The paper tends to make an empirical analysis on the experimental site of new countryside construction of Xianhong in Hubei, pointing out that the inner and outer dependence on routines of experimental construction. T...The paper tends to make an empirical analysis on the experimental site of new countryside construction of Xianhong in Hubei, pointing out that the inner and outer dependence on routines of experimental construction. The paper also puts forward the beneficial policies, focusing on the agricultural production and fostering professional farmers, to reduce much dependence on routines.展开更多
Innovation is managed through the development of processes and routines, considered as critical for business success and value creation. The identification of relevant routines as well as the understanding of which fa...Innovation is managed through the development of processes and routines, considered as critical for business success and value creation. The identification of relevant routines as well as the understanding of which factors affect business innovation is the main objective of this research, based on a survey applied in Portuguese companies and their experience shared in best practices guides. Conclusions highlighted 10 key innovation routines, reinforcing the idea that innovation must be supported through a systematic and sustained management process. Results also indicate that SMEs face greater difficulties in benefiting from the potential of innovation practices and collaboration may present opportunities to overcome their limited resources. Therefore, regardless of size, business activity, science and technology intensity or other factors influencing firms dynamic capabilities, innovation should be considered as a management imperative as it can influence not only the present but also the future of business success.展开更多
This study employs a Q methodology to explore the developmental routines of oral English ability for 12 English major students in China inspired by Complex and Dynamic Systems Theory(CDST).The data analysis suggests t...This study employs a Q methodology to explore the developmental routines of oral English ability for 12 English major students in China inspired by Complex and Dynamic Systems Theory(CDST).The data analysis suggests the next findings:(1)two developmental patterns emerge as the gradual improvement and the strong phase shift influenced by internal and external factors for interactions among different subsystems;(2)guided by CDST,the study proves the importance of self-organization and initial condition in previous studies.According to the above findings,It is highly suggested for teachers to form a holistic view of students’oral English development concerning the non-linear characteristic and individual differences.展开更多
As an important part in unique resources and capability of enterprises, organizational routines, on one hand, promote the success of enterprises, on the other hand, influence the future development of enterprises. Esp...As an important part in unique resources and capability of enterprises, organizational routines, on one hand, promote the success of enterprises, on the other hand, influence the future development of enterprises. Especially, organizational routines have the influences on the two factors of building up dynamic competitive advantages-strategic change and strategic flexibility and further influence the establishment of dynamic competitive advantages. This paper involves detailed analysis on the influences of organizational routines and on the approaches of establishing dynamic competitive advantages and puts forward the relevant countermeasures.展开更多
你的日常活动是什么样的呢?试着记录并改善它们吧!Daily routines can help us live a healthier,more productive life,with a little bit of motivation and discipline.From taking some time to exercise and eat right to setting ...你的日常活动是什么样的呢?试着记录并改善它们吧!Daily routines can help us live a healthier,more productive life,with a little bit of motivation and discipline.From taking some time to exercise and eat right to setting aside other times to study and set goals,you’ll find yourself living a balanced,fulfilling lifestyle.Here are some examples of productive daily routines.展开更多
String validation routines have been widely used in many real-world applications,such as email validation and postcode validation.String test cases are adopted to test these validation routines,to identify potential d...String validation routines have been widely used in many real-world applications,such as email validation and postcode validation.String test cases are adopted to test these validation routines,to identify potential defects and security risks.Random Testing(RT)is a well-known testing approach to randomly generate string test cases from the input domain(i.e.,the set of all possible test inputs),which is simple to implement at a low cost.However,its testing effectiveness may be unsatisfactory for string validation routines.The main reason for this is that RT may have a high probability to generate invalid rather than valid string test cases,due to its randomness property.This research proposes a new RT approach based on the output types(i.e.,valid and invalid strings)for string validation routines,namely Output-type-guided Random Testing(RTO),which attempts to randomly generate both valid and invalid string test cases with a certain probability.This research performed an empirical study involving several real-world string validation routines collected from ten Java open-source projects,to investigate and compare testing performances of RT-O against the previous two widely-used RT methods.The results show that the generated string test cases by RT-O outperform test cases generated by other RT methods.展开更多
