Airport disruptions often pose challenges in assigning aircraft to gates,resulting in infeasible planned schedules.In particular,a large number of transfer passengers miss their connections in the context of disruptio...Airport disruptions often pose challenges in assigning aircraft to gates,resulting in infeasible planned schedules.In particular,a large number of transfer passengers miss their connections in the context of disruptions,which cause huge economic losses to airlines and serious passengers’dissatisfaction.This paper proposes a set-partitioning-based model to optimize Aircraft-Gate Reassignment with Transfer Passenger Connections(AGRP-TPC),which incorporates flexible gate-swap and aircraft-delay operations to mitigate the overall impact of disruptions.To efficiently solve the model,we introduce the concepts of additive-transfer and nonstop-transfer to handle passenger connections,and develop a Hierarchical Column-and-Row Generation(HCRG)approach guided by airport terminal space attribute.The column generation and row generation procedures solve iteratively until no new variables and constraints are generated.In addition,a follow-on strategy and a diving heuristic are designed to efficiently obtain high-quality solutions.We evaluate the proposed approach using various instances from a major Chinese international airport.Computational results demonstrate that our approach outperforms the comparison algorithms and produces good solutions within the time limit.Detailed results indicate that our approach effectively reduces overall losses in aircraft-gate reassignment following disruptions,and it can serve as an auxiliary decision-making tool for airport operators and airlines.展开更多
Two novel diketopiperazines(1 and 5),along with ten known compounds(2−4,6−12)demonstrating significant skin inflammation inhibition,were isolated from a marine-derived fungus identified as Aspergillus sp.FAZW0001.The ...Two novel diketopiperazines(1 and 5),along with ten known compounds(2−4,6−12)demonstrating significant skin inflammation inhibition,were isolated from a marine-derived fungus identified as Aspergillus sp.FAZW0001.The structural elucidation and configurational reassessments of compounds 1−5 were established through comprehensive spectral analyses,with their absolute configurations determined via single crystal X-ray diffraction using Cu Kαradiation,Marfey’s method,and comparison between experimental and calculated electronic circular dichroism(ECD)spectra.Compounds 1,2,and 8 exhibited significant anti-inflammatory activities in Propionibacterium acnes(P.acnes)-induced human monocyte cell lines.Compound 8 demonstrated the ability to down-regulate interleukin-1β(IL-1β)expression by inhibiting Toll-like receptor 2(TLR2)expression and modulating the activation of myeloid differentiation factor 88(MyD88),mitogen-activated protein kinase(MAPK),and nuclear factorκB(NF-κB)signaling pathways,thus reducing the cellular inflammatory response induced by P.acnes.Additionally,compound 8 showed the capacity to suppress mitochondrial reactive oxygen species(ROS)production and nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation,thereby reducing IL-1βmaturation and secretion.A three-dimensional quantitative structure-activity relationships(3D-QSAR)model was applied to compounds 5−12 to analyze their anti-inflammatory structure-activity relationships.展开更多
In this paper, we first analyzed cloud drift wind(CDW) data distribution in the vertical direction, and then reassigned the height of every CDW in the research domain in terms of background information, and finally, c...In this paper, we first analyzed cloud drift wind(CDW) data distribution in the vertical direction, and then reassigned the height of every CDW in the research domain in terms of background information, and finally, conducted contrast numerical experiments of assimilating the CDW data before and after reassignment to examine the impacts on the forecast of the track of Typhoon Chanthu(1003) from 00:00(Coordinated Universal Time) 21 July to 00:00 UTC23 July, 2010. The analysis results of the CDW data indicate that the number of CDWs is mainly distributed in the midand upper-troposphere above 500 h Pa, with the maximum number at about 300 h Pa. The height reassigning method mentioned in this work may update the height effectively, and the CDW data are distributed reasonably and no obvious contradiction occurs in the horizontal direction after height reassignment. After assimilating the height-reassigned CDW data, especially the water vapor CDW data, the initial wind field around Typhoon Chanthu(1003) became more reasonable, and then the steering current leading the typhoon to move to the correct location became stronger. As a result, the numerical track predictions are improved.展开更多
