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Deep Learning-Based Health Assessment Method for Benzene-to-Ethylene Ratio Control Systems under Incomplete Data
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作者 Huichao Cao Honghe Du +3 位作者 Dongnian Jiang Wei Li Lei Du Jianfeng Yang 《Structural Durability & Health Monitoring》 2025年第5期1305-1325,共21页
In the production processes of modern industry,accurate assessment of the system’s health state and traceability non-optimal factors are key to ensuring“safe,stable,long-term,full load and optimal”operation of the ... In the production processes of modern industry,accurate assessment of the system’s health state and traceability non-optimal factors are key to ensuring“safe,stable,long-term,full load and optimal”operation of the production process.The benzene-to-ethylene ratio control system is a complex system based on anMPC-PID doublelayer architecture.Taking into consideration the interaction between levels,coupling between loops and conditions of incomplete operation data,this paper proposes a health assessment method for the dual-layer control system by comprehensively utilizing deep learning technology.Firstly,according to the results of the pre-assessment of the system layers and loops bymultivariate statisticalmethods,seven characteristic parameters that have a significant impact on the health state of the system are identified.Next,aiming at the problem of incomplete assessment data set due to the uneven distribution of actual system operating health state,the original unbalanced dataset is augmented using aWasserstein generative adversarial network with gradient penalty term,and a complete dataset is obtained to characterise all the health states of the system.On this basis,a new deep learning-based health assessment framework for the benzeneto-ethylene ratio control system is constructed based on traditionalmultivariate statistical assessment.This framework can overcome the shortcomings of the linear weighted fusion related to the coupling and nonlinearity of the subsystem health state at different layers,and reduce the dependence of the prior knowledge.Furthermore,by introducing a dynamic attention mechanism(AM)into the convolutional neural network(CNN),the assessment model integrating both assessment and traceability is constructed,which can achieve the health assessment and trace the non-optimal factors of the complex control systems with the double-layer architecture.Finally,the effectiveness and superiority of the proposed method have been verified by the benzene-ethylene ratio control system of the alkylation process unit in a styrene plant. 展开更多
关键词 The benzene-to-ethylene ratio control system health assessment data augmentation Wasserstein generative adversarial network with gradient penalty term dynamic attention mechanism into the convolutional neural network
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Adaptive Air-Fuel Ratio Control with MLP Network 被引量:3
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作者 Shi-Wei Wang Ding-Li Yu 《International Journal of Automation and computing》 EI 2005年第2期125-133,共9页
This paper presents an application of adaptive neural network model-based predictive control (MPC) to the air-fuel ratio of an engine simulation. A multi-layer perceptron (MLP) neural network is trained using two on-l... This paper presents an application of adaptive neural network model-based predictive control (MPC) to the air-fuel ratio of an engine simulation. A multi-layer perceptron (MLP) neural network is trained using two on-line training algorithms: a back propagation algorithm and a recursive least squares (RLS) algorithm. It is used to model parameter uncertainties in the nonlinear dynamics of internal combustion (IC) engines. Based on the adaptive model, an MPC strategy for controlling air-fuel ratio is realized, and its control performance compared with that of a traditional PI controller. A reduced Hessian method, a newly developed sequential quadratic programming (SQP) method for solving nonlinear programming (NLP) problems, is implemented to speed up nonlinear optimization in the MPC. Keywords Air-fuel ratio control - IC engine - adaptive neural networks - nonlinear programming - model predictive control Shi-Wei Wang PhD student, Liverpool John Moores University; MSc in Control Systems, University of Sheffield, 2003; BEng in Automatic Technology, Jilin University, 2000; Current research interests automotive engine control, model predictive control, sliding mode control, neural networks.Ding-Li Yu obtained B.Eng from Harbin Civil Engineering College, Harbin, China in 1981, M.Sc from Jilin University of Technology, Changchun, China in 1986 and PhD from Coventry University, U.K. in 1995, all in control engineering. He is currently a Reader in Process Control at Liverpool John Moores University, U.K. His current research interests are in process control, engine control, fault detection and adaptive neural nets. He is a member of SAFEPROCESS TC in IFAC and an associate editor of the IJMIC and the IJISS. 展开更多
