Polycystic kidney disease (PKD) is an autosomal dominant genetic disorder that causes the formation of multiple cysts in the kidneys, leading to kidney failure. PKD is a common condition affecting approximately 1 in 5...Polycystic kidney disease (PKD) is an autosomal dominant genetic disorder that causes the formation of multiple cysts in the kidneys, leading to kidney failure. PKD is a common condition affecting approximately 1 in 500 individuals worldwide. The most prevalent type of PKD is autosomal dominant PKD (ADPKD). ADPKD is caused by mutations in either the PKD1 or PKD2 genes, which encode for proteins involved in cell growth and differentiation. These mutations lead to the formation of fluid-filled cysts in the kidneys, which can eventually lead to kidney failure. In addition to affecting the kidneys, PKD can also cause cysts in other organs, such as the liver, pancreas, and spleen. PKD can also lead to various complications, including high blood pressure, heart valve abnormalities, and brain aneurysms. This review focuses on the inheritance, pathophysiology, and treatment of PKD, with a specific emphasis on its effects on the cardiovascular system. Currently, there is no cure for PKD. However, several treatments are available to manage the symptoms and complications of the disease. These treatments include medications to control blood pressure, pain relievers, antibiotics for infections, and dialysis or kidney transplantation for kidney failure. Tolvaptan is the only FDA-approved drug specifically for ADPKD and has been shown to slow disease progression. In addition to summarizing current treatment options, this review will discuss promising future treatments, such as gene therapy and stem cell therapy.展开更多
Craniometaphyseal dysplasia(CMD),a rare craniotubular disorder,occurs in an autosomal dominant(AD)or autosomal recessive(AR)form.CMD is characterized by hyperostosis of craniofacial bones and metaphyseal flaring of lo...Craniometaphyseal dysplasia(CMD),a rare craniotubular disorder,occurs in an autosomal dominant(AD)or autosomal recessive(AR)form.CMD is characterized by hyperostosis of craniofacial bones and metaphyseal flaring of long bones.Many patients with CMD suffer from neurological symptoms.The pathogenesis of CMD is not fully understood.展开更多
Beach groynes are structures for erosion protection along sandy coasts near inlets and can reduce the coastal erosion substantially,but open groynes cannot stop erosion completely because sand can be removed from the ...Beach groynes are structures for erosion protection along sandy coasts near inlets and can reduce the coastal erosion substantially,but open groynes cannot stop erosion completely because sand can be removed from the groyne compartments by cross-shore processes.Beach groynes should be designed with sufficient bypassing of sand to minimise erosion.Regular beach maintenance is required to keep a sufficient beach width for recreational purposes.The effectiveness of groyne compartments can be significantly improved by using T-head groynes or by using a submerged sill or breakwater in between the groynes.An economic evaluation shows that the beach maintenance costs over 50 years may be substantially higher than the construction costs of a submerged breakwater.An important parameter to be studied is the longshore transport,which requires detailed information of the wave climate,preferably based on measured data(offshore buoys)in combination with deep water wave modelling.Various models have been used to determine the net longshore sand transport and coastline changes.The design of groynes to reduce coastal erosion is illustrated by three field cases(Atlantic coast near Soulac,France;Lagos coast,Nigeria and Black Sea coast,Romania).These example cases show that beach groynes are effective structures,but sufficient bypassing of longshore sand transport is essential to minimise erosion.Regular beach fills in the groyne compartments may be required at high-energy(exposed)coasts.A submerged or emerged breakwater can be built between the groynes to protect the beach in the groyne compartments against erosion by cross-shore processes.展开更多
BACKGROUND Fixed esotropia in high myopia,characterized by irreversible inward ocular deviation and abduction limitation,presents unique therapeutic challenges for athletes requiring precise binocular coordination.The...BACKGROUND Fixed esotropia in high myopia,characterized by irreversible inward ocular deviation and abduction limitation,presents unique therapeutic challenges for athletes requiring precise binocular coordination.The combination of Yokoyama surgery and medial rectus muscle recession has been proposed as an advanced technique addresses both myopia-induced globe displacement and muscular imbalance offering potential advantages over conventional strabismus surgery in this population.AIM To investigate the effects of the modified Yokoyama surgery coupled with medial rectus muscle recession in restoring ocular motility and correcting esotropia among athletes with high myopia and fixed esotropia.METHODS A retrospective study analyzed 30 highly myopia athletes(57 eyes)with fixed esotropia treated at our hospital from January 2022 to April 2024.The participants were allocated into two groups based on the surgical method:The traditional group(n=15,29 eyes)received conventional strabismus surgery,and the combined group(n=15,28 eyes)underwent modified Yokoyama surgery in combination with medial rectus muscle recession.Eye movement improvement,esotropia alleviation,and complications were compared preoperatively and at 1,3,and 6 months post-treatment.RESULTS Both surgical groups exhibited similar baseline scores(traditional:-4.04±0.38 vs combined:-4.12±0.45,P>0.05),showing severe preoperative limitations in ocular motility.Following the intervention,the combined group achieved significantly better outcomes at both 1 month(combined:-2.25±0.28 vs traditional:-2.67±0.32)and 3 months(combined:-1.48±0.28 vs traditional:-1.76±0.43),with statistically significant improvements(P<0.05).However,by 6 months,no significant difference was observed between the two groups(combined:-0.93±0.13;traditional:-1.03±0.18;P>0.05).Prior to treatment,all patients in both groups exhibited a compensatory head posture(CHP).Following treatment,the incidence of CHP decreased to 6.67%in the combined group and 20.00%in the traditional group,both reductions being significant compared to pretreatment levels(P<0.05).Nevertheless,the difference in CHP incidence between the two groups after treatment was not significant(P>0.05).The rates of improvement in esotropia showed an increasing trend in both groups at 1 month(46.43%vs 34.48%),3 months(78.57%vs 51.728%),and 6 months(100.00%vs 89.66%)post-treatment.Notably,the combined group had a significantly higher improvement rate than the traditional group at the 3-month follow-up(P<0.05).No significant difference was observed in the esotropia improvement rates between the two groups at 1 and 6 months post-treatment(P>0.05).The combined group experienced slightly lower but not significant(combined group:0.00%vs traditional:3.45%)as opposed to the traditional group(3.45%;P>0.05).CONCLUSION The combination of modified Yokoyama surgery and medial rectus muscle recession provides effective and safe approach to improving in eye movement and esotropia in athletes with high myopia and fixed esotropia,offering reliable clinical benefits.展开更多
