目的为临床上安全使用奥马环素和莫西沙星治疗社区获得性肺炎提供参考。方法利用美国食品药品监督管理局(Food and Drug Administration,FDA)不良事件报告系统(Adverse Event Reporting System,FAERS)数据库收集奥马环素与莫西沙星从200...目的为临床上安全使用奥马环素和莫西沙星治疗社区获得性肺炎提供参考。方法利用美国食品药品监督管理局(Food and Drug Administration,FDA)不良事件报告系统(Adverse Event Reporting System,FAERS)数据库收集奥马环素与莫西沙星从2004年第1季度至2024年第1季度的药品不良事件(ADE)报告,采用计算报告比值比(ROR)法以及英国药品和健康产品管理局(Medicines and Healthcare Products Regulatory Agency,MHRA)的综合标准法来挖掘两药的ADE信号并进行分析。结果共收集到奥马环素和莫西沙星的ADE报告分别为527、16614份,性别构成比均为男性多于女性。经信号筛选,得到奥马环素45个ADE信号、莫西沙星607个ADE信号。药物发生频次最多的3个ADE信号奥马环素为恶心、呕吐、腹泻(分别为108、61、37例),在其药品说明书中均有记载,而莫西沙星分别为皮疹、头晕、超敏反应(分别为1198、1157、945例),其中头晕未在说明书中记载。按信号强度排序,奥马环素的输液部位静脉炎(ROR值为635.83)和莫西沙星的虹膜缺失检测阳性(ROR值为3478.69)位列第一,奥马环素被其药品说明书记载,而莫西沙星说明书中未被记载。结论奥马环素ADE主要累及到各类损伤、中毒及操作并发症和胃肠系统疾病;而莫西沙星主要累及神经系统疾病和全身性疾病及给药部位各种反应,且新的可疑风险信号较多。展开更多
In this paper, a biquartic finite volume element method based on Lobatto- Guass structure is presented for variable coefficient elliptic equation on rectangular partition. Not only the optimal H1 and L2 error estimate...In this paper, a biquartic finite volume element method based on Lobatto- Guass structure is presented for variable coefficient elliptic equation on rectangular partition. Not only the optimal H1 and L2 error estimates but also some superconvergent properties are available and could be proved for this method. The numerical results obtained by this finite volume element scheme confirm the validity of the theoretical analysis and the effectiveness of this method.展开更多
文摘目的为临床上安全使用奥马环素和莫西沙星治疗社区获得性肺炎提供参考。方法利用美国食品药品监督管理局(Food and Drug Administration,FDA)不良事件报告系统(Adverse Event Reporting System,FAERS)数据库收集奥马环素与莫西沙星从2004年第1季度至2024年第1季度的药品不良事件(ADE)报告,采用计算报告比值比(ROR)法以及英国药品和健康产品管理局(Medicines and Healthcare Products Regulatory Agency,MHRA)的综合标准法来挖掘两药的ADE信号并进行分析。结果共收集到奥马环素和莫西沙星的ADE报告分别为527、16614份,性别构成比均为男性多于女性。经信号筛选,得到奥马环素45个ADE信号、莫西沙星607个ADE信号。药物发生频次最多的3个ADE信号奥马环素为恶心、呕吐、腹泻(分别为108、61、37例),在其药品说明书中均有记载,而莫西沙星分别为皮疹、头晕、超敏反应(分别为1198、1157、945例),其中头晕未在说明书中记载。按信号强度排序,奥马环素的输液部位静脉炎(ROR值为635.83)和莫西沙星的虹膜缺失检测阳性(ROR值为3478.69)位列第一,奥马环素被其药品说明书记载,而莫西沙星说明书中未被记载。结论奥马环素ADE主要累及到各类损伤、中毒及操作并发症和胃肠系统疾病;而莫西沙星主要累及神经系统疾病和全身性疾病及给药部位各种反应,且新的可疑风险信号较多。
文摘In this paper, a biquartic finite volume element method based on Lobatto- Guass structure is presented for variable coefficient elliptic equation on rectangular partition. Not only the optimal H1 and L2 error estimates but also some superconvergent properties are available and could be proved for this method. The numerical results obtained by this finite volume element scheme confirm the validity of the theoretical analysis and the effectiveness of this method.
