In the field of Raman spectroscopy detection,the quest for a non–noble metal,recyclable,and highly sensitive detection substrate is of utmost importance.In this work,a new crystalline and noble metal–free substrate ...In the field of Raman spectroscopy detection,the quest for a non–noble metal,recyclable,and highly sensitive detection substrate is of utmost importance.In this work,a new crystalline and noble metal–free substrate of[Bi(DMF)_(8)][PMo_(12)O_(40)](Bi–PMo_(12))is designed,which is composed of[PMo_(12)O_(40)]^(3−)and solvated[Bi(DMF)_(8)]^(3+)cations.Mechanistic studies have revealed that Raman scattering quenching phenomenon arises from two main factors.Firstly,it arises from the absorption of the scattered light due to the transition of a single electron in the reduced state of MoV between 4d orbitals.Secondly,after the interaction between the substrate and hydrazine,the surface undergoes varying degrees of roughening,leading to an impact on the scattered light intensity.These two effects collectively contribute to the detection of low concentrations of N_(2)H_(4).As a result,Bi–PMo_(12)opens up a novel Raman scattering quenching mechanism to realize the detection of reduced N_(2)H_(4)small molecules.A remarkably low detection limit of 4.5×10^(−9)ppm for N_(2)H_(4)is achieved on the Bi–PMo_(12)substrate.This detection has a lower concentration than the currently known SERS detection of N_(2)H_(4).Moreover,Bi–PMo_(12)can be recovered and reused through recrystallization,achieving a recovery rate of up to ca.51%.This study reveals the underlying potential of crystalline polyoxometalate materials in the field of Raman detection,thus opening up new avenues for highly sensitive analysis using Raman techniques.展开更多
In order to meet the high-resolution and wide spectrum range of the backscattering Raman system, this paper designs and builds a Raman test system based on the echelle spectrometer. In the optical splitting system, co...In order to meet the high-resolution and wide spectrum range of the backscattering Raman system, this paper designs and builds a Raman test system based on the echelle spectrometer. In the optical splitting system, compared with the ordinary planar grating spectrometer, the use of the echelle improves the resolution of the system without increasing the volume of the system. The use of intensified charge-coupled device(ICCD) in the detection system improves the signal-to-noise ratio(SNR) and the detection limit of weak spectrum. Finally, the Raman system was spectrally calibrated. The broadband backscattering Raman experimental results are given and discussed. The experimental results show that the system has an excellent application prospect for broadband and high-resolution Raman spectrum measurement.展开更多
The intrinsic property of MXenes to adsorb dyes with high Raman scattering cross-sections makes them promising candidates for surface-enhanced Raman scattering(SERS)biosensors.In the study,we report a vanadium carbide...The intrinsic property of MXenes to adsorb dyes with high Raman scattering cross-sections makes them promising candidates for surface-enhanced Raman scattering(SERS)biosensors.In the study,we report a vanadium carbide MXene(V_(2)CT_(x))-based SERS biosensor tag,V_(2)CT_(x)@Thi(thionine)@Au NPs(gold nanoparticles)-Ab(antibody),owing to its large interlayer spacing and superior dye adsorption capacity.The tag V_(2)CT_(x)@Thi@Au NPs-Ab was fully characterized and validated,demonstrating a significantly enhanced Raman signal through both electromagnetic and chemical enhancement mechanisms.Using a handheld Raman spectrometer as a readout tool,the developed handheld SERS biosensor was successfully applied for the detection of viral antigens.The biosensor exhibited excellent linearity(1.562–100 nM)and achieved a low limit of detection(LOD)1.562 nM.Moreover,the biosensor demonstrated good selectivity and stability for detecting the target S protein in saliva samples.Our study highlights the potential of V_(2)CT_(x)MXene as a powerful material for handheld SERS biosensors,paving the way for portable and efficient viral diagnostics.展开更多