[Objective] This study aimed to investigate the effect of mating factor recombination on the development of edible mushroom,and explore the possibility for using self-crossing to breed sporeless/low sporing mushroom s...[Objective] This study aimed to investigate the effect of mating factor recombination on the development of edible mushroom,and explore the possibility for using self-crossing to breed sporeless/low sporing mushroom strains.[Method] Selecting Agrocybe salicacola strain YAASM0711 as the self-crossing material,six self-crossed combinations were directionally constructed with single spore growth rate as an indicator,to carry out comprehensive analysis of the qualitative traits（color,deformity and growth characteristics）,quantitative traits（shape,yield,size and number of fruit bodies） and mating types of its self-crossed F1 progenies.[Result] After mating factor recombination,self-crossed single spore progenies showed serious genetic differentiation,the average mycelial growth rate and agronomic traits of inbred progenies were lower than those of the parents.The phenotype in fruiting body formation could be divided into normal fruiting and abnormal fruiting（including abnormal fruiting bodies,sporeless or low sporing fruiting bodies,no fruiting）.To be specific,18% self-crossed strains had superior agronomic traits to the parents,which can be used for selecting predominant strains from self-crossed progeny populations based on different breeding purposes.[Conclusion] The genes controlling mycelial growth rate of single spore were linked with mating factors.The mating factor-recombinant single spore strains could be selected according to the correlation between mating type and growth rate.The fruiting result of self-crossed strains indicated that the genes related to sporeless/low sporing development were recessive.Not only genetic materials harboring development-deficient genes in edible mushroom can be obtained by self-crossing,but also the sporeless/low sporing mutant strains with important application prospects can be bred.展开更多
[ Objective] The study was to investigate the agronomic traits and breeding characteristics of genic male sterile material Mian 7AB-4- 2 in Brassica napus. [ Method] The differences in agronomic traits and polymorphis...[ Objective] The study was to investigate the agronomic traits and breeding characteristics of genic male sterile material Mian 7AB-4- 2 in Brassica napus. [ Method] The differences in agronomic traits and polymorphisms in SSR markers, between the genic male sterile material Mian 7AB-4-2 in Brassica napus and its sisterly line Mian 7AB-4-1 were investigated by hybridization and molecular identification; and the percentage of sterile individuals of Mian 7AB-4-2 and of the hybrids with its sisterly line Mian 7AB-4-1 from test cross and back cross were also studled. [ Result] Mian 7AB-4-2 was not significantly different in agronomic traits from its sisterly line Mian 7AB-4-1 at 0.05 probability level. The per- centages of sterile individuals in the pollinated fertile Mian 7AB-4-2 plants were over 60%, and that in its sisterly line Mian 7AB-4-1 was about 25%. In test crosses with other nine sterile lines, Mian 7AB-4-1 kept the percentage of sterile individuals of sterile lines over 90%, and the percentage of sterile individuals from back cross over 80%. With regard to molecular markers, Mian 7AB-4-2 and its sisterly line Mian 7AB-4-1 were different in the band number from SSR primers a2 and E10. [ Conclusion] The results indicate that Mian 7AB-4-2 is helpful for rapeseed breeding, quickening the application of new materials in field breeding.展开更多
Fragrant camphor tree is the city tree of Hangzhou which takes a large proportion of the ancient trees in Hangzhou City. Recently, with the free open of the attractions around the West Lake and the implementation of t...Fragrant camphor tree is the city tree of Hangzhou which takes a large proportion of the ancient trees in Hangzhou City. Recently, with the free open of the attractions around the West Lake and the implementation of the comprehensive pro- ject for protecting the West Lake, a part of ancient fragrant camphor trees are fac- ing problems such as altered living conditons. Some of them are showing a decline in growth vigor or even close to death, which will produce extremely negative influ- ences on the maintaining and sustainable development of the West Lake Scenic Area if without any timely measures for the rescue and rejuvenation of the trees. Therefore, strengthening the protection and management of ancient fragrant camphor trees at the West Lake Scenic Area and carrying out researches on the procedure for diagnosing the reasons for the growth recession of the ancient fragrant camphor trees at the West Lake Scenic Area are of great significance for the future protec- tion and rejuvenation of the ancient trees around the West Lake. The factors influ- encing the growth of ancient trees and indexes for judging the growth condition were listed and the reasons for the growth recession were systematically summa- rized in this paper. In addition, measures for the rejuvenation of the ancient fragrant camphor trees were also simply discussed.展开更多
From the random mating population of maize, the relationship between heterosis and albino seedling was analyzed by means of mathematical theory, further the square logistic model for the appearance of lethal recessive...From the random mating population of maize, the relationship between heterosis and albino seedling was analyzed by means of mathematical theory, further the square logistic model for the appearance of lethal recessive homozygous genotype was deduced. The model shows that heterosis can determine the genetic structure and proportion of population. It approves, that the proportion of aa in each generation of maize seedlings shows a similar Logistic curve in growth process till equilibrium, so long as Aa containins lethal gene a from mutation presents heterosis. The ratio of equilibrium state of aa is determined by the ratio of AA-Aa fitness. Heterosis is helpful for the keeping of genetic diversity of population.展开更多
