Background:Missing data are frequently occurred in clinical studies.Due to the development of precision medicine,there is an increased interest in N-of-1 trial.Bayesian models are one of main statistical methods for a...Background:Missing data are frequently occurred in clinical studies.Due to the development of precision medicine,there is an increased interest in N-of-1 trial.Bayesian models are one of main statistical methods for analyzing the data of N-of-1 trials.This simulation study aimed to compare two statistical methods for handling missing values of quantitative data in Bayesian N-of-1 trials.Methods:The simulated data of N-of-1 trials with different coefficients of autocorrelation,effect sizes and missing ratios are obtained by SAS 9.1 system.The missing values are filled with mean filling and regression filling respectively in the condition of different coefficients of autocorrelation,effect sizes and missing ratios by SPSS 25.0 software.Bayesian models are built to estimate the posterior means by Winbugs 14 software.Results:When the missing ratio is relatively small,e.g.5%,missing values have relatively little effect on the results.Therapeutic effects may be underestimated when the coefficient of autocorrelation increases and no filling is used.However,it may be overestimated when mean or regression filling is used,and the results after mean filling are closer to the actual effect than regression filling.In the case of moderate missing ratio,the estimated effect after mean filling is closer to the actual effect compared to regression filling.When a large missing ratio(20%)occurs,data missing can lead to significantly underestimate the effect.In this case,the estimated effect after regression filling is closer to the actual effect compared to mean filling.Conclusion:Data missing can affect the estimated therapeutic effects using Bayesian models in N-of-1 trials.The present study suggests that mean filling can be used under situation of missing ratio≤10%.Otherwise,regression filling may be preferable.展开更多
[Objective] The study aimed to research the nutrients release of ponds sediment.[Method] The sediments which from a new pond(A) and an old one (B) these analyses used to carry out indoor experiment under the anaerobic...[Objective] The study aimed to research the nutrients release of ponds sediment.[Method] The sediments which from a new pond(A) and an old one (B) these analyses used to carry out indoor experiment under the anaerobic dark condition for researching on nutrient release. The N(nitrogenous) and P(phosphorous) release were analyzed every two days.[Result] At the prophase, the N release in B was bigger than that in A, while the decline sediment release in A was gentle.[Conclusion] There was no accumulation of organic compound during the breeding time. The NH4-N was the main form of N release; and the P release was correlated with N release, while PO4-P was the main form of P release.展开更多
Ultrasound imaging is the most widely used noninvasive medical imaging modality. Its latest elite concept is Superharmonic Imaging which is the most talked-about future of medical diagnostic ultrasound. In this paper,...Ultrasound imaging is the most widely used noninvasive medical imaging modality. Its latest elite concept is Superharmonic Imaging which is the most talked-about future of medical diagnostic ultrasound. In this paper, the computational and analytical study for superharmonic field generation from phased array transducer of 16 × 16 elements is presented. For this, the model preferred, includes the calculation for diffraction effect in frequency domain and nonlinear effect in time domain. The attenuation is included along with the diffraction in frequency domain as well. The comparative analysis of superharmonic field is also carried out with simulated fundamental and second harmonic fields by the same model. Similarly, the comparison with the results from the literature is also reported.展开更多
Based on the principle of RH process and the mechanism of decarburization, a three-dimensional mathematical model to represent the flow and decarburization of molten steel was established. The model was verified and t...Based on the principle of RH process and the mechanism of decarburization, a three-dimensional mathematical model to represent the flow and decarburization of molten steel was established. The model was verified and the effect of operating parameters on the process was investigated.展开更多