In light-sheet fluorescence microscopy,the axial resolution and field of view are mutually constrained.Axially swept light-sheet microscopy(ASLM)can decouple the trade-off,but the confocal detection scheme using a rol...In light-sheet fluorescence microscopy,the axial resolution and field of view are mutually constrained.Axially swept light-sheet microscopy(ASLM)can decouple the trade-off,but the confocal detection scheme using a rolling shutter also rejects fluorescence signals from the specimen in the field of interest,which sacrifices the photon efficiency.Here,we report a laterally swept light-sheet microscopy(LSLM)scheme in which the focused beam is first scanned along the axial direction and subsequently laterally swept with the rolling shutter.We show that LSLM can obtain a higher photon efficiency when similar axial resolution and field of view can be achieved.Moreover,based on the principle of image scanning microscopy,applying the pixel reassignment to the LSLM images,hereby named iLSLM,improves the optical sectioning.Both simulation and experimental results demonstrate the higher photon efficiency with similar axial resolution and optical sectioning.Our proposed scheme is suitable for volumetric imaging of specimens that are susceptible to photobleaching or phototoxicity.展开更多
We present a case of a transsexual patient who underwent a partial pelvectomy and genital reconstruction for anal cancer after chemoradiation. This is the first case in literature reporting on the occurrence of anal c...We present a case of a transsexual patient who underwent a partial pelvectomy and genital reconstruction for anal cancer after chemoradiation. This is the first case in literature reporting on the occurrence of anal cancer after male-to-female sex reassignment surgery. We describe the surgical approach presenting our technique to avoid postoperative complications and preserve the sexual reassignment.展开更多
A group of 39 Transgender subjects, 17 Female to Male (FtM) and 22 Male to Female (MtF), have been evaluated about their sexual desire, activity, and satisfaction during the period before and after Sex Reassignment by...A group of 39 Transgender subjects, 17 Female to Male (FtM) and 22 Male to Female (MtF), have been evaluated about their sexual desire, activity, and satisfaction during the period before and after Sex Reassignment by Surgery (SRS). Visual Analogue Scale from 0 to 10 has been used to assess sexual desire and satisfaction, number of sexual partners and number of sexual intercourses/ month have been evaluated to assess sexual activity. Moreover, after the surgery, the Sexual Desire Inventory-2 (SDI-2) was administered to patients and related to testosterone (total or free) levels. In FtM, after hysterectomy and bilateral ovariectomy, mean value of sexual desire (VAS 0 - 10) was 7.5 before beginning testosterone therapy, this value increased after six months of therapy and after one year. Just before SRS the value decreased, but increased to 8.42 after SRS. In the same patients the values (VAS 0 - 10) on sexual satisfaction were respectively 6.5, 6.9, 7.1, 6.5 and 7. Mean number of partners was 4, with 7.07 mean frequency of sexual intercourse/month, before starting therapy (after hysterectomy). During hormonal therapy (testosterone), No. of partners was 2.46 and 8.96 intercourses/month, while after SRS the partners were 1.25 and intercouses/month 7.91. MtF patients reported a sexual desire (VAS 0 - 10) before therapy of 7, this remained almost constant after 6 months, decreases after 12 months and just before surgery, and finally increased to 7.76 after SRS. For sexual satisfaction mean values of VAS were respectively: 6.1, 6.2, 6.3, 6, and 6.8. Regarding sexual activity, MtF report 3.81 mean No. of partners and 9.27 intercouses/month before the beginning of hormonal therapy, 1.36 partners and 4.36 intercourses after therapy, and 1.3 partners and 4.54 intercourses after SRS.展开更多