According to the theory of Chinese veterinary medicine and characteristics of Chinese herbal medicine, four different preparations of compound Chinese medicine ＂Zengrujianniusan＂ were composed, and the prepared wate...According to the theory of Chinese veterinary medicine and characteristics of Chinese herbal medicine, four different preparations of compound Chinese medicine ＂Zengrujianniusan＂ were composed, and the prepared water decoction was used to carry on the bacteriostatic test on main pathogens of cow recessiveness mastitis. The results showed that the four different prescriptions of water decoction all had antibacterial effects. The prescription 3 was sensitive to Staphylococcus aureus and Streptococcus agalactiae, while the other three prescriptions showed high sensitivity, and the prescription 3 had the strongest bacteriostatic effects.展开更多
[Objective] This study aimed to investigate the action of mutant gene o2 and its effect on nutritional quality of different maize combinations. [Method] A total of 33 normal maize combinations from 18 inbred lines wer...[Objective] This study aimed to investigate the action of mutant gene o2 and its effect on nutritional quality of different maize combinations. [Method] A total of 33 normal maize combinations from 18 inbred lines were compared with 33 combinations including gene o2 from the corresponding o2 near-isogenic lines （o2-NILs）, to study the effect of o2 gene introduction on maize grain quality. [Result] The contents of lysine, protein and oil in o2-NILs were greatly more than that of normal maize combinations. Except for lysine, contents of other 14 amino acids changed when o2 gene was introduced. Contents of aspartic acid, threonine, glycine, isoleucine, histidine, arginine and proline were improved; while contents of serine, glutamic acid, alanine, valine, leucine, tyrosine and phenylalanine were decreased. Correlation analysis showed that contents of aspartic acid, arginine and threonine had the highest correlation with lysine content. Protein and oil contents had higher correlation with lysine content （0.48 and 0.38）. Analysis of 33 o2-NILs revealed that the o2 combinations CAL58×Ji477and CA156×196 showed high comprehensive quality and high yield with greater development potential. [Conclusion] This study will provide theoretical and material basis for improving the quality of temperate maize germplasm by introducing o2 gene.展开更多
In the perspective of dominant and recessive beauty,the aesthetic effect of bamboos in landscape design has been illustrated from four aspects,which are"bamboos leading to a secluded spot"and"simplicity...In the perspective of dominant and recessive beauty,the aesthetic effect of bamboos in landscape design has been illustrated from four aspects,which are"bamboos leading to a secluded spot"and"simplicity and magnificence","bamboos at windows"and"bamboo shadows on white walls","bamboos,waters,rocks and plants setting each other off"and literati's feeling about bamboos.On this basis,by combining with different characteristics of Chinese and western landscapes,the paper has proposed the application tendency of bamboos in landscape design,and emphasized integrating the essence of Chinese traditional landscape with western rational theory,so as to create more appealing bamboo landscapes.展开更多
Objective: Vacuolating megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a recently described syndrome with autosomal recessive mode of inheritance. Its possible gene was located on chromosomal 22q ...Objective: Vacuolating megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a recently described syndrome with autosomal recessive mode of inheritance. Its possible gene was located on chromosomal 22q tel with 3-cM. The purpose of this study was to narrow down the genetical distance on chromosomal 22q tel with MLC. Methods: Thirty-nine MLC patients in 33 families were collected,and the linkage analysis and haplotype analysis of twelve informative families were done, using seven microsatellite markers and four SNP markers. Results: The maximum tow-point LOD score for marker 355c18 was 6.65 at recombination fraction 0.02. The haplotype analysis narrowed down the critical region of MLC to 250 kb on chromosomal 22q tel. Conclusion: One of the causing genes of MLC was located on chromosomal 22q tel with 250 kb. Four candidate genes were considered. The heterogeneity of one informative family indicated possible existence of a second locus for MLC.展开更多
Similar to most mountain glaciers in the world, Urumqi Glacier No. 1 （UG1）, the best observed glacier in China with continued glaciological and climatological monitoring records of longer than 50 years has experienc...Similar to most mountain glaciers in the world, Urumqi Glacier No. 1 （UG1）, the best observed glacier in China with continued glaciological and climatological monitoring records of longer than 50 years has experienced an accelerated recession during the past several decades. The purpose of this study is to investigate the acceleration of recession. By taking UG1 as an example, we analyze the generic mechanisms of acceleration of shrinkage of continental mountain glaciers. The results indicate that the acceleration of mass loss of UG1 commenced first in 1985 and second in 1996 and that the lat- ter was more vigorous. The air temperature rises during melting season, the ice temperature augment of the glacier and the albedo reduction on the glacier surface are considered responsible for the accelerated recession. In addition, the simulations of the accelerated shrinkage of UG1 are introduced in this article.展开更多
