Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functi...Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome(BAC)clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated.This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC,outlining their genomic origins,molecular mechanisms,and biological significance.We highlight their roles in metabolic reprogramming,microRNA network modulation,and tumor progression,as well as their diagnostic and prognostic value in tissue and serum-based analyses.Finally,we discuss therapeutic opportunities and propose future directions to translate RP11-derived lncRNAs into clinically actionable biomarkers and targets for precision liver cancer therapy.展开更多
提出用 API RP 11L推荐作法设计钢丝绳连续抽油杆采油系统中的抽油钢丝绳绳杆柱 ,推导了与钢抽油杆柱类似的振动系统模型和边界条件 ,给出了用 API设计方法设计钢丝绳采油系统绳杆柱的设计步骤 ,特别给出了设计参数 :绳杆柱的等效弹性...提出用 API RP 11L推荐作法设计钢丝绳连续抽油杆采油系统中的抽油钢丝绳绳杆柱 ,推导了与钢抽油杆柱类似的振动系统模型和边界条件 ,给出了用 API设计方法设计钢丝绳采油系统绳杆柱的设计步骤 ,特别给出了设计参数 :绳杆柱的等效弹性模量、等效密度、等效刚度以及固有频率的计算公式 ,并以一种国产抽油钢丝绳的基本参数为依据 ,给出了钢丝绳采油系统绳杆柱的频率系数表 ,利用现文的方法和数据 ,可以参照 API RP展开更多
基金supported by the National Research Foundation of Korea(NRF),funded by the Ministry of Science and ICT(MSIT),Republic of Korea(grant numbers:RS-2022-NR070489 and RS-2023-00210847)the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health and Welfare,Republic of Korea(grant number HR21C1003).
文摘Hepatocellular carcinoma(HCC)remains one of the most prevalent and lethal malignancies worldwide.Long non-coding RNAs(lncRNAs)have emerged as crucial regulators of gene expression and cancer progression,yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome(BAC)clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated.This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC,outlining their genomic origins,molecular mechanisms,and biological significance.We highlight their roles in metabolic reprogramming,microRNA network modulation,and tumor progression,as well as their diagnostic and prognostic value in tissue and serum-based analyses.Finally,we discuss therapeutic opportunities and propose future directions to translate RP11-derived lncRNAs into clinically actionable biomarkers and targets for precision liver cancer therapy.
文摘提出用 API RP 11L推荐作法设计钢丝绳连续抽油杆采油系统中的抽油钢丝绳绳杆柱 ,推导了与钢抽油杆柱类似的振动系统模型和边界条件 ,给出了用 API设计方法设计钢丝绳采油系统绳杆柱的设计步骤 ,特别给出了设计参数 :绳杆柱的等效弹性模量、等效密度、等效刚度以及固有频率的计算公式 ,并以一种国产抽油钢丝绳的基本参数为依据 ,给出了钢丝绳采油系统绳杆柱的频率系数表 ,利用现文的方法和数据 ,可以参照 API RP
