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Wavelet Detection and Estimation of Change Points in Nonparametric Regression Models under Random Design 被引量:2
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作者 ZHAO Wen Zhi TIAN Zheng XIA Zhi Ming 《Journal of Mathematical Research and Exposition》 CSCD 2009年第2期247-256,共10页
A wavelet method of detection and estimation of change points in nonparametric regression models under random design is proposed. The confidence bound of our test is derived by using the test statistics based on empir... A wavelet method of detection and estimation of change points in nonparametric regression models under random design is proposed. The confidence bound of our test is derived by using the test statistics based on empirical wavelet coefficients as obtained by wavelet transformation of the data which is observed with noise. Moreover, the consistence of the test is proved while the rate of convergence is given. The method turns out to be effective after being tested on simulated examples and applied to IBM stock market data. 展开更多
关键词 random design nonparametric regression model change point wavelet transformation consistent test rate of convergence.
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Methods of Random Fatigue Design for Vehicle Transmission System Components
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作者 项昌乐 陈欣 钟其水 《Journal of Beijing Institute of Technology》 EI CAS 2000年第4期353-357,共5页
Some representative working conditions were measured, and the amplitude distribution rule of each representative working condition after analysis of measured data was got. The building of 2 D distributing function be... Some representative working conditions were measured, and the amplitude distribution rule of each representative working condition after analysis of measured data was got. The building of 2 D distributing function between the range and the mean of random load was discussed. Experiment was carried out to get the fatigue strength data of the material of transmission component. Accessing the P S a S m N camber of combined load of bending and torsion on this material after analysis. And the process of calculating the 2 D fatigue life in multi working condition was discussed. 展开更多
关键词 random fatigue design rainflow counting working condition distributing function PSa SmNcambP
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ON DESIGN METHOD OF THE PRECISION CAM PROFILE WITH RANDOM PROCESSING ERRORS 被引量:4
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作者 Zhao ZhisuMechatronics Engineering andAutomation Institute,National University ofDefense Technology,Changsha 410073, China 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2003年第1期10-12,共3页
Based on probability and statistic, a design method of precision cam profileconcerning the influence of random processing errors is advanced. Combining the design with theprocess, which can be used to predict that cam... Based on probability and statistic, a design method of precision cam profileconcerning the influence of random processing errors is advanced. Combining the design with theprocess, which can be used to predict that cam profiles will be successfully processed or not in thedesign stage, design of the cam can be done by balancing the economization and reliability. Inaddition, an fuzzy deduction method based on Bayers formula is advanced to estimate processingreasonable of the designed precision cam profile, and it take few samples. 展开更多
关键词 Cam profiles design random processing errors Probability and statistic