If you're tired of megacities that feel like nothing but glass,steel,and constant rush,Guangzhou moves at its own pace.Here,a 19th-century ancestral hall stands next to a 600-meter tower,and the day begins with te...If you're tired of megacities that feel like nothing but glass,steel,and constant rush,Guangzhou moves at its own pace.Here,a 19th-century ancestral hall stands next to a 600-meter tower,and the day begins with tea and delicate steamed treats instead of coffee.展开更多
Extant research mostly focuses on the impact of big data on product development(PD)process and performance,and yet there is a lack of theoretical exploration of the transformation path,realization mechanism and transf...Extant research mostly focuses on the impact of big data on product development(PD)process and performance,and yet there is a lack of theoretical exploration of the transformation path,realization mechanism and transformation paradigm while moving from experience-based PD(EBPD)to data-driven PD(DDPD).This paper,from the integrated perspective of adaptive change and organizational routines,and based on an in-depth case study of HSTYLE,proposes a two-stage transformation model for moving from EBPD to DDPD,dissects the adaptive change mechanism of organizational routines for DDPD,puts forward a theoretical model for the transformation paradigm for DDPD,and provides an innovative interpretation of the connotation of data-driven.This paper constructs a theory for DDPD transformation that comprises three aspects:transformation path,realization mechanism and transformation paradigm.Conclusions of this paper have policy implications for enterprises in their practice on data-driven product innovation in the digital economy era.展开更多
At the opening ceremony of the Beiig Paralympic Winter Games on the evening of March 4,90 performners,including hearing-impaired ones,put on a show called"Winter Paralympic Waltz."They danced gracefully,disp...At the opening ceremony of the Beiig Paralympic Winter Games on the evening of March 4,90 performners,including hearing-impaired ones,put on a show called"Winter Paralympic Waltz."They danced gracefully,displaying the friendship between people and the vitality of life.展开更多
OBJECTIVE:To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN)patients by literature research and expert investigation(interviews and a Delphi met...OBJECTIVE:To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN)patients by literature research and expert investigation(interviews and a Delphi method).METHODS:Our study was consistent with T/CACM 1336-2020.We searched the monographs and references published in the past 40 years(1983-2022),and established the diagnostic criteria pool of waterdampness syndrome and dampness-turbidity syndrome in Traditional Chinese Medicine(TCM)based on literature by using frequency statistics and correlation analysis.Expert investigation(interview method and two rounds of Delphi method)was used to form the diagnostic criteria of water-dampness syndrome and dampnessturbidity syndrome of idiopathic membranous nephropathy.Clinical diagnostic test research was carried out,and compared with“Diagnostic Criteria for dampness syndrome”(T/CACM 1454-2023)to evaluate the authenticity,reliability and clinical application value of the standard.RESULTS:A total of 122 relevant guides,standards,monographs and documents were included through searching books and Chinese databases.Four experts were interviewed and two rounds of delphi method(75 experts nationwide)were carried out.The experts'opinions are relatively concentrated and the differences are small.Based on the weight of each index,the diagnostic criteria indexes of water-dampness syndrome and dampness-turbidity syndrome were selected.After discussion by the core group members,the diagnostic model of"necessary symptoms and optional symptoms"was established,and the final diagnostic criteria of waterdampness syndrome and dampness-turbidity syndrome were established.One hundred and ninety-one inpatients and outpatients of Guangdong Provincial Hospital of Chinese Medicine from January 2021 to February 2023 were included in Diagnostic test study.There was no statistical difference in gender,age and course of disease(P>0.05).The sensitivity and specificity of the trial standard were 90.34%and 73.33%respectively,while the sensitivity and specificity of T/CACM 1454-2023 were 99.43%and 6.67%,respectively.CONCLUSIONS:The consensus-based diagnostic criteria for IMN can be widely incorporated in TCM.A further clinical study will be conducted to analyze the diagnosis value and cut-off score of our IMN criteria.展开更多
To evaluate the subchronic and chronic toxicity of Fuyanxiao capsules,Sprague-Dawley(SD)rats were used in toxicity studies.In the subchronic toxicity study,50 female rats were randomly divided into a high-dose group(5...To evaluate the subchronic and chronic toxicity of Fuyanxiao capsules,Sprague-Dawley(SD)rats were used in toxicity studies.In the subchronic toxicity study,50 female rats were randomly divided into a high-dose group(5.4g/kg/day)and a control group,with 15 rats in each,and medium(2.7g/kg/day)and low(1.35g/kg/day)dose groups,with 10 rats in each.The test substance was administered orally(mixed with feed,twice daily)for 90 consecutive days.In the chronic toxicity study,40 female rats were randomly divided into high,medium,and low dose groups and a control group,with 10 rats in each.The test substance was administered orally in the same manner for 180 consecutive days.Clinical signs,body weight,and food consumption were observed and recorded daily.At the end of the terminal phase(the first 10 rats from each group,1 day after the last dose)and the recovery phase(the last 5 rats from the control group and the high-dose group,observed for an additional 28 days after the last dose),blood and urine samples,as well as organs,were collected.Organ coefficients were calculated,and various hematological and urinary indicators were detected,followed by pathological analysis.The results showed that there were no significant differences in body weight,food consumption,or organ coefficients between any of the dose groups and the control group in both subchronic and chronic toxicity studies(P>0.05).Histopathological examination revealed no lesions,suggesting no tissue or organ damage in any of the dose groups.The rats exhibited good mental status,and hematological and urinary physiological indicators were within normal ranges,indicating stable liver and kidney function,hematopoietic system of the bone marrow,and internal environment in all dose groups.Therefore,Fuyanxiao capsule has no obvious subchronic or chronic toxicity in SD rats,and it is safe and reliable to use at reasonable dosage in clinical practice.展开更多
