骨质疏松症由于其严重的致病后果同时较高的发病率已经成为我国老年人的头号健康潜在威胁,而OPG/RANK/RANKL信号通路主要通过影响破骨细胞分化成熟,从而在骨质疏松症的发病机制中占据了重要地位,是许多抗骨质疏松药品开发的重要研究靶...骨质疏松症由于其严重的致病后果同时较高的发病率已经成为我国老年人的头号健康潜在威胁,而OPG/RANK/RANKL信号通路主要通过影响破骨细胞分化成熟,从而在骨质疏松症的发病机制中占据了重要地位,是许多抗骨质疏松药品开发的重要研究靶点之一。为了探究OPG/RANK/RANKL信号通路在骨质疏松症中的作用机制及中医药干预现状和进展,通过CNKI、WANFANG DATE、中华医学期刊全文数据库、Web of Science、Pub Med数据库,以骨质疏松症、OPG/RANK/RANKL、中药和中药方剂为关键词检索近10年相关文献报道,结果显示许多中药及其有效成分和中药方剂都可通过调控OPG/RANK/RANKL信号通路抑制破骨细胞,改善骨质疏松症,增加骨强度,提示中药及其有效成分和中药方剂能有效防治骨质疏松症,同时在药物研发方面具有极大的潜力和应用前景。展开更多
In this paper,we first generalize the constant dimension and orbit codes over finite fields to the constant rank and orbit codes over finite chain rings.Then we provide a relationship between constant rank codes over ...In this paper,we first generalize the constant dimension and orbit codes over finite fields to the constant rank and orbit codes over finite chain rings.Then we provide a relationship between constant rank codes over finite chain rings and constant dimension codes over the residue fields.In particular,we prove that an orbit submodule code over a finite chain ring is a constant rank code.Finally,for special finite chain ring F_(q)+γF_(q),we define a Gray mapφfrom(F_(q)+γF_(q))^(n)to F^(2n)_(q),and by using cyclic codes over F_(q)+γF_(q),we obtain a method of constructing an optimum distance constant dimension code over F_(q).展开更多
Steroidal alkaloids are the main active components in many medicinal plants and exhibit diverse biological activities.Axillaridine A(AA)is a newly discovered steroidal alkaloid.However,whether AA could suppress osteoc...Steroidal alkaloids are the main active components in many medicinal plants and exhibit diverse biological activities.Axillaridine A(AA)is a newly discovered steroidal alkaloid.However,whether AA could suppress osteoclastogenesis and alleviate ovariectomy-induced bone loss in mice remains unknown.In vitro,AA significantly suppressed the receptor activator of nuclear factor-κB(NF-κB)ligand(RANKL)-induced osteoclast differentiation via downregulating the expression of osteoclastogenesis-related marker genes,proteins,and transcriptional regulators,including tartrate-resistant acid phosphatase(TRAP),c-Src,matrix metallopeptidase-9(MMP-9),cathepsin K,nuclear factor of activated T cells,cytoplasmic 1(NFATc1),and c-Fos.This was achieved by blocking RANKL-RANK interaction and inhibiting RANKL-mediated RANK signaling pathways,including NF-κB,AKT,and mitogen-activated protein kinases(MAPKs)in osteoclast precursors.In vivo,AA significantly inhibited the ovariectomized(OVX)-induced body weight gain and blood glucose increase in mice.AA did not adversely affect the histomorphologies,weights,and indices of the kidney and liver in OVX mice.AA effectively ameliorated bone loss in OVX mice by inhibiting osteoclastogenesis.AA significantly inhibited the serum levels of tartrate-resistant acid phosphatase 5b(TRACP-5b)and C-telopeptide of type I collagen(CTX-I).AA significantly inhibited the OVX-induced expression of osteoclastogenesis-related marker genes and proteins in the femur.In summary,AA alleviates ovariectomy-induced bone loss in mice by suppressing osteoclastogenesis via inhibition of RANKL-mediated RANK signaling pathways and could be potentially used for the prevention and treatment of osteoclastrelated diseases such as osteoporosis.展开更多
