Savannah,Ga.,April 22,2025-Gulfstream Aerospace Corp.today announced its fleet has achieved an industry-leading 700 city-pair speed records with a Gulfstream G700 flight from Taipei to Miami.This flight commemorates t...Savannah,Ga.,April 22,2025-Gulfstream Aerospace Corp.today announced its fleet has achieved an industry-leading 700 city-pair speed records with a Gulfstream G700 flight from Taipei to Miami.This flight commemorates the 50-year anniversary of Gulfstream's first U.S.National Aeronautic Association(NAA)accredited speed record,set in 1975 by the Gulfstream GII.展开更多
Anthropogenic climate change is altering species distributions globally.While species distributions are expected to shift to higher latitudes and elevations under global warming,empirical evidence on distribution shif...Anthropogenic climate change is altering species distributions globally.While species distributions are expected to shift to higher latitudes and elevations under global warming,empirical evidence on distribution shifts is mixed,and factors mediating the direction and magnitude of range shifts remain unclear.Using a dataset of 132new provincial records for 96 resident bird species from 2000 to 2023,we measured geographic distance,latitudinal shift,and temperature shift from each new record to the historical range for each species to test for poleward shifts.We assessed taxonomic variation in the magnitude of range shifts and used phylogenetic generalized linear mixed models to quantify relationships between species traits and the extent of range shifts.Our results revealed that new records occurred at a mean geographic distance of 420 km from historical ranges,with mean latitudinal shifts of+1.68°(poleward)and temperature shifts of-1.33℃(toward colder climates).The magnitude of geographic range shifts was strongly constrained by phylogenetic relatedness.Habitat breadth,habitat openness,and centroid latitude of historical ranges emerged as significant predictors of range shifts.Our results suggest that resident bird species'geographic ranges in China are shifting poleward,but the magnitude of these shifts is non-random across lineages.Species with broader habitat preferences and those from warmer climates are more likely to shift farther from their historical ranges and toward higher latitudes.This study emphasizes taxonomic variation in species range shifts and highlights the need for species-and site-specific conservation strategies under global warming.展开更多
BACKGROUND The neurological and psychiatric sequelae of coronavirus disease 2019(COVID-19)have been documented,yet further data are needed to thoroughly evaluate the impact of COVID-19 on brain health years after the ...BACKGROUND The neurological and psychiatric sequelae of coronavirus disease 2019(COVID-19)have been documented,yet further data are needed to thoroughly evaluate the impact of COVID-19 on brain health years after the infection.AIM To examine whether COVID-19 infection is associated with exacerbation,recurrence,or progression of pre-existing neurological or psychiatric disorders-a highrisk population that is underrepresented in COVID-19 outcome research in National Guard Health Affair patients in 4-years following a COVID-19 diagnosis.METHODS For this multicenter retrospective cohort study,we used data from the National Guard hospitals electronic health records network(BestCare)with over 10 million patients.Our cohort comprised patients who had a COVID-19 diagnosis;a matched control cohort included patient did not expose to COVID-19 in same period.Age and sex were matching factors.We estimated the incidence of 14 neurological and psychiatric outcomes in nearly 4 years after a confirmed diagnosis of COVID-19.Using a multiple logistic regression,we compared incidences with those in propensity score-matched cohorts of patients with no exposure to COVID-19.Ramadan M et al.Neurological and psychiatric risks post-COVID-19 RESULTS Our primary cohort comprised 4437 patients diagnosed with COVID-19,and our propensity-score 1:1 matched control cohort comprised 4437 individuals.Nearly two-third of the COVID-19 cohort(71%)were diagnosed in 2020,and 2021.The most prevalent diagnoses for both cohorts were epilepsy 30.68%,mood disorder 23.92%,and nerve plexus disorder 22.13%.Dementia was nearly 4 times higher among COVID-19 cohort(8.27%)compared to the control cohort(2.57%).Five neurological and psychiatric outcomes had odds ratios(OR)that were significantly higher than 1 for people who had COVID-19 compared to people who had never been infected.These outcomes were cognitive deficit OR=1.54,95%confidence interval(CI):1.23-1.91,P=0.0001;nerve plexus disorder OR=1.13,95%CI:1.01-1.25,P=0.02;substance use disorder OR=1.95,95%CI:1.12-3.38,P=0.01;mood disorder OR=1.16,95%CI:1.05-1.29,P=0.003;and anxiety disorder OR=1.39,95%CI:1.07-1.79,P=0.01.CONCLUSION The study highlights the persistent risk of neurological and psychiatric conditions in COVID-19 survivors up to four years post-infection.Although the incidence was lower than in previous large studies,long-term consequences remain significant,emphasizing the need for ongoing monitoring and support in mental health and neurological care.展开更多
Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)d...Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.展开更多
A new Megaselia species： Megaselia angustirostris Fang ＆ Liu, sp. nov., is described and illustrated and two species of the genus, M. nigra （Meigen） and M. albicaudata （Wood）, are reported for the first time fro...A new Megaselia species： Megaselia angustirostris Fang ＆ Liu, sp. nov., is described and illustrated and two species of the genus, M. nigra （Meigen） and M. albicaudata （Wood）, are reported for the first time from China. The type specimens are deposited in College of Biological and Environmental Engineering, Shenyang University.展开更多
In order to improve the accuracy and integrality of mining data records from the web, the concepts of isomorphic page and directory page and three algorithms are proposed. An isomorphic web page is a set of web pages ...In order to improve the accuracy and integrality of mining data records from the web, the concepts of isomorphic page and directory page and three algorithms are proposed. An isomorphic web page is a set of web pages that have uniform structure, only differing in main information. A web page which contains many links that link to isomorphic web pages is called a directory page. Algorithm 1 can find directory web pages in a web using adjacent links similar analysis method. It first sorts the link, and then counts the links in each directory. If the count is greater than a given valve then finds the similar sub-page links in the directory and gives the results. A function for an isomorphic web page judgment is also proposed. Algorithm 2 can mine data records from an isomorphic page using a noise information filter. It is based on the fact that the noise information is the same in two isomorphic pages, only the main information is different. Algorithm 3 can mine data records from an entire website using the technology of spider. The experiment shows that the proposed algorithms can mine data records more intactly than the existing algorithms. Mining data records from isomorphic pages is an efficient method.展开更多
