Patients admitted with prediabetes and atrial fibrillation are at high risk for major adverse cardiac or cerebrovascular events independent of confounding variables.The shared pathophysiology between these three serio...Patients admitted with prediabetes and atrial fibrillation are at high risk for major adverse cardiac or cerebrovascular events independent of confounding variables.The shared pathophysiology between these three serious but common diseases and their association with atherosclerotic cardiovascular risk factors establish a vicious circle culminating in high atherogenicity.Because of that,it is of paramount importance to perform risk stratification of patients with prediabetes to define phenotypes that benefit from various interventions.Furthermore,stress hyperglycemia assessment of hospitalized patients and consensus on the definition of prediabetes is vital.The roles lifestyle and metformin play in prediabetes are well established.However,the role of glucagon-like peptide agonists and metabolic surgery is less clear.Prediabetes is considered an intermediate between normoglycemia and diabetes along the blood glucose continuum.One billion people are expected to suffer from prediabetes by the year 2045.Therefore,realworld randomized controlled trials to assess major adverse cardiac or cerebrovascular event risk reduction and reversal/prevention of type 2 diabetes among patients are needed to determine the proper interventions.展开更多
Previous studies have indicated a global reversal of near-surface wind speeds from a declining trend to an increasing trend around 2010;however,it remains unclear whether upper-air wind speeds exhibit a similar revers...Previous studies have indicated a global reversal of near-surface wind speeds from a declining trend to an increasing trend around 2010;however,it remains unclear whether upper-air wind speeds exhibit a similar reversal.This study evaluates reanalysis products using surface and radiosonde observations to analyze upper-air wind speed variations in the Northern Hemisphere,focusing on their seasonal and latitudinal differences.Results demonstrate that JRA-55 effectively captures wind speed variations in the Northern Hemisphere.Notably,upper-air wind speeds over land experienced a reversal in winter 2010 with significant latitudinal differences.The trend reversal of upper wind speed between the midlatitudes and subtropics presents a dipole pattern.From 1990 to 2010,upper-air wind speeds in the midlatitudes(40°-70°N)significantly declined,while the subtropical zone(20°-40°N)displayed an opposite trend.However,during 2010-2020,wind speeds in the midlatitudes shifted to a significant positive trend,whereas the subtropics experienced a significant negative trend.The variations in Northern Hemisphere winter wind speeds can be attributed to changes in low-level baroclinicity driven by tropical diabatic heating and midlatitude transient eddy feedback.Enhanced diabatic heating and weakened eddy feedback during 1990-2010 contributed to reduced wind speeds in the midlatitudes and increased speeds in the subtropics,while reduced diabatic heating and strengthened eddy feedback during 2010-2020 resulted in increased wind speeds in the midlatitudes and decreased speeds in the subtropics.The reversal of upper-air wind speeds could affect surface wind speeds by downward momentum transfer,which could contribute to the reversal of surface wind speeds.展开更多
Cancer multidrug resistance(MDR)impairs the therapeutic efficacy of various chemotherapeutics.Novel approaches,particularly the development of MDR reversal agents,are critically needed to address this challenge.This s...Cancer multidrug resistance(MDR)impairs the therapeutic efficacy of various chemotherapeutics.Novel approaches,particularly the development of MDR reversal agents,are critically needed to address this challenge.This study demonstrates that tenacissoside I(TI),a compound isolated from Marsdenia tenacissima(Roxb.)Wight et Arn,traditionally used in clinical practice as an ethnic medicine for cancer treatment,exhibits significant MDR reversal effects in ABCB1-mediated MDR cancer cells.TI reversed the resistance of SW620/AD300 and KBV200 cells to doxorubicin(DOX)and paclitaxel(PAC)by downregulating ABCB1 expression and reducing ABCB1 drug transport function.Mechanistically,protein arginine methyltransferase 1(PRMT1),whose expression correlates with poor prognosis and shows positive association with both ABCB1 and EGFR expressions in tumor tissues,was differentially expressed in TI-treated SW620/AD300 cells.SW620/AD300 and KBV200 cells exhibited elevated levels of EGFR asymmetric dimethylarginine(aDMA)and enhanced PRMT1-EGFR interaction compared to their parental cells.Moreover,TI-induced PRMT1 downregulation impaired PRMT1-mediated aDMA of EGFR,PRMT1-EGFR interaction,and EGFR downstream signaling in SW620/AD300 and KBV200 cells.These effects were significantly reversed by PRMT1 overexpression.Additionally,TI demonstrated resistance reversal to PAC in xenograft models without detectable toxicities.This study establishes TI's MDR reversal effect in ABCB1-mediated MDR human cancer cells through inhibition of PRMT1-mediated aDMA of EGFR,suggesting TI's potential as an MDR modulator for improving chemotherapy outcomes.展开更多