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Universal Designated Multi Verifier Signature Scheme without Random Oracles 被引量:1
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作者 MING Yang WANG Yumin 《Wuhan University Journal of Natural Sciences》 CAS 2008年第6期685-691,共7页
In this paper, we re-formalize the security notions of universal designated multi verifier signature (UDMVS) schemes. Then the first UDMVS scheme is presented in the standard model (i.e. without random oracles) ba... In this paper, we re-formalize the security notions of universal designated multi verifier signature (UDMVS) schemes. Then the first UDMVS scheme is presented in the standard model (i.e. without random oracles) based on Waters' signature scheme. In this setting, a signature holder can to designate the signature to multi verifiers. Moreover, the security of our proposed scheme is based on the Gap Bilinear Difffie-Hellman assumption. 展开更多
关键词 universal designated multi verifier signature random oracle bilinear pairing
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BOUND ON THE MAXIMUM NUMBER OF CLEAR TWO-FACTOR INTERACTIONS FOR 2^(n-(n-k)) DESIGNS 被引量:1
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作者 赵胜利 张润楚 《Acta Mathematica Scientia》 SCIE CSCD 2008年第4期949-954,共6页
Clear effects criterion is an important criterion for selecting fractional factorial designs[1].Tang et al.[2]derived upper and lower bounds on the maximum number of clear two-factor interactions(2fi's)in 2^n-(n-k... Clear effects criterion is an important criterion for selecting fractional factorial designs[1].Tang et al.[2]derived upper and lower bounds on the maximum number of clear two-factor interactions(2fi's)in 2^n-(n-k)designs of resolution Ⅲ and Ⅳ by constructing 2^n-(n-k)designs.But the method in[2]does not perform well sometimes when the resolution is Ⅲ.This article modifies the construction method for 2^n-(n-k) designs of resolution Ⅲ in[2].The modified method is a great improvement on that used in[2]. 展开更多
关键词 random fractional design CLEAR resolution
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Topology Optimization of Strength-Safe Continuum Structures Considering Random Damage
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作者 Jiazheng Du Xue Cong Ying Zhang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第8期1091-1120,共30页
Spacecraft in the aerospace field and military equipment in the military field are at risk of being impacted by external objects,which can cause local damage to the structure.The randomness of local damage is a newcha... Spacecraft in the aerospace field and military equipment in the military field are at risk of being impacted by external objects,which can cause local damage to the structure.The randomness of local damage is a newchallenge for structural design,and it is essential to take random damage into account in the conceptual design phase for the purpose of improving structure’s resistance to external shocks.In this article,a random damaged structure is assumed to have damages of the same size and shape at random locations,and the random damage is considered as multiple damage conditions of the structure.In order to improve the randomness and comprehensiveness of the multiple damage conditions,the stacking strategy is used to generate the distribution of the damage area.Following this strategy,the topology optimization design of the random damaged structure,which is to minimize the weight of the structure with a constraint on the stress of the structure under multiple damage conditions,is formulated based on the independent continuousmapping(ICM)method.The dual sequence quadratic programming(DSQP)algorithm combined with the stress globalization method is adopted to solve the optimization problem.The numerical examples demonstrate the effectiveness and applicability of the proposed method in the topology optimization of strength-safe continuum structures. 展开更多