In this Letter, the surface-enhanced Raman scattering(SERS) signal of early breast cancer(BRC) patient serum is obtained by a composite silver nanoparticles(Ag NPs) PSi Bragg reflector SERS substrate. Based on these a...In this Letter, the surface-enhanced Raman scattering(SERS) signal of early breast cancer(BRC) patient serum is obtained by a composite silver nanoparticles(Ag NPs) PSi Bragg reflector SERS substrate. Based on these advantages, the serum SERS signals of 30 normal people and 30 early BRC patients were detected by this substrate. After a baseline correction of the experimental data, principal component analysis and linear discriminant analysis were used to complete the data processing. The results showed that the diagnostic accuracy, specificity,and sensitivity of the composite Ag NPs PSi Bragg reflector SERS substrate were 95%, 96.7%, and 93.3%, respectively. The results of this exploratory study prove that the detection of early BRC serum based on a composite Ag NPs PSi Bragg reflector SERS substrate is with a stable strong SERS signal, and an unmarked and noninvasive BRC diagnosis technology. In the future, this technology can serve as a noninvasive clinical tool to detect cancer diseases and have a considerable impact on clinical medical detection.展开更多
Nowadays, there are about 415 million adults suffering from diabetesN. At present, the treatment for diabetes patients is monitoring their blood glucose level frequently and then taking the appropriate amount of oral ...Nowadays, there are about 415 million adults suffering from diabetesN. At present, the treatment for diabetes patients is monitoring their blood glucose level frequently and then taking the appropriate amount of oral hypogly- cemic drugs and insulin to control their blood glucose level.展开更多
Recently,various semiconductor/metal composites have been developed to fabricate surfaceenhanced Raman spectroscopy substrates.However,low metal loading on semiconductors is still a challenge.In this study,cystine was...Recently,various semiconductor/metal composites have been developed to fabricate surfaceenhanced Raman spectroscopy substrates.However,low metal loading on semiconductors is still a challenge.In this study,cystine was introduced to increase the accumulation of gold nanoparticles on zinc oxide,owing to the biomineralization_property of_cystine.Morphological analysis revealed that the obtained ZnO/Au/cystine composite not only had a higher metal loading but also formed a porous structure,which is beneficial for Raman performance.Compared with ZnO/Au,the ZnO/Au/cystine substrate displayed a 40-fold enhancement in the Raman signal and a lower limit of detection(10^(-11) mol·L^(-1))in the detection of rhodamine 6G.Moreover,the substrate has favorable homogeneity and stability.Finally,ZnO/Au/cystine displayed excellent performance toward crystal violet and methylene blue in a test based on river water samples.This study provided a promising method to fabricate sensitive semiconductor/noblemetal-based surface-enhanced Ramans spectroscopy substrates for Raman detection.展开更多
Mercury ion(Hg^(2+)),known as one of the highly toxic and soluble heavy metal ions,is causing serious environmental pollution and irreversible damage to the health.It is urgent to develop some rapid and ultrasensitive...Mercury ion(Hg^(2+)),known as one of the highly toxic and soluble heavy metal ions,is causing serious environmental pollution and irreversible damage to the health.It is urgent to develop some rapid and ultrasensitive methods for detecting trace mercury ions in the environment especially drink water.Surface-enhanced Raman scattering(SERS)is considered as a novel and powerful optical analysis technique since it has the significant advantages of ultra-sensitivity and high specificity.In recent years,the SERS technique and its application in the detection of Hg^(2+)have become more prevalent and compelling.This review provides an overall survey of the development of SERS-based Hg^(2+)detections and presents a summary relating to the basic principles,detection strategies,recent advances and current challenges of SERS for Hg^(2+)detections.展开更多
基金the financial support from the National Natural Science Foundation of China(No.21971085)the Natural Science Foundation of Shandong Province(No.ZR2021MB008)。