The effective intracellular accumulation of doxorubicin(DOX)is crucial for improving antitumor efficacy,which is severely impeded by limited drug penetration,uncontrollable drug release,and drug resistance.In this stu...The effective intracellular accumulation of doxorubicin(DOX)is crucial for improving antitumor efficacy,which is severely impeded by limited drug penetration,uncontrollable drug release,and drug resistance.In this study,a thermal-deformative polymer embedding ultrasmall ceria(CeO_(2))was rationally designed for deep tumor drug shuttling and hypoxia reversal to improve chemotherapy.Structurally,the CeO_(2)nanozyme was covalently grafted with a polymer of p(NIPAM-co-AM)that could sharply shrink for DOX loading,which was consolidated with polydopamine(PDA)film encapsulation.Thereafter,a tumor penetration guide of apolipoprotein A-I(apoA-I)conjugated iRGD peptide(apoA-I-iRGD)was further decorated onto the PDA shell via Michael addition for preparing CeO_(2)P/DOX@iAPDA.With the aid of apoA-I-iRGD,CeO_(2)P/DOX@iAPDA penetrated both the tumor spheroids(∼78μm)and the tumors of the mouse model deeply.After internalization by tumor cells and triggering by low pH in lysosomes,rapid DOX release was achieved by peeling off the PDA shell and thermosensitive deformation of p(NIPAM-co-AM).CeO_(2)P/DOX@iAPDA provided 66.4%tumor suppression in 4T1-derived tumor spheroids and 63.2%in 4T1-tumorbearing mice,respectively.Preliminary mechanistic research involving western blotting and immunohistochemistry revealed that CeO_(2)P/DOX@iAPDA reversed resistance through the through HIF-1α-P-gp/lipid axis.Collectively,this study intelligently integrated CeO_(2)nanozymes,temperature-sensitive polymers,and imitated biochemical modifications to improve chemotherapy for breast cancer.展开更多
BACKGROUND There is an increased maturation of laparoscopic intracorporeal anastomosis techniques.However,research on its application for small bowel stoma reversal in patients with Crohn's disease(CD)is limited.T...BACKGROUND There is an increased maturation of laparoscopic intracorporeal anastomosis techniques.However,research on its application for small bowel stoma reversal in patients with Crohn's disease(CD)is limited.Therefore,in this study,we compared the perioperative outcomes between laparoscopic intracorporeal ileostomy reversal(LIIR)and open ileostomy reversal(OIR).AIM To compare the safety,feasibility,bowel function recovery,and short-and longterm LIIR and OIR outcomes in patients with CD.METHODS This study included patients who underwent ileal reversal for CD between January 2021 and January 2023 at our institution.The baseline data,postoperative recovery,and complication indicators were retrospectively analyzed.Logistic regression analysis was conducted to explore factors that significantly influenced the development of enteral nutrition intolerance-related symptoms.RESULTS Notably,15 of the 45 patients in this study underwent OIR,and the remaining 30 received LIIR.Notably,no statistically significant differences were found between the two groups regarding clinical baseline characteristics,operation time,intraoperative hemorrhage,anastomotic site,enterolysis range,first postoperative flatus,postoperative complications,reoperation rate,or incidence of postoperative enteral nutrition intolerance.Compared with the OIR group,the LIIR group had a shorter postoperative hospital stay(P=0.045),lower incidence of enteral nutrition intolerance symptoms(P=0.019),and earlier postoperative total enteral nutrition initiation(P=0.033);however,it incurred higher total hospital costs(P=0.038).Furthermore,multivariate logistic regression analysis revealed that the duration of surgery and anastomotic technique were independent risk factors for postoperative symptoms of enteral nutrition intolerance(P<0.05).CONCLUSION Laparoscopic intracorporeal anastomosis for ileostomy reversal is safe and feasible.Patients who underwent this technique demonstrated improved tolerance to postoperative enteral nutrition and quicker resumption of total enteral nutrition.展开更多
