We and others have firmly established that surface IgM receptor (sIgM-R) crosslinking with antibodies to the i heavy chain (anti-i) leads to growth arrest and apoptosis in a series of well characterized B-cell lymphom...We and others have firmly established that surface IgM receptor (sIgM-R) crosslinking with antibodies to the i heavy chain (anti-i) leads to growth arrest and apoptosis in a series of well characterized B-cell lymphomas. This requires ablation of c-Myc protein expression and the concomitant induction of the cyclin-dependent-kinase inhibitor, p27Kip1. The signaling mechanisms regulating c-Myc and p27Kip1 protein expression are poorly understood. However, we recently established that sIgM-R mediated down-modulation of the PI-3K pathway directly affected c-Myc and p27Kip1 expression and accurately predicted growth展开更多
为降低部分跟随机器人在无线定位方面的成本,提高定位效果,设计一种基于Raspberry Pi的自动跟随机器人。该机器人以小车为载体,采用Raspberry Pi 3B+作为主控器,运用超声波测距模块实现避障功能,并通过GPS模块实现机器人的定位;利用蓝...为降低部分跟随机器人在无线定位方面的成本,提高定位效果,设计一种基于Raspberry Pi的自动跟随机器人。该机器人以小车为载体,采用Raspberry Pi 3B+作为主控器,运用超声波测距模块实现避障功能,并通过GPS模块实现机器人的定位;利用蓝牙模块实现手机与树莓派之间的数据传输,由手机APP实现机器人的按键控制、重力控制、语音控制和跟随控制。这些控制模式之间存在互锁关系,保证在某个模式下其他模式不会产生误动作,确保实时实现自动跟随、避障等功能,以满足不同的操作需求,方便人们的日常使用,使得智能化程度进一步提高。展开更多
The objective of the study was to determine the role of vitamin D3(VD3) in regulating adaptation and mechanism of rats to low-phosphorus(P) diets. Rats were assigned to 4 diets containing 0.2%, 0.4%, 0.6%,or 0.8% P co...The objective of the study was to determine the role of vitamin D3(VD3) in regulating adaptation and mechanism of rats to low-phosphorus(P) diets. Rats were assigned to 4 diets containing 0.2%, 0.4%, 0.6%,or 0.8% P consisting of 5 replicate cages with 6 rats per replicate cage and fed for 7 days. Four rats from each replicate cage were treated with ethane-1-hydroxy-1,1-diphosphonicacid, tetrasodium salt(EHDP)and 2 rats remained untreated. Twelve hours prior to preparation on d 7, two of the EHDP-treated rats received an intraperitoneal injection of VD3 [1,25-(OH)_2 D_3] at 600 ng per kg body weight, while two rats did not receive the injection. Rats that did not receive VD_3 injection had decreased(P < 0.001) P absorption, but injection of VD3 resulted in increased(P < 0.001) absorption. The effect of VD3 injection was greater(P < 0.001) for rats fed 0.2% P diet than rats fed 0.8% P diet in ileum. Sodium dependent phosphate cotransporter type IIb(Na/Pi-IIb) and 25-hydroxyvitamin D 1-α hydroxylase(CYP27 B1) mRNA level showed the same trend with P absorption. Serum concentration of VD3 and la-hydroxylase activity in rats fed 0.2% P diet were lower than those fed 0.8% P diet. The injection of VD3 increased(P < 0.001)serum concentration of VD3 and la-hydroxylase activity. Thus, VD3 increased Na/Pi-Ⅱb and CYP27 B1 mRNA level and improved serum concentration of VD3 and la-hydroxylase activity in rats fed low-P diets.展开更多
针对物联网系统中对底层步进电机设备进行远程精确控制的需求,提出了基于移动终端的步进电机驱动系统模型设计方案,使用HTML5构建可在移动终端设备访问的用户端操作界面,通过Web服务器接收用户的操作指令并向终端设备转发,指令的解析与...针对物联网系统中对底层步进电机设备进行远程精确控制的需求,提出了基于移动终端的步进电机驱动系统模型设计方案,使用HTML5构建可在移动终端设备访问的用户端操作界面,通过Web服务器接收用户的操作指令并向终端设备转发,指令的解析与电机驱动电平信号的操作发送采用Raspberry Pi 3B平台构建控制终端实现。经试验表明,该方案具有对电机状态控制实时精确、系统工作性能稳定、使用便捷等特点,为新型移动端物联网应用系统的设计提供了参考。展开更多