关键词 Air-fuel ratio control IC engine adaptive neural networks nonlinear programming model predictive control
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EXPERIMENT STUDY ON SPEED RATIO CONTROL OF METAL V-BELT TYPE CVT 被引量:2
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作者 WangHongyan QinDatong +1 位作者 ZhangBoying QiuXiding 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2004年第1期11-15,共5页
Based on the control scheme of force and position, the controlling andtesting system of metal V-belt type CVT is developed. Having taken account of the complex nonlinearcharacteristics of the CVT shift dynamics and th... Based on the control scheme of force and position, the controlling andtesting system of metal V-belt type CVT is developed. Having taken account of the complex nonlinearcharacteristics of the CVT shift dynamics and the saturation and nonlinear characteristics of thespeed ratio control valve, the speed ratio fuzzy controller based on the speed ratio feedback isdesigned. The experiment results show that the developed speed ratio control system is practical andfeasible. 展开更多
关键词 CVT Speed ratio control Fuzzy control EXPERIMENT
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Real Time Automation and Ratio Control Using PLC&SCADA in Industry 4.0
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作者 Basant Tomar Narendra Kumar Mini Sreejeth 《Computer Systems Science & Engineering》 SCIE EI 2023年第5期1495-1516,共22页
Industrial Control Systems(ICS)and SCADA(Supervisory Control and Data Acquisition)systems play a critical role in the management and regulation of critical infrastructure.SCADA systems brings us closer to the real-tim... Industrial Control Systems(ICS)and SCADA(Supervisory Control and Data Acquisition)systems play a critical role in the management and regulation of critical infrastructure.SCADA systems brings us closer to the real-time application world.All process and equipment control capability is typically provided by a Distributed Control System(DCS)in industries such as power stations,agricultural systems,chemical and water treatment plants.Instead of control through DCS,this paper proposes a SCADA and PLC(Programmable Logic Controller)system to control the ratio control division and the assembly line division inside the chemical plant.A specific design and implementation method for development of SCADA/PLC based real time ratio control and automated assembly line system in a chemical plant is introduced.The assembly line division is further divided into sorting stage,filling stage and the auxiliary stage,which includes the capping unit,labelling unit and then the storage.In the ratio control division,we have defined the levels inside the mixer and ratio of the raw materials through human machine interface(HMI)panel.The ratio of raw materials is kept constant on the basis of flow rates of wild stream and manipulated stream.There is a flexibility in defining new levels and the ratios of the raw materials inside the mixer.But here we taken the predefined levels(low,medium,high)and ratios(3:4,2:1,2:5).Control valves are used for regulating the flow of the compositions.In the assembly line division,the containers are sorted on the basis of size and type of material used i.e.,big sized metallic containers and small sized non-metallic containers by inductive and capacitive proximity sensors.All the processes are facilitated with laser beam type or reflective type sensors on the conveyor system.Building a highly stable and dependable PLC/SCADA system instead of Distributed Control System is required to achieve automatic management and control of chemical industry processes to reduce waste manpower and physical resources,as well as to improve worker safety. 展开更多
关键词 Industry 4.0 ratio control AUTOMATION PLC SCADA control valves proximity sensors conveyor system solenoid valves
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Transient Air-Fuel Ratio Control in a CNG Engine Using Fuzzy Neural Networks 被引量:2
