Intense room-temperature near infrared （NIR） photoluminescence （980 nm and 1032 nm） is observed from Yb,Al co-implanted SiO2 films on silicon. The optical transitions occur between the ^2F5/2 and ^2F7/2 levels of ...Intense room-temperature near infrared （NIR） photoluminescence （980 nm and 1032 nm） is observed from Yb,Al co-implanted SiO2 films on silicon. The optical transitions occur between the ^2F5/2 and ^2F7/2 levels of Yb^3＋ in SiO2. The additional Al-implantation into SiO2 films can effectively improve the concentration quenching effect of Yb^3＋ in SiO2. Photoluminescence excitation spectroscopy shows that the NIR photoluminescence is due to the non-radiative energy transfer from Al-implantation-induced non-bridging oxygen hole defects in SiO2 to Yb^3＋ in the Yb-related luminescent complexes. It is believed that the defect-mediated luminescence of rare-earth ions in SiO2 is very effective.展开更多
Simulating the typical carbonation step in a mineral CO_2 sequestration, precipitated calcium carbonate(PCC) was prepared by bubbling CO_2 gas into a rich Ca solution. These carbonation reactions were conducted at thr...Simulating the typical carbonation step in a mineral CO_2 sequestration, precipitated calcium carbonate(PCC) was prepared by bubbling CO_2 gas into a rich Ca solution. These carbonation reactions were conducted at three p H ranges, namely 10.0–9.0, 9.0–8.0, and 8.0–7.0, in which temperature and CO_2 flow rate are additional experimental variables. The PCC obtained in experiments was examined by Fourier transform infrared spectroscopy(FTIR)and X-ray diffraction(XRD). It was found that supersaturation determined by p H value and flow rate of CO_2 has significant influence on polymorph of PCC. Vaterite was preferably formed at high supersaturation, while dissolution of metastable vaterite and crystallization of calcite occurred at low supersaturation. High temperature is a critical factor for the formation of aragonite. At 70 °C, vaterite, calcite and aragonite were observed to coexist in PCC because transformation from vaterite to aragonite via calcite occurred at this temperature. Scanning electron microscopy(SEM) technology was performed on prepared PCC, and various morphologies consistent with polymorphs were observed.展开更多
Objective The Jiaodong area in Shandong Province of eastern China hosts abundant high-quality groundwater. Most of the mineral water sources in this area, including those in the Laoshan and Kunyu Mountains, occur in ...Objective The Jiaodong area in Shandong Province of eastern China hosts abundant high-quality groundwater. Most of the mineral water sources in this area, including those in the Laoshan and Kunyu Mountains, occur in Mesozoic granites. The groundwater and mineral waters contain metasilicic acid and strontium but the latter is potable. Mineral water is also found in the Jiaolai Basin, hosting in the basalts of the Wangshi group in Anjiagou Village, Jiaozhou City. The rapeutic groundwater, however, is rarely found in this area, except for the recent discovery of CO：-Li-Sr rich therapeutic and potable groundwater, which is reported in this study.展开更多
Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in y-secretase component genes.We and other researchers showed that nicastrin (NCSTN) ...Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in y-secretase component genes.We and other researchers showed that nicastrin (NCSTN) is the most frequently mutated gene in familial AI.In this study,we generated a keratin 5-Cre-driven epidermis-specific Ncstn conditional knockout mutant in mice.We determined that this mutant recapitulated the major phenotypes of AI,including hyperkeratosis of hair follicles and inflammation.In Ncstnflox/flox;K5-Cre mice,the IL-36a expression level markedly increased starting from postnatal day 0 (P0),and this increase occurred much earlier than those of TNF-α,IL-23A,IL-1 3,and TLR4.RNA-Seq analysis indicated that Sprr2d,a member of the small proline-rich protein 2 family,in the skin tissues of the Ncstnflox/flox,;K5-Cre mice was also upregulated on P0.Quantitative reverse-transcription polymerase chain reaction showed that other Sprr2 genes had a similar expression pattern.Our findings suggested that IL-36a might be a key inflammatory cytokine in the pathophysiology of AI and implicate malfunction of the skin barrier in the pathogenesis of AI.展开更多
Background:Malaria rapid diagnostic tests have become a primary and critical tool for malaria diagnosis in malariaendemic countries where Plasmodium falciparum Histidine Rich Protein 2-based rapid diagnostic tests(Pfl...Background:Malaria rapid diagnostic tests have become a primary and critical tool for malaria diagnosis in malariaendemic countries where Plasmodium falciparum Histidine Rich Protein 2-based rapid diagnostic tests(PflHRP2-based RDTs)are widely used.However,in the last decade,the accuracy of PflHRP2-based RDTs has been challenged by the emerge nee of P.falciparum strains harbouring deletions of the P.falciparum histidine rich protein 2(pflnrp2)gene,resulting in false-negative results.In the Democratic Republic of Congo(D.R.Congo),little is known about the prevalence of the pfhrp2 gene deletion among P.falciparum isolates infecting symptomatic patients,especially in low to moderate transmission areas where pfhrp2 deletion parasites are assumed to emerge and spread.Here we determine the local prevalence and factors associated with pfhrp2 gene deletions among symptomatic malaria patients in the Kwilu Province of the D.R.Congo.展开更多
文摘Intense room-temperature near infrared （NIR） photoluminescence （980 nm and 1032 nm） is observed from Yb,Al co-implanted SiO2 films on silicon. The optical transitions occur between the ^2F5/2 and ^2F7/2 levels of Yb^3＋ in SiO2. The additional Al-implantation into SiO2 films can effectively improve the concentration quenching effect of Yb^3＋ in SiO2. Photoluminescence excitation spectroscopy shows that the NIR photoluminescence is due to the non-radiative energy transfer from Al-implantation-induced non-bridging oxygen hole defects in SiO2 to Yb^3＋ in the Yb-related luminescent complexes. It is believed that the defect-mediated luminescence of rare-earth ions in SiO2 is very effective.