文摘In the field of Raman spectroscopy detection,the quest for a non–noble metal,recyclable,and highly sensitive detection substrate is of utmost importance.In this work,a new crystalline and noble metal–free substrate of[Bi(DMF)_(8)][PMo_(12)O_(40)](Bi–PMo_(12))is designed,which is composed of[PMo_(12)O_(40)]^(3−)and solvated[Bi(DMF)_(8)]^(3+)cations.Mechanistic studies have revealed that Raman scattering quenching phenomenon arises from two main factors.Firstly,it arises from the absorption of the scattered light due to the transition of a single electron in the reduced state of MoV between 4d orbitals.Secondly,after the interaction between the substrate and hydrazine,the surface undergoes varying degrees of roughening,leading to an impact on the scattered light intensity.These two effects collectively contribute to the detection of low concentrations of N_(2)H_(4).As a result,Bi–PMo_(12)opens up a novel Raman scattering quenching mechanism to realize the detection of reduced N_(2)H_(4)small molecules.A remarkably low detection limit of 4.5×10^(−9)ppm for N_(2)H_(4)is achieved on the Bi–PMo_(12)substrate.This detection has a lower concentration than the currently known SERS detection of N_(2)H_(4).Moreover,Bi–PMo_(12)can be recovered and reused through recrystallization,achieving a recovery rate of up to ca.51%.This study reveals the underlying potential of crystalline polyoxometalate materials in the field of Raman detection,thus opening up new avenues for highly sensitive analysis using Raman techniques.
基金supported by the Shaanxi Province Introduces Special Funds for Domestic Doctors (No.F2020221016)the Special Fund for Basic Scientific Research Business Expenses of Northwest Agriculture and Forestry University (No.Z1090321031)+1 种基金the National Natural Science Foundation of China (No.12004312)the Innovation and Entrepreneurship Training Program of Shanxi Province (Nos.S202010712512 and S202110712187)。
文摘In order to meet the high-resolution and wide spectrum range of the backscattering Raman system, this paper designs and builds a Raman test system based on the echelle spectrometer. In the optical splitting system, compared with the ordinary planar grating spectrometer, the use of the echelle improves the resolution of the system without increasing the volume of the system. The use of intensified charge-coupled device(ICCD) in the detection system improves the signal-to-noise ratio(SNR) and the detection limit of weak spectrum. Finally, the Raman system was spectrally calibrated. The broadband backscattering Raman experimental results are given and discussed. The experimental results show that the system has an excellent application prospect for broadband and high-resolution Raman spectrum measurement.
基金supported by the National Natural Science Foundation of China(No.82030065 to Qin Zhou)“Spring Goose”Talent Team Support Program of Heilongjiang Province(No.2022CYCX0202)+2 种基金Natural Science Foundation of Heilongjiang Province(Excellent Young Scholars Program,JJ2024YX0560)Funding Program for Preferential Returned Scholars of Heilongjiang Province(No.21032240006)Young Elite Scientist Sponsorship Program of Heilongjiang Province(No.20240NTJ018)
文摘The intrinsic property of MXenes to adsorb dyes with high Raman scattering cross-sections makes them promising candidates for surface-enhanced Raman scattering(SERS)biosensors.In the study,we report a vanadium carbide MXene(V_(2)CT_(x))-based SERS biosensor tag,V_(2)CT_(x)@Thi(thionine)@Au NPs(gold nanoparticles)-Ab(antibody),owing to its large interlayer spacing and superior dye adsorption capacity.The tag V_(2)CT_(x)@Thi@Au NPs-Ab was fully characterized and validated,demonstrating a significantly enhanced Raman signal through both electromagnetic and chemical enhancement mechanisms.Using a handheld Raman spectrometer as a readout tool,the developed handheld SERS biosensor was successfully applied for the detection of viral antigens.The biosensor exhibited excellent linearity(1.562–100 nM)and achieved a low limit of detection(LOD)1.562 nM.Moreover,the biosensor demonstrated good selectivity and stability for detecting the target S protein in saliva samples.Our study highlights the potential of V_(2)CT_(x)MXene as a powerful material for handheld SERS biosensors,paving the way for portable and efficient viral diagnostics.