Objective To determine whether frailty is a risk factor for hospitalization and mortality in older adults enrolled in the "Chronic Heart Failure Program" at a hospital in Lima, Peru, between 2018–2021.Metho...Objective To determine whether frailty is a risk factor for hospitalization and mortality in older adults enrolled in the "Chronic Heart Failure Program" at a hospital in Lima, Peru, between 2018–2021.Methods This was an ambispective cohort study. A total of 85 older adults participating in the Chronic Heart Failure Program at Guillermo Almenara National Hospital were included. Each had an initial frailty assessment, forming two cohorts: frail and non-frail older adults. Medical records were reviewed, and patients were followed for one year to track events of interest(hospitalization and mortality). Overall survival and risk factors for hospitalization and death were determined.Results During follow-up, 15.3% of the older adults died, and frailty was identified in 58.8% of the patients. Overall survival using the Kaplan-Meier method was 96.5% at 3 months after entering the Chronic Heart Failure Program;92.9% at 6 months;and85.9% at one year. Multivariate analysis using Poisson regression found that frailty was not a risk factor for hospitalization(a RR =0.92;95% CI: 0.42–2.03). Survival analysis using the Cox proportional hazards model showed that frailty was also not a risk factor for mortality after one year of follow-up(a HR = 1.32;95% CI: 0.27–6.53).Conclusions Our research does not confirm frailty as a risk factor for hospitalization or mortality in older adults enrolled in the“Chronic Heart Failure Program” after one year of follow-up.展开更多
As healthcare systems increasingly embrace digitalization,effective management of electronic health records(EHRs)has emerged as a critical priority,particularly in inpatient settings where data sensitivity and realtim...As healthcare systems increasingly embrace digitalization,effective management of electronic health records(EHRs)has emerged as a critical priority,particularly in inpatient settings where data sensitivity and realtime access are paramount.Traditional EHR systems face significant challenges,including unauthorized access,data breaches,and inefficiencies in tracking follow-up appointments,which heighten the risk of misdiagnosis and medication errors.To address these issues,this research proposes a hybrid blockchain-based solution for securely managing EHRs,specifically designed as a framework for tracking inpatient follow-ups.By integrating QR codeenabled data access with a blockchain architecture,this innovative approach enhances privacy protection,data integrity,and auditing capabilities,while facilitating swift and real-time data retrieval.The architecture adheres to Role-Based Access Control(RBAC)principles and utilizes robust encryption techniques,including SHA-256 and AES-256-CBC,to secure sensitive information.A comprehensive threat model outlines trust boundaries and potential adversaries,complemented by a validated data transmission protocol.Experimental results demonstrate that the framework remains reliable in concurrent access scenarios,highlighting its efficiency and responsiveness in real-world applications.This study emphasizes the necessity for hybrid solutions in managing sensitive medical information and advocates for integrating blockchain technology and QR code innovations into contemporary healthcare systems.展开更多
An unprecedented extreme gale and dust event struck East Asia during 10-14 April2025.A record-breaking gale swept across most regions of China.It carried large amounts of dust from northern deserts,resulting in nation...An unprecedented extreme gale and dust event struck East Asia during 10-14 April2025.A record-breaking gale swept across most regions of China.It carried large amounts of dust from northern deserts,resulting in nationwide dust weather.Gales affected more than 3.5 million km^(2),and the windspeeds in North China were the strongest in April since 1940(Fig.1a,b).展开更多
The present paper deals with two new ethmid moths from China: Ethmia damaoshanae sp.nov. and Ethmia jingdongensis sp.nov. Another two species Ethmia dodecea (Haworth) and Ethmia ultima Sattler are reported for the f...The present paper deals with two new ethmid moths from China: Ethmia damaoshanae sp.nov. and Ethmia jingdongensis sp.nov. Another two species Ethmia dodecea (Haworth) and Ethmia ultima Sattler are reported for the first time from the country. The genitalia of the new species are figured.展开更多
Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission ...Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission are associated with pathophysiological and neurodegenerative disorders,whereas glucagon-like peptide-1 has demonstrated neuroprotective effects.However,it is not yet clear whether diabetes causes alterations in inhibitory input to retinal ganglion cells and whether and how glucagon-like peptide-1 protects against neurodegeneration in the diabetic retina through regulating inhibitory synaptic transmission to retinal ganglion cells.In the present study,we used the patch-clamp technique to recordγ-aminobutyric acid subtype A receptor-mediated miniature inhibitory postsynaptic currents in retinal ganglion cells from streptozotocin-induced diabetes model rats.We found that early diabetes(4 weeks of hyperglycemia)decreased the frequency of GABAergic miniature inhibitory postsynaptic currents in retinal ganglion cells without altering their amplitude,suggesting a reduction in the spontaneous release ofγ-aminobutyric acid to retinal ganglion cells.Topical administration of glucagon-like peptide-1 eyedrops over a period of 2 weeks effectively countered the hyperglycemia-induced downregulation of GABAergic mIPSC frequency,subsequently enhancing the survival of retinal ganglion cells.Concurrently,the protective effects of glucagon-like peptide-1 on retinal ganglion cells in diabetic rats were eliminated by topical administration of exendin-9-39,a specific glucagon-like peptide-1 receptor antagonist,or SR95531,a specific antagonist of theγ-aminobutyric acid subtype A receptor.Furthermore,extracellular perfusion of glucagon-like peptide-1 was found to elevate the frequencies of GABAergic miniature inhibitory postsynaptic currents in both ON-and OFF-type retinal ganglion cells.This elevation was shown to be mediated by activation of the phosphatidylinositol-phospholipase C/inositol 1,4,5-trisphosphate receptor/Ca2+/protein kinase