A method for using height reassignment to improve the quality of satellite-derived atmospheric motion vectors （AMVs） is presented. The rationale underlying height reassignment is explored, and the technical details ...A method for using height reassignment to improve the quality of satellite-derived atmospheric motion vectors （AMVs） is presented. The rationale underlying height reassignment is explored, and the technical details are studied by applying three height reassignment schemes that use NCEP reanalysis winds. The quality of the AMVs is generally improved following reassignment, although the magnitude of the improve- ment differs according to the scheme applied. Scheme 3 provides the best quality and stability, followed by Scheme 1 and Scheme 2. The negative biases in the zonal components of the AMVs decrease from [ 5, 4] m s^-1 to 〈- 1 m s 1 following reassignment. The meridional components also improve. The AMVs derived from the infrared and water vapor channels improve by 58.7% and 25%, respectively, The feasibility of using Scheme 3 in the operational derivation of AMVs is studied by incorporating the forecast wind field predicted by a T511 medium-range numerical weather prediction （NWP） system. Incorporating the 12-h forecast reduces the negative biases in zonal winds and positive biases in meridional winds retrieved from the water vapor channel, improving the overall quality of the AMVs by 26.7%. Extending the validity period of the forecast field linearly reduces the improvement in retrieved AMVs, but the magnitude of this reduction is small. Incorporating the 120-h forecast field still results in a 13% improvement, although it may eliminate a larger number of AMVs of good quality.展开更多
Serializable snapshot isolation(SSI)is a promising technique to exploit parallelism for multi-core databases.However,SSI suffers from excessive transaction aborts.Existing remedies have three drawbacks:1)tracking proh...Serializable snapshot isolation(SSI)is a promising technique to exploit parallelism for multi-core databases.However,SSI suffers from excessive transaction aborts.Existing remedies have three drawbacks:1)tracking prohibitively transitive dependencies;2)aborting on every writewrite conflict;and 3)requiring manual annotation on transaction programs.In this paper,we propose to suppress transaction aborts by reassigning timestamps.We combine static analysis with augmented query plan.In this way,we save both aborts caused by read-write and write-write conflicts,without tracking transitive dependency and annotating transaction programs.As such,our approach does not exhibit drawbacks of existing methods.Extensive experiments demonstrate the effectiveness and practicality of our approach.展开更多
Penile reconstruction still represents a formidable challenge for the urologist. In this review, the most recent advances in penile reconstruction after trauma, excision of benign and malignant disease and in patients...Penile reconstruction still represents a formidable challenge for the urologist. In this review, the most recent advances in penile reconstruction after trauma, excision of benign and malignant disease and in patients with micropenis, aphallia or female to male gender dysphoria are reported.展开更多
Image scanning microscopy based on pixel reassignment can improve the confocal resolution limit without losing the image signal-to-noise ratio(SNR)greatly[C.J.R.Sheppard,"Super resolution in confocal imaging,&quo...Image scanning microscopy based on pixel reassignment can improve the confocal resolution limit without losing the image signal-to-noise ratio(SNR)greatly[C.J.R.Sheppard,"Super resolution in confocal imaging,"Optik 80(2)53-54(1988).C.B.Miller,E.Jorg,"Image scanning microscopy,"Phys.Reu.Lett.104(19)198101(2010).C.J.R.Sheppard,s.B.Mehta,R Heintzmann,"Superresolution by image scanning microscopy using pixel reassignment,"Opt.Lett.38(15)28892892(2013)].Here,we use a tailor-made optical fiber and 19 avalanche pho-todiodes(APDs)as parallel detectors to upgrade our existing confocal microscopy,termed as parallel-detection super resolution(PDSR)microscopy.In order to obtain the correct shift value,we use the normalized 2D cross correlation to calculate the shifting value of each image.We characterized our system performance by imaging fuorescence beads and applied this system to observing the 3D structure of biological specimen.展开更多
Background:This study aimed to evaluate the long-term penile size among patients who underwent extensive metoidioplasty.Methods:An evaluation was conducted on 7 out of 14 patients(mean age:29.71±13.76 years)who p...Background:This study aimed to evaluate the long-term penile size among patients who underwent extensive metoidioplasty.Methods:An evaluation was conducted on 7 out of 14 patients(mean age:29.71±13.76 years)who participated in a 2015 study that introduced a postoperative protocol to improve penile size after extensive metoidioplasty.Five transsexual females(46XX karyotype)and two patients with 5-alpha reductase deficiency were retrospectively followed up in 2023 to assess the long-term efficacy of the protocol at a specialized clinic in a general hospital in Tehran,Iran.All participants were informed about the study and consented to participate.Results:Five patients achieved increased penile size from their 2015 measurements(mean,29.00±13.34 mm).Five patients requested a larger sized penile traction device to continue the protocol.Conclusion:The long-term implementation of this protocol can result in increased penile size.We advise highly motivated patients to continue practicing the protocol to achieve better results.展开更多