Tom is an American student.He is ten years old.But he does not live in the USA now.He lives with his father,mother and grandfather in a small city in China.Tom has a Chinese name,Tang Mu.He is in Grade Three at a prim...Tom is an American student.He is ten years old.But he does not live in the USA now.He lives with his father,mother and grandfather in a small city in China.Tom has a Chinese name,Tang Mu.He is in Grade Three at a primary school.He goes to school from Monday to Friday.Every morning,he gets up at 6:30.He brushes his teeth and washes his face.Then he has breakfast with his family.His parents often cook eggs and noodles.At 7:30,Tom goes to school.He walks to school with his best friend,Mike.Mike is a Chinese boy.His Chinese name is Ma Ke.Mike is his English name.Tom's house is to the left of Mike's.It is about 80 metres away from Mike's.展开更多
BACKGROUND Acute respiratory infections(ARI)and diarrhoea are among the leading causes of infant and under-five mortality worldwide.Zinc,the second most abundant trace element in the human body,is widely used in the t...BACKGROUND Acute respiratory infections(ARI)and diarrhoea are among the leading causes of infant and under-five mortality worldwide.Zinc,the second most abundant trace element in the human body,is widely used in the treatment of both conditions.It mitigates diarrhoea by restoring mucosal integrity and enhancing enterocyte brush border enzyme activity.In ARI,zinc boosts immune function,promotes epithelial regeneration,and inhibits the replication of respiratory viruses.AIM To assess the effectiveness of prophylactic intermittent zinc supplementation in preventing acute diarrhoea and ARI in infants.METHODS This open-label,randomized controlled trial with a 1:1 allocation ratio was conducted over 15 months(October 2022 to December 2023)at a tertiary care hospital in Eastern India.A total of 320 infants attending the outpatient department for routine vaccinations were enrolled and randomly assigned to intervention and control groups.The intervention group received zinc drops for two weeks,with the regimen repeated one month later and again at six months during subsequent vaccination visits.The control group received no placebo or alternative treatment.Outcomes were assessed after the final follow-up at nine months.RESULTS The mean annual incidence of ARI and diarrhoea was significantly lower in the zinc group than in the control group[ARI:0.25±0.61 vs 0.92±1.22;mean difference=-0.67(95%CI:-0.88 to-0.45),P<0.001,Cohen’s d=-0.69]and[diarrhoea:1.04±1.30 vs 2.07±2.09;mean difference=-1.03(95%CI:-1.42 to-0.65),P<0.001,Cohen's d=-0.59],respectively.Additionally,the zinc group showed significantly greater gains in length[10±0.6 cm vs 8.6±0.4 cm;mean difference=1.4(95%CI:1.3-1.5),P<0.001,Cohen’s d=2.74]and weight[3150±108 g vs 2818±76 g;mean difference=332(95%CI:310-352),P<0.001,Cohen's d=3.56].CONCLUSION Prophylactic intermittent zinc supplementation administered alongside routine immunization substantially reduces the incidence of ARI and diarrhoea in infants and promotes improved growth.This affordable strategy holds promise for reducing infant morbidity and mortality without increasing healthcare burdens.展开更多
Objective:To compare the nursing effects of routine care and specialized nursing intervention on patients with dysphagia during acute stroke.Methods:A total of 188 patients with acute stroke and dysphagia who received...Objective:To compare the nursing effects of routine care and specialized nursing intervention on patients with dysphagia during acute stroke.Methods:A total of 188 patients with acute stroke and dysphagia who received treatment at our hospital from May 2022 to December 2024 were selected as study subjects.The patients were randomly divided into a control group and an observation group,with 94 patients in each group.The control group received routine nursing intervention,while the observation group received specialized nursing intervention.The general information,swallowing function,quality of life,and nursing satisfaction were compared between the two groups.Results:There was no statistically significant difference in general information between the two groups(P>0.05).The SAS score of the observation group after nursing was significantly lower than that of the control group(t=19.463,P=0.000<0.001).After intervention,the number of patients with lung infection in the observation group was significantly lower than that in the control group(χ2=7.309,P=0.007<0.01).The overall quality of life score of the observation group was significantly better than that of the control group after intervention(P<0.001).The nursing satisfaction of the observation group was significantly higher than that of the control group(χ^(2)=15.865,P=0.000<0.001).Conclusion:Compared with routine care,specialized nursing intervention can effectively improve the swallowing function of patients with dysphagia during acute stroke,enhance their quality of life,and increase nursing satisfaction.展开更多
Every day,people follow a routine.What is your morning routine?Maybe you wake up at six or seven.You wash your face and brush your hair.You dress for school or work.Maybe you eat breakfast at home.