A water model and a high-speed video camera were utilized in the 300-t RH equipment to study the effect of steel flow patterns in a vacuum chamber on fast decarburization and a superior flow-pattern map was obtained d...A water model and a high-speed video camera were utilized in the 300-t RH equipment to study the effect of steel flow patterns in a vacuum chamber on fast decarburization and a superior flow-pattern map was obtained during the practical RH process. There are three flow patterns with different bubbling characteristics and steel surface states in the vacuum chamber： boiling pattern（BP）, transition pattern（TP）, and wave pattern（WP）. The effect of the liquid-steel level and the residence time of the steel in the chamber on flow patterns and decarburization reaction were investigated, respectively. The liquid-steel level significantly affected the flow-pattern transition from BP to WP, and the residence time and reaction area were crucial to evaluate the whole decarburization process rather than the circulation flow rate and mixing time. A superior flow-pattern map during the practical RH process showed that the steel flow pattern changed from BP to TP quickly, and then remained as TP until the end of decarburization.展开更多
The effect of the valence band tail width on the open circuit voltage of P3HT：PCBM bulk heterojunction solar cell is investigated by using the AMPS-1D computer program. An effective medium model with exponential vale...The effect of the valence band tail width on the open circuit voltage of P3HT：PCBM bulk heterojunction solar cell is investigated by using the AMPS-1D computer program. An effective medium model with exponential valence and conduction band tail states is used to simulate the photovoltaic cell. The simulation result shows that the open circuit voltage depends Iinearly on the logarithm of the generation rate and the slope depends on the width of the valence band tail. The open circuit voltage decreases with the increasing width of the band tail. The dark and light ideality factors increase with the width of the valence band tail.展开更多
为量化评价RH浸渍管吹气孔堵塞个数及分布对混合特性的影响,为RH真空槽是否下线提供依据,针对马钢300 t RH精炼装置开展了水模型研究。结果表明:当浸渍管气孔堵塞个数为1个或2个时,循环流量大于或接近正常状态下的循环流量,混匀时间接...为量化评价RH浸渍管吹气孔堵塞个数及分布对混合特性的影响,为RH真空槽是否下线提供依据,针对马钢300 t RH精炼装置开展了水模型研究。结果表明:当浸渍管气孔堵塞个数为1个或2个时,循环流量大于或接近正常状态下的循环流量,混匀时间接近正常状态下的混匀时间;当浸渍管三孔集中堵塞并且集中堵塞气孔沿浸渍管中心轴线方向,并靠近钢包壁方向时,循环流量大幅降低,在此情况下,RH真空槽不能继续使用。在其它位置分布状态下的单孔、双孔以及三孔堵塞,RH真空槽都可以继续使用。展开更多
The method of using dielectrophoresis （DEP） to assemble graphene between micro-electrodes has been proven to be simple and efficient. We present an optimization method for the kinetic formula of graphene DEP, and di...The method of using dielectrophoresis （DEP） to assemble graphene between micro-electrodes has been proven to be simple and efficient. We present an optimization method for the kinetic formula of graphene DEP, and discuss the simulation of the graphene assembly process based on the finite element method. The simulated results illustrate that the accelerated motion of graphene is in agreement with the distribution of the electric field squared gradient. We also conduct research on the controllable parameters of the DEP assembly such as the alternating current （AC） frequency, the shape of micro-electrodes, and the ratio of the gap between electrodes to the characteristic/geometric length of graphene （λ）. The simulations based on the Clausius-Mossotti factor reveal that both graphene velocity and direction are influenced by the AC frequency. When graphene is close to the electrodes, the shape of micro-electrodes will exert great influence on the velocity of graphene. Also, λ has a great influence on the velocity of graphene. Generally, the velocity of graphene would be greater when λ is in the range of 0.4 0.6. The study is of a theoretical guiding significance in improving the precision and efficiency of the graphene DEP assembly.展开更多
A transport simulation has been done by using a i.5D time dependent transportcode to reproduce a formation of the ITB on electron temperature Profile during the long pu1seLHCD in JT-60U tokamak. The transport coeffici...A transport simulation has been done by using a i.5D time dependent transportcode to reproduce a formation of the ITB on electron temperature Profile during the long pu1seLHCD in JT-60U tokamak. The transport coefficients were assumed to reduce with a reversedmagnetic shear and the LH driven current profile was evaluated by fitting dynamic change inthe measured current profile. The gradual increase in the central electron temperature could beexplained by the change in the current profile during LHCD in the present simulation model. Theestimated LH-driven current profile by the transport code analysis shows a finite current densityat the plasma center. Analysis of transport simulation suggests some mechanisms for broadeningthe LH-driven current profile at the central region of the plasma.展开更多