C signaling pathway downstream of glucagon-like peptide-1 receptor activation.Moreover,multielectrode array recordings revealed that glucagon-like peptide-1 functionally augmented the photoresponses of ON-type retinal ganglion cells.Optomotor response tests demonstrated that diabetic rats exhibited reductions in visual acuity and contrast sensitivity that were significantly ameliorated by topical administration of glucagon-like peptide-1.These results suggest that glucagon-like peptide-1 facilitates the release ofγ-aminobutyric acid onto retinal ganglion cells through the activation of glucagon-like peptide-1 receptor,leading to the de-excitation of retinal ganglion cell circuits and the inhibition of excitotoxic processes associated with diabetic retinopathy.Collectively,our findings indicate that theγ-aminobutyric acid system has potential as a therapeutic target for mitigating early-stage diabetic retinopathy.Furthermore,the topical administration of glucagon-like peptide-1 eyedrops represents a non-invasive and effective treatment approach for managing early-stage diabetic retinopathy.展开更多
Objectives Medical knowledge extraction (MKE) plays a key role in natural language processing (NLP) research in electronic medical records (EMR),which are the important digital carriers for recording medical activitie...Objectives Medical knowledge extraction (MKE) plays a key role in natural language processing (NLP) research in electronic medical records (EMR),which are the important digital carriers for recording medical activities of patients.Named entity recognition (NER) and medical relation extraction (MRE) are two basic tasks of MKE.This study aims to improve the recognition accuracy of these two tasks by exploring deep learning methods.Methods This study discussed and built two application scenes of bidirectional long short-term memory combined conditional random field (BiLSTM-CRF) model for NER and MRE tasks.In the data preprocessing of both tasks,a GloVe word embedding model was used to vectorize words.In the NER task,a sequence labeling strategy was used to classify each word tag by the joint probability distribution through the CRF layer.In the MRE task,the medical entity relation category was predicted by transforming the classification problem of a single entity into a sequence classification problem and linking the feature combinations between entities also through the CRF layer.Results Through the validation on the I2B2 2010 public dataset,the BiLSTM-CRF models built in this study got much better results than the baseline methods in the two tasks,where the F1-measure was up to 0.88 in NER task and 0.78 in MRE task.Moreover,the model converged faster and avoided problems such as overfitting.Conclusion This study proved the good performance of deep learning on medical knowledge extraction.It also verified the feasibility of the BiLSTM-CRF model in different application scenarios,laying the foundation for the subsequent work in the EMR field.展开更多
Three genera, Cuspicona Dallas, Hermolaus Distant and Oncinoproctus Breddin, and six species （Cuspicona antica Vollenhoven, Hermolaus typicus Distant, Menida atkinsoni Distant, Oncinoproctus griseolus Breddin, Paterc...Three genera, Cuspicona Dallas, Hermolaus Distant and Oncinoproctus Breddin, and six species （Cuspicona antica Vollenhoven, Hermolaus typicus Distant, Menida atkinsoni Distant, Oncinoproctus griseolus Breddin, Paterculus aberrans Distant, and Rolstoniellus malacanicus （Yang）） of Pentatomidae are reported from China for the first time. Both dorsal and ventral habitus and genital illustrations of each species are provided. All specimens studied were from Institute of Entomology, Nankai University, Tianjin, China （NKUM） except Cuspicona antica Vollenhoven, 1868 whose involved species are kept at the Institute of Zoology, Chinese Academy of Sciences （IZCAS）.展开更多
Studies of lithology, sedimentary facies and the distribution regularity of SiO2 and Al2O3 contents and Al2O3/SiO2 ratio allow us to divide the Upper Pleistocene-Holocene Series represented by the MUanggouwan section ...Studies of lithology, sedimentary facies and the distribution regularity of SiO2 and Al2O3 contents and Al2O3/SiO2 ratio allow us to divide the Upper Pleistocene-Holocene Series represented by the MUanggouwan section in China＇s Salawnsu River valley into six segments： MGS1, MGS2, MGS3, MGS4, MGS5 and MGS6. The boundary ages for MGS1 （the Dishaogouwan and Dagouwan Formations）, MGS2 （the upper Chengchuan Formation）, MGS3 （the middle Chengchuan Formation）, MGS4 （the lower Chengchuan Formation）, MGS5 （most strata of the Salawusu Formation） and MGS6 （the bottom of the Salawusu Formation and the top of the Lishi Formation） correspond to those of MIS1, MIS2, MIS3, MIS4, MISS and MIS6, respectively, from deep sea sediments or continental glaciers. MGS5 can be subdivided into five subsegments （MGS5a, MGS5b, MGS5c, MGS5d and MGS5e） and the boundary ages of these subsegments correspond to those of MISSa, MISSb, MIS5c, MIS5d and MIS5e, respectively. Based on the paleoenvironment and paleoecology indicated by the primary chemical elements, fossil vertebrates, mollusks and pollen grains, we hypothesize that MGS1, MGS2, MGS3, MGS4, MGS5 and MGS6 and the subsegments of MGS5 match the corresponding stages for oxygen isotopes in the deep sea sediments and continental glaciers, and the substages of MIS5 in terms of climatic characters, further explaining the phenomena that determined the formation of the late Quaternary strata and the paleontology of the Salawusu River valley. These phenomena relate to fluctuations in the global climate （and particularly in the East Asian monsoon） during the glacial and interglacial periods.展开更多
The Yishu fault zone （mid-segment of the Tanlu fault zone） was formed in the Presinian. Periodic tectonic activities and strong seismic events have occurred along the fault zone. During the initial stage of the Cale...The Yishu fault zone （mid-segment of the Tanlu fault zone） was formed in the Presinian. Periodic tectonic activities and strong seismic events have occurred along the fault zone. During the initial stage of the Caledonian Movement, with the proceeding of the marine transgression from the Yishu paleo-channel to the western Shandong, uneven thick sediments, composed mainly of sand, mud and carbonates of littoral, lagoon, and neritic facies, were deposited in the Yishu fault zone and western Shandong, and constructed the bottom part of the Lower Cambrian consisting of the Liguan and Zhushadong formations. Through field observations and the lab-examinations, various paleoseismic records have been discovered in the Liguan Formation and the Zhushadong Formations of the Yishu fault zone and its vicinity, including some layers with syn-sedimentary deformation structures that were triggered by strong earthquakes （i.e. seismite, seismo-olistostrome, and