[Objective]The paper was to analyze the correlation between drug resistance and resistant genotypes of pathogenic Klebsiella peneumoniae from racoon dog to fluoroquinolones.[Method]The drug resistance and resistant ge...[Objective]The paper was to analyze the correlation between drug resistance and resistant genotypes of pathogenic Klebsiella peneumoniae from racoon dog to fluoroquinolones.[Method]The drug resistance and resistant genes of 24 strains of pathogenic K.peneumoniae from racoon dog to fluoroquinolones were detected by K-B drug susceptibility paper and PCR.[Result]Multiple drug-resistant strains were dominant among 24 strains of pathogenic K.peneumoniae,and the drug resistance to levofloxacin,enrofloxacin,ciprofloxacin and norfloxacin was 70.8%-79.2%;the strains resistant to 4,3 and 2 antibiotics were 58.3%,29.2%and 8.3%,respectively.The detection rates of drug-resistant genes TEM,gyrB,parC,parE,gyrA and SHV were 75%-100%,and the number of strains carrying 9,8,7,6,4 and 3 drug-resistant genes was 4.2%-41.7%.Comparison of drug-resistant genes and drug resistance showed that the coincidence rates of levofloxacin,enrofloxacin,ciprofloxacin and norfloxacin were 78.9%-100%.[Conclusion]There were certain correlation between drug resistance and resistant genotypes of 24 strains of pathogenic Klebsiella peneumo-niae to fluoroquinolones.展开更多
基金Supported by Project of Hebei Department of Science and Technology(18246629G)Project of Shijiazhuang Science and Technology Bureau(171500953A)Project of Hebei Department of Education(ZD2017234)
文摘[Objective]The paper was to analyze the correlation between drug resistance and resistant genotypes of pathogenic Klebsiella peneumoniae from racoon dog to fluoroquinolones.[Method]The drug resistance and resistant genes of 24 strains of pathogenic K.peneumoniae from racoon dog to fluoroquinolones were detected by K-B drug susceptibility paper and PCR.[Result]Multiple drug-resistant strains were dominant among 24 strains of pathogenic K.peneumoniae,and the drug resistance to levofloxacin,enrofloxacin,ciprofloxacin and norfloxacin was 70.8%-79.2%;the strains resistant to 4,3 and 2 antibiotics were 58.3%,29.2%and 8.3%,respectively.The detection rates of drug-resistant genes TEM,gyrB,parC,parE,gyrA and SHV were 75%-100%,and the number of strains carrying 9,8,7,6,4 and 3 drug-resistant genes was 4.2%-41.7%.Comparison of drug-resistant genes and drug resistance showed that the coincidence rates of levofloxacin,enrofloxacin,ciprofloxacin and norfloxacin were 78.9%-100%.[Conclusion]There were certain correlation between drug resistance and resistant genotypes of 24 strains of pathogenic Klebsiella peneumo-niae to fluoroquinolones.
