BACKGROUND：Rheum ribes L.is a plant native to China,Iran,Turkey,India,and a few other countries.Antidiarrheal activity is considered to be one of its important properties according to various systems of traditional m...BACKGROUND：Rheum ribes L.is a plant native to China,Iran,Turkey,India,and a few other countries.Antidiarrheal activity is considered to be one of its important properties according to various systems of traditional medicine.An increasing rate of bacterial resistance to antibiotics has led to treatment failure in some cases of shigellosis in children,and underlines a need for safe,efficient and valid options.OBJECTIVE：The purpose of this study is to evaluate the efficacy of R.ribes syrup as a complementary medicine for treatment of shigellosis in children.DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS：This randomized,doubleblind,placebocontrolled trial started with a group of 150 children aged between 12–72 months with suspected Shigella dysentery.R.ribes syrup or placebo syrup was administered to the intervention and control groups,respectively for 5 days.In addition,the standard antibiotic treatment（ceftriaxone for the first 3 days and cefixime syrup for 2 further days）was administered to both groups.MAIN OUTCOME MEASURES：Body temperature,abdominal pain,need for antipyretics,defecation frequency,stool volume and consistency and microscopic stool examination were recorded as outcome measures.Any observed adverse effects were also recorded.RESULTS：Mean duration of fever and diarrhea in the R.ribes group was significantly lower than that in the placebo group（P=0.016 and 0.001,respectively）.In addition,patients in the R.ribes group showed shorter duration of need for antipyretics and shorter duration of abdominal pain（P=0.012 and 0.001,respectively）.However,there were no significant differences between the two groups regarding the microscopic stool analyses.Furthermore,no adverse effect was reported.CONCLUSION：R.ribes syrup can be recommended as a complementary treatment for children with Shigella dysentery.展开更多
Aim Ethnopharmacological relevance： Ribes diacanthum Pall. （Saxifragaceae） , a Mongolian folk me- dicinal plant, was used to treat urinary system diseases. The present work aims to investigate the protective effect...Aim Ethnopharmacological relevance： Ribes diacanthum Pall. （Saxifragaceae） , a Mongolian folk me- dicinal plant, was used to treat urinary system diseases. The present work aims to investigate the protective effects of Ribes diacanthum Pall （RDP） against cisplatin-induced nephrotoxicity. Methods The renal injury was mod- eled by intraperitoneal injection of cisplatin for 5 consecutive days （5 mg·kg^-1 ）. Nephroprotection of RDP was investigated by oral administration of RDP aqueous extract at a daily dose of 40 mg · kg^- 1 for 14 consecutive days, starting 7 days prior to cisplatin administration. Results We demonstrated that pretreatment with RDP aqueous ex- tract protected the mice from death induced by cisplatin administration. RDP treatment also significantly reduced blood urea nitrogen （BUN） and serum creatinine （Cr） levels observed in cisplatin-administrated mice. Histopatho- logical analysis demonstrated that RDP administration protected cisplatin-induced renal tubular cell apoptosis. Fur- ther western blotting analysis revealed that RDP significantly reversed cisplatin-increased expression levels of cleaved-Caspase-3, Bax and cisplatin-decreased expression level of Bcl-2 in renal tissue. Finally, RDP markedly enhanced enzyme activities of reduced superoxide dismutase （SOD）, Heine oxygenase 1 （HO-1） and catalase （CAT）, suppressed lipid peroxidation as well as reactive oxygen species （ROS） production. Conclusion We concluded that RDP displayed nephroprotective effects against cisplatin-induced renal tubular cell apoptosis, possi- bly associated with both enhanced antioxidase activity and suppressed ROS generation. Given the major nephrotox- icity of cisplatin cancer chemotherapy, RDP might be a potential candidate for neoadjuvant chemotherapy.展开更多
