目的基于药品再评价上报管理系统分析参芪扶正注射液的RWS(real world study),为临床规范合理使用本品提供参考。方法对于在"药品再评价上报管理系统"进行填报的930例使用过参芪扶正注射液患者的信息进行归纳、整理,并运用统...目的基于药品再评价上报管理系统分析参芪扶正注射液的RWS(real world study),为临床规范合理使用本品提供参考。方法对于在"药品再评价上报管理系统"进行填报的930例使用过参芪扶正注射液患者的信息进行归纳、整理,并运用统计方法对适应证、用法用量、疗程、合并用药、不良反应等信息进行统计分析。结果参芪扶正注射液主要用于病情一般的患者,用量基本符合说明书要求,使用者中有过敏史者达13.87%。使用最多的疾病为肿瘤,达51.935%,其次是外科系统、心血管、消化、呼吸等系统疾病。71.720%患者适应证基本符合说明书要求,20.654%患者完全符合。气虚、血瘀、阴虚等为最常见7个主要证候因素,气虚出现频率为73.441%;有85.806%的患者证候基本符合说明书,49.785%患者证候完全符合。平均使用疗程(8.7±2.41)d,其中疗程≤3 d的占20.000%,≤7 d的占62.151%,≤10 d的占73.225%,>14 d的占11.613%。合并用药率达96.451%,同时合并其他注射剂静脉给药者为60.537%;合并中药注射剂静脉给药者有33.225%,合并2种以上注射剂静脉给药者有31.616%;合并用药中超过30次的有苦参碱注射液、艾迪注射液、香菇多糖、甘露聚糖肽针和甘露聚糖肽针。3例发生不良反应,发生率为3.22‰,表现为全身过敏反应症状,程度均为轻、中度,经对症处理后消失,判断与本品很可能有关。存在非适应病、非适应证、超量使用和超疗程使用(>21 d)等4种不合理使用情况,比例分别为28.280%、14.194%、0.215%和2.473%。结论参芪扶正注射液临床应用非常广泛,多数患者符合说明书规定病症、用量、疗程,但仍然存在较多不合理用药现象,其安全性高,但临床使用仍要注意监测。展开更多
The monoclonal antibody (MAb) RWS4 specific to membrane-associated antigen of human gastric adenocarcinoma was purified by protein A-Sepharose 4B affinity chromatography and labeled with 131I by chloramine-T method. 1...The monoclonal antibody (MAb) RWS4 specific to membrane-associated antigen of human gastric adenocarcinoma was purified by protein A-Sepharose 4B affinity chromatography and labeled with 131I by chloramine-T method. 131-RWS,, was injected (65 μCi/10μg/0.2 ml, intraperitoneally) into the stomach cancer-bearing nude mice (solid tumor about 1 cm in diameter), and its biodistribution was studied by SPECT and gamma-counter over a peroid of 7 days. A clear image of transplanted tumor was observed on the 4th day, and the image became more clear on the 6th day. After SPECT scanning, the animals were killed on the 3rd to 7th day separately and radioactivity was detected in various organs. The ratios of T/NT were calculated. The results were shown as follows: tumor/blood, was 3.41±0.29 on the 6th day and the tumor/other organs (liver, spleen, stomach, lung, heart, kidney and brain etc.) were>3. The specificity of the 131I-RWS4 was 7.74±0.65.展开更多
In complex water environments,search tasks often involve multiple Autonomous Underwater Vehicles(AUVs),and a single centralized control cannot handle the complexity and computational burden of large-scale systems.Targ...In complex water environments,search tasks often involve multiple Autonomous Underwater Vehicles(AUVs),and a single centralized control cannot handle the complexity and computational burden of large-scale systems.Target search in complex water environments has always been a major challenge in the field of underwater robots.To address this problem,this paper proposes a multi-biomimetic robot fish collaborative target search method based on Distributed Model Predictive Control(DMPC).First,we established a bionic robot fish kinematic model and a multi-biomimetic robot fish communication model;second,this paper proposed a distributed model predictive control algorithm based on the distributed search theory framework,so that the bionic robot fish can dynamically adjust their search path according to each other’s position information and search status,avoid repeated coverage or missing areas,and thus improve the search efficiency;third,we conducted simulation experiments based on DMPC,and the results showed that the proposed method has a target search success rate of more than 90%in static targets,dynamic targets,and obstacle environments.Finally,we compared this method with Centralized Model Predictive Control(CMPC)and Random Walk(RW)algorithms.The DMPC approach demonstrates significant advantages,achieving a remarkable target search success rate of 94.17%.These findings comprehensively validate the effectiveness and superiority of the proposed methodology.It can be seen that DMPC can effectively dispatch multiple bionic robot fish to work together to achieve efficient search of vast waters.It can significantly improve the flexibility,scalability,robustness and cooperation efficiency of the system and has broad application prospects.展开更多