Background: Few school settings offer opportunities for preschool children to engage in structured physical activity, and only a few studies have been conducted examining exergaming's effectiveness on health outco...Background: Few school settings offer opportunities for preschool children to engage in structured physical activity, and only a few studies have been conducted examining exergaming's effectiveness on health outcomes in this age group. This study's purpose, therefore, was to examine a school-based exergaming intervention's effect on preschool children's perceived competence(PC), motor skill competence(MSC), and physical activity versus usual care(recess), as well as to examine gender differences for these outcomes.Methods: A total of 65 preschool children from 2 underserved urban schools were assigned to 1 of 2 conditions, with the school as the experimental unit:(1) usual care recess group(8 weeks of 100 min of recess/week(5 days ￡ 20 min)) and(2) exergaming intervention group(8 weeks of100 min of exergaming/week(5 days ￡ 20 min) at school). All children underwent identical assessments of PC, MSC, and moderate-to-vigorous physical activity(MVPA) at baseline and at the end of the 8 th week.Results: A significant Group ￡ Time effect was observed for MVPA, F(1, 52) = 4.37, p = 0.04, h2 p= 0.04, but not for PC, F(1, 52) = 0.83, p = 0.37,h2 p= 0.02, or MSC, F(1, 52) = 0.02, p = 0.88, h2 p= 0.00. Specifically, the intervention children displayed significantly greater increased MVPA after8 weeks than the comparison children. Additionally, there was a significant time effect for MSC, F(1, 52) = 15.61, p < 0.01, h2 p= 0.23, and gender effect for MVPA, F(1, 52) = 5.06, p = 0.02, h2 p= 0.09. Although all preschoolers' MSC improved across time, boys demonstrated greater MVPA than girls at both time points.Conclusion: Exergaming showed a positive effect in promoting preschool children's MVPA at school and has the potential to enhance PC and MSC. More research with larger sample sizes and longer study durations are warranted.展开更多
AIM：To evaluate the functional and aesthetic outcomes of upper eyelid cicatricial entropion（UCE） correction using anterior lamellar recession（ALR） with addressing the associated conditions including dermatochalas...AIM：To evaluate the functional and aesthetic outcomes of upper eyelid cicatricial entropion（UCE） correction using anterior lamellar recession（ALR） with addressing the associated conditions including dermatochalasis,brow ptosis,blepharoptosis,and lid retraction.METHODS：Chart review of patients with upper lid cicatricial entropion who had undergone ALR from 2013 to 2016 was reviewed.Success was defi ned as the lack of any lash in contact with the globe,no need for a second procedure,and acceptable cosmesis at the fi nal follow up.RESULTS：Sixty eight patients（97 eyelids） were operated by ALR with simultaneous correction of associated lid problems in each case when necessary.The mean followup time was 17.8 mo（range,6.0-24.0 mo）.Concomitantly,levator tucking was performed in 19 eyelids（19.6%）,upper lid retractor recession in 18 eyelids（18.6%）,and internal browpexy in 31 eyelids（32.0%）.In 95.8% of patients（95%CI：0.85-0.96）,satisfactory functional and cosmetic outcome was achieved with a single surgical procedure.CONCLUSION：Based on the principles of lamellar recession and concurrently addressing the associated lid problems,this approach is an effective and safe treatment of UCE.展开更多
Xiangxi River Basin, located in western Hubei Province in central China, is a karst ridge-trough area with an inhomogeneous and complicated distribution of water resources. This paper compares the characteristics of s...Xiangxi River Basin, located in western Hubei Province in central China, is a karst ridge-trough area with an inhomogeneous and complicated distribution of water resources. This paper compares the characteristics of surface and subsurface floods in this karst basin, utilizing a one-parameter Darcian model and the traditional exponential model. The observed hydrographs and inferred water components are strikingly similar for surface and subsurface floods. The Darcian model and the exponential model are based on different views of the flood generation process, with the former fitting the entire hydrograph with a single time constant, and the latter fitting only the recession limb with multiple time constants. Due to the anisotropy and heterogeneity of karst media, a combination of physical and chemical techniques including the use of 3S（remote sensing, geographical information system, global positioning system） method is proposed for an enhanced hydrological investigation to assess and characterize karst water resources in mountainous areas.展开更多
Charcot-Marie-Tooth（CMT） disease is a common neurogenetic disorder and its heterogeneity is a challenge for genetic diagnostics. The genetic diagnostic procedures for a CMT patient can be explored according to the e...Charcot-Marie-Tooth（CMT） disease is a common neurogenetic disorder and its heterogeneity is a challenge for genetic diagnostics. The genetic diagnostic procedures for a CMT patient can be explored according to the electrophysiological criteria： very slow motor nerve conduction velocity（MNCV）（〈15 m/s）, slow MNCV（15–25 m/s）, intermediate MNCV（25–45 m/s）, and normal MNCV（〉45 m/s）. Based on the inheritance pattern, intermediate CMT can be divided into dominant（DI-CMT） and recessive types（RI-CMT）. GJB1 is currently considered to be associated with X-linked DI-CMT, and MPZ, INF2, DNM2, YARS, GNB4, NEFL, and MFN2 are associated with autosomal DI-CMT. Moreover, GDAP1, KARS, and PLEKHG5 are associated with RI-CMT. Identification of these genes is not only important for patients and families but also provides new information about pathogenesis. It is hoped that this review will lead to a better understanding of intermediate CMT and provide a detailed diagnostic procedure for intermediate CMT.展开更多
Based on the field surveys and repeated cross-profile observations combined with the comparison of many years’ topog-raphic maps,this study shows the spatial variability and varying patterns of coastal erosion along ...Based on the field surveys and repeated cross-profile observations combined with the comparison of many years’ topog-raphic maps,this study shows the spatial variability and varying patterns of coastal erosion along the west coast of the Taiwan Strait.Regional differentiation in the Meso-Cenozoic coastal tectonics determined the irregular coastline and geological background for large-scale coastal erosion distribution.The intensity of coastal erosion on the west side of the Taiwan Strait is mild in the northern region,severe in the central region and modest in the southern region.The beaches along the coast are mainly backed by dunes,sea-walls or cliffs.The dunes and beaches show periodic erosion and recovery along the coast adjacent to river mouths,while persistent retreat of frontal dunes and beaches tends to occur in other areas.The beach erosion occurs mainly in front of seawalls.Due to the low strength of the unconsolidated sediment the soft cliffs suffer the severest coastline recession.Sea level rise and river sediment discharge reduction are main causes of coastal erosion.Storm surge is common in the studied area and plays an important role in the progress of coastal erosion.Human activities including coastal constructions and sand mining also tend to interfere strongly with the balance of sediment budget in some coastal cells.展开更多