In this paper we have accomplished one of the tasks of cognitive radio i.e. dynamic spectrum sensing by using wavelet based Synchrosqueezing transform [1], a novel technique, which was proposed to analyze a signal in ...In this paper we have accomplished one of the tasks of cognitive radio i.e. dynamic spectrum sensing by using wavelet based Synchrosqueezing transform [1], a novel technique, which was proposed to analyze a signal in time-frequency plane. The distinctive feature of this transform compared to other techniques is that it enables us to decompose amplitude and frequency modulated signals and allows individual reconstruction of these components. The objective is also to separate the occupied band into amplitude modulated and frequency modulated bands.展开更多
A unified protecting group-free approach to two stemarene and two betaerene diterpenoids through a bioinspired two-phase strategy has been developed,and three of them were obtained for the first time via chemical synt...A unified protecting group-free approach to two stemarene and two betaerene diterpenoids through a bioinspired two-phase strategy has been developed,and three of them were obtained for the first time via chemical synthesis.Starting from a common intermediate,two distinct tetracyclic frameworks containing diastereoisomeric bridged bicycles were constructed by a divergent ring reorganization strategy.Late-stage C–H functionalization through a xanthylation-oxygenation protocol furnished the corresponding oxygenated stereocenters or oxo functionality in high regio-and diastereoselective fashion within a complex hydrocarbon system.The stereochemical puzzles in(–)-2-acetoxybetaer13(17)-ene and(+)-7-acetoxybetaer-13(17)-ene were first predicted by the comparison of density functional theory(DFT)-nuclear magnetic resonance(NMR)data with the reported data and then unambiguously addressed through the total syntheses of natural products and three diastereomers.展开更多
It is essential to provide responses to queries within time deadlines,even if not exact and complete.To reduce the query latency,systems usually partition large-scale data computations as a series of tasks over many p...It is essential to provide responses to queries within time deadlines,even if not exact and complete.To reduce the query latency,systems usually partition large-scale data computations as a series of tasks over many processes and aggregate them to reduce the response time by using aggregation trees.An obstacle is that the involved processes of a query usually differ in their speeds,thus not all processes can complete their tasks in time.This would directly degrade the response quality(the number of outputs received by the root of an aggregation tree).In this paper,we propose a general aggregation tree model,Tarot,to maximize the response quality by systematically addressing the following challenging issues:(1)fine-grained partition of the query deadline along the multi-level aggregation tree;(2)learning the distribution of durations at each level in the aggregation tree to optimize the wait durations at aggregators;(3)adaptively reassigning tasks over processes according to their status;(4)performing periodic aggregation of received outputs from the low level to avoid missing the deadline.The prior model does not consider the four aspects simultaneously.Extensive evaluations indicate that Tarot can adapt to multi-level trees and considerably improve the response quality compared to prior work while guaranteeing the query deadline.展开更多
In comparison to the arduous process of rights advocacy in Hong Kong, transsexuals in China＇s mainland achieved their right to marry via some ＂silent changes＂ there was no legal activism from transsexual communitie...In comparison to the arduous process of rights advocacy in Hong Kong, transsexuals in China＇s mainland achieved their right to marry via some ＂silent changes＂ there was no legal activism from transsexual communities, no debates or hearings in the legislature, and no landmark judgments made by the judiciary. From a perspective of comparative law, transsexuals＇ right It endeavors to dis this article attempts to analyze the legal changes regarding to marry in China＇s mainland in light of the struggles in Hong Kong. cuss to what extent the seemingly ＂smooth＂ and ＂unintended＂ way of opening up marriage to transsexuals in China＇s mainland could be beneficial to trans rights and equality in general.展开更多
基金supported by the National Natural Science Foundation of China(No.U2333218).