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作者 李国岫 张欣 《Journal of Beijing Institute of Technology》 EI CAS 2005年第1期100-103,共4页
The fuzzy neural networks has been used as means of precisely controlling the air-fuel ratio of a lean-burn compressed natural gas (CNG) engine. A control algorithm, without based on engine model, has been (utilized) ... The fuzzy neural networks has been used as means of precisely controlling the air-fuel ratio of a lean-burn compressed natural gas (CNG) engine. A control algorithm, without based on engine model, has been (utilized) to construct a feedforward/feedback control scheme to regulate the air-fuel ratio. Using fuzzy neural networks, a fuzzy neural hybrid controller is obtained based on PI controller. The new controller, which can adjust parameters online, has been tested in transient air-fuel ratio control of a CNG engine. 展开更多
关键词 air-fuel (A/F) ratio fuzzy neural network hybrid controller
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Simple adaptive air-fuel ratio control of a port injection SI engine with a cylinder pressure sensor 被引量:2
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作者 Chanyut KHAJORNTRAIDET Kazuhisa ITO 《Control Theory and Technology》 EI CSCD 2015年第2期141-150,共3页
The problem of air-fuel ratio(AFR) control of the port injection spark ignition(SI) engine is still of considerable importance because of stringent demands on emission control. In this paper, the static AFR calculatio... The problem of air-fuel ratio(AFR) control of the port injection spark ignition(SI) engine is still of considerable importance because of stringent demands on emission control. In this paper, the static AFR calculation model based on in-cylinder pressure data and on the adaptive AFR control strategy is presented. The model utilises the intake manifold pressure, engine speed, total heat release, and the rapid burn angle, as input variables for the AFR computation. The combustion parameters, total heat release,and rapid burn angle, are calculated from in-cylinder pressure data. This proposed AFR model can be applied to the virtual lambda sensor for the feedback control system. In practical applications, simple adaptive control(SAC) is applied in conjunction with the AFR model for port-injected fuel control. The experimental results show that the proposed model can estimate the AFR, and the accuracy of the estimated value is applicable to the feedback control system. Additionally, the adaptive controller with the AFR model can be applied to regulate the AFR of the port injection SI engine. 展开更多
关键词 Spark ignition engine in-cylinder pressure simple adaptive control air-fuel ratio estimation and control
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Variable Gear Ratio Control Using Vehicle Body Slip Angle
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作者 Takahiko Yoshino Hiromichi Nozaki 《Engineering(科研)》 2014年第8期439-448,共10页
Vehicles with variable steering characteristics have long been studied and compared with those having typical fixed gear ratio steering, and the variable gear ratio properties are reported to have improved maneuverabi... Vehicles with variable steering characteristics have long been studied and compared with those having typical fixed gear ratio steering, and the variable gear ratio properties are reported to have improved maneuverability and stability in high-speed lane changes and on slippery low-friction road surfaces. However, it is not clear how gear ratios should be set for individual vehicle characteristics. Therefore, the present study has investigated a variable steering gear system using body slip angle feedback for the purpose of improved maneuverability and stability in the critical cornering range and upwards, in excess of the critical limit, and into the countersteer range. The results of a driving simulator experiment show that the steering effect improves and maneuverability and stability increase in the critical cornering range and upwards, in excess of the critical limit, and into the countersteer range by applying linear-variable control to the steering ratio from a body slip angle of 5?. This result is seen both in double lane changes, such as in hazard avoidance, and in J-turns with long drifting. Moreover, it shows an improvement in drift controllability through prompt countersteering. Overall, the present system can enhance the driver’s hazard avoidance capability. 展开更多
关键词 Motion control AUTOMOBILE Vehicle Dynamics MANEUVERABILITY Variable GEAR ratio