seismo-turbidite）. Paleoseismic records developed in the Zhushadong Formation are mainly seismites with soft-sediment deformation structures, such as liquefied diapir, small liquefied-carbonate lime-mud volcano, liquefied vein, liquefied breccia, convolute deformation （seismic fold）, graded fault, soft siliceous vein, and deformation stromatolite, as well as seismites with brittle deformation structures of semiconsolidated sediments. Paleoseismic records preserved in the Liguan Formation are not only seismo-olistostrome with a slump fold, load structure, and ball-and-pillows, but also seismo-turbidite with convolution bedding, graded bedding and wavy-bedding. However, in the western Shandong area, the closer to the Yishu fault zone, the greater the thickness of the Liguan Formation and the Zhushadong Formation, the greater the number and type of layers with paleoseismic records, and the higher the earthquake intensity reflected by associations of seismic records. This evidence indicates that tectonic taphrogenesis accompanied by strong earthquake events occurred in the Yishu fault zone during the initial stage of the Caledonian Movement, which embodied the break-up of the Sino-Korean Plate along the Paleo-Tanlu fault zone at that time.展开更多
Guinness Book of World Records(《吉尼期世界纪录在全》) is a famous collection of world records in human life, including many kinds of specific skills. But do you know how the book came out?On November 10, 1951, an Eng...Guinness Book of World Records(《吉尼期世界纪录在全》) is a famous collection of world records in human life, including many kinds of specific skills. But do you know how the book came out?On November 10, 1951, an Englishman, Sir Beveagh, was having a discussion with his friends. They couldn展开更多
The authors analyzed the lead-lag connection of the Atlantic Multidecadal Oscillation (AMO) with East Asian surface air temperatures (EATs) using instrumental records, and compared the results with the Pacific Decadal...The authors analyzed the lead-lag connection of the Atlantic Multidecadal Oscillation (AMO) with East Asian surface air temperatures (EATs) using instrumental records, and compared the results with the Pacific Decadal Oscillation (PDO). The maximum correlation was found when EATs led the AMO by five to seven years (with a correlation coefficient of 0.72, whereas the correlation coefficient was 0.91 when the AMO led EATs by 24-28 years). This is different from the PDO, which mostly correlated with EATs when the PDO led EATs by 13-15 years (with a correlation coefficient of 0.67, whereas the correlation coefficient was 0.76 when EATs led the PDO by 24-26 years). The PDO led the AMO by 19-21 years (with a correlation coefficient of 0.71, whereas the correlation coefficient was 0.84 when the AMO led the PDO by 16-18 years). These results support a previous understanding that EATs positively correlate with the AMO, and imply that the observed East Asian warming trend may have been slowing down since the early 2010s.展开更多
The East China Sea continental shelf is a unique area for the study of land-sea interactions and paleoenvironmental change because it receives a large amount of terrestrial material inputs. In recent decades, human ac...The East China Sea continental shelf is a unique area for the study of land-sea interactions and paleoenvironmental change because it receives a large amount of terrestrial material inputs. In recent decades, human activities and global climate change have greatly aff ected river discharges into the sea. However, changes in the deposition process caused by these factors in the East China Sea continental shelf are unclear. We collected eight short sediment cores from the East China Sea inner shelf(ECSIS) using a box core sampler in 2012 and 2015. The grainsize, 2 10 Pb, and 1 37 Cs of these cores were analyzed in order to reconstruct the deposition history since the 1950 s, and to reveal human activity and climate change influences on sediment deposition in the ECSIS. Results indicated that sediment grain size became finer after 1969, turned coarser after 1987, and then further coarser since 2003, corresponding well to the three steps of sediment load drop in the Changjiang(Yangtze) River, which are mainly caused by human activities(particularly the closure of the Three Gorges Dam). Simultaneously, the East Asian Monsoon influenced the deposition process in the ECSIS by changing the intensity of coastal currents. Mean grain size variations in the fine-grained population(divided by grain size vs. standard deviation method) coincided with that of the East Asian Winter Monsoon strength and reflected its weakness in 1987. Abrupt changes in sediment grain size over a short time scale in these sediment cores were generally caused by floods and typhoons. Spectral analyses of the sediment cores showed periodicities of 10–11 and 20–22 years, corresponding to the periodicity of solar activity(Schwabe cycle and Hale cycle). Mean grain size time series also displayed a 3–8 year periodicity corresponding to El Ni?o Southern Oscillation periodic change.展开更多
During the great Wenchuan earthquake, about 460 permanent free-field stations in National Strong Motion Observation Network System （NSMONS） of China captured the main shock acceleration records. These records can be...During the great Wenchuan earthquake, about 460 permanent free-field stations in National Strong Motion Observation Network System （NSMONS） of China captured the main shock acceleration records. These records can be applied to site effect analyses, and then the site classification of those permanent stations can be carried out firstly, which will served as the fundamental information for further research. In this paper, the site of near-fault stations is classified by horizontal-to-vertical spectral ratio （HVSR） method according to the site class description of Japan earthquake resistant design code and response spectral shapes （RSS） method following the site class description of the 1997 Uniform Building Code （UBC） provisions. Then based on the detailed borehole data of those free-field stations, the equivalent shear wave velocity and overburden thickness are calculated and the site classifications are given by Chinese code for seismic design of buildings. Furthermore, for the stations having successful microtremor test data, the site dominant periods are computed to verify the results of site classification. Finally, combined with all the above results, the recommended site classes of near-fault permanent free-field stations are given.展开更多
文摘Savannah,Ga.,April 22,2025-Gulfstream Aerospace Corp.today announced its fleet has achieved an industry-leading 700 city-pair speed records with a Gulfstream G700 flight from Taipei to Miami.This flight commemorates the 50-year anniversary of Gulfstream's first U.S.National Aeronautic Association(NAA)accredited speed record,set in 1975 by the Gulfstream GII.
