR=0.43,95%CI:0.29-0.64;P=0.000).The results of the CMA,sorted by publication year,duration of treatment,and sample size,confirmed that combined treatment remedy was superior to TT monopoly in respect of ER of H.pylori and SRR.Conclusions:The present study obtained reliable and convincing evidence suggesting that TCHM plus TT remedy was efficacious and safe in treating H.pylori-induced CAG.展开更多
Renormalization group recursions are obtained by virtue of the variational cumulant expansion method. Good qualitative estimates are obtained for the d=2 square Ising system.
This paper presents a novel approach to structure determination of linear systems along with the choice of system orders and parameters. AutoRegressive （AR）, Moving Average （MA） or AutoRegressive-Moving Average （...This paper presents a novel approach to structure determination of linear systems along with the choice of system orders and parameters. AutoRegressive （AR）, Moving Average （MA） or AutoRegressive-Moving Average （ARMA） model structure can be extracted blindly from the Third Order Cumulants （TOC） of the system output ts, where the unknown system is driven by an unobservable stationary independent identically distributed （i.i.d.） non-Gaussian signal. By means of the system order recursion, whether the system has an AR structure or has AR part of an ARMA structure is firstly investigated. MA features in the TOC domain is then applied as a threshold to decide if the system is an MA model or has MA part of an ARMA model. Numerical simulations illustrate the generality of the proposed blind structure identification methodology that may serve as a guideline for blind, linear system modeling.展开更多
An adaptive interference cancler algorithm based on fourth-order cumulant is proposed to overcome the fault of conventional autocorrelation-based Least Mean Square (LMS)algorithm which cannot suppress the correlated G...An adaptive interference cancler algorithm based on fourth-order cumulant is proposed to overcome the fault of conventional autocorrelation-based Least Mean Square (LMS)algorithm which cannot suppress the correlated Gaussian noises. The recursive formulation of the proposed algorithm is given to reduce its computational complexity. The simulation results are presented to demonstrate the effectiveness of this novel approach.展开更多
Regarding the performance of traditional endpoint detection algorithms degrades as the environment noise level increases, a recursive calculating algorithm for higher-order cu- mulants over a sliding window is propose...Regarding the performance of traditional endpoint detection algorithms degrades as the environment noise level increases, a recursive calculating algorithm for higher-order cu- mulants over a sliding window is proposed. Then it is applied to the speech endpoint detection. Furthermore, endpoint detection is carried out with the feature of energy. Experimental results show that both the computational efficiency and the robustness against noise of the proposed algorithm are improved remarkably compared with traditional algorithm. The average prob- ability of correct point detection （Pc-point） of the proposed voice activity detection （VAD） is 6.07% higher than that of G.729b VAD in different noisy at different signal-noise ratios （SNRs） environments.展开更多
Meta分析包括已发表文献的Meta分析(meta-analysis of the published literature,MPL)和单个病例资料的Meta分析(meta-analysis of individual patient data,MIPD)。递归累积Meta分析是一种可对已有资料重新整理并及时更新,还能对现有...Meta分析包括已发表文献的Meta分析(meta-analysis of the published literature,MPL)和单个病例资料的Meta分析(meta-analysis of individual patient data,MIPD)。递归累积Meta分析是一种可对已有资料重新整理并及时更新,还能对现有试验的延续随访进行分析的Meta分析方法,递归累积Meta分析在每纳入一项新研究或纳入更新的研究时,可以检测每一合并步骤中效应量的波动,从而判断纳入研究间是否存在偏倚或异质性,并判断合并结果的稳定性。本文主要介绍了递归累积Meta分析的概念并结合具体实例来讲解如何实现。展开更多
文摘Background:Carbapenems are effective against severe Pseudomonas aeruginosa nosocomial infections.Therefore,carbapenem-resistant Pseudomonas aeruginosa is a serious public health threat.An understanding of the risk of inappropriate exposure to different antimicrobials in resistant Pseudomonas aeruginosa infection could help in elucidating the effective approach towards using antimicrobials in vulnerable patients with CRPA infection.Object:To investigate the association between exposure ofβ-lactam antimicrobials and CRPA infection relative to control patients.Methods:The MEDLINE/PubMed and OVID/Embase databases were used to search case-control and cohort studies in English language which reported antimicrobial exposure as risk factors for CRPA infection.The pooled odds ratios(OR)were calculated using a random-effect and fixed-effect model,and forest plots from a cumulative meta-analysis method were used to better show how pooled OR changed as updated evidence accumulated.Results:A total of 24 studies comprising 7039 participants were included for cumulative meta-analysis.A positive correlation was found between development of CRPA infection and exposure of beta-lactam antimicrobials:carbapenems(OR=7.60,95%CI:3.95 to 14.62,P<0.0001),imipenem(OR=9.81,95%CI:5.56 to 17.33),ampicillin(OR=1.86,95%CI:1.14 to 2.41),piperacillin(OR=2.82,95%CI:1.46 to 2.43),penicillins(OR=1.42,95%CI:0.90 to 2.24),cephalosporins(OR=1.88,95%CI:1.46 to 2.43)andβlactamase inhibitors(OR=1.96,95%CI:1.44 to 2.67).Further,exposure of other antimicrobial agents like quinolone(OR=2.35,95%CI:1.78 to 3.10),ciprofloxacin(OR=2.35,95%CI:1.66 to 3.95),aminoglycoside(OR=2.17,95%CI:1.60 to 2.95),amikacin(OR=3.11,95%CI:2.10 to 4.61),glycopeptides(OR=3.02,95%CI:1.92 to 4.75)and vancomycin(OR=3.26,95%CI:1.48 to 7.18),were also found to be positively associated with development of CRPA infection.Conclusions:Exposure of all kinds ofβ-lactams is significantly associated with development of carbapenemresistant Pseudomonas aeruginosa infection.These findings provide an impetus to take a more active approach while usingβ-lactam antimicrobials in patients with resistant Pseudomonas aeruginosa infections.