In recent years,the network public opinion reversal governance events have occurred frequently.Over time,the repeated truth of the matter will not only weaken the rational judgment of the public to a certain extent,so...In recent years,the network public opinion reversal governance events have occurred frequently.Over time,the repeated truth of the matter will not only weaken the rational judgment of the public to a certain extent,so that its negative emotions accumulate,but also have a serious impact on the credibility of the media and the government,and may even further intensify social contradictions.Therefore,in the face of such a complex online public opinion space,accurately identifying the truth behind the incident and how to carry out the reversal of online public opinion governance is particularly critical.And blockchain technology,with its advantages of decentralization and immutable information,provides new technical support for the network public opinion reversal governance.Based on this,this paper gives an overview and analysis of blockchain technology and network public opinion reversal,and on this basis introduces the network public opinion reversal governance mechanism based on blockchain technology,aiming to further optimize the network public opinion reversal governance process,for reference only.展开更多
BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after s...BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after stoma reversal.No studies have analyzed the risk factors for stoma-related complications and overall postoperative com-plications separately.AIM To analyze the risk factors for overall complications and stoma-related complications after ileostomy reversal for patients with RC.METHODS This was a retrospective study of 439 patients who underwent ileostomy reversal at a clinical center and were followed up between September 2012 and September 2022.Continuous variables are expressed as the mean±SD and were analyzed with independent-sample t tests,while frequency variables are expressed as n(%),and theχ2 test or Fisher’s exact test was used.Univariate and multivariate logistic regression analyses were used to identify predictors of overall complications and stoma-related complications.RESULTS The overall complication rate after ileostomy reversal was 11.4%.Patients with lower preoperative albumin concentration(P<0.01),greater blood loss(P=0.017),and longer operative times(P<0.01)were more likely to experience postoperative complications.The incidence of stoma-related complications was 6.4%.Analysis of the study showed that a higher body mass index(BMI)(P<0.01),preoperative comorbid hypertension(P=0.049),time from primary surgery to ileostomy reversal(P<0.01)and longer operation time(P=0.010)were more likely to result in stomarelated complications postoperatively.Multivariate logistic regression analysis revealed that a lower preoperative albumin level(P<0.01,OR=0.888,95%CI:0.828-0.958)was an independent risk factor for overall complications.Moreover,multivariate analysis revealed that BMI(P<0.01,OR=1.176,95%CI:1.041-1.330)and time from primary surgery to ileostomy reversal(P<0.01,OR=1.140,95%CI:1.038-1.252)were independent risk factors for stoma-related complications after stoma reversal.CONCLUSION The preoperative albumin level was a predictor of overall complications.Preoperative BMI and the time from primary surgery to ileostomy reversal were predictors of stoma-related complications.展开更多
BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical...BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical evidence on their combined efficacy remains limited.AIM To evaluate the efficacy of CBT combined with HRT on anxiety disorders in children with Tourette’s syndrome(TS).METHODS Clinical data of children with TS admitted to our hospital from January 2022 to June 2023 were collected,and the patients were grouped into the conventional therapy(control)group and the CBT combined with HRT group.Baseline charac-teristics,anxiety scores,tic severity scores,treatment adherence,and parental satisfaction were assessed.Statistical analysis was performed using t-tests,chi-square tests,and correlation analysis.RESULTS A total of 136 patients,including 65 patients in the control group and 71 patients in the CBT combined with HRT group,were included.The CBT combined with HRT group showed remarkable improvements compared with the control group.Post-intervention assessment revealed a decrease in anxiety scores from 63.52±1.81 to 40.53±1.64(t=2.022,P=0.045),and the Yale Global Tic Severity Scale total score decreased from 22.14±5.67 to 16.28±4.91(t=2.288,P=0.024).Treatment adherence was significantly higher in the CBT combined with HRT group(85.47±7.62%)compared with the control group(82.32±6.54%;t=2.596,P=0.010).Parental satisfaction scores were also higher in the CBT combined with HRT group(8.69±1.77)compared with the control group(7.87±1.92;t=2.592,P=0.011).CONCLUSION This study demonstrates that CBT combined with HRT significantly reduces anxiety symptoms and tic severity in children with TS,with higher treatment adherence and parental satisfaction.These findings support the potential application of this comprehensive therapeutic approach for TS treatment.展开更多