基金supported by grants from the National Natural Science Foundation of China(Grant No.32271733)Guangdong Basic and Applied Basic Research Foundation(Grant No.2023A1515011045)+1 种基金Science and Technology Projects in Guangzhou(Grant No.2023A04J0121)SCNU Training Program of Innovation for Undergraduates,China。
文摘Anthropogenic climate change is altering species distributions globally.While species distributions are expected to shift to higher latitudes and elevations under global warming,empirical evidence on distribution shifts is mixed,and factors mediating the direction and magnitude of range shifts remain unclear.Using a dataset of 132new provincial records for 96 resident bird species from 2000 to 2023,we measured geographic distance,latitudinal shift,and temperature shift from each new record to the historical range for each species to test for poleward shifts.We assessed taxonomic variation in the magnitude of range shifts and used phylogenetic generalized linear mixed models to quantify relationships between species traits and the extent of range shifts.Our results revealed that new records occurred at a mean geographic distance of 420 km from historical ranges,with mean latitudinal shifts of+1.68°(poleward)and temperature shifts of-1.33℃(toward colder climates).The magnitude of geographic range shifts was strongly constrained by phylogenetic relatedness.Habitat breadth,habitat openness,and centroid latitude of historical ranges emerged as significant predictors of range shifts.Our results suggest that resident bird species'geographic ranges in China are shifting poleward,but the magnitude of these shifts is non-random across lineages.Species with broader habitat preferences and those from warmer climates are more likely to shift farther from their historical ranges and toward higher latitudes.This study emphasizes taxonomic variation in species range shifts and highlights the need for species-and site-specific conservation strategies under global warming.
文摘BACKGROUND The neurological and psychiatric sequelae of coronavirus disease 2019(COVID-19)have been documented,yet further data are needed to thoroughly evaluate the impact of COVID-19 on brain health years after the infection.AIM To examine whether COVID-19 infection is associated with exacerbation,recurrence,or progression of pre-existing neurological or psychiatric disorders-a highrisk population that is underrepresented in COVID-19 outcome research in National Guard Health Affair patients in 4-years following a COVID-19 diagnosis.METHODS For this multicenter retrospective cohort study,we used data from the National Guard hospitals electronic health records network(BestCare)with over 10 million patients.Our cohort comprised patients who had a COVID-19 diagnosis;a matched control cohort included patient did not expose to COVID-19 in same period.Age and sex were matching factors.We estimated the incidence of 14 neurological and psychiatric outcomes in nearly 4 years after a confirmed diagnosis of COVID-19.Using a multiple logistic regression,we compared incidences with those in propensity score-matched cohorts of patients with no exposure to COVID-19.Ramadan M et al.Neurological and psychiatric risks post-COVID-19 RESULTS Our primary cohort comprised 4437 patients diagnosed with COVID-19,and our propensity-score 1:1 matched control cohort comprised 4437 individuals.Nearly two-third of the COVID-19 cohort(71%)were diagnosed in 2020,and 2021.The most prevalent diagnoses for both cohorts were epilepsy 30.68%,mood disorder 23.92%,and nerve plexus disorder 22.13%.Dementia was nearly 4 times higher among COVID-19 cohort(8.27%)compared to the control cohort(2.57%).Five neurological and psychiatric outcomes had odds ratios(OR)that were significantly higher than 1 for people who had COVID-19 compared to people who had never been infected.These outcomes were cognitive deficit OR=1.54,95%confidence interval(CI):1.23-1.91,P=0.0001;nerve plexus disorder OR=1.13,95%CI:1.01-1.25,P=0.02;substance use disorder OR=1.95,95%CI:1.12-3.38,P=0.01;mood disorder OR=1.16,95%CI:1.05-1.29,P=0.003;and anxiety disorder OR=1.39,95%CI:1.07-1.79,P=0.01.CONCLUSION The study highlights the persistent risk of neurological and psychiatric conditions in COVID-19 survivors up to four years post-infection.Although the incidence was lower than in previous large studies,long-term consequences remain significant,emphasizing the need for ongoing monitoring and support in mental health and neurological care.
基金supported by the National Key Research&Development Program of China(No.2024YFC3505800)the National Natural Science Foundation of China(Nos.82474334,82474335 and 72174132)+3 种基金National Science Fund for Distinguished Young Scholars(No.82225049)the Key Research&Development Projects of Sichuan Provincial Department of Science and Technology(Nos.2024YFFK0174 and 2024YFFK0152)1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYYC24010 and ZYGD23004)the Special Fund for Traditional Chinese Medicine of Sichuan Provincial Administration of Traditional Chinese Medicine(No.2024zd023).
文摘Objectives:Electronic health records(EHRs)offer valuable real-world data(RWD)for Chinese medicine research.However,significant methodological challenges remain in developing integrative Chinese-Western medicine(ICWM)databases.This study aims to establish a best-practice methodological framework,referred to as BRIDGE,to guide the construction of ICWM databases using EHRs.Methods:We developed the methodological framework through a comprehensive process,including systematic literature review,synthesis of empirical experiences,thematic expert discussions,and consultation with an external panel to reach consensus.Results:The BRIDGE framework outlines 6 core components for ICWM-EHR database development:Overall design,database architecture,data extraction and linkage,data governance,data verification,and data quality evaluation.Key data elements include variables related to study population,treatment or exposure,outcomes,and confounders.These databases support various research applications,particularly in evaluating the effectiveness and safety of integrative therapies.To demonstrate its practical value,we developed an ICWM-EHR database on women’s reproductive lifespan,encompassing 2,064,482 patients.This database captures women’s health conditions across the life course,from reproductive age to older adulthood.Conclusions:The BRIDGE methodological framework provides a standardized approach to building high-quality ICWM-EHR databases.It offers a unique opportunity to strengthen the methodological rigor and real-world relevance of Chinese medicine research in integrated healthcare settings.