关键词 random damage-safety design topology optimization ICM method stacking strategy
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Prediction of alloy composition and microhardness by random forest in maraging stainless steels based on a cluster formula 被引量:1
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作者 Zhen Li Dong-hui Wen +5 位作者 Yue Ma QingWang Guo-qing Chen Rui-qian Zhang Rui Tang Huan He 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2018年第7期717-723,共7页
Fe-Ni-Cr-based super-high-strength maraging stainless steels were generally realized by multiple-element alloying under a given heat treatment processing. A series of alloy compositions were designed with a uniform cl... Fe-Ni-Cr-based super-high-strength maraging stainless steels were generally realized by multiple-element alloying under a given heat treatment processing. A series of alloy compositions were designed with a uniform cluster formula of [Ni16Fe192](Cr32(Ni16-x-y-z-m-n MoxTiyNbzAlmVn)) (at.%) that was developed out of a unique alloy design tool, a cluster- plus-glue-atom model. Alloy rods with a diameter of 6 mm were prepared by copper-mold suction-cast processing under the argon atmosphere. These alloy samples were solid-solutioned at 1273 K for 1 h, followed by water-quenching, and then aged at 783 K for 3 h. The effect of the valence electron concentration, characterized with the number of valence electrons per unit cluster (VE/uc) formula of 16 atoms, on microhardness of these designed maraging stainless steels at both solid- solutioned and aged states was investigated. The relationship between alloy compositions and microhardness in maraging stainless steels was firstly established by the random forest (RF, a kind of machine learning methods) based on the experimental results. It was found that not only the microhardness of any given composition alloy within the frame of cluster formula, but also the alloy composition with a maximum microhardness for any given VE/uc, could be predicted in good agreement with the guidance of the relationship by RF. The contributions of minor-alloying elements to the microhardness of the aged alloys were also discussed. 展开更多
关键词 Maraging stainless steel Composition design MICROHARDNESS Valence electron concentration random forest
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On the Loads for Strength Design of Cutterhead of Full Face Rock Tunnel Boring Machine 被引量:2
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作者 Meidong Han Zongxi Cai Chuanyong Qu 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2019年第6期60-71,共12页
Cutterhead loads are the key mechanical parameters for the strength design of the full face hard rock tunnel boring machine(TBM).Due to the brittle rock-breaking mechanism,the excavation loads acting on cutters fluctu... Cutterhead loads are the key mechanical parameters for the strength design of the full face hard rock tunnel boring machine(TBM).Due to the brittle rock-breaking mechanism,the excavation loads acting on cutters fluctuate strongly and show some randomness.The conventional method that using combinations of some special static loads to perform the strength design of TBM cutterhead