文摘骨质疏松症由于其严重的致病后果同时较高的发病率已经成为我国老年人的头号健康潜在威胁,而OPG/RANK/RANKL信号通路主要通过影响破骨细胞分化成熟,从而在骨质疏松症的发病机制中占据了重要地位,是许多抗骨质疏松药品开发的重要研究靶点之一。为了探究OPG/RANK/RANKL信号通路在骨质疏松症中的作用机制及中医药干预现状和进展,通过CNKI、WANFANG DATE、中华医学期刊全文数据库、Web of Science、Pub Med数据库,以骨质疏松症、OPG/RANK/RANKL、中药和中药方剂为关键词检索近10年相关文献报道,结果显示许多中药及其有效成分和中药方剂都可通过调控OPG/RANK/RANKL信号通路抑制破骨细胞,改善骨质疏松症,增加骨强度,提示中药及其有效成分和中药方剂能有效防治骨质疏松症,同时在药物研发方面具有极大的潜力和应用前景。
基金Supported by Research Funds of Hubei Province(D20144401,Q20174503)。
文摘In this paper,we first generalize the constant dimension and orbit codes over finite fields to the constant rank and orbit codes over finite chain rings.Then we provide a relationship between constant rank codes over finite chain rings and constant dimension codes over the residue fields.In particular,we prove that an orbit submodule code over a finite chain ring is a constant rank code.Finally,for special finite chain ring F_(q)+γF_(q),we define a Gray mapφfrom(F_(q)+γF_(q))^(n)to F^(2n)_(q),and by using cyclic codes over F_(q)+γF_(q),we obtain a method of constructing an optimum distance constant dimension code over F_(q).
基金supported by the grants from the National Natural Science Foundation of China(82404638)the Xingdian Talent Plan of Yunnan Province(XDYC-QNRC-2023-0427 and XDYC-YLXZ2022-0025)the Natural Science Foundation of Yunnan Province(202101BD070001-034,202101BD070001-049,202201AT070267,and 202201AU070183)。
文摘Steroidal alkaloids are the main active components in many medicinal plants and exhibit diverse biological activities.Axillaridine A(AA)is a newly discovered steroidal alkaloid.However,whether AA could suppress osteoclastogenesis and alleviate ovariectomy-induced bone loss in mice remains unknown.In vitro,AA significantly suppressed the receptor activator of nuclear factor-κB(NF-κB)ligand(RANKL)-induced osteoclast differentiation via downregulating the expression of osteoclastogenesis-related marker genes,proteins,and transcriptional regulators,including tartrate-resistant acid phosphatase(TRAP),c-Src,matrix metallopeptidase-9(MMP-9),cathepsin K,nuclear factor of activated T cells,cytoplasmic 1(NFATc1),and c-Fos.This was achieved by blocking RANKL-RANK interaction and inhibiting RANKL-mediated RANK signaling pathways,including NF-κB,AKT,and mitogen-activated protein kinases(MAPKs)in osteoclast precursors.In vivo,AA significantly inhibited the ovariectomized(OVX)-induced body weight gain and blood glucose increase in mice.AA did not adversely affect the histomorphologies,weights,and indices of the kidney and liver in OVX mice.AA effectively ameliorated bone loss in OVX mice by inhibiting osteoclastogenesis.AA significantly inhibited the serum levels of tartrate-resistant acid phosphatase 5b(TRACP-5b)and C-telopeptide of type I collagen(CTX-I).AA significantly inhibited the OVX-induced expression of osteoclastogenesis-related marker genes and proteins in the femur.In summary,AA alleviates ovariectomy-induced bone loss in mice by suppressing osteoclastogenesis via inhibition of RANKL-mediated RANK signaling pathways and could be potentially used for the prevention and treatment of osteoclastrelated diseases such as osteoporosis.