BACKGROUND Narrative nursing uses narrative methods to establish an interaction between nursing staff and patients,in which the experience of the patient’s illness is understood and comprehended.By listening,the pati...BACKGROUND Narrative nursing uses narrative methods to establish an interaction between nursing staff and patients,in which the experience of the patient’s illness is understood and comprehended.By listening,the patient’s understanding,comprehension,and acceptance of their own disease symptoms,quality of life,and living conditions are understood,thereby providing a basis for formulating corresponding nursing plans for the patient,further promoting the psychological and physical rehabilitation of the patient.AIM To explore the impact of the new narrative nursing model on postoperative recovery,psychological status,and satisfaction of patients.METHODS A total of 108 patients with resectable gastric cancer who were treated from January 2024 to December 2024 were selected as the study subjects.They were divided into a routine nursing group and a narrative nursing group using a random number table method.Postoperative recovery indicators were compared between the two groups,and questionnaires and position and postoperative nausea and vomiting were conducted on the day of discharge.RESULTS There were statistically significant differences in visual analogue scale pain scores at 12-96 hours postoperatively,the time of first ambulation postoperatively,and the length of postoperative hospital stay between the two groups(P<0.05).There were statistically significant differences in postoperative self-rating anxiety scale,self-rating depression scale,and satisfaction scores between the two groups(P<0.05).Further analysis using a binary logistic regression model found that the new narrative nursing model adopted postoperatively could improve patients’satisfaction with the work of nursing staff during their hospitalization.CONCLUSION The new narrative nursing model not only eliminated the negative emotions of patients,but also further promoted their postoperative recovery,and gained patients’trust and satisfaction with the nursing staff.展开更多
Objective To determine the impact of planned preoperative phenazopyridine administration on operative times and costs compared with as-needed intravenous agent use during routine cystoscopy following minimally invasiv...Objective To determine the impact of planned preoperative phenazopyridine administration on operative times and costs compared with as-needed intravenous agent use during routine cystoscopy following minimally invasive hysterectomy for benign indications.Method This prospective cohort study examined patients who underwent laparoscopic or robotic-assisted total or supracervical hysterectomy for benign indications between January 27,2023 and March 11,2024,with one of our minimally invasive gynecologic surgeons at Stony Brook University Hospital.Patients were assigned to the non-phenazopyridine group or the phenazopyridine group.The time needed to visualize the ureteral jets during cystoscopy and the total surgery duration were recorded.A cost analysis was then performed.Results In total,106 patients were included,with 53 patients in each group.Compared with the non-phenazopyridine group,the phenazopyridine group had significantly shorter times from the start of cystoscopy to visualization of the first ureteral jet(31 s vs.42 s,p<0.05).However,there were no significant differences observed for visualization of the second jet,total jet time,or surgery duration.Two patients in the non-phenazopyridine group required the administration of intravenous agents intraoperatively.Routine phenazopyridine was found to be more cost-efficient when medication costs and operative times were examined.Conclusion Routine phenazopyridine use does not significantly shorten overall cystoscopy times,but it is the more cost-efficient option given increased rates of costly intravenous medication use in the non-phenazopyridine group.展开更多
Objective:To investigate the preventive effect of targeted nursing interventions on deep vein thrombosis in patients with hemodialysis catheter indwelling.Methods:A prospective study was conducted involving patients w...Objective:To investigate the preventive effect of targeted nursing interventions on deep vein thrombosis in patients with hemodialysis catheter indwelling.Methods:A prospective study was conducted involving patients who underwent hemodialysis catheter indwelling and were admitted between August 2023 and August 2025,totaling 108 cases.These patients were randomly divided into two groups using a random number table method,with 54 cases in each group.The control group received routine nursing interventions,while the observation group received targeted nursing interventions.The incidence of deep vein thrombosis and hemodynamic indicators were compared between the two groups.Results:The incidence of deep vein thrombosis in the observation group was lower than that in the control group(p<0.05).After two weeks of nursing,the hemodynamic indicators in the observation group were higher than those in the control group(p<0.05).Conclusion:Targeted nursing interventions can effectively prevent deep vein thrombosis and improve hemodynamics in patients with hemodialysis catheter indwelling,making them worthy of clinical promotion.展开更多
基金Supported by the Social and Scientific Funds Projects of Hubei Province in 2009 (203004)
文摘The paper tends to make an empirical analysis on the experimental site of new countryside construction of Xianhong in Hubei, pointing out that the inner and outer dependence on routines of experimental construction. The paper also puts forward the beneficial policies, focusing on the agricultural production and fostering professional farmers, to reduce much dependence on routines.
