OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control ...OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control group （20）. Both groups were given basic treat- ment with prednisone. The treatment group was given FGs, and the control group was given Jinshui- bao capsules （JCs）. Treatment lasted for 6 months. The Medical Research Council Dyspnea Scale （MRCDS）, the Saint George＇s Hospital Respiratory Questionnaire （SGHRQ）, pulmonary function, the Traditional Chinese Medicine Syndrome Score （TC- MSS）, 6-min walking test （6MWT） and blood gas analyses were recorded before the study as well as 3 months and 6 months after treatment.RESULTS： FGs showed greater efficacy than the control in certain parameters between before the study and 6 months, and between 3 months and 6 months, in the MRCDS, some indicators in the SGHRQ, and the TCMSS. There were no significant differences between the treatment group and con- trol group in the remainder of the indices evaluat- ed. In the treatment group, there were significant differences in before and after treatment in the MRCDS, SGHRQ, TCMSS and 6MWT.展开更多
In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn mo...In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn model. Rabbits were randomized to receive an operation only or an operation+medical chitosan intraperitoneally. Twenty-two rabbits from each group were euthanized at one of five different times(Day 3, 7, 14, 28, or 42), and adhesion formation was given gross and histopathological scores. Reductions were observed in adhesion extent(P=0.0337) and tenacity(P=0.0271) as well as inflammation(P<0.0001) on Day 3 when medical chitosan was applied. Prior to Day 14, fibrosis was less obvious in the medical chitosan group(P<0.0005). The tenacity scores were significantly lower in the medical chitosan group following Day 14(P<0.05), while the type scores were lower in the medical chitosan group following Day 28(P<0.03). Thus, medical chitosan decreased both the gross and the histopathological scores of the induced adhesions.展开更多
基金Supported by the Special Scientific Research for Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine of China:Effects of Feiwei Granules in the treatment of IPF(No.200807046)
文摘OBJECTIVE： To document the therapeutic effects of Feiwei granules （FGs） for idiopathic pulmonary fi-brosis （IPF）.METHODS： One hundred cases with IPF were ran- domized into the treatment group （80） and control group （20）. Both groups were given basic treat- ment with prednisone. The treatment group was given FGs, and the control group was given Jinshui- bao capsules （JCs）. Treatment lasted for 6 months. The Medical Research Council Dyspnea Scale （MRCDS）, the Saint George＇s Hospital Respiratory Questionnaire （SGHRQ）, pulmonary function, the Traditional Chinese Medicine Syndrome Score （TC- MSS）, 6-min walking test （6MWT） and blood gas analyses were recorded before the study as well as 3 months and 6 months after treatment.RESULTS： FGs showed greater efficacy than the control in certain parameters between before the study and 6 months, and between 3 months and 6 months, in the MRCDS, some indicators in the SGHRQ, and the TCMSS. There were no significant differences between the treatment group and con- trol group in the remainder of the indices evaluat- ed. In the treatment group, there were significant differences in before and after treatment in the MRCDS, SGHRQ, TCMSS and 6MWT.
文摘In previous studies, N,O-carboxymethyl chitosan has been shown to decrease the incidence and intensity of abdominal adhesions. In the present study, adhesions were induced in 220 rabbits using a double uterine horn model. Rabbits were randomized to receive an operation only or an operation+medical chitosan intraperitoneally. Twenty-two rabbits from each group were euthanized at one of five different times(Day 3, 7, 14, 28, or 42), and adhesion formation was given gross and histopathological scores. Reductions were observed in adhesion extent(P=0.0337) and tenacity(P=0.0271) as well as inflammation(P<0.0001) on Day 3 when medical chitosan was applied. Prior to Day 14, fibrosis was less obvious in the medical chitosan group(P<0.0005). The tenacity scores were significantly lower in the medical chitosan group following Day 14(P<0.05), while the type scores were lower in the medical chitosan group following Day 28(P<0.03). Thus, medical chitosan decreased both the gross and the histopathological scores of the induced adhesions.