文摘Polycystic kidney disease (PKD) is an autosomal dominant genetic disorder that causes the formation of multiple cysts in the kidneys, leading to kidney failure. PKD is a common condition affecting approximately 1 in 500 individuals worldwide. The most prevalent type of PKD is autosomal dominant PKD (ADPKD). ADPKD is caused by mutations in either the PKD1 or PKD2 genes, which encode for proteins involved in cell growth and differentiation. These mutations lead to the formation of fluid-filled cysts in the kidneys, which can eventually lead to kidney failure. In addition to affecting the kidneys, PKD can also cause cysts in other organs, such as the liver, pancreas, and spleen. PKD can also lead to various complications, including high blood pressure, heart valve abnormalities, and brain aneurysms. This review focuses on the inheritance, pathophysiology, and treatment of PKD, with a specific emphasis on its effects on the cardiovascular system. Currently, there is no cure for PKD. However, several treatments are available to manage the symptoms and complications of the disease. These treatments include medications to control blood pressure, pain relievers, antibiotics for infections, and dialysis or kidney transplantation for kidney failure. Tolvaptan is the only FDA-approved drug specifically for ADPKD and has been shown to slow disease progression. In addition to summarizing current treatment options, this review will discuss promising future treatments, such as gene therapy and stem cell therapy.
基金supported by NIH/NIDCR grant R01DE025664 to IPC.
文摘Craniometaphyseal dysplasia(CMD),a rare craniotubular disorder,occurs in an autosomal dominant(AD)or autosomal recessive(AR)form.CMD is characterized by hyperostosis of craniofacial bones and metaphyseal flaring of long bones.Many patients with CMD suffer from neurological symptoms.The pathogenesis of CMD is not fully understood.
文摘Beach groynes are structures for erosion protection along sandy coasts near inlets and can reduce the coastal erosion substantially,but open groynes cannot stop erosion completely because sand can be removed from the groyne compartments by cross-shore processes.Beach groynes should be designed with sufficient bypassing of sand to minimise erosion.Regular beach maintenance is required to keep a sufficient beach width for recreational purposes.The effectiveness of groyne compartments can be significantly improved by using T-head groynes or by using a submerged sill or breakwater in between the groynes.An economic evaluation shows that the beach maintenance costs over 50 years may be substantially higher than the construction costs of a submerged breakwater.An important parameter to be studied is the longshore transport,which requires detailed information of the wave climate,preferably based on measured data(offshore buoys)in combination with deep water wave modelling.Various models have been used to determine the net longshore sand transport and coastline changes.The design of groynes to reduce coastal erosion is illustrated by three field cases(Atlantic coast near Soulac,France;Lagos coast,Nigeria and Black Sea coast,Romania).These example cases show that beach groynes are effective structures,but sufficient bypassing of longshore sand transport is essential to minimise erosion.Regular beach fills in the groyne compartments may be required at high-energy(exposed)coasts.A submerged or emerged breakwater can be built between the groynes to protect the beach in the groyne compartments against erosion by cross-shore processes.
文摘BACKGROUND Fixed esotropia in high myopia,characterized by irreversible inward ocular deviation and abduction limitation,presents unique therapeutic challenges for athletes requiring precise binocular coordination.The combination of Yokoyama surgery and medial rectus muscle recession has been proposed as an advanced technique addresses both myopia-induced globe displacement and muscular imbalance offering potential advantages over conventional strabismus surgery in this population.AIM To investigate the effects of the modified Yokoyama surgery coupled with medial rectus muscle recession in restoring ocular motility and correcting esotropia among athletes with high myopia and fixed esotropia.METHODS A retrospective study analyzed 30 highly myopia athletes(57 eyes)with fixed esotropia treated at our hospital from January 2022 to April 2024.The participants were allocated into two groups based on the surgical method:The traditional group(n=15,29 eyes)received conventional strabismus surgery,and the combined group(n=15,28 eyes)underwent modified Yokoyama surgery in combination with medial rectus muscle recession.Eye movement improvement,esotropia alleviation,and complications were compared preoperatively and at 1,3,and 6 months post-treatment.RESULTS Both surgical groups exhibited similar baseline scores(traditional:-4.04±0.38 vs combined:-4.12±0.45,P>0.05),showing severe preoperative limitations in ocular motility.Following the intervention,the combined group achieved significantly better outcomes at both 1 month(combined:-2.25±0.28 vs traditional:-2.67±0.32)and 3 months(combined:-1.48±0.28 vs traditional:-1.76±0.43),with statistically significant improvements(P<0.05).However,by 6 months,no significant difference was observed between the two groups(combined:-0.93±0.13;traditional:-1.03±0.18;P>0.05).Prior to treatment,all patients in both groups exhibited a compensatory head posture(CHP).Following treatment,the incidence of CHP decreased to 6.67%in the combined group and 20.00%in the traditional group,both reductions being significant compared to pretreatment levels(P<0.05).Nevertheless,the difference in CHP incidence between the two groups after treatment was not significant(P>0.05).The rates of improvement in esotropia showed an increasing trend in both groups at 1 month(46.43%vs 34.48%),3 months(78.57%vs 51.728%),and 6 months(100.00%vs 89.66%)post-treatment.Notably,the combined group had a significantly higher improvement rate than the traditional group at the 3-month follow-up(P<0.05).No significant difference was observed in the esotropia improvement rates between the two groups at 1 and 6 months post-treatment(P>0.05).The combined group experienced slightly lower but not significant(combined group:0.00%vs traditional:3.45%)as opposed to the traditional group(3.45%;P>0.05).CONCLUSION The combination of modified Yokoyama surgery and medial rectus muscle recession provides effective and safe approach to improving in eye movement and esotropia in athletes with high myopia and fixed esotropia,offering reliable clinical benefits.
