Several recent studies in Virologica Sinica and other journals have highlighted the enormous international challenge of emerging arboviral diseases,such as Zika virus disease,dengue,and chikungunya(Islam et al.,2015;M...Several recent studies in Virologica Sinica and other journals have highlighted the enormous international challenge of emerging arboviral diseases,such as Zika virus disease,dengue,and chikungunya(Islam et al.,2015;Maurice et al.,2015;Dai et al.,2016;Deng et al.,2016;Song et al.,2016;Wang et al.,2016;Xu et al.,2016;Zhang et al.,2016;Zhou展开更多
Left ventricular assist device (LVAD) is being used increasingly in recent years for end stage heart failure as a bridge to transplant (BTT) and also as a destination therapy (DT). Patients with end stage heart failur...Left ventricular assist device (LVAD) is being used increasingly in recent years for end stage heart failure as a bridge to transplant (BTT) and also as a destination therapy (DT). Patients with end stage heart failure have some degree of elevated pulmonary capillary wedge pressure, causing right ventricular hypertrophy which in due course leads to decreased dilatation of the RV and fall in cardiac output & severe tricuspid regurgitation (TR) presenting with features of RV failure (RVF). Implantation of LVAD improves left heart function at the cost of right ventricular output with an incidence of 25%-30%. RVF may lead to impaired LVAD flow, difficulty in weaning from cardio-pulmonary bypass (CPB), decreased tissue perfusion and multi-organ failure. In this article we comprehended the pathophysiology leading to RVF post LVAD implantation and its preoperative predictors and the various treatment modalities for managing RVF post LVAD implantation.展开更多
裂谷热(Rift Valley fever,RVF)是一种以蚊子为传播媒介的病毒性人兽共患传染病,可引发人致命性出血热和反刍动物大量死亡。对RVF流行情况的分析表明,近年来RVF疫情形势总体平稳,主要在非洲国家流行,且涉及人和多种动物。由于频繁的国...裂谷热(Rift Valley fever,RVF)是一种以蚊子为传播媒介的病毒性人兽共患传染病,可引发人致命性出血热和反刍动物大量死亡。对RVF流行情况的分析表明,近年来RVF疫情形势总体平稳,主要在非洲国家流行,且涉及人和多种动物。由于频繁的国际往来与贸易、病例报告不足与瞒报以及环境因素等,之前未受感染地区有很大的RVF传入风险。目前暂无批准的RVF疫苗用于接种人,仅在个别流行国家允许使用动物疫苗,提示生活在流行地区和去流行地区旅行的人员应提高对该病暴露风险的认识,做好相关生物安全防控。在我国,人员流动和动物国际贸易等活动加剧了RVF传入风险,同时也存在自然发生RVF疫情的风险。因此,应制定并严格执行进口动物生物安全防控制度,加快疫苗和检测技术研究,同时结合“同一健康”计划,做好流行风险评估与生物安全防控,降低RVF传入传播风险。展开更多
A collaborative team led by Profs George Fu Gao(高福)and Yan JingHua(严景华)from the Institute of Microbiology,Chinese Academy of Sciences(CAS),reported the identification of neutralizing monoclonal antibodies(MAbs)fr...A collaborative team led by Profs George Fu Gao(高福)and Yan JingHua(严景华)from the Institute of Microbiology,Chinese Academy of Sciences(CAS),reported the identification of neutralizing monoclonal antibodies(MAbs)from a convalescent Rift Valley fever(RVF)patient,which facilitates the development of MAbs-based therapeutics and vaccines against Rift Valley fever virus(RVFV)infection.This work was published in Nature Microbiology(April 1st,2019),with the support from the National Natural Science Foundation of China and the Chinese Academy of Sciences.Drs.Wang QiHui(王奇慧),Chen ZhiHai(陈志海)and Wu Yan(吴燕),as well as Miss Ma Tong(马桐)contributed equally to this work.展开更多
基金supported in part by the National Natural Science Foundation of China(Grant No.31402224 and 31272564)the Public Welfare Special Funds for Agriculture Scientific Research(Grant No.201203039)the Modern Agro-Industry Technology Research System(CARS-36)
文摘Several recent studies in Virologica Sinica and other journals have highlighted the enormous international challenge of emerging arboviral diseases,such as Zika virus disease,dengue,and chikungunya(Islam et al.,2015;Maurice et al.,2015;Dai et al.,2016;Deng et al.,2016;Song et al.,2016;Wang et al.,2016;Xu et al.,2016;Zhang et al.,2016;Zhou
文摘Left ventricular assist device (LVAD) is being used increasingly in recent years for end stage heart failure as a bridge to transplant (BTT) and also as a destination therapy (DT). Patients with end stage heart failure have some degree of elevated pulmonary capillary wedge pressure, causing right ventricular hypertrophy which in due course leads to decreased dilatation of the RV and fall in cardiac output & severe tricuspid regurgitation (TR) presenting with features of RV failure (RVF). Implantation of LVAD improves left heart function at the cost of right ventricular output with an incidence of 25%-30%. RVF may lead to impaired LVAD flow, difficulty in weaning from cardio-pulmonary bypass (CPB), decreased tissue perfusion and multi-organ failure. In this article we comprehended the pathophysiology leading to RVF post LVAD implantation and its preoperative predictors and the various treatment modalities for managing RVF post LVAD implantation.
文摘裂谷热(Rift Valley fever,RVF)是一种以蚊子为传播媒介的病毒性人兽共患传染病,可引发人致命性出血热和反刍动物大量死亡。对RVF流行情况的分析表明,近年来RVF疫情形势总体平稳,主要在非洲国家流行,且涉及人和多种动物。由于频繁的国际往来与贸易、病例报告不足与瞒报以及环境因素等,之前未受感染地区有很大的RVF传入风险。目前暂无批准的RVF疫苗用于接种人,仅在个别流行国家允许使用动物疫苗,提示生活在流行地区和去流行地区旅行的人员应提高对该病暴露风险的认识,做好相关生物安全防控。在我国,人员流动和动物国际贸易等活动加剧了RVF传入风险,同时也存在自然发生RVF疫情的风险。因此,应制定并严格执行进口动物生物安全防控制度,加快疫苗和检测技术研究,同时结合“同一健康”计划,做好流行风险评估与生物安全防控,降低RVF传入传播风险。
基金supported by the Doctoral Subject Science Foundation of China(20136501110001)the National Natural Science Foundation of China(11271312,11401512,11261056)
文摘A collaborative team led by Profs George Fu Gao(高福)and Yan JingHua(严景华)from the Institute of Microbiology,Chinese Academy of Sciences(CAS),reported the identification of neutralizing monoclonal antibodies(MAbs)from a convalescent Rift Valley fever(RVF)patient,which facilitates the development of MAbs-based therapeutics and vaccines against Rift Valley fever virus(RVFV)infection.This work was published in Nature Microbiology(April 1st,2019),with the support from the National Natural Science Foundation of China and the Chinese Academy of Sciences.Drs.Wang QiHui(王奇慧),Chen ZhiHai(陈志海)and Wu Yan(吴燕),as well as Miss Ma Tong(马桐)contributed equally to this work.