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Water medium retarders for heavy-duty vehicles:Computational fluid dynamics and experimental analysis of filling ratio control method 被引量:3
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作者 郑宏鹏 雷雨龙 宋鹏翔 《Journal of Hydrodynamics》 SCIE EI CSCD 2017年第6期1067-1075,共9页
The water medium(WM) retarder is an auxiliary braking device that could convert the kinetic energy of the vehicle to the thermal energy of the coolant, and it is used instead of the service brake under non-emergency... The water medium(WM) retarder is an auxiliary braking device that could convert the kinetic energy of the vehicle to the thermal energy of the coolant, and it is used instead of the service brake under non-emergency braking conditions. This paper analyzes the flow distribution based on a mathematical model and analyzes the key factors that could affect the filling ratio and the braking torque of the WM retarder. Computational fluid dynamics(CFD) simulations are conducted to compute the braking torque, and theresults are verified by experiments. It is shown that the filling ratio and the braking torque can be expressed by the mathematical model proposed in this paper. Compared with the Reynolds averaged Navier-Stokes(RANS) turbulent model, the shear stress transport(SST) turbulent model can more accurately simulate the braking torque. Finally, the flow distribution and the flow character in the WM retarders are analyzed. 展开更多
关键词 Heavy duty vehicle braking system water medium retarder computational fluid dynamics filling ratio control method
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Research on the novel discretized ratio control strategies and hardware-in-the-loop test for continuous variable transmission system
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作者 Deng Tao Li Zhifei Yin Yanli 《International Journal of Modeling, Simulation, and Scientific Computing》 EI 2019年第3期43-64,共22页
Based on traditional continuous control strategy for Continuously Variable Transmission(CVT)ratio,according to the principles of shift control strategy for stepped automatic transmission,the influences of throttle ope... Based on traditional continuous control strategy for Continuously Variable Transmission(CVT)ratio,according to the principles of shift control strategy for stepped automatic transmission,the influences of throttle opening and external resistance or vehicle speed on CVT ratio control are analyzed on bumpy road.Under the same variation of external resistance condition,the differences between optimal economic control strategy and optimal dynamic control strategy are discussed.Then,the traditional continuous optimal dynamic and economic control lines are divided into multi-step upshift points.Meanwhile,the corresponding downshift points are set to avoid the interference near shift points.After that,the novel discretized ratio control methods for CVT system are proposed.By respectively discretizing throttle opening and vehicle speed,the discretized ratio control strategy for throttle opening,and the integrated discretized ratio control strategy for throttle opening and vehicle speed are further proposed and simulated.Furthermore,the hardware-in-the-loop(HIL)test system is built to further verify the feasibility and accuracy of discretized ratio control strategies.Both simulation and HIL test results show that the sensitivity of throttle opening and vehicle speed to ratio control is reduced dramatically,the fluctuation of ratio is decreased considerably,the transmission efficiency is increased significantly,and the jerk is declined moderately. 展开更多
关键词 Continuously Variable Transmission(CVT) discretized ratio control simulation hardware-in-the-loop(HIL)test
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Air flow control based on optimal oxygen excess ratio in fuel cells for vehicles 被引量:1
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作者 Ai Guo Weirong Chen +2 位作者 Qi Li Zhixiang Liu Haidan Que 《Journal of Modern Transportation》 2013年第2期79-85,共7页