This paper investigates the asymptotic behavior of high-order vector rogue wave(RW)solutions for any multi-component nonlinear Schr¨odinger equation(denoted as n-NLSE)with multiple internal large parameters.We re...This paper investigates the asymptotic behavior of high-order vector rogue wave(RW)solutions for any multi-component nonlinear Schr¨odinger equation(denoted as n-NLSE)with multiple internal large parameters.We report some novel RW patterns,including nonmultiple root(NMR)-type patterns with distinct shapes such as semicircular sector,acute sector,pseudo-hexagram,and pseudo-rhombus shapes,as well as multiple root(MR)-type patterns characterized by right double-arrow and right arrow shapes.We demonstrate that these RW patterns are intrinsically related to the root structures of a novel class of polynomials,termed generalized mixed Adler-Moser(GMAM)polynomials,which feature multiple arbitrary free parameters.The RW patterns can be interpreted as straightforward expansions and slight shifts of the root structures for the GMAM polynomials to some extent.In the(x,t)-plane,they asymptotically converge to a first-order RW at the location corresponding to each simple root of the polynomials and to a lower-order RW at the location associated with each multiple root.Notably,the position of the lower-order RW within these patterns can be flexibly adjusted to any desired location in the(x,t)-plane by tuning the free parameters of the corresponding GMAM polynomials.展开更多
Wolfberry(Lycium barbarum L.)is a medicinal herb with anti-aging and neuroprotective effects.The purpose of this study was to explore the enhanced neuroprotective effects of red wolfberry water extract(RW),and brown w...Wolfberry(Lycium barbarum L.)is a medicinal herb with anti-aging and neuroprotective effects.The purpose of this study was to explore the enhanced neuroprotective effects of red wolfberry water extract(RW),and brown wolfberry water extract(BBW).The reduced percentage of reducing sugar in BBW was shown to be 62.8%,64.3%,39.8%,and 11.6%for glucose,fructose,maltose,and lactose compared to those of RW,as well as free amino acids.And the contents of total phenols and total flavonoids were increased by 62.0%and 51.0%.Melanoidins(1.00%)were first isolated from BBW.RW and BBW increased anti-stress abilities(oxidative stress:24.2%vs.35.7%,and heat stress:17.78%vs.57.57%)while decreasing the reactive oxygen species(ROS)levels in vivo.RW and BBW reduced the rate of paralysis and odor cognitive deficits.At the same time,RW and BBW reduced the number of fluorescent spots of Aβ::GFP.The RW and BBW activated autophagy by upregulating the gene levels(bec-1,lgg-1,lgg-2,unc-51,vps-34,atg-5,atg-18,and sqst-1).Additionally,BBW promoted the nuclear-cytoplasmic ratio of DAF-16::GFP and fluorescence intensity of SOD-3::GFP by 39.4 and 1.16 fold.This study laid a new insight for exploring the Maillard reaction in improving the anti-Alzheimer’s disease(AD)activity of wolfberry.展开更多
自20世纪末提出真实世界研究(real-world study,RWS)的概念至今,这一基于临床实际的研究方法近年来愈发受到关注。美国食品和药物管理局(Food and Drug Administration,FDA)在2016—2019年颁布的一系列文件,肯定了真实世界证据(real wor...自20世纪末提出真实世界研究(real-world study,RWS)的概念至今,这一基于临床实际的研究方法近年来愈发受到关注。美国食品和药物管理局(Food and Drug Administration,FDA)在2016—2019年颁布的一系列文件,肯定了真实世界证据(real world evidence,RWE)在医药和生物制品审批和监管中的作用,推动RWS成为临床研究的热点。展开更多
文摘The monoclonal antibody (MAb) RWS4 specific to membrane-associated antigen of human gastric adenocarcinoma was purified by protein A-Sepharose 4B affinity chromatography and labeled with 131I by chloramine-T method. 131-RWS,, was injected (65 μCi/10μg/0.2 ml, intraperitoneally) into the stomach cancer-bearing nude mice (solid tumor about 1 cm in diameter), and its biodistribution was studied by SPECT and gamma-counter over a peroid of 7 days. A clear image of transplanted tumor was observed on the 4th day, and the image became more clear on the 6th day. After SPECT scanning, the animals were killed on the 3rd to 7th day separately and radioactivity was detected in various organs. The ratios of T/NT were calculated. The results were shown as follows: tumor/blood, was 3.41±0.29 on the 6th day and the tumor/other organs (liver, spleen, stomach, lung, heart, kidney and brain etc.) were>3. The specificity of the 131I-RWS4 was 7.74±0.65.
基金funded by National Natural Science Foundation of China(Nos.62473236,62073196).