基金Supported by China Agricultural Research System(CARS-24)Natural Science Foundation of Yunnan Province(2011FZ214)National Natural Science Foundation of China(31101591)~~
文摘[Objective] This study aimed to investigate the effect of mating factor recombination on the development of edible mushroom,and explore the possibility for using self-crossing to breed sporeless/low sporing mushroom strains.[Method] Selecting Agrocybe salicacola strain YAASM0711 as the self-crossing material,six self-crossed combinations were directionally constructed with single spore growth rate as an indicator,to carry out comprehensive analysis of the qualitative traits（color,deformity and growth characteristics）,quantitative traits（shape,yield,size and number of fruit bodies） and mating types of its self-crossed F1 progenies.[Result] After mating factor recombination,self-crossed single spore progenies showed serious genetic differentiation,the average mycelial growth rate and agronomic traits of inbred progenies were lower than those of the parents.The phenotype in fruiting body formation could be divided into normal fruiting and abnormal fruiting（including abnormal fruiting bodies,sporeless or low sporing fruiting bodies,no fruiting）.To be specific,18% self-crossed strains had superior agronomic traits to the parents,which can be used for selecting predominant strains from self-crossed progeny populations based on different breeding purposes.[Conclusion] The genes controlling mycelial growth rate of single spore were linked with mating factors.The mating factor-recombinant single spore strains could be selected according to the correlation between mating type and growth rate.The fruiting result of self-crossed strains indicated that the genes related to sporeless/low sporing development were recessive.Not only genetic materials harboring development-deficient genes in edible mushroom can be obtained by self-crossing,but also the sporeless/low sporing mutant strains with important application prospects can be bred.
基金Supported by National High-tech R&D Program of China(2001AA241104, 2004AA241104)Key Breeding Project of Sichuan Province (200107001-1-6-1, 2006YZGG-5)Key Quality Project of Sichuan Province(2006YZGG-23)~~
文摘[ Objective] The study was to investigate the agronomic traits and breeding characteristics of genic male sterile material Mian 7AB-4- 2 in Brassica napus. [ Method] The differences in agronomic traits and polymorphisms in SSR markers, between the genic male sterile material Mian 7AB-4-2 in Brassica napus and its sisterly line Mian 7AB-4-1 were investigated by hybridization and molecular identification; and the percentage of sterile individuals of Mian 7AB-4-2 and of the hybrids with its sisterly line Mian 7AB-4-1 from test cross and back cross were also studled. [ Result] Mian 7AB-4-2 was not significantly different in agronomic traits from its sisterly line Mian 7AB-4-1 at 0.05 probability level. The per- centages of sterile individuals in the pollinated fertile Mian 7AB-4-2 plants were over 60%, and that in its sisterly line Mian 7AB-4-1 was about 25%. In test crosses with other nine sterile lines, Mian 7AB-4-1 kept the percentage of sterile individuals of sterile lines over 90%, and the percentage of sterile individuals from back cross over 80%. With regard to molecular markers, Mian 7AB-4-2 and its sisterly line Mian 7AB-4-1 were different in the band number from SSR primers a2 and E10. [ Conclusion] The results indicate that Mian 7AB-4-2 is helpful for rapeseed breeding, quickening the application of new materials in field breeding.
基金Supported by the Key Project of Hangzhou Bureau for Gardens and Cultural Relics(2009-003)~~
文摘Fragrant camphor tree is the city tree of Hangzhou which takes a large proportion of the ancient trees in Hangzhou City. Recently, with the free open of the attractions around the West Lake and the implementation of the comprehensive pro- ject for protecting the West Lake, a part of ancient fragrant camphor trees are fac- ing problems such as altered living conditons. Some of them are showing a decline in growth vigor or even close to death, which will produce extremely negative influ- ences on the maintaining and sustainable development of the West Lake Scenic Area if without any timely measures for the rescue and rejuvenation of the trees. Therefore, strengthening the protection and management of ancient fragrant camphor trees at the West Lake Scenic Area and carrying out researches on the procedure for diagnosing the reasons for the growth recession of the ancient fragrant camphor trees at the West Lake Scenic Area are of great significance for the future protec- tion and rejuvenation of the ancient trees around the West Lake. The factors influ- encing the growth of ancient trees and indexes for judging the growth condition were listed and the reasons for the growth recession were systematically summa- rized in this paper. In addition, measures for the rejuvenation of the ancient fragrant camphor trees were also simply discussed.
