Radiation-induced pulmonary injury is a major dose-limiting toxicity that occurs due to thoracic radiotherapy.And the most widely used high-throughput technology,16S ribosomal RNA sequencing,is adopted for bacterial c...Radiation-induced pulmonary injury is a major dose-limiting toxicity that occurs due to thoracic radiotherapy.And the most widely used high-throughput technology,16S ribosomal RNA sequencing,is adopted for bacterial classification and identification of airway microbiome analysis.In this study,we provide novel insights into the composition pattern and predicted function of the lung microbiome in RIPI rats.Certain genus and species change in a dose-dependent manner,which might be capable of serving as novel bacterial biomarkers,as well as the potential targets for the future diagnosis or treatment of RIPI.In summary,our findings provide a vital reference for RIPI study,and will contribute to investigate the novel therapeutic or preventive management for RIPI.展开更多
基金This study was supported by the National Natural Science Foundation of China(No.81773226,U1967220,and 82073476)Key Laboratory of Radiation Medicine and Protection,Soochow University(GZN1202101)+1 种基金China Postdoctoral Science Foundation(No.2017M611908 and 2017M610351)Jiangsu Province Postdoctoral Science Foundation(No.1701177B).
文摘Radiation-induced pulmonary injury is a major dose-limiting toxicity that occurs due to thoracic radiotherapy.And the most widely used high-throughput technology,16S ribosomal RNA sequencing,is adopted for bacterial classification and identification of airway microbiome analysis.In this study,we provide novel insights into the composition pattern and predicted function of the lung microbiome in RIPI rats.Certain genus and species change in a dose-dependent manner,which might be capable of serving as novel bacterial biomarkers,as well as the potential targets for the future diagnosis or treatment of RIPI.In summary,our findings provide a vital reference for RIPI study,and will contribute to investigate the novel therapeutic or preventive management for RIPI.