文摘Innovation is managed through the development of processes and routines, considered as critical for business success and value creation. The identification of relevant routines as well as the understanding of which factors affect business innovation is the main objective of this research, based on a survey applied in Portuguese companies and their experience shared in best practices guides. Conclusions highlighted 10 key innovation routines, reinforcing the idea that innovation must be supported through a systematic and sustained management process. Results also indicate that SMEs face greater difficulties in benefiting from the potential of innovation practices and collaboration may present opportunities to overcome their limited resources. Therefore, regardless of size, business activity, science and technology intensity or other factors influencing firms dynamic capabilities, innovation should be considered as a management imperative as it can influence not only the present but also the future of business success.
文摘This study employs a Q methodology to explore the developmental routines of oral English ability for 12 English major students in China inspired by Complex and Dynamic Systems Theory(CDST).The data analysis suggests the next findings:(1)two developmental patterns emerge as the gradual improvement and the strong phase shift influenced by internal and external factors for interactions among different subsystems;(2)guided by CDST,the study proves the importance of self-organization and initial condition in previous studies.According to the above findings,It is highly suggested for teachers to form a holistic view of students’oral English development concerning the non-linear characteristic and individual differences.
文摘As an important part in unique resources and capability of enterprises, organizational routines, on one hand, promote the success of enterprises, on the other hand, influence the future development of enterprises. Especially, organizational routines have the influences on the two factors of building up dynamic competitive advantages-strategic change and strategic flexibility and further influence the establishment of dynamic competitive advantages. This paper involves detailed analysis on the influences of organizational routines and on the approaches of establishing dynamic competitive advantages and puts forward the relevant countermeasures.
文摘你的日常活动是什么样的呢?试着记录并改善它们吧!Daily routines can help us live a healthier,more productive life,with a little bit of motivation and discipline.From taking some time to exercise and eat right to setting aside other times to study and set goals,you’ll find yourself living a balanced,fulfilling lifestyle.Here are some examples of productive daily routines.
基金supported by the Science and Technology Development Fund of Macao,Macao SAR(Nos.0021/2023/RIA1 and 0046/2021/A)a Faculty Research Grant of Macao University of Science and Technology(No.FRG-22-103-FIE)supported by the National Natural Science Foundation of China(Nos.61872167 and 61502205).
文摘String validation routines have been widely used in many real-world applications,such as email validation and postcode validation.String test cases are adopted to test these validation routines,to identify potential defects and security risks.Random Testing(RT)is a well-known testing approach to randomly generate string test cases from the input domain(i.e.,the set of all possible test inputs),which is simple to implement at a low cost.However,its testing effectiveness may be unsatisfactory for string validation routines.The main reason for this is that RT may have a high probability to generate invalid rather than valid string test cases,due to its randomness property.This research proposes a new RT approach based on the output types(i.e.,valid and invalid strings)for string validation routines,namely Output-type-guided Random Testing(RTO),which attempts to randomly generate both valid and invalid string test cases with a certain probability.This research performed an empirical study involving several real-world string validation routines collected from ten Java open-source projects,to investigate and compare testing performances of RT-O against the previous two widely-used RT methods.The results show that the generated string test cases by RT-O outperform test cases generated by other RT methods.
文摘If you're tired of megacities that feel like nothing but glass,steel,and constant rush,Guangzhou moves at its own pace.Here,a 19th-century ancestral hall stands next to a 600-meter tower,and the day begins with tea and delicate steamed treats instead of coffee.
基金This paper is the best paper of China Enterprise Management Cases and Qualitative Research Forum 2019.This paper is supported by the National Natural Science Foundation of China(No.71832014,71771223,71902193)the China Postdoctoral Science Foundation(No.2019M653258).