基金the National Natural Science Foundation of China (Nos. 61665012,61575168,61765014)the International Science Cooperation Project of the Ministry of Education of the People’s Republic of China (No. 2016–2196)the Reserve Talents Project of National High-level Personnel of the Special Support Program (No. QN2016YX0324)。
文摘In this Letter, the surface-enhanced Raman scattering(SERS) signal of early breast cancer(BRC) patient serum is obtained by a composite silver nanoparticles(Ag NPs) PSi Bragg reflector SERS substrate. Based on these advantages, the serum SERS signals of 30 normal people and 30 early BRC patients were detected by this substrate. After a baseline correction of the experimental data, principal component analysis and linear discriminant analysis were used to complete the data processing. The results showed that the diagnostic accuracy, specificity,and sensitivity of the composite Ag NPs PSi Bragg reflector SERS substrate were 95%, 96.7%, and 93.3%, respectively. The results of this exploratory study prove that the detection of early BRC serum based on a composite Ag NPs PSi Bragg reflector SERS substrate is with a stable strong SERS signal, and an unmarked and noninvasive BRC diagnosis technology. In the future, this technology can serve as a noninvasive clinical tool to detect cancer diseases and have a considerable impact on clinical medical detection.
基金supported by the National Natural Science Foundation of China(NSFC)under Grant No.61308086
文摘Nowadays, there are about 415 million adults suffering from diabetesN. At present, the treatment for diabetes patients is monitoring their blood glucose level frequently and then taking the appropriate amount of oral hypogly- cemic drugs and insulin to control their blood glucose level.
基金the National Natural Science Foundation of China(Grant Nos.21621004 and 22178260)the Tianjin Development Program for Innovation and Entrepreneurship(2018)the Cooperative Program of Technical Center of Gongbei Customs District of China(Grant No.2020GKF-0281).
文摘Recently,various semiconductor/metal composites have been developed to fabricate surfaceenhanced Raman spectroscopy substrates.However,low metal loading on semiconductors is still a challenge.In this study,cystine was introduced to increase the accumulation of gold nanoparticles on zinc oxide,owing to the biomineralization_property of_cystine.Morphological analysis revealed that the obtained ZnO/Au/cystine composite not only had a higher metal loading but also formed a porous structure,which is beneficial for Raman performance.Compared with ZnO/Au,the ZnO/Au/cystine substrate displayed a 40-fold enhancement in the Raman signal and a lower limit of detection(10^(-11) mol·L^(-1))in the detection of rhodamine 6G.Moreover,the substrate has favorable homogeneity and stability.Finally,ZnO/Au/cystine displayed excellent performance toward crystal violet and methylene blue in a test based on river water samples.This study provided a promising method to fabricate sensitive semiconductor/noblemetal-based surface-enhanced Ramans spectroscopy substrates for Raman detection.
基金the National Basic Research Program of China(2012CB933301)the National Natural Science Foundation of China(21475064)+4 种基金the Natural Science Foundation of Jiangsu Province of China(BM2012010)the Natural Science Fund for Colleges and Universities in Jiangsu Province(13KJB140009)the Sci-tech Support Plan of Jiangsu Province(BE2014719)the Research Innovation Program for College Graduates of Jiangsu Province(SJZZ15_0107)the Priority Academic Program Development of Jiangsu Higher Education Institutions(YX03001)
文摘Mercury ion(Hg^(2+)),known as one of the highly toxic and soluble heavy metal ions,is causing serious environmental pollution and irreversible damage to the health.It is urgent to develop some rapid and ultrasensitive methods for detecting trace mercury ions in the environment especially drink water.Surface-enhanced Raman scattering(SERS)is considered as a novel and powerful optical analysis technique since it has the significant advantages of ultra-sensitivity and high specificity.In recent years,the SERS technique and its application in the detection of Hg^(2+)have become more prevalent and compelling.This review provides an overall survey of the development of SERS-based Hg^(2+)detections and presents a summary relating to the basic principles,detection strategies,recent advances and current challenges of SERS for Hg^(2+)detections.
