In a recent publication in Nature,Sakoguchi et al.reveal a long-sought missing link between pathogen-derived ligands and activating human natural killer(NK)cell receptors.1 The study identifies a clade of Plasmodium f...In a recent publication in Nature,Sakoguchi et al.reveal a long-sought missing link between pathogen-derived ligands and activating human natural killer(NK)cell receptors.1 The study identifies a clade of Plasmodium falciparum(P.falciparum)repetitive interspersed family(RIFIN)proteins that not only bind to the inhibitory KIR2DL1 receptor but,strikingly,also engage the activating KIR2DS1 receptor,thereby offering new insight into NK cell regulation in malaria and expanding our understanding of host–pathogen interaction in innate immune responses.展开更多
Dear Editor,Malaria,predominantly caused by Plasmodium falciparum(P.falciparum),remains a critical global health challenge,particularly in sub-Saharan Africa(World Health Organization,2023).The emergence of drug-resis...Dear Editor,Malaria,predominantly caused by Plasmodium falciparum(P.falciparum),remains a critical global health challenge,particularly in sub-Saharan Africa(World Health Organization,2023).The emergence of drug-resistant P.falciparum strains complicates control efforts,indicating the urgent need for innovative treatments and vaccines.During the blood stage,P.falciparum employs surface antigens,notably repetitive interspersed families of polypeptide(RIFIN),to evade immune detection,which in turn hampers the development of acquired immunity.展开更多
文摘In a recent publication in Nature,Sakoguchi et al.reveal a long-sought missing link between pathogen-derived ligands and activating human natural killer(NK)cell receptors.1 The study identifies a clade of Plasmodium falciparum(P.falciparum)repetitive interspersed family(RIFIN)proteins that not only bind to the inhibitory KIR2DL1 receptor but,strikingly,also engage the activating KIR2DS1 receptor,thereby offering new insight into NK cell regulation in malaria and expanding our understanding of host–pathogen interaction in innate immune responses.
基金supported by the National Key Research and Development Program of China(2023YFA1607500)the National Natural Science Foundation of China(32371362,82025023,82230079)+1 种基金the Anhui Major Basic Research Projects(2023z04020016)supported by the High Magnetic Field Laboratory of Anhui Province.
文摘Dear Editor,Malaria,predominantly caused by Plasmodium falciparum(P.falciparum),remains a critical global health challenge,particularly in sub-Saharan Africa(World Health Organization,2023).The emergence of drug-resistant P.falciparum strains complicates control efforts,indicating the urgent need for innovative treatments and vaccines.During the blood stage,P.falciparum employs surface antigens,notably repetitive interspersed families of polypeptide(RIFIN),to evade immune detection,which in turn hampers the development of acquired immunity.