In recent decades, tokamak discharges with zero total toroidal current have been reported in tokamak experiments, and this is one of the key problems in alternating current(AC) operations.An efficient free-boundary eq...In recent decades, tokamak discharges with zero total toroidal current have been reported in tokamak experiments, and this is one of the key problems in alternating current(AC) operations.An efficient free-boundary equilibrium code is developed to investigate such advanced tokamak discharges with current reversal equilibrium configuration. The calculation results show that the reversal current equilibrium can maintain finite pressure and also has considerable effects on the position of the X-point and the magnetic separatrix shape, and hence also on the position of the strike point on the divertor plates, which is extremely useful for magnetic design, MHD stability analysis, and experimental data analysis etc. for the AC plasma current operation on tokamaks.展开更多
We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is know...We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is known to Alice while the two-qubit state which is a non-maximally entangled Bell state is known to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describe the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describe the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown by numerical computation in specific examples of the states to be created. Finally, we show that it is possible to maintain the label of fidelity to some extent and hence to decrease the effect of noise by the application of weak and reversal measurements. We also present a scheme for the generation of the five-qubit entangled resource which we require as a quantum channel. The generation scheme is run on the IBMQ platform.展开更多
In the sedimentary strata dating of estuarial coastal areas,it is often found that there is phenomenon of time-reversal in strata.The seabed sediments could be liquefied under storm waves.A laboratory wave flume exper...In the sedimentary strata dating of estuarial coastal areas,it is often found that there is phenomenon of time-reversal in strata.The seabed sediments could be liquefied under storm waves.A laboratory wave flume experiment demonstrated that storm-induced liquefaction deposits are formed by the oscillations of liquefied sediments.In this paper,the particle size distribution and ^(210)Pb_(ex) specific activity of the sediment samples from the liquefaction disturbed zone and adjacent stable zone of the Yellow River Delta were tested.The stratigraphic divisions based on storm liquefaction deposit sequence can effectively explain the vertical changes in particle size and ^(210)Pb_(ex) specific activity.Due to the differentiation of particles during the storm induced liquefaction,coarse and fine particles regrouped,which could explain the phenomenon of time-reversal in dating data.展开更多
The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic st...The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic status.Not all individuals of T1DM progress in that specific sequence.We hereby present a case of T1DM with a classical third phase(honeymoon phase)and discuss the intri-cacies of this interesting phase along with a possible future promise of“cure”with the use of immunotherapies.We now know that the course of T1DM may not be in only one direction towards further progression;rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being discussed.The third phase popularly called the“honeymoon phase”,is of special interest as this phase is complex in its pathogenesis.The honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive“diabetes reversal”in T1DM.Identifying this phase is therefore the key,with a lot of varying criteria having been proposed.展开更多
BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic calcification.Metastatic calcification involving the heart ...BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic calcification.Metastatic calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular block.This case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular block.CASE SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus nephropathy.She developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular block.Then,she underwent parathyroidectomy(PTX)with autotransplantation.Unfortunately,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was reversed.CONCLUSION This case revealed that metastatic cardiac calcification can result in complete atrioventricular blockage.Following parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular block.It is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.展开更多
This study was conducted to determine the effective dose of 17α-methyltestosterone(MT)that produces all-male fry of black-chinned tilapia,Sarotherodon melanotheron.Five concentrations:0,30,60,90 and 120 mg 17α-methy...This study was conducted to determine the effective dose of 17α-methyltestosterone(MT)that produces all-male fry of black-chinned tilapia,Sarotherodon melanotheron.Five concentrations:0,30,60,90 and 120 mg 17α-methyltestosterone(17α-MT)per kilogram feed were prepared using the ethanol evaporation method,and administered orally to black-chinned tilapia fry for 28 days in triplicate aquarium glass tanks.After the treatment period,triplicates of 60 fry from each treatment were stocked in hapas and further cultured in freshwater ponds.They were fed with commercial fish feed ad libitum.The sex ratio,growth performance and survival were evaluated after 60 and 180 days.At the end of the 60-day period,the sex ratio of 30 fish from each treatment was determined by using the gonadal squash method.The remaining 30 fish from each treatment were grown further for 180 days and their sex ratio determined using the genital papillae.The results demonstrated that 17α-methyltestosterone was effective in producing phenotypic male in S.melanotheron.However,in both 60-day and 180-day experiments,no treatment gave 100%male population.The 90 mg/kg MT yielded the highest all-male fish of 84.13%,highest survival of 70%and highest final mean body weight of 103.99±7.92 g.展开更多
Financial performance analysis is of vital importance those involved in a business(e.g.,shareholders,creditors,partners,and company managers).An accurate and appropriate performance measurement is critical for decisio...Financial performance analysis is of vital importance those involved in a business(e.g.,shareholders,creditors,partners,and company managers).An accurate and appropriate performance measurement is critical for decision-makers to achieve efficient results.Integrated performance measurement,by its nature,consists of multiple criteria with different levels of importance.Multiple Criteria Decision Analysis(MCDA)methods have become increasingly popular for solving complex problems,especially over the last two decades.There are different evaluation methodologies in the literature for selecting the most appropriate one among over 200 MCDA methods.This study comprehensively analyzed 41 companies traded on the Borsa Istanbul Corporate Governance Index for 10 quarters using SWARA,CRITIC,and SD integrated with eight different MCDA method algorithms to determine the position of Turkey's most transparent companies in terms of financial performance.In this study,we propose"stock returns"as a benchmark in comparing and evaluating MCDA methods.Moreover,we calculate the"rank reversal performance of MCDA methods".Finally,we performed a"standard deviation"analysis to identify the objective and characteristic trends for each method.Interestingly,all these innovative comparison procedures suggest that PROMETHEE II(preference ranking organization method for enrichment of evaluations II)and FUCA(Faire Un Choix Adéquat)are the most suitable MCDA methods.In other words,these methods produce a higher correlation with share price;they have fewer rank reversal problems,the distribution of scores they produce is wider,and the amount of information is higher.Thus,it can be said that these advantages make them preferable.The results show that this innovative methodological procedure based on'knowledge discovery'is verifiable,robust and efficient when choosing the MCDA method.展开更多
Aim To analyze the transient speciality of nonlinear, anisotropic, AC+DC coupling electric field, and to compare the withstand voltage strength of different insulation structures. Methods The transient process o...Aim To analyze the transient speciality of nonlinear, anisotropic, AC+DC coupling electric field, and to compare the withstand voltage strength of different insulation structures. Methods The transient process of polarity reversal is analyzed, considering the anisotropic property of oil immersed press board, a new finite element model based on Galerkin method is presented and verified. The model developed is applied to calculate the electric field distribution in four typical winding end structures of the converter transformer. Results\ The whole ring structure possesses the best insulation characteristics. Conclusion\ By introducing reasonable insulation components, insulation strength with the same surrounding sizes can be improved more than 30%.展开更多
