Currently,a variety of viruses are assaulting people’s bodies,making it especially crucial to enhance immunity.Akkermansia,a potential next-generation probiotic,has been reported to keep human health.Akkermansia PROB...Currently,a variety of viruses are assaulting people’s bodies,making it especially crucial to enhance immunity.Akkermansia,a potential next-generation probiotic,has been reported to keep human health.Akkermansia PROBIO is a safety stain obtained for improving gut flora health.This study aimed to investigate the protective effects of Akkermansia PROBIO against immunosuppression induced by cyclophosphamide in mice.The findings indicated that Akkermansia PROBIO has the potential to alleviate immune damage caused by cyclophosphamide by restoring cytokine levels and regulating the expression of Claudins-1,ZO-1,and Occludin.Importantly,Akkermansia PROBIO would keep intestinal health via re-balancing microbiota composition including increasing Lactobacillus levels and reducing Proteobacteria levels.Simultaneously,a more in-depth investigation was conducted to reveal important associations between various microbiomes and the levels of short-chain fatty acids,aiming to examine the immune restoration process linked to Akkermansia PROBIO.The findings indicate that Akkermansia PROBIO is vital in influencing the gut microbiome,thus aiding in broader immune defense.This research offers potential probiotic candidates for enhancing human immunity.展开更多
In recent years,the booming of the Bike Sharing System(BSS)has played an important role in offering a convenient means of public transport.The BSS is also viewed as a solution to the first/last mile connection issue i...In recent years,the booming of the Bike Sharing System(BSS)has played an important role in offering a convenient means of public transport.The BSS is also viewed as a solution to the first/last mile connection issue in urban cities.The BSS can be classified into dock and dock-less.However,due to imbalance in bike usage over spatial and temporal domains,stations in the BSS may exhibit overflow(full stations)or underflow(empty stations).In this paper,we will take a holistic view of the BSS design by examining the following four components:system design,system prediction,system balancing,and trip advisor.We will focus on system balancing,addressing the issue of overflow/underflow.We will look at two main methods of bike re-balancing:with trucks and with workers.Discussion on the other three components that are related to system balancing will also be given.Specifically,we will study various algorithmic solutions with the availability of data in spacial and temporal domains.Finally,we will discuss several key challenges and opportunities of the BSS design and applications as well as the future of dock and dock-less BSS in a bigger setting of the transportation system.展开更多
文摘Currently,a variety of viruses are assaulting people’s bodies,making it especially crucial to enhance immunity.Akkermansia,a potential next-generation probiotic,has been reported to keep human health.Akkermansia PROBIO is a safety stain obtained for improving gut flora health.This study aimed to investigate the protective effects of Akkermansia PROBIO against immunosuppression induced by cyclophosphamide in mice.The findings indicated that Akkermansia PROBIO has the potential to alleviate immune damage caused by cyclophosphamide by restoring cytokine levels and regulating the expression of Claudins-1,ZO-1,and Occludin.Importantly,Akkermansia PROBIO would keep intestinal health via re-balancing microbiota composition including increasing Lactobacillus levels and reducing Proteobacteria levels.Simultaneously,a more in-depth investigation was conducted to reveal important associations between various microbiomes and the levels of short-chain fatty acids,aiming to examine the immune restoration process linked to Akkermansia PROBIO.The findings indicate that Akkermansia PROBIO is vital in influencing the gut microbiome,thus aiding in broader immune defense.This research offers potential probiotic candidates for enhancing human immunity.
文摘In recent years,the booming of the Bike Sharing System(BSS)has played an important role in offering a convenient means of public transport.The BSS is also viewed as a solution to the first/last mile connection issue in urban cities.The BSS can be classified into dock and dock-less.However,due to imbalance in bike usage over spatial and temporal domains,stations in the BSS may exhibit overflow(full stations)or underflow(empty stations).In this paper,we will take a holistic view of the BSS design by examining the following four components:system design,system prediction,system balancing,and trip advisor.We will focus on system balancing,addressing the issue of overflow/underflow.We will look at two main methods of bike re-balancing:with trucks and with workers.Discussion on the other three components that are related to system balancing will also be given.Specifically,we will study various algorithmic solutions with the availability of data in spacial and temporal domains.Finally,we will discuss several key challenges and opportunities of the BSS design and applications as well as the future of dock and dock-less BSS in a bigger setting of the transportation system.