In this experiment,the biological characteristics,the number of spikes per plant,the average number of panicles,the average spike length,and the average yield per plant of the wild Ribes rubrum Linn. were observed and...In this experiment,the biological characteristics,the number of spikes per plant,the average number of panicles,the average spike length,and the average yield per plant of the wild Ribes rubrum Linn. were observed and determined and the analytic hierarchy process( AHP)was applied to evaluate the economic value of 8 different sources of excellent plants of R. rubrum Linn. The results indicated that " RXF02", " RXF03" and " RXM05" performed well in the number of spikes per plant,average number of panicles,average yield per plant,and cold resistance,and the comprehensive scores were 9. 68,9. 44 and 9. 41,respectively.展开更多
Embelia ribes Burm f., also known as Vidanga or Baibidanga, belonging to the family of Myrsinaceae, is an important but vulnerable medicinal woody climber. Recent survey and observations of E. ribes in different aspec...Embelia ribes Burm f., also known as Vidanga or Baibidanga, belonging to the family of Myrsinaceae, is an important but vulnerable medicinal woody climber. Recent survey and observations of E. ribes in different aspects like distribution, population structure, growth habit, climate, natural regeneration and seedling ecology in Karnataka have been thoroughly discussed. This is the first report on artificial regeneration through seeds of diverse origins in ex-situ and in situ conditions and field planting of them in its natural environment. Field planting of in vitro and nursery raised seedlings showed better field performance in terms of survival and growth in its natural growing areas only. Current studies and observations have shown that this species has low ecological gradient and is a “habitat specialist”. E. ribes being a threatened species with small populations coupled with low ecological gradient and virtually no natural regeneration, a modified approach of quasi in situ conservation where in in-situ raising of seedlings of diverse origin with an aim to enrich the diversity of existing population was attempted with considerable success.展开更多
Three new biphenyls, 4,7,8-trimethoxy-2,3-methylenedioxydibenzofuran （1）, 7-hydroxy-4,8- dimethoxy-2,3-methylenedioxydibenzofuran （2）, and 3＇,5-dimethoxy-3,4-methylenedioxybiphenyl （3）, along with eighteen know...Three new biphenyls, 4,7,8-trimethoxy-2,3-methylenedioxydibenzofuran （1）, 7-hydroxy-4,8- dimethoxy-2,3-methylenedioxydibenzofuran （2）, and 3＇,5-dimethoxy-3,4-methylenedioxybiphenyl （3）, along with eighteen known compounds （4-21） were isolated from the aerial part of Ribes takare D. Don. Their structures were elucidated on the basis of spectroscopic data. Compound I and compound 2 showed mild α-glucosidase inhibitory activity.展开更多
黑穗醋栗属于皮部生根型。厚皮品种插条不定根的排列以簇生和纵生为主,薄皮品种以簇生和散生为主。解剖观察表明,黑穗醋栗具有先成不定根原基,起源于髓射线或次生射线与维管形成层交叉处。茎的结构及茎内营养物质含量均影响生根。生根...黑穗醋栗属于皮部生根型。厚皮品种插条不定根的排列以簇生和纵生为主,薄皮品种以簇生和散生为主。解剖观察表明,黑穗醋栗具有先成不定根原基,起源于髓射线或次生射线与维管形成层交叉处。茎的结构及茎内营养物质含量均影响生根。生根期间全碳、全氮呈现规律性变化。厚皮品种硬枝各部位作插条,50 ppm NAA 或 IBA 处理1～5 min 生根较好,水培和土培方法均可采用;薄皮品种绿枝下部作插条,50 ppm NAA 处理1 min 或30 min 生根均较好,且以水培方法为宜。展开更多
Ribes plants,like most of other fruit trees,are characterized by their large number but small size of somatic chromosomes.In the light of these special characteristics,we have examined several factorial combinations o...Ribes plants,like most of other fruit trees,are characterized by their large number but small size of somatic chromosomes.In the light of these special characteristics,we have examined several factorial combinations of material, pretreatment,slide preparing method and stain to identify the most promising techique for studying the chromosomes and further analyzing the karyotypes and chromosome banding of Ribes plants. The resuts indicated that the combination of root tip with pretreatment of 2 m molL-1 8-hydroxyquinoline plus 0.05% colchicine or 0.3% balm for 3～5 hours at 14℃,pre-hypotonic trcarment of 0.07mol L-1 KCl for 30 min, fixation in Carnoy's fluid,hydrolysis in 5% cellulase and 5% pectinase mixture for 4～5 hours at 25℃, post-hypotonic treatment in distilled water for half an hour and staining in Giemsa could make the chromosome prepa ration superior to other treatment combinations.展开更多