文摘Extant research mostly focuses on the impact of big data on product development(PD)process and performance,and yet there is a lack of theoretical exploration of the transformation path,realization mechanism and transformation paradigm while moving from experience-based PD(EBPD)to data-driven PD(DDPD).This paper,from the integrated perspective of adaptive change and organizational routines,and based on an in-depth case study of HSTYLE,proposes a two-stage transformation model for moving from EBPD to DDPD,dissects the adaptive change mechanism of organizational routines for DDPD,puts forward a theoretical model for the transformation paradigm for DDPD,and provides an innovative interpretation of the connotation of data-driven.This paper constructs a theory for DDPD transformation that comprises three aspects:transformation path,realization mechanism and transformation paradigm.Conclusions of this paper have policy implications for enterprises in their practice on data-driven product innovation in the digital economy era.
文摘At the opening ceremony of the Beiig Paralympic Winter Games on the evening of March 4,90 performners,including hearing-impaired ones,put on a show called"Winter Paralympic Waltz."They danced gracefully,displaying the friendship between people and the vitality of life.
基金the Special Project of State Key Laboratory of Dampness Syndrome of Chinese Medicine:Study on Criteria for Diagnosis of Dampness Syndrome of Idiopathic Membranous Nephropathy,Cohort Study on Pathogenesis and Material Basis of Dampness Syndrome of Idiopathic Membranous Nephropathy,Randomized Controlled Clinical Study of Sanqi Qushi Granule in Treatment of Membranous Nephropathy(No.SZ2021ZZ02,SZ2021ZZ09 and SZ2021ZZ36)the 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund:Guangdong-Hong Kong-Macao Joint Lab(No.2020B1212030006)+2 种基金the Natural Science Foundation of Guangdong Province:Study on the Mechanism of Sanqi Qushi Prescription Delaying Podocellular Senescence in Membranous Nephropathy based on Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase-Stimulator of Interferon Genes-Nuclear Factor Kappa-B Signaling Pathway(No.2022A1515011628)the Guangzhou Science and Technology Plan Project:to Explore the Mechanism of Treating Membranous Nephropathy from the Perspective of Regulating Amino Acid Metabolism Disorder(No.2023A03J0746)Special Funding for Scientific and Technological Research on Traditional Chinese Medicine,Guangdong Provincial Hospital of Chinese Medicine:a Multimodular Machine Learning Prediction Model based on Pathological Image-transcriptomics and Traditional Chinese Medicine Syndromes was Used to Investigate the Prognostic Correlation of Long non-coding RNA Molecules in Nephropathy and the Intervention Mechanism of Sanqi Qushi Formula,to Investigate the Pathogenesis and Microbiological Mechanism of Dampness Syndrome of Membranous Nephropathy based on the Microecological Changes of Tongue Coating(No.YN2023MB02,YN2023MB10)。
文摘OBJECTIVE:To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN)patients by literature research and expert investigation(interviews and a Delphi method).METHODS:Our study was consistent with T/CACM 1336-2020.We searched the monographs and references published in the past 40 years(1983-2022),and established the diagnostic criteria pool of waterdampness syndrome and dampness-turbidity syndrome in Traditional Chinese Medicine(TCM)based on literature by using frequency statistics and correlation analysis.Expert investigation(interview method and two rounds of Delphi method)was used to form the diagnostic criteria of water-dampness syndrome and dampnessturbidity syndrome of idiopathic membranous nephropathy.Clinical diagnostic test research was carried out,and compared with“Diagnostic Criteria for dampness syndrome”(T/CACM 1454-2023)to evaluate the authenticity,reliability and clinical application value of the standard.RESULTS:A total of 122 relevant guides,standards,monographs and documents were included through searching books and Chinese databases.Four experts were interviewed and two rounds of delphi method(75 experts nationwide)were carried out.The experts'opinions are relatively concentrated and the differences are small.Based on the weight of each index,the diagnostic criteria indexes of water-dampness syndrome and dampness-turbidity syndrome were selected.After discussion by the core group members,the diagnostic model of"necessary symptoms and optional symptoms"was established,and the final diagnostic criteria of waterdampness syndrome and dampness-turbidity syndrome were established.One hundred and ninety-one inpatients and outpatients of Guangdong Provincial Hospital of Chinese Medicine from January 2021 to February 2023 were included in Diagnostic test study.There was no statistical difference in gender,age and course of disease(P>0.05).The sensitivity and specificity of the trial standard were 90.34%and 73.33%respectively,while the sensitivity and specificity of T/CACM 1454-2023 were 99.43%and 6.67%,respectively.CONCLUSIONS:The consensus-based diagnostic criteria for IMN can be widely incorporated in TCM.A further clinical study will be conducted to analyze the diagnosis value and cut-off score of our IMN criteria.