文摘Airport disruptions often pose challenges in assigning aircraft to gates,resulting in infeasible planned schedules.In particular,a large number of transfer passengers miss their connections in the context of disruptions,which cause huge economic losses to airlines and serious passengers’dissatisfaction.This paper proposes a set-partitioning-based model to optimize Aircraft-Gate Reassignment with Transfer Passenger Connections(AGRP-TPC),which incorporates flexible gate-swap and aircraft-delay operations to mitigate the overall impact of disruptions.To efficiently solve the model,we introduce the concepts of additive-transfer and nonstop-transfer to handle passenger connections,and develop a Hierarchical Column-and-Row Generation(HCRG)approach guided by airport terminal space attribute.The column generation and row generation procedures solve iteratively until no new variables and constraints are generated.In addition,a follow-on strategy and a diving heuristic are designed to efficiently obtain high-quality solutions.We evaluate the proposed approach using various instances from a major Chinese international airport.Computational results demonstrate that our approach outperforms the comparison algorithms and produces good solutions within the time limit.Detailed results indicate that our approach effectively reduces overall losses in aircraft-gate reassignment following disruptions,and it can serve as an auxiliary decision-making tool for airport operators and airlines.
基金supported by the National Natural Science Foundation of China(Nos.41876189 and 81703388)the State Key Laboratory of Bioreactor Engineering and Shanghai Collaborative Innovation Center for Biomanufacturing Technology.
文摘Two novel diketopiperazines(1 and 5),along with ten known compounds(2−4,6−12)demonstrating significant skin inflammation inhibition,were isolated from a marine-derived fungus identified as Aspergillus sp.FAZW0001.The structural elucidation and configurational reassessments of compounds 1−5 were established through comprehensive spectral analyses,with their absolute configurations determined via single crystal X-ray diffraction using Cu Kαradiation,Marfey’s method,and comparison between experimental and calculated electronic circular dichroism(ECD)spectra.Compounds 1,2,and 8 exhibited significant anti-inflammatory activities in Propionibacterium acnes(P.acnes)-induced human monocyte cell lines.Compound 8 demonstrated the ability to down-regulate interleukin-1β(IL-1β)expression by inhibiting Toll-like receptor 2(TLR2)expression and modulating the activation of myeloid differentiation factor 88(MyD88),mitogen-activated protein kinase(MAPK),and nuclear factorκB(NF-κB)signaling pathways,thus reducing the cellular inflammatory response induced by P.acnes.Additionally,compound 8 showed the capacity to suppress mitochondrial reactive oxygen species(ROS)production and nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation,thereby reducing IL-1βmaturation and secretion.A three-dimensional quantitative structure-activity relationships(3D-QSAR)model was applied to compounds 5−12 to analyze their anti-inflammatory structure-activity relationships.