We evaluate the impact of temperature on the output behavior of a carbon nanotube field effect transistor （CNFET） based chaotic generator. The sources cause the variations in both current-voltage characteristics of ...We evaluate the impact of temperature on the output behavior of a carbon nanotube field effect transistor （CNFET） based chaotic generator. The sources cause the variations in both current-voltage characteristics of the CNFET device and an overall chaotic circuit is pointed out. To verify the effect of temperature variation on the output dynamics of the chaotic circuit, a simulation is performed by employing the CNFET compact model of Wong et al. in HSPICE with a temperature range from -100℃ to 100℃. The obtained results with time series, frequency spectra, and bifurcation diagram from the simulation demonstrate that temperature plays a significant role in the output dynamics of the CNFET-based chaotic circuit. Thus, temperature-related issues should be taken into account while designing a high-quality chaotic generator with high stability.展开更多
The boiler is one of the key parts of power station. Monitoring the operation of the boiler automatically, continuously and accurately is very important. In case of malfunctions, an expert system might be helpful to f...The boiler is one of the key parts of power station. Monitoring the operation of the boiler automatically, continuously and accurately is very important. In case of malfunctions, an expert system might be helpful to find the sources of faults, and thereafter will assist the operator to act correctly and to prevent the fault from further development.In this paper, a simulation study of an expert system, which can diagnose the running faults of boiler system, is conducted. Shallow and deep two-layer knowledge base structure is used in this two layers of knowledge base. So. this kind of expert system can overcome the disadvantages of the old types of expert systems, which are only able to deal with experience rules base.A simulator of power boiler is used for the research on fault diagnose expert system. This boiler simulator gives all necessary information for the diagnosis. The knowledge base of expert system is built in hierarchies, so the speed of reasoning may be invreased. After the reasoning the展开更多
基金supported by the National Natural Science Foundation of China (No.81973705).
文摘Background:Missing data are frequently occurred in clinical studies.Due to the development of precision medicine,there is an increased interest in N-of-1 trial.Bayesian models are one of main statistical methods for analyzing the data of N-of-1 trials.This simulation study aimed to compare two statistical methods for handling missing values of quantitative data in Bayesian N-of-1 trials.Methods:The simulated data of N-of-1 trials with different coefficients of autocorrelation,effect sizes and missing ratios are obtained by SAS 9.1 system.The missing values are filled with mean filling and regression filling respectively in the condition of different coefficients of autocorrelation,effect sizes and missing ratios by SPSS 25.0 software.Bayesian models are built to estimate the posterior means by Winbugs 14 software.Results:When the missing ratio is relatively small,e.g.5%,missing values have relatively little effect on the results.Therapeutic effects may be underestimated when the coefficient of autocorrelation increases and no filling is used.However,it may be overestimated when mean or regression filling is used,and the results after mean filling are closer to the actual effect than regression filling.In the case of moderate missing ratio,the estimated effect after mean filling is closer to the actual effect compared to regression filling.When a large missing ratio(20%)occurs,data missing can lead to significantly underestimate the effect.In this case,the estimated effect after regression filling is closer to the actual effect compared to mean filling.Conclusion:Data missing can affect the estimated therapeutic effects using Bayesian models in N-of-1 trials.The present study suggests that mean filling can be used under situation of missing ratio≤10%.Otherwise,regression filling may be preferable.