文摘To evaluate the subchronic and chronic toxicity of Fuyanxiao capsules,Sprague-Dawley(SD)rats were used in toxicity studies.In the subchronic toxicity study,50 female rats were randomly divided into a high-dose group(5.4g/kg/day)and a control group,with 15 rats in each,and medium(2.7g/kg/day)and low(1.35g/kg/day)dose groups,with 10 rats in each.The test substance was administered orally(mixed with feed,twice daily)for 90 consecutive days.In the chronic toxicity study,40 female rats were randomly divided into high,medium,and low dose groups and a control group,with 10 rats in each.The test substance was administered orally in the same manner for 180 consecutive days.Clinical signs,body weight,and food consumption were observed and recorded daily.At the end of the terminal phase(the first 10 rats from each group,1 day after the last dose)and the recovery phase(the last 5 rats from the control group and the high-dose group,observed for an additional 28 days after the last dose),blood and urine samples,as well as organs,were collected.Organ coefficients were calculated,and various hematological and urinary indicators were detected,followed by pathological analysis.The results showed that there were no significant differences in body weight,food consumption,or organ coefficients between any of the dose groups and the control group in both subchronic and chronic toxicity studies(P>0.05).Histopathological examination revealed no lesions,suggesting no tissue or organ damage in any of the dose groups.The rats exhibited good mental status,and hematological and urinary physiological indicators were within normal ranges,indicating stable liver and kidney function,hematopoietic system of the bone marrow,and internal environment in all dose groups.Therefore,Fuyanxiao capsule has no obvious subchronic or chronic toxicity in SD rats,and it is safe and reliable to use at reasonable dosage in clinical practice.
文摘Tom is an American student.He is ten years old.But he does not live in the USA now.He lives with his father,mother and grandfather in a small city in China.Tom has a Chinese name,Tang Mu.He is in Grade Three at a primary school.He goes to school from Monday to Friday.Every morning,he gets up at 6:30.He brushes his teeth and washes his face.Then he has breakfast with his family.His parents often cook eggs and noodles.At 7:30,Tom goes to school.He walks to school with his best friend,Mike.Mike is a Chinese boy.His Chinese name is Ma Ke.Mike is his English name.Tom's house is to the left of Mike's.It is about 80 metres away from Mike's.
文摘BACKGROUND Acute respiratory infections(ARI)and diarrhoea are among the leading causes of infant and under-five mortality worldwide.Zinc,the second most abundant trace element in the human body,is widely used in the treatment of both conditions.It mitigates diarrhoea by restoring mucosal integrity and enhancing enterocyte brush border enzyme activity.In ARI,zinc boosts immune function,promotes epithelial regeneration,and inhibits the replication of respiratory viruses.AIM To assess the effectiveness of prophylactic intermittent zinc supplementation in preventing acute diarrhoea and ARI in infants.METHODS This open-label,randomized controlled trial with a 1:1 allocation ratio was conducted over 15 months(October 2022 to December 2023)at a tertiary care hospital in Eastern India.A total of 320 infants attending the outpatient department for routine vaccinations were enrolled and randomly assigned to intervention and control groups.The intervention group received zinc drops for two weeks,with the regimen repeated one month later and again at six months during subsequent vaccination visits.The control group received no placebo or alternative treatment.Outcomes were assessed after the final follow-up at nine months.RESULTS The mean annual incidence of ARI and diarrhoea was significantly lower in the zinc group than in the control group[ARI:0.25±0.61 vs 0.92±1.22;mean difference=-0.67(95%CI:-0.88 to-0.45),P<0.001,Cohen’s d=-0.69]and[diarrhoea:1.04±1.30 vs 2.07±2.09;mean difference=-1.03(95%CI:-1.42 to-0.65),P<0.001,Cohen's d=-0.59],respectively.Additionally,the zinc group showed significantly greater gains in length[10±0.6 cm vs 8.6±0.4 cm;mean difference=1.4(95%CI:1.3-1.5),P<0.001,Cohen’s d=2.74]and weight[3150±108 g vs 2818±76 g;mean difference=332(95%CI:310-352),P<0.001,Cohen's d=3.56].CONCLUSION Prophylactic intermittent zinc supplementation administered alongside routine immunization substantially reduces the incidence of ARI and diarrhoea in infants and promotes improved growth.This affordable strategy holds promise for reducing infant morbidity and mortality without increasing healthcare burdens.