基金supported by the National Natural Science Foundation of China(30270187)
文摘A new Megaselia species： Megaselia angustirostris Fang ＆ Liu, sp. nov., is described and illustrated and two species of the genus, M. nigra （Meigen） and M. albicaudata （Wood）, are reported for the first time from China. The type specimens are deposited in College of Biological and Environmental Engineering, Shenyang University.
文摘In order to improve the accuracy and integrality of mining data records from the web, the concepts of isomorphic page and directory page and three algorithms are proposed. An isomorphic web page is a set of web pages that have uniform structure, only differing in main information. A web page which contains many links that link to isomorphic web pages is called a directory page. Algorithm 1 can find directory web pages in a web using adjacent links similar analysis method. It first sorts the link, and then counts the links in each directory. If the count is greater than a given valve then finds the similar sub-page links in the directory and gives the results. A function for an isomorphic web page judgment is also proposed. Algorithm 2 can mine data records from an isomorphic page using a noise information filter. It is based on the fact that the noise information is the same in two isomorphic pages, only the main information is different. Algorithm 3 can mine data records from an entire website using the technology of spider. The experiment shows that the proposed algorithms can mine data records more intactly than the existing algorithms. Mining data records from isomorphic pages is an efficient method.
文摘Objective To determine whether frailty is a risk factor for hospitalization and mortality in older adults enrolled in the "Chronic Heart Failure Program" at a hospital in Lima, Peru, between 2018–2021.Methods This was an ambispective cohort study. A total of 85 older adults participating in the Chronic Heart Failure Program at Guillermo Almenara National Hospital were included. Each had an initial frailty assessment, forming two cohorts: frail and non-frail older adults. Medical records were reviewed, and patients were followed for one year to track events of interest(hospitalization and mortality). Overall survival and risk factors for hospitalization and death were determined.Results During follow-up, 15.3% of the older adults died, and frailty was identified in 58.8% of the patients. Overall survival using the Kaplan-Meier method was 96.5% at 3 months after entering the Chronic Heart Failure Program;92.9% at 6 months;and85.9% at one year. Multivariate analysis using Poisson regression found that frailty was not a risk factor for hospitalization(a RR =0.92;95% CI: 0.42–2.03). Survival analysis using the Cox proportional hazards model showed that frailty was also not a risk factor for mortality after one year of follow-up(a HR = 1.32;95% CI: 0.27–6.53).Conclusions Our research does not confirm frailty as a risk factor for hospitalization or mortality in older adults enrolled in the“Chronic Heart Failure Program” after one year of follow-up.
基金funded by Multimedia University,Cyberjaya,Selangor,Malaysia(Grant Number:PostDoc(MMUI/240029)).
文摘As healthcare systems increasingly embrace digitalization,effective management of electronic health records(EHRs)has emerged as a critical priority,particularly in inpatient settings where data sensitivity and realtime access are paramount.Traditional EHR systems face significant challenges,including unauthorized access,data breaches,and inefficiencies in tracking follow-up appointments,which heighten the risk of misdiagnosis and medication errors.To address these issues,this research proposes a hybrid blockchain-based solution for securely managing EHRs,specifically designed as a framework for tracking inpatient follow-ups.By integrating QR codeenabled data access with a blockchain architecture,this innovative approach enhances privacy protection,data integrity,and auditing capabilities,while facilitating swift and real-time data retrieval.The architecture adheres to Role-Based Access Control(RBAC)principles and utilizes robust encryption techniques,including SHA-256 and AES-256-CBC,to secure sensitive information.A comprehensive threat model outlines trust boundaries and potential adversaries,complemented by a validated data transmission protocol.Experimental results demonstrate that the framework remains reliable in concurrent access scenarios,highlighting its efficiency and responsiveness in real-world applications.This study emphasizes the necessity for hybrid solutions in managing sensitive medical information and advocates for integrating blockchain technology and QR code innovations into contemporary healthcare systems.
基金supported by the National Natural Science Foundation of China(42088101).
文摘An unprecedented extreme gale and dust event struck East Asia during 10-14 April2025.A record-breaking gale swept across most regions of China.It carried large amounts of dust from northern deserts,resulting in nationwide dust weather.Gales affected more than 3.5 million km^(2),and the windspeeds in North China were the strongest in April since 1940(Fig.1a,b).
文摘The present paper deals with two new ethmid moths from China: Ethmia damaoshanae sp.nov. and Ethmia jingdongensis sp.nov. Another two species Ethmia dodecea (Haworth) and Ethmia ultima Sattler are reported for the first time from the country. The genitalia of the new species are figured.