文摘BACKGROUND：Rheum ribes L.is a plant native to China,Iran,Turkey,India,and a few other countries.Antidiarrheal activity is considered to be one of its important properties according to various systems of traditional medicine.An increasing rate of bacterial resistance to antibiotics has led to treatment failure in some cases of shigellosis in children,and underlines a need for safe,efficient and valid options.OBJECTIVE：The purpose of this study is to evaluate the efficacy of R.ribes syrup as a complementary medicine for treatment of shigellosis in children.DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS：This randomized,doubleblind,placebocontrolled trial started with a group of 150 children aged between 12–72 months with suspected Shigella dysentery.R.ribes syrup or placebo syrup was administered to the intervention and control groups,respectively for 5 days.In addition,the standard antibiotic treatment（ceftriaxone for the first 3 days and cefixime syrup for 2 further days）was administered to both groups.MAIN OUTCOME MEASURES：Body temperature,abdominal pain,need for antipyretics,defecation frequency,stool volume and consistency and microscopic stool examination were recorded as outcome measures.Any observed adverse effects were also recorded.RESULTS：Mean duration of fever and diarrhea in the R.ribes group was significantly lower than that in the placebo group（P=0.016 and 0.001,respectively）.In addition,patients in the R.ribes group showed shorter duration of need for antipyretics and shorter duration of abdominal pain（P=0.012 and 0.001,respectively）.However,there were no significant differences between the two groups regarding the microscopic stool analyses.Furthermore,no adverse effect was reported.CONCLUSION：R.ribes syrup can be recommended as a complementary treatment for children with Shigella dysentery.
文摘Aim Ethnopharmacological relevance： Ribes diacanthum Pall. （Saxifragaceae） , a Mongolian folk me- dicinal plant, was used to treat urinary system diseases. The present work aims to investigate the protective effects of Ribes diacanthum Pall （RDP） against cisplatin-induced nephrotoxicity. Methods The renal injury was mod- eled by intraperitoneal injection of cisplatin for 5 consecutive days （5 mg·kg^-1 ）. Nephroprotection of RDP was investigated by oral administration of RDP aqueous extract at a daily dose of 40 mg · kg^- 1 for 14 consecutive days, starting 7 days prior to cisplatin administration. Results We demonstrated that pretreatment with RDP aqueous ex- tract protected the mice from death induced by cisplatin administration. RDP treatment also significantly reduced blood urea nitrogen （BUN） and serum creatinine （Cr） levels observed in cisplatin-administrated mice. Histopatho- logical analysis demonstrated that RDP administration protected cisplatin-induced renal tubular cell apoptosis. Fur- ther western blotting analysis revealed that RDP significantly reversed cisplatin-increased expression levels of cleaved-Caspase-3, Bax and cisplatin-decreased expression level of Bcl-2 in renal tissue. Finally, RDP markedly enhanced enzyme activities of reduced superoxide dismutase （SOD）, Heine oxygenase 1 （HO-1） and catalase （CAT）, suppressed lipid peroxidation as well as reactive oxygen species （ROS） production. Conclusion We concluded that RDP displayed nephroprotective effects against cisplatin-induced renal tubular cell apoptosis, possi- bly associated with both enhanced antioxidase activity and suppressed ROS generation. Given the major nephrotox- icity of cisplatin cancer chemotherapy, RDP might be a potential candidate for neoadjuvant chemotherapy.