may lead to strength failure during working practice.In this paper,a three-dimensional finite element model for coupled Cutterhead–Rock is developed to determine the cutterhead loads.Then the distribution characteristics and the influence factors of cutterhead loads are analyzed based on the numerical results.It is found that,as time changes,the normal and tangential forces acting on cutters and the total torque acting on the cutterhead approximately distribute log normally,while the total thrusts acting on the cutterhead approximately show a normal distribution.Furthermore,the statistical average values of cutterhead loads are proportional to the uniaxial compressive strength(UCS)of cutting rocks.The values also change with the penetration and the diameter of cutterhead following a power function.Based on these findings,we propose a three-parameter model for the mean of cutterhead loads and a method of generating the random cutter forces.Then the strength properties of a typical cutterhead are analyzed in detail using loads generated by the new method.The optimized cutterhead has been successfully applied in engineering.The method in this paper may provide a useful reference for the strength design of TBM cutterhead. 展开更多
关键词 TBM cutterhead Strength design Numerical simulation Three-parameter model random cutter forces
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Research on Optimal Design for Reliability of Fuze Components
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作者 张涛 汪波 《Defence Technology(防务技术)》 SCIE EI CAS 2009年第4期277-280,共4页
Reliability optimal design is an integrated approach widely adopted in engineering. The fuze components are designed by a BP neural network combined with an optimal design approach based on their multi-failure modes. ... Reliability optimal design is an integrated approach widely adopted in engineering. The fuze components are designed by a BP neural network combined with an optimal design approach based on their multi-failure modes. Their reliability probabilities in multi-failure modes are transformed into deterministic design parameters. The designed results by an example of optimizing the fuze spring under a certain reliability show that the integrated approach is practical and efficient. 展开更多
关键词 system engineering reliability design neural network fuze components random simulation
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具有灵活性的指定验证者云审计方案
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作者 赵巨涛 常金勇 《计算机应用与软件》 北大核心 2025年第4期335-339,共5页
在最近的研究工作中,Yan等[13]设计了一个具有指定验证者的云审计协议。研究发现,Yan等的协议具有很高的通信冗余。为了降低这一通信冗余,提出一种具有灵活性的改进方案,该方案将多个数据段对应的标签进行“聚合”,从而可以极大地减少... 在最近的研究工作中,Yan等[13]设计了一个具有指定验证者的云审计协议。研究发现,Yan等的协议具有很高的通信冗余。为了降低这一通信冗余,提出一种具有灵活性的改进方案,该方案将多个数据段对应的标签进行“聚合”,从而可以极大地减少通信冗余。同时,基于计算性的Diffie-Hellman假设给出了改进方案的安全性证明。通过具体实例展示了改进后的方案在整体通信冗余上比Yan等的协议有明显降低。 展开更多
关键词 云审计方案 指定验证者 随机谕言机模型 云存储
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共享随机丢包信道下多输入系统均方可镇定–调度与控制协同设计
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作者 邬依林 沈志萍 +2 位作者 赵倩 张谦 张菲菲 《控制理论与应用》 北大核心 2025年第5期989-998,共10页
借助有限容量信道进行设备间信息交互的网络化系统,其整体性能依赖于控制策略和通信机制.本文基于调度与控制协同设计思想,解决多个输入在共享数量有限的通信信道场景下,所面临的网络化系统反馈控制镇定问题.其中,每个通信信道建模为随... 借助有限容量信道进行设备间信息交互的网络化系统,其整体性能依赖于控制策略和通信机制.本文基于调度与控制协同设计思想,解决多个输入在共享数量有限的通信信道场景下,所面临的网络化系统反馈控制镇定问题.其中,每个通信信道建模为随机丢包模型.首先,根据多控制器系统性质,将多输入系统通过共享信道状态反馈可镇定问题,转化为切换线性系统在一个调度周期内可镇定问题.其次,针对多个输入共享单个随机丢包信道的情况,采用等价转变思想,将闭环系统的稳定性问题转化为易于求解的线性算子的稳定性问题.进一步,根据系统旺纳姆分解技术和系统最优补灵敏度,构造出适当的调度策略和控制器,从而推导出网络化系统可镇定的充分条件,该条件用丢包率与系统不稳定度关系来表示.然后,将上述结论推广到多个输入共享多个随机丢包信道情况.接下来,根据控制不等式理论、线性编码和解码技术,给出均匀调度策略下网络化系统可镇定时丢包率需要满足的条件.最后,通过数值算例和仿真结果,验证了所得结论的合理性. 展开更多