文摘In complex water environments,search tasks often involve multiple Autonomous Underwater Vehicles(AUVs),and a single centralized control cannot handle the complexity and computational burden of large-scale systems.Target search in complex water environments has always been a major challenge in the field of underwater robots.To address this problem,this paper proposes a multi-biomimetic robot fish collaborative target search method based on Distributed Model Predictive Control(DMPC).First,we established a bionic robot fish kinematic model and a multi-biomimetic robot fish communication model;second,this paper proposed a distributed model predictive control algorithm based on the distributed search theory framework,so that the bionic robot fish can dynamically adjust their search path according to each other’s position information and search status,avoid repeated coverage or missing areas,and thus improve the search efficiency;third,we conducted simulation experiments based on DMPC,and the results showed that the proposed method has a target search success rate of more than 90%in static targets,dynamic targets,and obstacle environments.Finally,we compared this method with Centralized Model Predictive Control(CMPC)and Random Walk(RW)algorithms.The DMPC approach demonstrates significant advantages,achieving a remarkable target search success rate of 94.17%.These findings comprehensively validate the effectiveness and superiority of the proposed methodology.It can be seen that DMPC can effectively dispatch multiple bionic robot fish to work together to achieve efficient search of vast waters.It can significantly improve the flexibility,scalability,robustness and cooperation efficiency of the system and has broad application prospects.
基金supported by the NSFC(12471236)the Guangzhou Municipal Science and Technology Project(Guangzhou Science and Technology Plan,No.2024A04J6245)Guangdong Natural Science Foundation(2025A1515011868)。
文摘This paper investigates the asymptotic behavior of high-order vector rogue wave(RW)solutions for any multi-component nonlinear Schr¨odinger equation(denoted as n-NLSE)with multiple internal large parameters.We report some novel RW patterns,including nonmultiple root(NMR)-type patterns with distinct shapes such as semicircular sector,acute sector,pseudo-hexagram,and pseudo-rhombus shapes,as well as multiple root(MR)-type patterns characterized by right double-arrow and right arrow shapes.We demonstrate that these RW patterns are intrinsically related to the root structures of a novel class of polynomials,termed generalized mixed Adler-Moser(GMAM)polynomials,which feature multiple arbitrary free parameters.The RW patterns can be interpreted as straightforward expansions and slight shifts of the root structures for the GMAM polynomials to some extent.In the(x,t)-plane,they asymptotically converge to a first-order RW at the location corresponding to each simple root of the polynomials and to a lower-order RW at the location associated with each multiple root.Notably,the position of the lower-order RW within these patterns can be flexibly adjusted to any desired location in the(x,t)-plane by tuning the free parameters of the corresponding GMAM polynomials.
基金supported by grants from Tianjin Science and Technology Plan Project(22ZYQYSY00030)Tianjin Municipal Health Technology Project(TJWJ2022XK04)+1 种基金Tianjin Key Medical Discipline(Specialty)Construction Project(TJYXZDXK-062B)Shandong Provincial Natural Science Foundation,China(ZR2023QC145).
文摘Wolfberry(Lycium barbarum L.)is a medicinal herb with anti-aging and neuroprotective effects.The purpose of this study was to explore the enhanced neuroprotective effects of red wolfberry water extract(RW),and brown wolfberry water extract(BBW).The reduced percentage of reducing sugar in BBW was shown to be 62.8%,64.3%,39.8%,and 11.6%for glucose,fructose,maltose,and lactose compared to those of RW,as well as free amino acids.And the contents of total phenols and total flavonoids were increased by 62.0%and 51.0%.Melanoidins(1.00%)were first isolated from BBW.RW and BBW increased anti-stress abilities(oxidative stress:24.2%vs.35.7%,and heat stress:17.78%vs.57.57%)while decreasing the reactive oxygen species(ROS)levels in vivo.RW and BBW reduced the rate of paralysis and odor cognitive deficits.At the same time,RW and BBW reduced the number of fluorescent spots of Aβ::GFP.The RW and BBW activated autophagy by upregulating the gene levels(bec-1,lgg-1,lgg-2,unc-51,vps-34,atg-5,atg-18,and sqst-1).Additionally,BBW promoted the nuclear-cytoplasmic ratio of DAF-16::GFP and fluorescence intensity of SOD-3::GFP by 39.4 and 1.16 fold.This study laid a new insight for exploring the Maillard reaction in improving the anti-Alzheimer’s disease(AD)activity of wolfberry.
文摘自20世纪末提出真实世界研究(real-world study,RWS)的概念至今,这一基于临床实际的研究方法近年来愈发受到关注。美国食品和药物管理局(Food and Drug Administration,FDA)在2016—2019年颁布的一系列文件,肯定了真实世界证据(real world evidence,RWE)在医药和生物制品审批和监管中的作用,推动RWS成为临床研究的热点。