Air flow control is one of the most important control methods for maintaining the stability and reliability of a fuel cell system, which can avoid oxygen starvation or oxygen saturation. The oxygen excess ratio (OER... Air flow control is one of the most important control methods for maintaining the stability and reliability of a fuel cell system, which can avoid oxygen starvation or oxygen saturation. The oxygen excess ratio (OER) is often used to indicate the air flow condition. Based on a fuel cell system model for vehicles, OER performance was analyzed for different stack currents and temperatures in this paper, and the results show that the optimal OER was affected weakly by the stack temperature. In order to ensure the system working in optimal OER, a control scheme that includes an optimal OER regulator and a fuzzy control was proposed. According to the stack current, a reference value of air flow rate was obtained with the optimal OER regulator and then the air compressor motor voltage was controlled with the fuzzy controller to adjust the air flow rate provided by the air compressor. Simulation results show that the control method has good dynamic and static characteristics. 展开更多
关键词 Fuel cells Oxygen excess ratio Air flow Fuzzy control
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Optimizing the Aspect Ratio of Cephalexin in Reactive Crystallization by Controlling Supersaturation and Seeding Policy 被引量:3
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作者 Mingchen Li Zeren Shang Baohong Hou 《Transactions of Tianjin University》 EI CAS 2019年第4期348-356,共9页
Batch crystallization in acidic aqueous solution of cephalexin was conducted by reactive crystallization with or without seeding. Supersaturation was generated by mixing ammonia and acidic aqueous solution of cephalex... Batch crystallization in acidic aqueous solution of cephalexin was conducted by reactive crystallization with or without seeding. Supersaturation was generated by mixing ammonia and acidic aqueous solution of cephalexin and controlled by solution feeding rate and seeding conditions. UV and Morphologi G3 were used to measure supersaturation and aspect ratio. Experimental results demonstrated that burst nucleation occurred and the products were needle-like at high supersaturation;meanwhile, the products were plate-like and had high aspect ratio at low supersaturation. Analysis of the measured supersaturation profi les and corresponding aspect ratio explained the mechanisms governing the aspect ratio. The optimized operating parameters were also proposed (seeding supersaturation is equal to 1.3, seed mass ratio 8% and feeding rate 368 μL/min). 展开更多
关键词 Reactive CRYSTALLIZATION SUPERSATUratioN control ASPECT ratio Crystal HABIT
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Variable Tension Control for Discontinuous Tape Winding of Composites Based on Constant Extension Ratio 被引量:3
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作者 SHI Yaoyao YAN Long HE Xiaodong 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2012年第5期1022-1028,共7页
Discontinuous tape winding, which has obvious advantages in large extension ratio winding, is widely used in the molding of composites. Therefore, the research on technological parameters becomes the focus of many sch... Discontinuous tape winding, which has obvious advantages in large extension ratio winding, is widely used in the molding of composites. Therefore, the research on technological parameters becomes the focus of many scholars. However, how to accomplish the variable tension control is usually not fully considered. Accordingly, the constant extension ratio and the smoothness of winding process cannot be ensured. Aiming at the problem of tension control, this paper first gives a comparatively deep research on the control method and the interaction mechanism of tension, extension ratio, automatic lap and automatic rectification. Then, according to the winding process features, the mechanical device and the mathematical model of tension control system are established respectively. With regard to the characteristics of PID controller and fuzzy controller, the fuzzy self-tuning PID controller is designed. As a result, the variable tension control is realized during the winding and lapping process, and the constant extension ratio is guaranteed. Finally, a sample application is presented for demonstration. By presenting the variable tension control techniques for discontinuous tape winding, the constant extension ratio of tapes is achieved, the consecution and the automation degree of winding process is improved as well. Thus, the quality of wound products is guaranteed. 展开更多
关键词 tape winding tension control constant extension ratio automatic lap and rectification
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Design of flying vehicle control system by signal to noise ratio
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作者 孙龙大 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2001年第1期63-68,共6页