基金Supported by Key Project of Heilongjiang Forest Industry Administration(sgzjY 2013019)
文摘In this experiment,the biological characteristics,the number of spikes per plant,the average number of panicles,the average spike length,and the average yield per plant of the wild Ribes rubrum Linn. were observed and determined and the analytic hierarchy process( AHP)was applied to evaluate the economic value of 8 different sources of excellent plants of R. rubrum Linn. The results indicated that " RXF02", " RXF03" and " RXM05" performed well in the number of spikes per plant,average number of panicles,average yield per plant,and cold resistance,and the comprehensive scores were 9. 68,9. 44 and 9. 41,respectively.
文摘Embelia ribes Burm f., also known as Vidanga or Baibidanga, belonging to the family of Myrsinaceae, is an important but vulnerable medicinal woody climber. Recent survey and observations of E. ribes in different aspects like distribution, population structure, growth habit, climate, natural regeneration and seedling ecology in Karnataka have been thoroughly discussed. This is the first report on artificial regeneration through seeds of diverse origins in ex-situ and in situ conditions and field planting of them in its natural environment. Field planting of in vitro and nursery raised seedlings showed better field performance in terms of survival and growth in its natural growing areas only. Current studies and observations have shown that this species has low ecological gradient and is a “habitat specialist”. E. ribes being a threatened species with small populations coupled with low ecological gradient and virtually no natural regeneration, a modified approach of quasi in situ conservation where in in-situ raising of seedlings of diverse origin with an aim to enrich the diversity of existing population was attempted with considerable success.
基金supported financially by National Natural Science Foundation of China(Nos.21002098 and 20932007)‘Western Light’ Research Program from Chinese Academy of Sciences(No.Y1C1011)National New Drug Innovation Major Project of China(No.2011ZX09307-002-02)
文摘Three new biphenyls, 4,7,8-trimethoxy-2,3-methylenedioxydibenzofuran （1）, 7-hydroxy-4,8- dimethoxy-2,3-methylenedioxydibenzofuran （2）, and 3＇,5-dimethoxy-3,4-methylenedioxybiphenyl （3）, along with eighteen known compounds （4-21） were isolated from the aerial part of Ribes takare D. Don. Their structures were elucidated on the basis of spectroscopic data. Compound I and compound 2 showed mild α-glucosidase inhibitory activity.
文摘黑穗醋栗属于皮部生根型。厚皮品种插条不定根的排列以簇生和纵生为主,薄皮品种以簇生和散生为主。解剖观察表明,黑穗醋栗具有先成不定根原基,起源于髓射线或次生射线与维管形成层交叉处。茎的结构及茎内营养物质含量均影响生根。生根期间全碳、全氮呈现规律性变化。厚皮品种硬枝各部位作插条,50 ppm NAA 或 IBA 处理1～5 min 生根较好,水培和土培方法均可采用;薄皮品种绿枝下部作插条,50 ppm NAA 处理1 min 或30 min 生根均较好,且以水培方法为宜。
文摘Ribes plants,like most of other fruit trees,are characterized by their large number but small size of somatic chromosomes.In the light of these special characteristics,we have examined several factorial combinations of material, pretreatment,slide preparing method and stain to identify the most promising techique for studying the chromosomes and further analyzing the karyotypes and chromosome banding of Ribes plants. The resuts indicated that the combination of root tip with pretreatment of 2 m molL-1 8-hydroxyquinoline plus 0.05% colchicine or 0.3% balm for 3～5 hours at 14℃,pre-hypotonic trcarment of 0.07mol L-1 KCl for 30 min, fixation in Carnoy's fluid,hydrolysis in 5% cellulase and 5% pectinase mixture for 4～5 hours at 25℃, post-hypotonic treatment in distilled water for half an hour and staining in Giemsa could make the chromosome prepa ration superior to other treatment combinations.