基金supported by the National Natural Science Foundation of China,Nos.32070989(to YMZ),31872766(to YMZ),81790640(to XLY),and 82070993(to SJW)the grant from Sanming Project of Medicine in Shenzhen,No.SZSM202011015(to XLY)。
文摘Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission are associated with pathophysiological and neurodegenerative disorders,whereas glucagon-like peptide-1 has demonstrated neuroprotective effects.However,it is not yet clear whether diabetes causes alterations in inhibitory input to retinal ganglion cells and whether and how glucagon-like peptide-1 protects against neurodegeneration in the diabetic retina through regulating inhibitory synaptic transmission to retinal ganglion cells.In the present study,we used the patch-clamp technique to recordγ-aminobutyric acid subtype A receptor-mediated miniature inhibitory postsynaptic currents in retinal ganglion cells from streptozotocin-induced diabetes model rats.We found that early diabetes(4 weeks of hyperglycemia)decreased the frequency of GABAergic miniature inhibitory postsynaptic currents in retinal ganglion cells without altering their amplitude,suggesting a reduction in the spontaneous release ofγ-aminobutyric acid to retinal ganglion cells.Topical administration of glucagon-like peptide-1 eyedrops over a period of 2 weeks effectively countered the hyperglycemia-induced downregulation of GABAergic mIPSC frequency,subsequently enhancing the survival of retinal ganglion cells.Concurrently,the protective effects of glucagon-like peptide-1 on retinal ganglion cells in diabetic rats were eliminated by topical administration of exendin-9-39,a specific glucagon-like peptide-1 receptor antagonist,or SR95531,a specific antagonist of theγ-aminobutyric acid subtype A receptor.Furthermore,extracellular perfusion of glucagon-like peptide-1 was found to elevate the frequencies of GABAergic miniature inhibitory postsynaptic currents in both ON-and OFF-type retinal ganglion cells.This elevation was shown to be mediated by activation of the phosphatidylinositol-phospholipase C/inositol 1,4,5-trisphosphate receptor/Ca2+/protein kinase C signaling pathway downstream of glucagon-like peptide-1 receptor activation.Moreover,multielectrode array recordings revealed that glucagon-like peptide-1 functionally augmented the photoresponses of ON-type retinal ganglion cells.Optomotor response tests demonstrated that diabetic rats exhibited reductions in visual acuity and contrast sensitivity that were significantly ameliorated by topical administration of glucagon-like peptide-1.These results suggest that glucagon-like peptide-1 facilitates the release ofγ-aminobutyric acid onto retinal ganglion cells through the activation of glucagon-like peptide-1 receptor,leading to the de-excitation of retinal ganglion cell circuits and the inhibition of excitotoxic processes associated with diabetic retinopathy.Collectively,our findings indicate that theγ-aminobutyric acid system has potential as a therapeutic target for mitigating early-stage diabetic retinopathy.Furthermore,the topical administration of glucagon-like peptide-1 eyedrops represents a non-invasive and effective treatment approach for managing early-stage diabetic retinopathy.
基金Supported by the Zhejiang Provincial Natural Science Foundation(No.LQ16H180004)~~
文摘Objectives Medical knowledge extraction (MKE) plays a key role in natural language processing (NLP) research in electronic medical records (EMR),which are the important digital carriers for recording medical activities of patients.Named entity recognition (NER) and medical relation extraction (MRE) are two basic tasks of MKE.This study aims to improve the recognition accuracy of these two tasks by exploring deep learning methods.Methods This study discussed and built two application scenes of bidirectional long short-term memory combined conditional random field (BiLSTM-CRF) model for NER and MRE tasks.In the data preprocessing of both tasks,a GloVe word embedding model was used to vectorize words.In the NER task,a sequence labeling strategy was used to classify each word tag by the joint probability distribution through the CRF layer.In the MRE task,the medical entity relation category was predicted by transforming the classification problem of a single entity into a sequence classification problem and linking the feature combinations between entities also through the CRF layer.Results Through the validation on the I2B2 2010 public dataset,the BiLSTM-CRF models built in this study got much better results than the baseline methods in the two tasks,where the F1-measure was up to 0.88 in NER task and 0.78 in MRE task.Moreover,the model converged faster and avoided problems such as overfitting.Conclusion This study proved the good performance of deep learning on medical knowledge extraction.It also verified the feasibility of the BiLSTM-CRF model in different application scenarios,laying the foundation for the subsequent work in the EMR field.
基金supported by the Fundamental Research Funds for the Central Universities (65012421)the National Natural Science Foundation (30870328,J0930005)
文摘Three genera, Cuspicona Dallas, Hermolaus Distant and Oncinoproctus Breddin, and six species （Cuspicona antica Vollenhoven, Hermolaus typicus Distant, Menida atkinsoni Distant, Oncinoproctus griseolus Breddin, Paterculus aberrans Distant, and Rolstoniellus malacanicus （Yang）） of Pentatomidae are reported from China for the first time. Both dorsal and ventral habitus and genital illustrations of each species are provided. All specimens studied were from Institute of Entomology, Nankai University, Tianjin, China （NKUM） except Cuspicona antica Vollenhoven, 1868 whose involved species are kept at the Institute of Zoology, Chinese Academy of Sciences （IZCAS）.
基金This study was supported by the National Basic Research Program of China （No. 2004CB720206） the National Natural Science Foundation of China （No. 49971009）the RGC （HKU 7243/04H） Grant of the HKSAR and the Chinese Academy of Sciences （No. KZCX2-SW-118）
文摘Studies of lithology, sedimentary facies and the distribution regularity of SiO2 and Al2O3 contents and Al2O3/SiO2 ratio allow us to divide the Upper Pleistocene-Holocene Series represented by the MUanggouwan section in China＇s Salawnsu River valley into six segments： MGS1, MGS2, MGS3, MGS4, MGS5 and MGS6. The boundary ages for MGS1 （the Dishaogouwan and Dagouwan Formations）, MGS2 （the upper Chengchuan Formation）, MGS3 （the middle Chengchuan Formation）, MGS4 （the lower Chengchuan Formation）, MGS5 （most strata of the Salawusu Formation） and MGS6 （the bottom of the Salawusu Formation and the top of the Lishi Formation） correspond to those of MIS1, MIS2, MIS3, MIS4, MISS and MIS6, respectively, from deep sea sediments or continental glaciers. MGS5 can be subdivided into five subsegments （MGS5a, MGS5b, MGS5c, MGS5d and MGS5e） and the boundary ages of these subsegments correspond to those of MISSa, MISSb, MIS5c, MIS5d and MIS5e, respectively. Based on the paleoenvironment and paleoecology indicated by the primary chemical elements, fossil vertebrates, mollusks and pollen grains, we hypothesize that MGS1, MGS2, MGS3, MGS4, MGS5 and MGS6 and the subsegments of MGS5 match the corresponding stages for oxygen isotopes in the deep sea sediments and continental glaciers, and the substages of MIS5 in terms of climatic characters, further explaining the phenomena that determined the formation of the late Quaternary strata and the paleontology of the Salawusu River valley. These phenomena relate to fluctuations in the global climate （and particularly in the East Asian monsoon） during the glacial and interglacial periods.