关键词 网络化控制系统 随机丢包 均方可镇定 协同设计 调度
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Small-Scale CMOS Pseudo SRAM Module Design
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作者 李昀 刘振宇 韩月秋 《Journal of Beijing Institute of Technology》 EI CAS 2004年第2期127-130,共4页
An approach to design small scale CMOS static random access memory (SRAM) is proposed. The design of address decoder, memory cell, and the layout are included. This approach adopts flip-flop array structure. The flip-... An approach to design small scale CMOS static random access memory (SRAM) is proposed. The design of address decoder, memory cell, and the layout are included. This approach adopts flip-flop array structure. The flip-flops are used as the storage cells and they are stacked to form the whole SRAM module. The word select bit is generated from the address decoder. And one word at a time is selected for reading or writing. The design of the memory core's layout is also discussed since it should be optimized to save area and also should be convenient for realization. It's a full-custom layout. The address decoder is composed of combinational logic circuit and its layout is also designed as a full-custom layout. With all these modules, the integral structure of the SRAM is carried out. 展开更多
关键词 static random access memory (SRAM) memory core address decoder layout module design
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车载精密设备三维隔振系统设计、仿真及试验研究 被引量:1
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作者 程辉 梁珂 +2 位作者 李伟 文湘隆 张锦光 《中国工程机械学报》 北大核心 2025年第2期309-314,共6页
针对车载精密设备在机动环境下的振动响应,在已知设备特性和隔振性能要求的限制条件下,提出了一种基于弹簧与橡胶结构的新型组合式隔振器,然后通过并联隔振器设计了一款车载精密设备三维隔振系统。本文建立了隔振系统的三维模型,基于ABA... 针对车载精密设备在机动环境下的振动响应,在已知设备特性和隔振性能要求的限制条件下,提出了一种基于弹簧与橡胶结构的新型组合式隔振器,然后通过并联隔振器设计了一款车载精密设备三维隔振系统。本文建立了隔振系统的三维模型,基于ABAQUS分析了横向、纵向、垂向3个方向下系统的隔振性能,得到三向均方根加速度衰减率分别为0.82、0.94、0.93。同时,随机振动试验结果表明,三向均方根加速度衰减率分别为0.88、0.75、0.87,与仿真结果对比,误差均在10%以内,验证了仿真结果的准确性,满足了车载精密设备减振的需求。 展开更多
关键词 车载精密设备 随机振动 减振设计 有限元仿真
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《外科随机对照试验的统计与方法指南》解读:基于JAMA Surgery的报道(一) 被引量:1
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作者 胥月晴 孔雕 +2 位作者 彭伟 李川 文天夫 《中国普外基础与临床杂志》 2025年第1期28-34,共7页
为了应对外科临床研究中长期存在的挑战,现对2022-2023年期间在JAMA Surgery发表的关于随机对照试验(randomized controlled trials,RCT)方法指导的系列文章进行了深入解读。本部分内容重点介绍了RCT的设计、选择、伦理考量、质量控制... 为了应对外科临床研究中长期存在的挑战,现对2022-2023年期间在JAMA Surgery发表的关于随机对照试验(randomized controlled trials,RCT)方法指导的系列文章进行了深入解读。本部分内容重点介绍了RCT的设计、选择、伦理考量、质量控制、预算、经费支持等方面的内容,旨在增强研究者,特别是外科医生对RCT的全面理解,从而为临床外科医生开展更高质量和更具科学性的RCT研究提供方法学指导。 展开更多
关键词 随机对照试验 设计 伦理 质量控制 经费支持
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偏头痛中医临床研究思路与关键问题思考 被引量:1
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作者 吴宏赟 支洪伟 +4 位作者 李海涛 崔文强 魏盛 徐向青 张继伟 《山东中医药大学学报》 2025年第2期184-188,共5页
中医治疗偏头痛具有多层次、多靶点、多途径的特点。梳理中医防治偏头痛临床研究思路,加强随机对照试验和真实世界研究相结合的偏头痛临床疗效评价,加强以脑功能影像为实验手段的偏头痛中医临床机制研究,基于方法学进展探索新型临床设... 中医治疗偏头痛具有多层次、多靶点、多途径的特点。梳理中医防治偏头痛临床研究思路,加强随机对照试验和真实世界研究相结合的偏头痛临床疗效评价,加强以脑功能影像为实验手段的偏头痛中医临床机制研究,基于方法学进展探索新型临床设计方案。厘清中医防治偏头痛研究中存在的关键问题,规范临床研究设计和实施,保障中医证候诊断客观性和可重复性,合理设置安慰剂对照,制定体现中医特色的疗效观察指标,建立科学的疗效评价体系,最终形成规范报告,将临床疗效提升为高水平循证证据,提升中医药服务能力。 展开更多
关键词 偏头痛 多靶点 随机对照试验 真实世界研究 规范研究设计 疗效指标 评价体系 中医药服务能力
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考虑混凝土强度随机退化的长寿命斜拉桥主梁目标可靠指标确定方法 被引量:2
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作者 张振浩 田勇 梁高明 《中国公路学报》 北大核心 2025年第1期199-212,共14页