基金Supported by the National Natural Science Foundation of China(41471412)
文摘Simulating the typical carbonation step in a mineral CO_2 sequestration, precipitated calcium carbonate(PCC) was prepared by bubbling CO_2 gas into a rich Ca solution. These carbonation reactions were conducted at three p H ranges, namely 10.0–9.0, 9.0–8.0, and 8.0–7.0, in which temperature and CO_2 flow rate are additional experimental variables. The PCC obtained in experiments was examined by Fourier transform infrared spectroscopy(FTIR)and X-ray diffraction(XRD). It was found that supersaturation determined by p H value and flow rate of CO_2 has significant influence on polymorph of PCC. Vaterite was preferably formed at high supersaturation, while dissolution of metastable vaterite and crystallization of calcite occurred at low supersaturation. High temperature is a critical factor for the formation of aragonite. At 70 °C, vaterite, calcite and aragonite were observed to coexist in PCC because transformation from vaterite to aragonite via calcite occurred at this temperature. Scanning electron microscopy(SEM) technology was performed on prepared PCC, and various morphologies consistent with polymorphs were observed.
基金funded by the key R&D program of Shandong Province“Deep Gold Resources Evaluation Theories,Methodologies and Prognoses”(grant No.2017CXGC1604)the“Special Project Fund of Taishan Scholars of Shandong Province”(grant No.ts201511076)
文摘Objective The Jiaodong area in Shandong Province of eastern China hosts abundant high-quality groundwater. Most of the mineral water sources in this area, including those in the Laoshan and Kunyu Mountains, occur in Mesozoic granites. The groundwater and mineral waters contain metasilicic acid and strontium but the latter is potable. Mineral water is also found in the Jiaolai Basin, hosting in the basalts of the Wangshi group in Anjiagou Village, Jiaozhou City. The rapeutic groundwater, however, is rarely found in this area, except for the recent discovery of CO：-Li-Sr rich therapeutic and potable groundwater, which is reported in this study.
基金This work was financially supported by the National Key Research and Development Program of China(No.2016Y FC0905100)the CAMS Innovation Fund for Medical Sciences(No.2016-I2M-1-002)+3 种基金the National Natural Science Foundation of China(NSFCNos.81788101 and 81230015)the Beijing Municipal Science and Technology Commission(No.Z151100003915078)for Xue Zhangby the National NSFC(No.31271345)for Yaping Liu.
文摘Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in y-secretase component genes.We and other researchers showed that nicastrin (NCSTN) is the most frequently mutated gene in familial AI.In this study,we generated a keratin 5-Cre-driven epidermis-specific Ncstn conditional knockout mutant in mice.We determined that this mutant recapitulated the major phenotypes of AI,including hyperkeratosis of hair follicles and inflammation.In Ncstnflox/flox;K5-Cre mice,the IL-36a expression level markedly increased starting from postnatal day 0 (P0),and this increase occurred much earlier than those of TNF-α,IL-23A,IL-1 3,and TLR4.RNA-Seq analysis indicated that Sprr2d,a member of the small proline-rich protein 2 family,in the skin tissues of the Ncstnflox/flox,;K5-Cre mice was also upregulated on P0.Quantitative reverse-transcription polymerase chain reaction showed that other Sprr2 genes had a similar expression pattern.Our findings suggested that IL-36a might be a key inflammatory cytokine in the pathophysiology of AI and implicate malfunction of the skin barrier in the pathogenesis of AI.
文摘Background:Malaria rapid diagnostic tests have become a primary and critical tool for malaria diagnosis in malariaendemic countries where Plasmodium falciparum Histidine Rich Protein 2-based rapid diagnostic tests(PflHRP2-based RDTs)are widely used.However,in the last decade,the accuracy of PflHRP2-based RDTs has been challenged by the emerge nee of P.falciparum strains harbouring deletions of the P.falciparum histidine rich protein 2(pflnrp2)gene,resulting in false-negative results.In the Democratic Republic of Congo(D.R.Congo),little is known about the prevalence of the pfhrp2 gene deletion among P.falciparum isolates infecting symptomatic patients,especially in low to moderate transmission areas where pfhrp2 deletion parasites are assumed to emerge and spread.Here we determine the local prevalence and factors associated with pfhrp2 gene deletions among symptomatic malaria patients in the Kwilu Province of the D.R.Congo.