基金supported by the National Natural Science Foundation of China(Grant No.:41272066)the Scientific Research Key Project of Shandong Province’s Geoscience Forum(LDXHLT-2007-10-001)the China Geological Survey Project(Grant No.:1212010510509)
文摘The Yishu fault zone （mid-segment of the Tanlu fault zone） was formed in the Presinian. Periodic tectonic activities and strong seismic events have occurred along the fault zone. During the initial stage of the Caledonian Movement, with the proceeding of the marine transgression from the Yishu paleo-channel to the western Shandong, uneven thick sediments, composed mainly of sand, mud and carbonates of littoral, lagoon, and neritic facies, were deposited in the Yishu fault zone and western Shandong, and constructed the bottom part of the Lower Cambrian consisting of the Liguan and Zhushadong formations. Through field observations and the lab-examinations, various paleoseismic records have been discovered in the Liguan Formation and the Zhushadong Formations of the Yishu fault zone and its vicinity, including some layers with syn-sedimentary deformation structures that were triggered by strong earthquakes （i.e. seismite, seismo-olistostrome, and seismo-turbidite）. Paleoseismic records developed in the Zhushadong Formation are mainly seismites with soft-sediment deformation structures, such as liquefied diapir, small liquefied-carbonate lime-mud volcano, liquefied vein, liquefied breccia, convolute deformation （seismic fold）, graded fault, soft siliceous vein, and deformation stromatolite, as well as seismites with brittle deformation structures of semiconsolidated sediments. Paleoseismic records preserved in the Liguan Formation are not only seismo-olistostrome with a slump fold, load structure, and ball-and-pillows, but also seismo-turbidite with convolution bedding, graded bedding and wavy-bedding. However, in the western Shandong area, the closer to the Yishu fault zone, the greater the thickness of the Liguan Formation and the Zhushadong Formation, the greater the number and type of layers with paleoseismic records, and the higher the earthquake intensity reflected by associations of seismic records. This evidence indicates that tectonic taphrogenesis accompanied by strong earthquake events occurred in the Yishu fault zone during the initial stage of the Caledonian Movement, which embodied the break-up of the Sino-Korean Plate along the Paleo-Tanlu fault zone at that time.
文摘Guinness Book of World Records(《吉尼期世界纪录在全》) is a famous collection of world records in human life, including many kinds of specific skills. But do you know how the book came out?On November 10, 1951, an Englishman, Sir Beveagh, was having a discussion with his friends. They couldn
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA05090406)the special projects of China Meteorological Administration(Grant No.GYHY201006022)
文摘The authors analyzed the lead-lag connection of the Atlantic Multidecadal Oscillation (AMO) with East Asian surface air temperatures (EATs) using instrumental records, and compared the results with the Pacific Decadal Oscillation (PDO). The maximum correlation was found when EATs led the AMO by five to seven years (with a correlation coefficient of 0.72, whereas the correlation coefficient was 0.91 when the AMO led EATs by 24-28 years). This is different from the PDO, which mostly correlated with EATs when the PDO led EATs by 13-15 years (with a correlation coefficient of 0.67, whereas the correlation coefficient was 0.76 when EATs led the PDO by 24-26 years). The PDO led the AMO by 19-21 years (with a correlation coefficient of 0.71, whereas the correlation coefficient was 0.84 when the AMO led the PDO by 16-18 years). These results support a previous understanding that EATs positively correlate with the AMO, and imply that the observed East Asian warming trend may have been slowing down since the early 2010s.
基金Supported by the National Natural Science Foundation of China(No.41430965)the Open Fund of the Key Laboratory of Marine Geology and Environment,Chinese Academy of Sciences(No.MGE2015KG08)
文摘The East China Sea continental shelf is a unique area for the study of land-sea interactions and paleoenvironmental change because it receives a large amount of terrestrial material inputs. In recent decades, human activities and global climate change have greatly aff ected river discharges into the sea. However, changes in the deposition process caused by these factors in the East China Sea continental shelf are unclear. We collected eight short sediment cores from the East China Sea inner shelf(ECSIS) using a box core sampler in 2012 and 2015. The grainsize, 2 10 Pb, and 1 37 Cs of these cores were analyzed in order to reconstruct the deposition history since the 1950 s, and to reveal human activity and climate change influences on sediment deposition in the ECSIS. Results indicated that sediment grain size became finer after 1969, turned coarser after 1987, and then further coarser since 2003, corresponding well to the three steps of sediment load drop in the Changjiang(Yangtze) River, which are mainly caused by human activities(particularly the closure of the Three Gorges Dam). Simultaneously, the East Asian Monsoon influenced the deposition process in the ECSIS by changing the intensity of coastal currents. Mean grain size variations in the fine-grained population(divided by grain size vs. standard deviation method) coincided with that of the East Asian Winter Monsoon strength and reflected its weakness in 1987. Abrupt changes in sediment grain size over a short time scale in these sediment cores were generally caused by floods and typhoons. Spectral analyses of the sediment cores showed periodicities of 10–11 and 20–22 years, corresponding to the periodicity of solar activity(Schwabe cycle and Hale cycle). Mean grain size time series also displayed a 3–8 year periodicity corresponding to El Ni?o Southern Oscillation periodic change.
基金supported by the projects from the Ministry of Science and Technology of China (No.2009BK55B00)China Earthquake Administration (CEA) (No. 200808026)Institute of Engineering Mechanics of CEA (No. 0618001)
文摘During the great Wenchuan earthquake, about 460 permanent free-field stations in National Strong Motion Observation Network System （NSMONS） of China captured the main shock acceleration records. These records can be applied to site effect analyses, and then the site classification of those permanent stations can be carried out firstly, which will served as the fundamental information for further research. In this paper, the site of near-fault stations is classified by horizontal-to-vertical spectral ratio （HVSR） method according to the site class description of Japan earthquake resistant design code and response spectral shapes （RSS） method following the site class description of the 1997 Uniform Building Code （UBC） provisions. Then based on the detailed borehole data of those free-field stations, the equivalent shear wave velocity and overburden thickness are calculated and the site classifications are given by Chinese code for seismic design of buildings. Furthermore, for the stations having successful microtremor test data, the site dominant periods are computed to verify the results of site classification. Finally, combined with all the above results, the recommended site classes of near-fault permanent free-field stations are given.