针对混凝土斜拉桥长寿命设计时的材料参数取值以及PC主梁构件目标可靠指标取值问题,对混凝土强度的随机退化规律、考虑设计使用年限的材料参数取值方法、斜拉桥PC主梁构件考虑材料性能退化的目标可靠指标确定方法进行了研究。首先,基于... 针对混凝土斜拉桥长寿命设计时的材料参数取值以及PC主梁构件目标可靠指标取值问题,对混凝土强度的随机退化规律、考虑设计使用年限的材料参数取值方法、斜拉桥PC主梁构件考虑材料性能退化的目标可靠指标确定方法进行了研究。首先,基于相关实测数据,对冻融循环下混凝土抗压强度退化过程进行随机过程辨识,结果表明冻融循环下混凝土强度退化规律基本符合Gamma过程,并建立了Gamma过程辨识方法。其次,提出了一种考虑设计使用年限确定所需的材料性能值的方法。基于混凝土抗压强度退化基本服从Gamma过程的结论,获得混凝土性能退化过程在任意时间处的一维概率分布,根据其概率密度函数以α′=0.05分位值确定结构服役至设计使用年限时的混凝土强度退化量,从而确定能满足设计使用年限要求的混凝土抗压强度设计值。最后,在考虑混凝土强度退化及钢筋锈蚀、钢筋与混凝土协同工作能力退化的情况下计算斜拉桥PC主梁时变抗弯承载力;运用验算点法计算斜拉桥PC主梁的时变可靠指标,基于服役期可靠指标的退化量,建立了结构长寿命设计条件下考虑设计使用年限的斜拉桥PC主梁目标可靠指标确定方法。研究可为斜拉桥目标可靠指标合理定值提供参考。 展开更多
关键词 桥梁工程 斜拉桥 长寿命设计 性能随机退化 Gamma过程 材料参数设计值 目标可靠指标
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基于制导策略的多目标拦截器动力系统设计方法 被引量:1
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作者 李文韬 李文博 +3 位作者 何允钦 张艺仪 郑涵匀 梁国柱 《航空动力学报》 北大核心 2025年第7期437-453,共17页
为了进一步提升多目标拦截器(MOKV)固体姿轨控系统的能量管理的效能,获得其质量最小的总体方案,提出一种基于制导策略的MOKV动力系统设计方法。首先,提出一套基于线性协方差分析的多脉冲制导策略评估方法,可快速解析地确定每次机动所需... 为了进一步提升多目标拦截器(MOKV)固体姿轨控系统的能量管理的效能,获得其质量最小的总体方案,提出一种基于制导策略的MOKV动力系统设计方法。首先,提出一套基于线性协方差分析的多脉冲制导策略评估方法,可快速解析地确定每次机动所需的最大速度增量;然后,确定了对称双燃烧室三脉冲固体姿轨控动力系统的布局方案,具有结构简单、易于控制的特点;随后,给出了动力系统的性能参数模型和质量模型,建立了基于制导策略的动力系统优化设计流程。经过相图法迭代优化,可得到满足尺寸约束条件下的质量最优解,并进一步给出了子拦截器的设计指标。最后,针对典型应用场景开展案例设计并通过蒙特卡洛随机测试评估脱靶量。结果表明,案例MOKV可携带12枚子拦截器,总质量为49.43 kg,轴向尺寸为540.7 mm,径向尺寸为231.9 mm。三次脉冲点火后,MOKV最大脱靶量从千米级缩小至百米级直至十米级,可实现子拦截器精准拦截目标。所提出的理论与方法可为MOKV的高效能量管理和轻质化设计提供有力支撑。 展开更多
关键词 多目标拦截器 固体姿轨控系统 多脉冲制导策略 优化设计 蒙特卡罗随机测试
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基于数据挖掘的翼型气动隐身多学科分析 被引量:1
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作者 金世轶 陈树生 +1 位作者 杨华 高正红 《航空动力学报》 北大核心 2025年第8期160-173,共14页
在翼型气动隐身多学科设计中,涉及目标的多样性以及变量之间的相互耦合关系,增大了其优化设计的计算成本和研发周期。针对翼型升力系数、阻力系数、俯仰力矩系数、升阻比、垂直极化雷达散射面积、水平极化雷达散射面积这6个目标,开展了... 在翼型气动隐身多学科设计中,涉及目标的多样性以及变量之间的相互耦合关系,增大了其优化设计的计算成本和研发周期。针对翼型升力系数、阻力系数、俯仰力矩系数、升阻比、垂直极化雷达散射面积、水平极化雷达散射面积这6个目标,开展了基于随机森林、自适应增强集成学习、自组织映射、等度量映射这4种算法的数据挖掘。在目标与设计变量的分析中,翼型的气动隐身性能受设计变量前缘和后缘弯度影响较大,而受弦长段的影响次之。较大的前缘弯度可以减小阻力,改善隐身性能但增大俯仰力矩系数;较小的后缘弯度可以改善升力系数、升阻比和隐身性能,同时减小俯仰力矩系数。通过数据挖掘,给出了设计变量的具体参考范围以得到气动隐身性能较优的翼型。 展开更多
关键词 气动隐身设计 数据挖掘 随机森林 自适应增强算法 自组织映射 等度量映射
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阶梯设计整群随机对照试验项目报告清单解读
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作者 李航 左莹 +5 位作者 王科雯 孔德昭 王洋 刘悦 徐宁阳 张帆 《实用中医内科杂志》 2025年第6期115-120,共6页
阶梯设计整群随机对照试验(stepped wedge cluster randomizad trial,SW-CRTs)是公共卫生领域新兴的群组性随机对照试验方法,已在国内外健康医疗领域广泛应用。文章参照国际随机对照试验报告规范声明(CONSORT)及SW-CRTs的CONSORT扩展声... 阶梯设计整群随机对照试验(stepped wedge cluster randomizad trial,SW-CRTs)是公共卫生领域新兴的群组性随机对照试验方法,已在国内外健康医疗领域广泛应用。文章参照国际随机对照试验报告规范声明(CONSORT)及SW-CRTs的CONSORT扩展声明报告清单,全面整理、解读并例证,旨在为国内科研人员提供SW-CRTs研究的参考与借鉴。 展开更多
关键词 阶梯楔形设计 整群随机对照试验 SW-CRTs 报告清单 解读
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口服中药治疗支气管扩张症随机对照试验的文献特征及结局指标研究
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作者 王晓雨 冯贞贞 +3 位作者 王露 赵贵香 卫梦雨 李建生 《天津中医药》 2025年第11期1416-1424,共9页
[目的]系统梳理口服中药治疗支气管扩张症(简称“支扩”)随机对照试验(RCT)的文献特征及结局指标现状,为提高临床研究质量及构建核心指标集提供参考。[方法]计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国知网(CNKI... [目的]系统梳理口服中药治疗支气管扩张症(简称“支扩”)随机对照试验(RCT)的文献特征及结局指标现状,为提高临床研究质量及构建核心指标集提供参考。[方法]计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国知网(CNKI)、万方数据知识服务平台(Wangfang Database)、维普网(VIP)及中国生物医学文献服务系统(SinoMed)数据库中口服中药治疗支扩RCT相关文献,检索时间为2019年1月1日—2024年7月31日,提取基本信息、文献特征、结局指标等进行统计分析。[结果]共纳入117篇文献、9733例患者。1项为多中心研究,汤剂为最常用剂型,干预疗程多集中于8 d~2周,15篇文献提及随访,94篇文献报告患者中医证型。共得到106种结局指标,可归为9个指标域,总报告频次为889次,报告率前10位的指标依次是:有效率、不良反应、第1秒用力呼气容积(FEV1)、中医证候积分、C反应蛋白(CRP)、白细胞计数、用力肺活量(FVC)、FEV1/FVC、降钙素原(PCT)、中医症状积分。[结论]近5年口服中药治疗支扩RCT在研究方案设计及结局指标报告方面存在病例代表性差、疗程短、随访率低、辨证参考标准不一、结局指标应用不规范等诸多问题,未来仍需更多高质量RCT,同时需构建中医药治疗支扩核心指标集,以提高中医药循证证据质量。 展开更多
关键词 口服中药 支气管扩张症 随机对照试验 研究设计 结局指标
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