文摘From the random mating population of maize, the relationship between heterosis and albino seedling was analyzed by means of mathematical theory, further the square logistic model for the appearance of lethal recessive homozygous genotype was deduced. The model shows that heterosis can determine the genetic structure and proportion of population. It approves, that the proportion of aa in each generation of maize seedlings shows a similar Logistic curve in growth process till equilibrium, so long as Aa containins lethal gene a from mutation presents heterosis. The ratio of equilibrium state of aa is determined by the ratio of AA-Aa fitness. Heterosis is helpful for the keeping of genetic diversity of population.
基金Supported by the Scientific and Technological Development Program of Shijiazhuang City(08150132A)~~
文摘According to the theory of Chinese veterinary medicine and characteristics of Chinese herbal medicine, four different preparations of compound Chinese medicine ＂Zengrujianniusan＂ were composed, and the prepared water decoction was used to carry on the bacteriostatic test on main pathogens of cow recessiveness mastitis. The results showed that the four different prescriptions of water decoction all had antibacterial effects. The prescription 3 was sensitive to Staphylococcus aureus and Streptococcus agalactiae, while the other three prescriptions showed high sensitivity, and the prescription 3 had the strongest bacteriostatic effects.
基金Supported by Beijing Municipal Natural Science Foundation (6112003)~~
文摘[Objective] This study aimed to investigate the action of mutant gene o2 and its effect on nutritional quality of different maize combinations. [Method] A total of 33 normal maize combinations from 18 inbred lines were compared with 33 combinations including gene o2 from the corresponding o2 near-isogenic lines （o2-NILs）, to study the effect of o2 gene introduction on maize grain quality. [Result] The contents of lysine, protein and oil in o2-NILs were greatly more than that of normal maize combinations. Except for lysine, contents of other 14 amino acids changed when o2 gene was introduced. Contents of aspartic acid, threonine, glycine, isoleucine, histidine, arginine and proline were improved; while contents of serine, glutamic acid, alanine, valine, leucine, tyrosine and phenylalanine were decreased. Correlation analysis showed that contents of aspartic acid, arginine and threonine had the highest correlation with lysine content. Protein and oil contents had higher correlation with lysine content （0.48 and 0.38）. Analysis of 33 o2-NILs revealed that the o2 combinations CAL58×Ji477and CA156×196 showed high comprehensive quality and high yield with greater development potential. [Conclusion] This study will provide theoretical and material basis for improving the quality of temperate maize germplasm by introducing o2 gene.
文摘In the perspective of dominant and recessive beauty,the aesthetic effect of bamboos in landscape design has been illustrated from four aspects,which are"bamboos leading to a secluded spot"and"simplicity and magnificence","bamboos at windows"and"bamboo shadows on white walls","bamboos,waters,rocks and plants setting each other off"and literati's feeling about bamboos.On this basis,by combining with different characteristics of Chinese and western landscapes,the paper has proposed the application tendency of bamboos in landscape design,and emphasized integrating the essence of Chinese traditional landscape with western rational theory,so as to create more appealing bamboo landscapes.
文摘Objective: Vacuolating megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a recently described syndrome with autosomal recessive mode of inheritance. Its possible gene was located on chromosomal 22q tel with 3-cM. The purpose of this study was to narrow down the genetical distance on chromosomal 22q tel with MLC. Methods: Thirty-nine MLC patients in 33 families were collected,and the linkage analysis and haplotype analysis of twelve informative families were done, using seven microsatellite markers and four SNP markers. Results: The maximum tow-point LOD score for marker 355c18 was 6.65 at recombination fraction 0.02. The haplotype analysis narrowed down the critical region of MLC to 250 kb on chromosomal 22q tel. Conclusion: One of the causing genes of MLC was located on chromosomal 22q tel with 250 kb. Four candidate genes were considered. The heterogeneity of one informative family indicated possible existence of a second locus for MLC.
基金supported by the National Basic Research Program of China (No. 2007CB411501)the Knowledge Innovation Project of the Chinese Academy of Sciences (No. KZCX2-EW-311)the National Natural Science Foundation of China (Nos. 91025012, J0930003/J0109)
文摘Similar to most mountain glaciers in the world, Urumqi Glacier No. 1 （UG1）, the best observed glacier in China with continued glaciological and climatological monitoring records of longer than 50 years has experienced an accelerated recession during the past several decades. The purpose of this study is to investigate the acceleration of recession. By taking UG1 as an example, we analyze the generic mechanisms of acceleration of shrinkage of continental mountain glaciers. The results indicate that the acceleration of mass loss of UG1 commenced first in 1985 and second in 1996 and that the lat- ter was more vigorous. The air temperature rises during melting season, the ice temperature augment of the glacier and the albedo reduction on the glacier surface are considered responsible for the accelerated recession. In addition, the simulations of the accelerated shrinkage of UG1 are introduced in this article.