文摘Objective:To compare the nursing effects of routine care and specialized nursing intervention on patients with dysphagia during acute stroke.Methods:A total of 188 patients with acute stroke and dysphagia who received treatment at our hospital from May 2022 to December 2024 were selected as study subjects.The patients were randomly divided into a control group and an observation group,with 94 patients in each group.The control group received routine nursing intervention,while the observation group received specialized nursing intervention.The general information,swallowing function,quality of life,and nursing satisfaction were compared between the two groups.Results:There was no statistically significant difference in general information between the two groups(P>0.05).The SAS score of the observation group after nursing was significantly lower than that of the control group(t=19.463,P=0.000<0.001).After intervention,the number of patients with lung infection in the observation group was significantly lower than that in the control group(χ2=7.309,P=0.007<0.01).The overall quality of life score of the observation group was significantly better than that of the control group after intervention(P<0.001).The nursing satisfaction of the observation group was significantly higher than that of the control group(χ^(2)=15.865,P=0.000<0.001).Conclusion:Compared with routine care,specialized nursing intervention can effectively improve the swallowing function of patients with dysphagia during acute stroke,enhance their quality of life,and increase nursing satisfaction.
文摘Every day,people follow a routine.What is your morning routine?Maybe you wake up at six or seven.You wash your face and brush your hair.You dress for school or work.Maybe you eat breakfast at home.
文摘BACKGROUND Narrative nursing uses narrative methods to establish an interaction between nursing staff and patients,in which the experience of the patient’s illness is understood and comprehended.By listening,the patient’s understanding,comprehension,and acceptance of their own disease symptoms,quality of life,and living conditions are understood,thereby providing a basis for formulating corresponding nursing plans for the patient,further promoting the psychological and physical rehabilitation of the patient.AIM To explore the impact of the new narrative nursing model on postoperative recovery,psychological status,and satisfaction of patients.METHODS A total of 108 patients with resectable gastric cancer who were treated from January 2024 to December 2024 were selected as the study subjects.They were divided into a routine nursing group and a narrative nursing group using a random number table method.Postoperative recovery indicators were compared between the two groups,and questionnaires and position and postoperative nausea and vomiting were conducted on the day of discharge.RESULTS There were statistically significant differences in visual analogue scale pain scores at 12-96 hours postoperatively,the time of first ambulation postoperatively,and the length of postoperative hospital stay between the two groups(P<0.05).There were statistically significant differences in postoperative self-rating anxiety scale,self-rating depression scale,and satisfaction scores between the two groups(P<0.05).Further analysis using a binary logistic regression model found that the new narrative nursing model adopted postoperatively could improve patients’satisfaction with the work of nursing staff during their hospitalization.CONCLUSION The new narrative nursing model not only eliminated the negative emotions of patients,but also further promoted their postoperative recovery,and gained patients’trust and satisfaction with the nursing staff.
文摘Objective To determine the impact of planned preoperative phenazopyridine administration on operative times and costs compared with as-needed intravenous agent use during routine cystoscopy following minimally invasive hysterectomy for benign indications.Method This prospective cohort study examined patients who underwent laparoscopic or robotic-assisted total or supracervical hysterectomy for benign indications between January 27,2023 and March 11,2024,with one of our minimally invasive gynecologic surgeons at Stony Brook University Hospital.Patients were assigned to the non-phenazopyridine group or the phenazopyridine group.The time needed to visualize the ureteral jets during cystoscopy and the total surgery duration were recorded.A cost analysis was then performed.Results In total,106 patients were included,with 53 patients in each group.Compared with the non-phenazopyridine group,the phenazopyridine group had significantly shorter times from the start of cystoscopy to visualization of the first ureteral jet(31 s vs.42 s,p<0.05).However,there were no significant differences observed for visualization of the second jet,total jet time,or surgery duration.Two patients in the non-phenazopyridine group required the administration of intravenous agents intraoperatively.Routine phenazopyridine was found to be more cost-efficient when medication costs and operative times were examined.Conclusion Routine phenazopyridine use does not significantly shorten overall cystoscopy times,but it is the more cost-efficient option given increased rates of costly intravenous medication use in the non-phenazopyridine group.
文摘Objective:To investigate the preventive effect of targeted nursing interventions on deep vein thrombosis in patients with hemodialysis catheter indwelling.Methods:A prospective study was conducted involving patients who underwent hemodialysis catheter indwelling and were admitted between August 2023 and August 2025,totaling 108 cases.These patients were randomly divided into two groups using a random number table method,with 54 cases in each group.The control group received routine nursing interventions,while the observation group received targeted nursing interventions.The incidence of deep vein thrombosis and hemodynamic indicators were compared between the two groups.Results:The incidence of deep vein thrombosis in the observation group was lower than that in the control group(p<0.05).After two weeks of nursing,the hemodynamic indicators in the observation group were higher than those in the control group(p<0.05).Conclusion:Targeted nursing interventions can effectively prevent deep vein thrombosis and improve hemodynamics in patients with hemodialysis catheter indwelling,making them worthy of clinical promotion.
