Heterodimerization in RTKs is of vital importance in the RTK signaling and cell functions.Heterodimerization between RTKs can result in diversity of downstream signals,increasing the ability of cells to respond to ext...Heterodimerization in RTKs is of vital importance in the RTK signaling and cell functions.Heterodimerization between RTKs can result in diversity of downstream signals,increasing the ability of cells to respond to external experiments.Traditional RTKs heterodimerization always occur in the same families and is lack of agonists to activate the heterodimeric RTKs signaling pathway.Herein,we developed the DNA agonist based on bivalent aptamers for the heterodimerized RTKs of different families,AF/AM-1,which could simultaneously activate FGFR1 and c-Met signaling.It is the first agonist that realizing the heterodimerization and activation of FGFR1 and c-Met,two different RTK families.The activation of FGFR1/c-Met heterodimer result in the down-stream signals transduction,such as the phosphorylation of Akt and Erk,inducing the cell migration and proliferation.The DNA agonist for RTK heterodimer of different families would have potential applications in the fields of biomedicine.展开更多
建设工程验位测量是城市规划管理与工程质量保障的核心技术支撑。文章以广电新景住宅小区项目为研究对象,系统分析RTK、全站仪、无人机倾斜摄影测量三种核心测绘方法的技术原理、实施流程及适配场景,通过多维度精度分析,三种方法在实际...建设工程验位测量是城市规划管理与工程质量保障的核心技术支撑。文章以广电新景住宅小区项目为研究对象,系统分析RTK、全站仪、无人机倾斜摄影测量三种核心测绘方法的技术原理、实施流程及适配场景,通过多维度精度分析,三种方法在实际项目应用中均实现点位平面位置精度优于5 c m的技术指标,为规划监管部门提供精准数据支持。展开更多
基金the National Natural Science Foundation of China(Nos.22104158,82174104,U1903211)the Natural Science Foundation of Hunan Province(No.2021JJ40041)+1 种基金Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011346)Shenzhen Science and Technology Program(No.SZBH202130)。
文摘Heterodimerization in RTKs is of vital importance in the RTK signaling and cell functions.Heterodimerization between RTKs can result in diversity of downstream signals,increasing the ability of cells to respond to external experiments.Traditional RTKs heterodimerization always occur in the same families and is lack of agonists to activate the heterodimeric RTKs signaling pathway.Herein,we developed the DNA agonist based on bivalent aptamers for the heterodimerized RTKs of different families,AF/AM-1,which could simultaneously activate FGFR1 and c-Met signaling.It is the first agonist that realizing the heterodimerization and activation of FGFR1 and c-Met,two different RTK families.The activation of FGFR1/c-Met heterodimer result in the down-stream signals transduction,such as the phosphorylation of Akt and Erk,inducing the cell migration and proliferation.The DNA agonist for RTK heterodimer of different families would have potential applications in the fields of biomedicine.
文摘建设工程验位测量是城市规划管理与工程质量保障的核心技术支撑。文章以广电新景住宅小区项目为研究对象,系统分析RTK、全站仪、无人机倾斜摄影测量三种核心测绘方法的技术原理、实施流程及适配场景,通过多维度精度分析,三种方法在实际项目应用中均实现点位平面位置精度优于5 c m的技术指标,为规划监管部门提供精准数据支持。