Presents the new concept of ″Desired to be small″ based on the basic function of vehicle flight control system for an optimal design of flying vehicle control system, and the definition of S/N ratio and calculation ... Presents the new concept of ″Desired to be small″ based on the basic function of vehicle flight control system for an optimal design of flying vehicle control system, and the definition of S/N ratio and calculation formula for ″Desired to be small″ dynamic characteristics, and the S/N ratio method established for design of velicle flight control systems, by which, an orthogrnal table is used to arrange test schemes, and error facters are used to simulate various interferences, and the use of S/N ratio as a design criterion to synthesise the design of dynamic and static characteristics for definition of an optimal scheme, the application of S/N ratio method to the design of a type of vehicle control system and the single run success abtained in design of control system, technical evaluation test and design finalization flight test. 展开更多
关键词 S/N ratio method control system dynamic characteristics static characteristics parameter design
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Nonlinear General Integral Control Design via Equal Ratio Gain Technique
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作者 Baishun Liu 《International Journal of Modern Nonlinear Theory and Application》 2014年第5期256-266,共11页
This paper proposes two kinds of nonlinear general integral controllers, that is, one is generic and another is practical, for a class of uncertain nonlinear system. By extending equal ratio gain technique to a canoni... This paper proposes two kinds of nonlinear general integral controllers, that is, one is generic and another is practical, for a class of uncertain nonlinear system. By extending equal ratio gain technique to a canonical interval system matrix and using Lyapunov method, theorems to ensure regionally as well as semi-globally asymptotic stability are established in terms of some bounded information. Moreover, for the practical nonlinear integral controller, a real time method to evaluate the equal ratio coefficient is proposed such that its value can be chosen moderately. Theoretical analysis and simulation results demonstrated that not only nonlinear general integral control can effectively deal with the uncertain nonlinear system but also equal ratio gain technique is a powerful and practical tool to solve the control design problem of dynamics with the nonlinear and uncertain actions. 展开更多
关键词 General Integral control NONLINEAR control Robust control Generic controller Equal ratio GAIN TECHNIQUE Output Regulation
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Equal Ratio Gain Technique and Its Application in Linear General Integral Control
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作者 Baishun Liu 《International Journal of Modern Nonlinear Theory and Application》 2015年第1期21-36,共16页
In conjunction with linear general integral control, this paper proposes a fire-new control design technique, named Equal ratio gain technique, and then develops two kinds of control design methods, that is, Decomposi... In conjunction with linear general integral control, this paper proposes a fire-new control design technique, named Equal ratio gain technique, and then develops two kinds of control design methods, that is, Decomposition and Synthetic methods, for a class of uncertain nonlinear system. By Routh’s stability criterion, we demonstrate that a canonical system matrix can be designed to be always Hurwitz as any row controller gains, or controller and its integrator gains increase with the same ratio. By solving Lyapunov equation, we demonstrate that as any row controller gains, or controller and its integrator gains of a canonical system matrix tend to infinity with the same ratio, if it is always Hurwitz, and then the same row solutions of Lyapunov equation all tend to zero. By Equal ratio gain technique and Lyapunov method, theorems to ensure semi-globally asymptotic stability are established in terms of some bounded information. Moreover, the striking robustness of linear general integral control and PID control is clearly illustrated by Equal ratio gain technique. Theoretical analysis, design example and simulation results showed that Equal ratio gain technique is a powerful tool to solve the control design problem of uncertain nonlinear system. 展开更多
关键词 Equal ratio GAIN TECHNIQUE General INTEGRAL control Nonlinear control Robust control OUTPUT Regulation