自主设计与开发了一套基于QT的FAIMS气体传感器测控系统,与下位机系统配合使用。基于C++的QT框架进行GUI界面设计,使用Raspberry Pi 3B嵌入式开源硬件作为控制中心,搭载主流的嵌入式Linux操作系统。FAIMS气体传感器核心芯片采用PCB工艺...自主设计与开发了一套基于QT的FAIMS气体传感器测控系统,与下位机系统配合使用。基于C++的QT框架进行GUI界面设计,使用Raspberry Pi 3B嵌入式开源硬件作为控制中心,搭载主流的嵌入式Linux操作系统。FAIMS气体传感器核心芯片采用PCB工艺制作,上下极板间距0.2 mm。离子源采用与PCB板设计相结合的负直流针-环放电电极结构,针尖直径为200μm,环直径为3 mm。实验结果表明:系统实现了上位机与下位机的命令和数据收发、多种颜色的谱图在线及离线绘制、数据滤波、多谱图的数据提取和保存、多平台应用等功能,具有体积小、便携式、应用灵活、通用性好等特点。展开更多
文摘We and others have firmly established that surface IgM receptor (sIgM-R) crosslinking with antibodies to the i heavy chain (anti-i) leads to growth arrest and apoptosis in a series of well characterized B-cell lymphomas. This requires ablation of c-Myc protein expression and the concomitant induction of the cyclin-dependent-kinase inhibitor, p27Kip1. The signaling mechanisms regulating c-Myc and p27Kip1 protein expression are poorly understood. However, we recently established that sIgM-R mediated down-modulation of the PI-3K pathway directly affected c-Myc and p27Kip1 expression and accurately predicted growth
文摘为降低部分跟随机器人在无线定位方面的成本,提高定位效果,设计一种基于Raspberry Pi的自动跟随机器人。该机器人以小车为载体,采用Raspberry Pi 3B+作为主控器,运用超声波测距模块实现避障功能,并通过GPS模块实现机器人的定位;利用蓝牙模块实现手机与树莓派之间的数据传输,由手机APP实现机器人的按键控制、重力控制、语音控制和跟随控制。这些控制模式之间存在互锁关系,保证在某个模式下其他模式不会产生误动作,确保实时实现自动跟随、避障等功能,以满足不同的操作需求,方便人们的日常使用,使得智能化程度进一步提高。
基金supported by grants from the Nature Science Foundation (31201810, to M H Cao 31572419, to R J Fang)+1 种基金Education Department of Hunan Province(138039, to M H Cao)Innovation Team Funds Of Hunan Province (to J H He)
文摘The objective of the study was to determine the role of vitamin D3(VD3) in regulating adaptation and mechanism of rats to low-phosphorus(P) diets. Rats were assigned to 4 diets containing 0.2%, 0.4%, 0.6%,or 0.8% P consisting of 5 replicate cages with 6 rats per replicate cage and fed for 7 days. Four rats from each replicate cage were treated with ethane-1-hydroxy-1,1-diphosphonicacid, tetrasodium salt(EHDP)and 2 rats remained untreated. Twelve hours prior to preparation on d 7, two of the EHDP-treated rats received an intraperitoneal injection of VD3 [1,25-(OH)_2 D_3] at 600 ng per kg body weight, while two rats did not receive the injection. Rats that did not receive VD_3 injection had decreased(P < 0.001) P absorption, but injection of VD3 resulted in increased(P < 0.001) absorption. The effect of VD3 injection was greater(P < 0.001) for rats fed 0.2% P diet than rats fed 0.8% P diet in ileum. Sodium dependent phosphate cotransporter type IIb(Na/Pi-IIb) and 25-hydroxyvitamin D 1-α hydroxylase(CYP27 B1) mRNA level showed the same trend with P absorption. Serum concentration of VD3 and la-hydroxylase activity in rats fed 0.2% P diet were lower than those fed 0.8% P diet. The injection of VD3 increased(P < 0.001)serum concentration of VD3 and la-hydroxylase activity. Thus, VD3 increased Na/Pi-Ⅱb and CYP27 B1 mRNA level and improved serum concentration of VD3 and la-hydroxylase activity in rats fed low-P diets.
文摘针对物联网系统中对底层步进电机设备进行远程精确控制的需求,提出了基于移动终端的步进电机驱动系统模型设计方案,使用HTML5构建可在移动终端设备访问的用户端操作界面,通过Web服务器接收用户的操作指令并向终端设备转发,指令的解析与电机驱动电平信号的操作发送采用Raspberry Pi 3B平台构建控制终端实现。经试验表明,该方案具有对电机状态控制实时精确、系统工作性能稳定、使用便捷等特点,为新型移动端物联网应用系统的设计提供了参考。
文摘自主设计与开发了一套基于QT的FAIMS气体传感器测控系统,与下位机系统配合使用。基于C++的QT框架进行GUI界面设计,使用Raspberry Pi 3B嵌入式开源硬件作为控制中心,搭载主流的嵌入式Linux操作系统。FAIMS气体传感器核心芯片采用PCB工艺制作,上下极板间距0.2 mm。离子源采用与PCB板设计相结合的负直流针-环放电电极结构,针尖直径为200μm,环直径为3 mm。实验结果表明:系统实现了上位机与下位机的命令和数据收发、多种颜色的谱图在线及离线绘制、数据滤波、多谱图的数据提取和保存、多平台应用等功能,具有体积小、便携式、应用灵活、通用性好等特点。