基金Supported by the National High Technology Research and Development Program of China (863 Program)(2007AA10Z239)the National Key Technology R&D Program(2006BAD03B0102)+2 种基金the Natural Science Foundation of Guangdong Province(5004159)Scienceand Technology Planning Project of Guangdong Province(2005N33201012)the Open Fund of Key Laboratory of Genetic Breeding and Aquaculture Biology of Freshwater Fishes,Ministry of Agriculture(BM2007-03)~~
文摘[Objective] The study aimed to research the nutrients release of ponds sediment.[Method] The sediments which from a new pond(A) and an old one (B) these analyses used to carry out indoor experiment under the anaerobic dark condition for researching on nutrient release. The N(nitrogenous) and P(phosphorous) release were analyzed every two days.[Result] At the prophase, the N release in B was bigger than that in A, while the decline sediment release in A was gentle.[Conclusion] There was no accumulation of organic compound during the breeding time. The NH4-N was the main form of N release; and the P release was correlated with N release, while PO4-P was the main form of P release.
文摘Ultrasound imaging is the most widely used noninvasive medical imaging modality. Its latest elite concept is Superharmonic Imaging which is the most talked-about future of medical diagnostic ultrasound. In this paper, the computational and analytical study for superharmonic field generation from phased array transducer of 16 × 16 elements is presented. For this, the model preferred, includes the calculation for diffraction effect in frequency domain and nonlinear effect in time domain. The attenuation is included along with the diffraction in frequency domain as well. The comparative analysis of superharmonic field is also carried out with simulated fundamental and second harmonic fields by the same model. Similarly, the comparison with the results from the literature is also reported.
文摘Based on the principle of RH process and the mechanism of decarburization, a three-dimensional mathematical model to represent the flow and decarburization of molten steel was established. The model was verified and the effect of operating parameters on the process was investigated.
基金financially supported by the National Natural Science Foundation of China (No.51704203)the PhD Early Development Program of Taiyuan University of Science and Technology (Nos. 20152008, 20152013, and 20152018)+2 种基金Shanxi Province Science Foundation for Youths (No. 201601D202027)Key Project of Research and Development Plan of Shanxi Province (Nos. 201603D111004 and 201603D121010)NSFC-Shanxi Coal Based Low Carbon Joint Fund (No. U1510131)
文摘A water model and a high-speed video camera were utilized in the 300-t RH equipment to study the effect of steel flow patterns in a vacuum chamber on fast decarburization and a superior flow-pattern map was obtained during the practical RH process. There are three flow patterns with different bubbling characteristics and steel surface states in the vacuum chamber： boiling pattern（BP）, transition pattern（TP）, and wave pattern（WP）. The effect of the liquid-steel level and the residence time of the steel in the chamber on flow patterns and decarburization reaction were investigated, respectively. The liquid-steel level significantly affected the flow-pattern transition from BP to WP, and the residence time and reaction area were crucial to evaluate the whole decarburization process rather than the circulation flow rate and mixing time. A superior flow-pattern map during the practical RH process showed that the steel flow pattern changed from BP to TP quickly, and then remained as TP until the end of decarburization.
文摘The effect of the valence band tail width on the open circuit voltage of P3HT：PCBM bulk heterojunction solar cell is investigated by using the AMPS-1D computer program. An effective medium model with exponential valence and conduction band tail states is used to simulate the photovoltaic cell. The simulation result shows that the open circuit voltage depends Iinearly on the logarithm of the generation rate and the slope depends on the width of the valence band tail. The open circuit voltage decreases with the increasing width of the band tail. The dark and light ideality factors increase with the width of the valence band tail.