文摘Objective： To evaluate the effect of moxibustion on knee osteoarthritis patients with cumulative meta-analysis, and trial sequential analysis was applied to test the authenticity of results. Methods： We searched PubMed, EMbase, The Cochrane Library, CNKI and CBM to collect RCTs about moxibustion on knee osteoarthritis patients. The selection of literature, data extraction and evaluation of eligible literature were carried out independently by two reviewers. Then Stata11.0 software was used for data analysis. Result： Totally 11 RCTs involved 1005 patients were recruited. The results of meta-analysis showed that no significant differences were found between the two groups in VAS, moxibustion is better than drug therapy in effective rate [OR = 0.40, 95%CI （0.27, 0.60）] and knee score [SMD = -0.70, 95%CI （-1.22, -0.19）]. The result of trial sequential analysis indicated that the sample size didn＇t reach the TSA Boundary on VAS, the sample size of effectiveness achieved Require Information Size. In the indicator of knee score has obtained certain re- sult before reaching the Require Information Size. Conclusion： moxibustion is superior to drug therapy on treatment knee osteoarthritis. However, large sample size and high-quality studies are still needed.
基金The National Key Research and Development Program(No.2018YFC1704500).
文摘Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive access and electronic database search were carried out from inception to June 2020.Prospective randomized trials(TCHM plus TT vs.TT)were selected to assess the eradication rate of H.pylori(ER of H.pylori),clinical symptom relief rate(SRR),treatment-related adverse reactions(TRAR)and 95%confidence intervals(CI)in the meta-analysis and cumulative meta-analysis(CMA).Meta-regression analysis was used to analyze heterogeneity between studies and publication bias.Results:33 studies contained 3,226 participants were included.Compared with the TT group,TCHM plus TT group showed a significantly higher ER of H.pylori(OR=4.14,95%CI:3.21-5.35;P=0.000)and SRR(OR=4.50,95%CI:3.59-5.64).Meanwhile,the TRAR of TCHM plus TT remedy was significantly lower than TT monopoly(RR=0.43,95%CI:0.29-0.64;P=0.000).The results of the CMA,sorted by publication year,duration of treatment,and sample size,confirmed that combined treatment remedy was superior to TT monopoly in respect of ER of H.pylori and SRR.Conclusions:The present study obtained reliable and convincing evidence suggesting that TCHM plus TT remedy was efficacious and safe in treating H.pylori-induced CAG.
文摘Renormalization group recursions are obtained by virtue of the variational cumulant expansion method. Good qualitative estimates are obtained for the d=2 square Ising system.
基金Supported by the National Natural Science Foundation of China (No.60575006).
文摘This paper presents a novel approach to structure determination of linear systems along with the choice of system orders and parameters. AutoRegressive （AR）, Moving Average （MA） or AutoRegressive-Moving Average （ARMA） model structure can be extracted blindly from the Third Order Cumulants （TOC） of the system output ts, where the unknown system is driven by an unobservable stationary independent identically distributed （i.i.d.） non-Gaussian signal. By means of the system order recursion, whether the system has an AR structure or has AR part of an ARMA structure is firstly investigated. MA features in the TOC domain is then applied as a threshold to decide if the system is an MA model or has MA part of an ARMA model. Numerical simulations illustrate the generality of the proposed blind structure identification methodology that may serve as a guideline for blind, linear system modeling.
基金Supported by the National Natural Science Foundation of China(No.60232010) the Teaching and Research Award Program for Outstanding Young Teachers in Higher Educa- tion Institutions of Ministry of Education, P.R.C.
文摘An adaptive interference cancler algorithm based on fourth-order cumulant is proposed to overcome the fault of conventional autocorrelation-based Least Mean Square (LMS)algorithm which cannot suppress the correlated Gaussian noises. The recursive formulation of the proposed algorithm is given to reduce its computational complexity. The simulation results are presented to demonstrate the effectiveness of this novel approach.
基金supported by the National Natural Science Eoundation of China(61271352)
文摘Regarding the performance of traditional endpoint detection algorithms degrades as the environment noise level increases, a recursive calculating algorithm for higher-order cu- mulants over a sliding window is proposed. Then it is applied to the speech endpoint detection. Furthermore, endpoint detection is carried out with the feature of energy. Experimental results show that both the computational efficiency and the robustness against noise of the proposed algorithm are improved remarkably compared with traditional algorithm. The average prob- ability of correct point detection （Pc-point） of the proposed voice activity detection （VAD） is 6.07% higher than that of G.729b VAD in different noisy at different signal-noise ratios （SNRs） environments.
文摘Meta分析包括已发表文献的Meta分析(meta-analysis of the published literature,MPL)和单个病例资料的Meta分析(meta-analysis of individual patient data,MIPD)。递归累积Meta分析是一种可对已有资料重新整理并及时更新,还能对现有试验的延续随访进行分析的Meta分析方法,递归累积Meta分析在每纳入一项新研究或纳入更新的研究时,可以检测每一合并步骤中效应量的波动,从而判断纳入研究间是否存在偏倚或异质性,并判断合并结果的稳定性。本文主要介绍了递归累积Meta分析的概念并结合具体实例来讲解如何实现。