基金Specialized Science Project for Public Welfare Industries(Metrological Sector)(GYHY201206010,GYHY201406009)Science and Technology Planning Project for Guangdong Province(2012A061400012)+3 种基金Program for the 12th Five-Year Economic Development(2012BAC22B00)Natural Science Foundation of China(41075083)Program for Integration and Application of Key Meteorological Techniques from CMA(CMAGJ2012M36)Project from Guangdong Meteorological Bureau(2013A04)
文摘In this paper, we first analyzed cloud drift wind(CDW) data distribution in the vertical direction, and then reassigned the height of every CDW in the research domain in terms of background information, and finally, conducted contrast numerical experiments of assimilating the CDW data before and after reassignment to examine the impacts on the forecast of the track of Typhoon Chanthu(1003) from 00:00(Coordinated Universal Time) 21 July to 00:00 UTC23 July, 2010. The analysis results of the CDW data indicate that the number of CDWs is mainly distributed in the midand upper-troposphere above 500 h Pa, with the maximum number at about 300 h Pa. The height reassigning method mentioned in this work may update the height effectively, and the CDW data are distributed reasonably and no obvious contradiction occurs in the horizontal direction after height reassignment. After assimilating the height-reassigned CDW data, especially the water vapor CDW data, the initial wind field around Typhoon Chanthu(1003) became more reasonable, and then the steering current leading the typhoon to move to the correct location became stronger. As a result, the numerical track predictions are improved.
基金supported by the National Natural Science Foundation of China(62005116 and 51720105015)the Science and Technology Innovation Commission of Shenzhen(KQTD20170810110913065 and 20200925174735005).
文摘In light-sheet fluorescence microscopy,the axial resolution and field of view are mutually constrained.Axially swept light-sheet microscopy(ASLM)can decouple the trade-off,but the confocal detection scheme using a rolling shutter also rejects fluorescence signals from the specimen in the field of interest,which sacrifices the photon efficiency.Here,we report a laterally swept light-sheet microscopy(LSLM)scheme in which the focused beam is first scanned along the axial direction and subsequently laterally swept with the rolling shutter.We show that LSLM can obtain a higher photon efficiency when similar axial resolution and field of view can be achieved.Moreover,based on the principle of image scanning microscopy,applying the pixel reassignment to the LSLM images,hereby named iLSLM,improves the optical sectioning.Both simulation and experimental results demonstrate the higher photon efficiency with similar axial resolution and optical sectioning.Our proposed scheme is suitable for volumetric imaging of specimens that are susceptible to photobleaching or phototoxicity.
文摘We present a case of a transsexual patient who underwent a partial pelvectomy and genital reconstruction for anal cancer after chemoradiation. This is the first case in literature reporting on the occurrence of anal cancer after male-to-female sex reassignment surgery. We describe the surgical approach presenting our technique to avoid postoperative complications and preserve the sexual reassignment.
文摘A group of 39 Transgender subjects, 17 Female to Male (FtM) and 22 Male to Female (MtF), have been evaluated about their sexual desire, activity, and satisfaction during the period before and after Sex Reassignment by Surgery (SRS). Visual Analogue Scale from 0 to 10 has been used to assess sexual desire and satisfaction, number of sexual partners and number of sexual intercourses/ month have been evaluated to assess sexual activity. Moreover, after the surgery, the Sexual Desire Inventory-2 (SDI-2) was administered to patients and related to testosterone (total or free) levels. In FtM, after hysterectomy and bilateral ovariectomy, mean value of sexual desire (VAS 0 - 10) was 7.5 before beginning testosterone therapy, this value increased after six months of therapy and after one year. Just before SRS the value decreased, but increased to 8.42 after SRS. In the same patients the values (VAS 0 - 10) on sexual satisfaction were respectively 6.5, 6.9, 7.1, 6.5 and 7. Mean number of partners was 4, with 7.07 mean frequency of sexual intercourse/month, before starting therapy (after hysterectomy). During hormonal therapy (testosterone), No. of partners was 2.46 and 8.96 intercourses/month, while after SRS the partners were 1.25 and intercouses/month 7.91. MtF patients reported a sexual desire (VAS 0 - 10) before therapy of 7, this remained almost constant after 6 months, decreases after 12 months and just before surgery, and finally increased to 7.76 after SRS. For sexual satisfaction mean values of VAS were respectively: 6.1, 6.2, 6.3, 6, and 6.8. Regarding sexual activity, MtF report 3.81 mean No. of partners and 9.27 intercouses/month before the beginning of hormonal therapy, 1.36 partners and 4.36 intercourses after therapy, and 1.3 partners and 4.54 intercourses after SRS.