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Power Ratio Gain Technique and General Integral Control
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作者 Baishun Liu 《Applied Mathematics》 2015年第4期663-669,共7页
In conjunction with general integral control, and synthesizing Singular perturbation and Equal ratio gain techniques, this paper proposes a new control design technique, named Power ratio gain technique, and then by L... In conjunction with general integral control, and synthesizing Singular perturbation and Equal ratio gain techniques, this paper proposes a new control design technique, named Power ratio gain technique, and then by Lyapunov method, theorem to ensure regionally as well as semi-globally asymptotic stability is established in terms of some bounded information. The highlight point is that it not only inherits all the essences of Singular perturbation and Equal ratio gain techniques but also makes up for their shortcomings, and then the conservatism of control input can be improved by compromising the Power ratio coefficients. Theoretical analysis, design example and simulation results show that Power ratio gain technique is a simple, practical and powerful tool to deal with the uncertain nonlinear system. 展开更多
关键词 GENERAL Integral control Nonlinear control Robust control Equal ratio GAIN TECHNIQUE SINGULAR Perturbation TECHNIQUE Power ratio GAIN TECHNIQUE Output Regulation
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基于多步预测的永磁同步电机三矢量模型预测转矩控制
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作者 闫宏亮 周杉杉 《机械设计与研究》 北大核心 2025年第5期313-318,325,共7页
多步模型预测控制虽然可以延长预测步长,统筹考虑更长时域的控制情况并求得全局最优解,但依旧只考虑了单个电压矢量作用于控制系统,且通常第二电压矢量只能选择零矢量,仍会导致较大的转矩脉动。基于永磁同步电机多步模型预测控制,提出... 多步模型预测控制虽然可以延长预测步长,统筹考虑更长时域的控制情况并求得全局最优解,但依旧只考虑了单个电压矢量作用于控制系统,且通常第二电压矢量只能选择零矢量,仍会导致较大的转矩脉动。基于永磁同步电机多步模型预测控制,提出一种新型三矢量多步模型预测转矩控制策略,在一个控制周期中通过矢量选择得到两个有效矢量,并通过改进的占空比转矩控制合成新的最优电压矢量,同时提出一种新的消除权重系数的成本函数,能够单独考虑每一步预测的权重从而得到其全局最优电压矢量。实验结果表明:所提出的控制策略相比于三矢量转矩控制与传统多步预测控制可以有效抑制转矩脉动,减小磁链波动并且通过总谐波失真(THD)电流分析证明电流谐波较小,实现了电机控制性能的改善。 展开更多
关键词 永磁同步电机 占空比控制 成本函数 多步三矢量模型预测转矩控制
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关于双向比的油气悬架半主动控制研究
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作者 章新 肖增亮 +1 位作者 董荻 李占龙 《中国工程机械学报》 北大核心 2025年第1期6-10,共5页
在多级阻尼切换的半主动悬架控制系统中,考虑减振器双向比和阻尼系数的最优匹配,以对车辆进行更优的阻尼控制。建立四级阻尼切换半主动控制悬架系统,将半主动控制方法与实际天棚阻尼控制方法及被动悬架系统进行对比验证。结果表明:在30 ... 在多级阻尼切换的半主动悬架控制系统中,考虑减振器双向比和阻尼系数的最优匹配,以对车辆进行更优的阻尼控制。建立四级阻尼切换半主动控制悬架系统,将半主动控制方法与实际天棚阻尼控制方法及被动悬架系统进行对比验证。结果表明:在30 km/h的B级路面谱和40 km/h的C级路面谱这两种不同的运行条件下,当以被动悬架为比较基准时,多级阻尼切换半主动控制方法对弹簧质量垂直加速度均方根值、悬架动挠度和车轮动载荷这3个性能指标的改善程度,约是实际天棚阻尼控制方法的2倍。 展开更多
关键词 液压减振器 多级阻尼切换 双向比 半主动控制
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靶向组织因子的抗体偶联药物的质量控制
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作者 杜加亮 聂东婷 +9 位作者 武刚 曹振坤 倪永波 李萌 崔永霏 郭璐韵 崔春博 张佳龄 梅玉婷 于传飞 《山西医科大学学报》 2025年第10期1160-1168,共9页
目的研究并建立靶向组织因子的抗体偶联药物(anti-TF-ADC)的关键质量属性(CQA)质量控制方法。方法从肽图鉴别、纯度和杂质、电荷异质性和活性等方面对anti-TF-ADC药物开展质量控制研究。采用反相高效液相色谱(RP-HPLC)技术对anti-TF-AD... 目的研究并建立靶向组织因子的抗体偶联药物(anti-TF-ADC)的关键质量属性(CQA)质量控制方法。方法从肽图鉴别、纯度和杂质、电荷异质性和活性等方面对anti-TF-ADC药物开展质量控制研究。采用反相高效液相色谱(RP-HPLC)技术对anti-TF-ADC药物进行肽图鉴别;采用分子排阻色谱法(SEC)和十二烷基硫酸钠毛细管电泳法(CE-SDS)分析anti-TFADC药物的纯度;采用毛细管等电聚焦电泳法(icIEF)分析anti-TF-ADC药物的电荷异质性;采用疏水相互作用色谱法(HIC)分析anti-TF-ADC药物的药物抗体偶联比(DAR);采用RP-HPLC分析anti-TF-ADC药物的游离细胞毒素残留;采用酶联免疫吸附试验(ELISA)、均相酶联免疫分析技术(AlphaLISA)和细胞增殖抑制法分析anti-TF-ADC药物的结合活性和生物学活性。结果对于anti-TF-ADC药物,肽图可识别其关键肽段,发挥特异性鉴别作用。经SEC和CE-SDS检测,其纯度分别为98.89%和97.99%。经icIEF检测,其主峰、酸性峰和碱性峰的面积百分比分别为61.73%,29.24%和9.03%。经HIC检测,其DAR值为3.92,以DAR4为主(49.2%)。经RP-HPLC检测,其游离细胞毒素残留均未检测出。anti-TF-ADC药物的结合活性和生物学活性测定所得数据均符合四参数方程式,其Fab端与靶点结合的EC_(50)值为13.13 ng/mL,其Fc端与Fc受体CD16a、CD32a和CD64结合的EC_(50)值分别为2695.83,14517.67,191.73 ng/mL,其细胞生物学活性的EC_(50)值为18.95 ng/mL。结论针对anti-TFADC药物的理化和生物学特性,研究并建立了针对其CQA的质量控制方法,从质量可控的角度确保该类产品的临床安全性和有效性。 展开更多
关键词 组织因子 抗体偶联药物 细胞毒素 关键质量属性 药物抗体偶联比 质量控制
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氢燃料电池发电系统的双闭环比值控制研究
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作者 刘春蕾 张盈盈 《仪表技术》 2025年第4期78-81,共4页
针对氢燃料电池中氢氧比例对性能的关键影响,设计精准策略以提升系统能量转化效率与电池寿命,推动其高效应用。通过机理分析明确氢氧比例对电池电化学反应及性能指标的影响规律,确定存在最佳氢氧治理范围,偏离该范围时电池性能下降;构... 针对氢燃料电池中氢氧比例对性能的关键影响,设计精准策略以提升系统能量转化效率与电池寿命,推动其高效应用。通过机理分析明确氢氧比例对电池电化学反应及性能指标的影响规律,确定存在最佳氢氧治理范围,偏离该范围时电池性能下降;构建双闭环比值控制系统,主回路调控氢气流量、从回路调节氧气流量以实现流量比值匹配,并采用工程整定与智能算法相结合的方式优化PID参数,兼顾系统稳定性、准确性与快速性;利用MATLAB搭建仿真模型,模拟不同氢氧比例及多种扰动工况,结果表明系统稳态运行时氧气流量可精准跟踪氢气流量,流量比值误差控制在极小范围内,面对扰动氧气流量能快速恢复设定比值,功率波动幅度较小且调节时间明显缩短;在氢氧比例适中时,电堆功率、能量转化效率均有显著提升,电池寿命得以延长。 展开更多
关键词 氢燃料电池 氢氧比例 双闭环比值控制 PID控制器
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