Cancer is a major cause of mortality globally,characterized by its multifactorial nature and intricate treatment procedures.The main treatment options include targeted drug therapies and chemotherapy.However,overcomin...Cancer is a major cause of mortality globally,characterized by its multifactorial nature and intricate treatment procedures.The main treatment options include targeted drug therapies and chemotherapy.However,overcoming drug resistance remains a significant challenge in curing cancer patients.In recent decades,substantial efforts have been made to explore the resistance of cancer cells to anti-cancer agents and to create methods to counteract this resistance.Cancer cell resistance can be attributed to various factors,including long non-coding RNAs(lncRNAs)involved in cell cycle dysregulation,abnormal DNA repair,cell proliferation,epithelial-mesenchymal transition,metastasis,apoptosis,autophagy,drug efflux transporters,epigenetic modifications,and the formation of cancer stem cells.Pseudogenes are genomic regions that harbor impaired or dysfunctional versions of genes.Although pseudogenes were traditionally considered non-functional,a growing number of them are now being found to serve important biological functions.Recent research has demonstrated that mutations and dysregulation of pseudogene-derived lncRNAs are linked with various human diseases,such as cancer drug resistance.This review concentrates on exploring the latest discoveries that elucidate the diverse molecular functions of regulatory pseudogene-derived lncRNAs implicated in cancer drug resistance and the therapeutic possibilities for overcoming drug resistance.展开更多
文摘Cancer is a major cause of mortality globally,characterized by its multifactorial nature and intricate treatment procedures.The main treatment options include targeted drug therapies and chemotherapy.However,overcoming drug resistance remains a significant challenge in curing cancer patients.In recent decades,substantial efforts have been made to explore the resistance of cancer cells to anti-cancer agents and to create methods to counteract this resistance.Cancer cell resistance can be attributed to various factors,including long non-coding RNAs(lncRNAs)involved in cell cycle dysregulation,abnormal DNA repair,cell proliferation,epithelial-mesenchymal transition,metastasis,apoptosis,autophagy,drug efflux transporters,epigenetic modifications,and the formation of cancer stem cells.Pseudogenes are genomic regions that harbor impaired or dysfunctional versions of genes.Although pseudogenes were traditionally considered non-functional,a growing number of them are now being found to serve important biological functions.Recent research has demonstrated that mutations and dysregulation of pseudogene-derived lncRNAs are linked with various human diseases,such as cancer drug resistance.This review concentrates on exploring the latest discoveries that elucidate the diverse molecular functions of regulatory pseudogene-derived lncRNAs implicated in cancer drug resistance and the therapeutic possibilities for overcoming drug resistance.