基金Supported by the National Natural Science Foundation of China (40705037)China Meteorological Administration Special Public Welfare Research Fund (GYHY201206002)
文摘A method for using height reassignment to improve the quality of satellite-derived atmospheric motion vectors （AMVs） is presented. The rationale underlying height reassignment is explored, and the technical details are studied by applying three height reassignment schemes that use NCEP reanalysis winds. The quality of the AMVs is generally improved following reassignment, although the magnitude of the improve- ment differs according to the scheme applied. Scheme 3 provides the best quality and stability, followed by Scheme 1 and Scheme 2. The negative biases in the zonal components of the AMVs decrease from [ 5, 4] m s^-1 to 〈- 1 m s 1 following reassignment. The meridional components also improve. The AMVs derived from the infrared and water vapor channels improve by 58.7% and 25%, respectively, The feasibility of using Scheme 3 in the operational derivation of AMVs is studied by incorporating the forecast wind field predicted by a T511 medium-range numerical weather prediction （NWP） system. Incorporating the 12-h forecast reduces the negative biases in zonal winds and positive biases in meridional winds retrieved from the water vapor channel, improving the overall quality of the AMVs by 26.7%. Extending the validity period of the forecast field linearly reduces the improvement in retrieved AMVs, but the magnitude of this reduction is small. Incorporating the 120-h forecast field still results in a 13% improvement, although it may eliminate a larger number of AMVs of good quality.
基金supported by the National Key R&D Program of China(2018YFB1004401)the National Natural Science Foundation of China Key Project(Grant No.61732014).
文摘Serializable snapshot isolation(SSI)is a promising technique to exploit parallelism for multi-core databases.However,SSI suffers from excessive transaction aborts.Existing remedies have three drawbacks:1)tracking prohibitively transitive dependencies;2)aborting on every writewrite conflict;and 3)requiring manual annotation on transaction programs.In this paper,we propose to suppress transaction aborts by reassigning timestamps.We combine static analysis with augmented query plan.In this way,we save both aborts caused by read-write and write-write conflicts,without tracking transitive dependency and annotating transaction programs.As such,our approach does not exhibit drawbacks of existing methods.Extensive experiments demonstrate the effectiveness and practicality of our approach.
文摘Penile reconstruction still represents a formidable challenge for the urologist. In this review, the most recent advances in penile reconstruction after trauma, excision of benign and malignant disease and in patients with micropenis, aphallia or female to male gender dysphoria are reported.
基金sponsored by National Natural Science Foundation of China(61827825 and 61735017)Fundamental Research Funds for the Central Universities(2019XZZX003-06)+1 种基金Natural Science Foundation of Zhejiang province(LR16F050001)Zhejiang Lab(2018EB0ZX01).
文摘Image scanning microscopy based on pixel reassignment can improve the confocal resolution limit without losing the image signal-to-noise ratio(SNR)greatly[C.J.R.Sheppard,"Super resolution in confocal imaging,"Optik 80(2)53-54(1988).C.B.Miller,E.Jorg,"Image scanning microscopy,"Phys.Reu.Lett.104(19)198101(2010).C.J.R.Sheppard,s.B.Mehta,R Heintzmann,"Superresolution by image scanning microscopy using pixel reassignment,"Opt.Lett.38(15)28892892(2013)].Here,we use a tailor-made optical fiber and 19 avalanche pho-todiodes(APDs)as parallel detectors to upgrade our existing confocal microscopy,termed as parallel-detection super resolution(PDSR)microscopy.In order to obtain the correct shift value,we use the normalized 2D cross correlation to calculate the shifting value of each image.We characterized our system performance by imaging fuorescence beads and applied this system to observing the 3D structure of biological specimen.