文摘为量化评价RH浸渍管吹气孔堵塞个数及分布对混合特性的影响,为RH真空槽是否下线提供依据,针对马钢300 t RH精炼装置开展了水模型研究。结果表明:当浸渍管气孔堵塞个数为1个或2个时,循环流量大于或接近正常状态下的循环流量,混匀时间接近正常状态下的混匀时间;当浸渍管三孔集中堵塞并且集中堵塞气孔沿浸渍管中心轴线方向,并靠近钢包壁方向时,循环流量大幅降低,在此情况下,RH真空槽不能继续使用。在其它位置分布状态下的单孔、双孔以及三孔堵塞,RH真空槽都可以继续使用。
基金Supported by the Basic Research Project of Shanxi Province under Grant No 2015021092the National Natural Science Foundation of China under Grant Nos 61471255,61474079,61501316,51505324 and 51622507the National High-Technology Research and Development Program of China under Grant No 2015AA042601
文摘The method of using dielectrophoresis （DEP） to assemble graphene between micro-electrodes has been proven to be simple and efficient. We present an optimization method for the kinetic formula of graphene DEP, and discuss the simulation of the graphene assembly process based on the finite element method. The simulated results illustrate that the accelerated motion of graphene is in agreement with the distribution of the electric field squared gradient. We also conduct research on the controllable parameters of the DEP assembly such as the alternating current （AC） frequency, the shape of micro-electrodes, and the ratio of the gap between electrodes to the characteristic/geometric length of graphene （λ）. The simulations based on the Clausius-Mossotti factor reveal that both graphene velocity and direction are influenced by the AC frequency. When graphene is close to the electrodes, the shape of micro-electrodes will exert great influence on the velocity of graphene. Also, λ has a great influence on the velocity of graphene. Generally, the velocity of graphene would be greater when λ is in the range of 0.4 0.6. The study is of a theoretical guiding significance in improving the precision and efficiency of the graphene DEP assembly.
文摘A transport simulation has been done by using a i.5D time dependent transportcode to reproduce a formation of the ITB on electron temperature Profile during the long pu1seLHCD in JT-60U tokamak. The transport coefficients were assumed to reduce with a reversedmagnetic shear and the LH driven current profile was evaluated by fitting dynamic change inthe measured current profile. The gradual increase in the central electron temperature could beexplained by the change in the current profile during LHCD in the present simulation model. Theestimated LH-driven current profile by the transport code analysis shows a finite current densityat the plasma center. Analysis of transport simulation suggests some mechanisms for broadeningthe LH-driven current profile at the central region of the plasma.
基金Supported by the Basic Science Research Program through the National Research Foundation of Korea Funded by the Ministry of Education,Science and Technology under Grant No 2012-0002777
文摘We evaluate the impact of temperature on the output behavior of a carbon nanotube field effect transistor （CNFET） based chaotic generator. The sources cause the variations in both current-voltage characteristics of the CNFET device and an overall chaotic circuit is pointed out. To verify the effect of temperature variation on the output dynamics of the chaotic circuit, a simulation is performed by employing the CNFET compact model of Wong et al. in HSPICE with a temperature range from -100℃ to 100℃. The obtained results with time series, frequency spectra, and bifurcation diagram from the simulation demonstrate that temperature plays a significant role in the output dynamics of the CNFET-based chaotic circuit. Thus, temperature-related issues should be taken into account while designing a high-quality chaotic generator with high stability.
文摘The boiler is one of the key parts of power station. Monitoring the operation of the boiler automatically, continuously and accurately is very important. In case of malfunctions, an expert system might be helpful to find the sources of faults, and thereafter will assist the operator to act correctly and to prevent the fault from further development.In this paper, a simulation study of an expert system, which can diagnose the running faults of boiler system, is conducted. Shallow and deep two-layer knowledge base structure is used in this two layers of knowledge base. So. this kind of expert system can overcome the disadvantages of the old types of expert systems, which are only able to deal with experience rules base.A simulator of power boiler is used for the research on fault diagnose expert system. This boiler simulator gives all necessary information for the diagnosis. The knowledge base of expert system is built in hierarchies, so the speed of reasoning may be invreased. After the reasoning the