基金funded by a grant from the National Institutes of Health (No. 1R56HL130078-01)
文摘Background: Few school settings offer opportunities for preschool children to engage in structured physical activity, and only a few studies have been conducted examining exergaming's effectiveness on health outcomes in this age group. This study's purpose, therefore, was to examine a school-based exergaming intervention's effect on preschool children's perceived competence(PC), motor skill competence(MSC), and physical activity versus usual care(recess), as well as to examine gender differences for these outcomes.Methods: A total of 65 preschool children from 2 underserved urban schools were assigned to 1 of 2 conditions, with the school as the experimental unit:(1) usual care recess group(8 weeks of 100 min of recess/week(5 days ￡ 20 min)) and(2) exergaming intervention group(8 weeks of100 min of exergaming/week(5 days ￡ 20 min) at school). All children underwent identical assessments of PC, MSC, and moderate-to-vigorous physical activity(MVPA) at baseline and at the end of the 8 th week.Results: A significant Group ￡ Time effect was observed for MVPA, F(1, 52) = 4.37, p = 0.04, h2 p= 0.04, but not for PC, F(1, 52) = 0.83, p = 0.37,h2 p= 0.02, or MSC, F(1, 52) = 0.02, p = 0.88, h2 p= 0.00. Specifically, the intervention children displayed significantly greater increased MVPA after8 weeks than the comparison children. Additionally, there was a significant time effect for MSC, F(1, 52) = 15.61, p < 0.01, h2 p= 0.23, and gender effect for MVPA, F(1, 52) = 5.06, p = 0.02, h2 p= 0.09. Although all preschoolers' MSC improved across time, boys demonstrated greater MVPA than girls at both time points.Conclusion: Exergaming showed a positive effect in promoting preschool children's MVPA at school and has the potential to enhance PC and MSC. More research with larger sample sizes and longer study durations are warranted.
文摘AIM：To evaluate the functional and aesthetic outcomes of upper eyelid cicatricial entropion（UCE） correction using anterior lamellar recession（ALR） with addressing the associated conditions including dermatochalasis,brow ptosis,blepharoptosis,and lid retraction.METHODS：Chart review of patients with upper lid cicatricial entropion who had undergone ALR from 2013 to 2016 was reviewed.Success was defi ned as the lack of any lash in contact with the globe,no need for a second procedure,and acceptable cosmesis at the fi nal follow up.RESULTS：Sixty eight patients（97 eyelids） were operated by ALR with simultaneous correction of associated lid problems in each case when necessary.The mean followup time was 17.8 mo（range,6.0-24.0 mo）.Concomitantly,levator tucking was performed in 19 eyelids（19.6%）,upper lid retractor recession in 18 eyelids（18.6%）,and internal browpexy in 31 eyelids（32.0%）.In 95.8% of patients（95%CI：0.85-0.96）,satisfactory functional and cosmetic outcome was achieved with a single surgical procedure.CONCLUSION：Based on the principles of lamellar recession and concurrently addressing the associated lid problems,this approach is an effective and safe treatment of UCE.
基金supported by the China Geological Survey (No. 12120113103800)
文摘Xiangxi River Basin, located in western Hubei Province in central China, is a karst ridge-trough area with an inhomogeneous and complicated distribution of water resources. This paper compares the characteristics of surface and subsurface floods in this karst basin, utilizing a one-parameter Darcian model and the traditional exponential model. The observed hydrographs and inferred water components are strikingly similar for surface and subsurface floods. The Darcian model and the exponential model are based on different views of the flood generation process, with the former fitting the entire hydrograph with a single time constant, and the latter fitting only the recession limb with multiple time constants. Due to the anisotropy and heterogeneity of karst media, a combination of physical and chemical techniques including the use of 3S（remote sensing, geographical information system, global positioning system） method is proposed for an enhanced hydrological investigation to assess and characterize karst water resources in mountainous areas.
文摘Charcot-Marie-Tooth（CMT） disease is a common neurogenetic disorder and its heterogeneity is a challenge for genetic diagnostics. The genetic diagnostic procedures for a CMT patient can be explored according to the electrophysiological criteria： very slow motor nerve conduction velocity（MNCV）（〈15 m/s）, slow MNCV（15–25 m/s）, intermediate MNCV（25–45 m/s）, and normal MNCV（〉45 m/s）. Based on the inheritance pattern, intermediate CMT can be divided into dominant（DI-CMT） and recessive types（RI-CMT）. GJB1 is currently considered to be associated with X-linked DI-CMT, and MPZ, INF2, DNM2, YARS, GNB4, NEFL, and MFN2 are associated with autosomal DI-CMT. Moreover, GDAP1, KARS, and PLEKHG5 are associated with RI-CMT. Identification of these genes is not only important for patients and families but also provides new information about pathogenesis. It is hoped that this review will lead to a better understanding of intermediate CMT and provide a detailed diagnostic procedure for intermediate CMT.
基金supported by the National Science Foundation of China (No.40976057)the State Oceanic Administration of China (No.908-02-03-04)
文摘Based on the field surveys and repeated cross-profile observations combined with the comparison of many years’ topog-raphic maps,this study shows the spatial variability and varying patterns of coastal erosion along the west coast of the Taiwan Strait.Regional differentiation in the Meso-Cenozoic coastal tectonics determined the irregular coastline and geological background for large-scale coastal erosion distribution.The intensity of coastal erosion on the west side of the Taiwan Strait is mild in the northern region,severe in the central region and modest in the southern region.The beaches along the coast are mainly backed by dunes,sea-walls or cliffs.The dunes and beaches show periodic erosion and recovery along the coast adjacent to river mouths,while persistent retreat of frontal dunes and beaches tends to occur in other areas.The beach erosion occurs mainly in front of seawalls.Due to the low strength of the unconsolidated sediment the soft cliffs suffer the severest coastline recession.Sea level rise and river sediment discharge reduction are main causes of coastal erosion.Storm surge is common in the studied area and plays an important role in the progress of coastal erosion.Human activities including coastal constructions and sand mining also tend to interfere strongly with the balance of sediment budget in some coastal cells.