In the present work,the magnetization reversal behavior for the melt spinning(Nd_(0.8)Ce_(0.2))_(2)Fe_(12)Co_(2-x)Zr_(x)B(x=0,0.5)permanent alloys with high coercivity was investigated by analyzing the hysteresis curv...In the present work,the magnetization reversal behavior for the melt spinning(Nd_(0.8)Ce_(0.2))_(2)Fe_(12)Co_(2-x)Zr_(x)B(x=0,0.5)permanent alloys with high coercivity was investigated by analyzing the hysteresis curves and the recoil loops.Compared to the Zr-free alloy,the Zr-doped sample obtains higher magnetic properties:coercivity of H_(cj)=650.5 kA·m^(-1),squareness of H_(k)/H_(cj)=0.76 and maximum energy product of(BH)_(max)=131.0 kJ·m^(-3).The first-order reversal curves(FORCs)analysis was taken to identify optimal conditions of exchange coupling for the Zr-free and Zr-doped alloys.The coercivity mechanism of theα-Fe/Nd_(2)Fe_(14)B nanocomposite alloys was analyzed by the angular dependence of the coercive field as measured for the Zr-doped sample.The results show that the magnetic reverse process of the Zr-doped sample can be explained by the pinning model.展开更多
This paper presents a detailed analysis of the effects of noise (reverberation) on the focusing performance of de-composition of the time reversal operator (DORT) in a noise-limited case and in a reverberation-limited...This paper presents a detailed analysis of the effects of noise (reverberation) on the focusing performance of de-composition of the time reversal operator (DORT) in a noise-limited case and in a reverberation-limited case, respectively. Quantitative results obtained from simulations and experiments are presented. The results show the DORT method can be effi-ciently applied to target detection with enough source level to yield significant backscatter. For a target placed on the bottom, the influence of the reverberation on the focusing performance is slight. However, distinguishing between a target and constant backscattering returning from strong local clutter on the bottom (false alarms) needs further research.展开更多
An efficient hybrid time reversal（TR） imaging method based on signal subspace and noise subspace is proposed for electromagnetic superresolution detecting and imaging. First, the locations of targets are estimated b...An efficient hybrid time reversal（TR） imaging method based on signal subspace and noise subspace is proposed for electromagnetic superresolution detecting and imaging. First, the locations of targets are estimated by the transmitting-mode decomposition of the TR operator（DORT） method employing the signal subspace. Then, the TR multiple signal classification（TR-MUSIC）method employing the noise subspace is used in the estimated target area to get the superresolution imaging of targets. Two examples with homogeneous and inhomogeneous background mediums are considered, respectively. The results show that the proposed hybrid method has advantages in CPU time and memory cost because of the combination of rough and fine imaging.展开更多
文摘Patients admitted with prediabetes and atrial fibrillation are at high risk for major adverse cardiac or cerebrovascular events independent of confounding variables.The shared pathophysiology between these three serious but common diseases and their association with atherosclerotic cardiovascular risk factors establish a vicious circle culminating in high atherogenicity.Because of that,it is of paramount importance to perform risk stratification of patients with prediabetes to define phenotypes that benefit from various interventions.Furthermore,stress hyperglycemia assessment of hospitalized patients and consensus on the definition of prediabetes is vital.The roles lifestyle and metformin play in prediabetes are well established.However,the role of glucagon-like peptide agonists and metabolic surgery is less clear.Prediabetes is considered an intermediate between normoglycemia and diabetes along the blood glucose continuum.One billion people are expected to suffer from prediabetes by the year 2045.Therefore,realworld randomized controlled trials to assess major adverse cardiac or cerebrovascular event risk reduction and reversal/prevention of type 2 diabetes among patients are needed to determine the proper interventions.