文摘Background:This study aimed to evaluate the long-term penile size among patients who underwent extensive metoidioplasty.Methods:An evaluation was conducted on 7 out of 14 patients(mean age:29.71±13.76 years)who participated in a 2015 study that introduced a postoperative protocol to improve penile size after extensive metoidioplasty.Five transsexual females(46XX karyotype)and two patients with 5-alpha reductase deficiency were retrospectively followed up in 2023 to assess the long-term efficacy of the protocol at a specialized clinic in a general hospital in Tehran,Iran.All participants were informed about the study and consented to participate.Results:Five patients achieved increased penile size from their 2015 measurements(mean,29.00±13.34 mm).Five patients requested a larger sized penile traction device to continue the protocol.Conclusion:The long-term implementation of this protocol can result in increased penile size.We advise highly motivated patients to continue practicing the protocol to achieve better results.
文摘In this paper we have accomplished one of the tasks of cognitive radio i.e. dynamic spectrum sensing by using wavelet based Synchrosqueezing transform [1], a novel technique, which was proposed to analyze a signal in time-frequency plane. The distinctive feature of this transform compared to other techniques is that it enables us to decompose amplitude and frequency modulated signals and allows individual reconstruction of these components. The objective is also to separate the occupied band into amplitude modulated and frequency modulated bands.
基金Financial support from the National Natural Science Foundation of China(nos.22071205,21772164,and 21572187)NFFTBS(no.J1310024),and PCSIRT is acknowledged.
文摘A unified protecting group-free approach to two stemarene and two betaerene diterpenoids through a bioinspired two-phase strategy has been developed,and three of them were obtained for the first time via chemical synthesis.Starting from a common intermediate,two distinct tetracyclic frameworks containing diastereoisomeric bridged bicycles were constructed by a divergent ring reorganization strategy.Late-stage C–H functionalization through a xanthylation-oxygenation protocol furnished the corresponding oxygenated stereocenters or oxo functionality in high regio-and diastereoselective fashion within a complex hydrocarbon system.The stereochemical puzzles in(–)-2-acetoxybetaer13(17)-ene and(+)-7-acetoxybetaer-13(17)-ene were first predicted by the comparison of density functional theory(DFT)-nuclear magnetic resonance(NMR)data with the reported data and then unambiguously addressed through the total syntheses of natural products and three diastereomers.
基金supported by the National Natural Science Foundation of China(Grant No.61772544)National Basic Research Program(973 program)(2014CB347800)+1 种基金the Hunan Provincial Natural Science Fund for Distinguished Young Scholars(2016JJ1002)the Guangxi Cooperative Innovation Center of Cloud Computing and Big Data(YD16507 and YD17X11).
文摘It is essential to provide responses to queries within time deadlines,even if not exact and complete.To reduce the query latency,systems usually partition large-scale data computations as a series of tasks over many processes and aggregate them to reduce the response time by using aggregation trees.An obstacle is that the involved processes of a query usually differ in their speeds,thus not all processes can complete their tasks in time.This would directly degrade the response quality(the number of outputs received by the root of an aggregation tree).In this paper,we propose a general aggregation tree model,Tarot,to maximize the response quality by systematically addressing the following challenging issues:(1)fine-grained partition of the query deadline along the multi-level aggregation tree;(2)learning the distribution of durations at each level in the aggregation tree to optimize the wait durations at aggregators;(3)adaptively reassigning tasks over processes according to their status;(4)performing periodic aggregation of received outputs from the low level to avoid missing the deadline.The prior model does not consider the four aspects simultaneously.Extensive evaluations indicate that Tarot can adapt to multi-level trees and considerably improve the response quality compared to prior work while guaranteeing the query deadline.
文摘In comparison to the arduous process of rights advocacy in Hong Kong, transsexuals in China＇s mainland achieved their right to marry via some ＂silent changes＂ there was no legal activism from transsexual communities, no debates or hearings in the legislature, and no landmark judgments made by the judiciary. From a perspective of comparative law, transsexuals＇ right It endeavors to dis this article attempts to analyze the legal changes regarding to marry in China＇s mainland in light of the struggles in Hong Kong. cuss to what extent the seemingly ＂smooth＂ and ＂unintended＂ way of opening up marriage to transsexuals in China＇s mainland could be beneficial to trans rights and equality in general.