基金supported by the National Natural Science Foundation of China[grant numbers U2442207,42122034,42075043,and 42330609]the Youth Innovation Promotion Association[grant number 2021427]+2 种基金the West Light Foundation[grant number xbzgzdsys-202409]of the Chinese Academy of Sciencesthe Key Talent Projects in Gansu Provincethe Central Guidance Fund for Local Science and Technology Development Projects in Gansu Province[grant number 24ZYQA031].
文摘Previous studies have indicated a global reversal of near-surface wind speeds from a declining trend to an increasing trend around 2010;however,it remains unclear whether upper-air wind speeds exhibit a similar reversal.This study evaluates reanalysis products using surface and radiosonde observations to analyze upper-air wind speed variations in the Northern Hemisphere,focusing on their seasonal and latitudinal differences.Results demonstrate that JRA-55 effectively captures wind speed variations in the Northern Hemisphere.Notably,upper-air wind speeds over land experienced a reversal in winter 2010 with significant latitudinal differences.The trend reversal of upper wind speed between the midlatitudes and subtropics presents a dipole pattern.From 1990 to 2010,upper-air wind speeds in the midlatitudes(40°-70°N)significantly declined,while the subtropical zone(20°-40°N)displayed an opposite trend.However,during 2010-2020,wind speeds in the midlatitudes shifted to a significant positive trend,whereas the subtropics experienced a significant negative trend.The variations in Northern Hemisphere winter wind speeds can be attributed to changes in low-level baroclinicity driven by tropical diabatic heating and midlatitude transient eddy feedback.Enhanced diabatic heating and weakened eddy feedback during 1990-2010 contributed to reduced wind speeds in the midlatitudes and increased speeds in the subtropics,while reduced diabatic heating and strengthened eddy feedback during 2010-2020 resulted in increased wind speeds in the midlatitudes and decreased speeds in the subtropics.The reversal of upper-air wind speeds could affect surface wind speeds by downward momentum transfer,which could contribute to the reversal of surface wind speeds.
基金supported by the National Natural Science Foundation of China(Nos.82274211 and 82474190)the Natural Science Foundation of Tianjin(Nos.24JCZDJC00120 and 24PTLYHZ00280)Liaoning Provincial Department of Education Basic Research Projects for Higher Education Institutions(No.LJ212510163021)。
文摘Cancer multidrug resistance(MDR)impairs the therapeutic efficacy of various chemotherapeutics.Novel approaches,particularly the development of MDR reversal agents,are critically needed to address this challenge.This study demonstrates that tenacissoside I(TI),a compound isolated from Marsdenia tenacissima(Roxb.)Wight et Arn,traditionally used in clinical practice as an ethnic medicine for cancer treatment,exhibits significant MDR reversal effects in ABCB1-mediated MDR cancer cells.TI reversed the resistance of SW620/AD300 and KBV200 cells to doxorubicin(DOX)and paclitaxel(PAC)by downregulating ABCB1 expression and reducing ABCB1 drug transport function.Mechanistically,protein arginine methyltransferase 1(PRMT1),whose expression correlates with poor prognosis and shows positive association with both ABCB1 and EGFR expressions in tumor tissues,was differentially expressed in TI-treated SW620/AD300 cells.SW620/AD300 and KBV200 cells exhibited elevated levels of EGFR asymmetric dimethylarginine(aDMA)and enhanced PRMT1-EGFR interaction compared to their parental cells.Moreover,TI-induced PRMT1 downregulation impaired PRMT1-mediated aDMA of EGFR,PRMT1-EGFR interaction,and EGFR downstream signaling in SW620/AD300 and KBV200 cells.These effects were significantly reversed by PRMT1 overexpression.Additionally,TI demonstrated resistance reversal to PAC in xenograft models without detectable toxicities.This study establishes TI's MDR reversal effect in ABCB1-mediated MDR human cancer cells through inhibition of PRMT1-mediated aDMA of EGFR,suggesting TI's potential as an MDR modulator for improving chemotherapy outcomes.
基金supported by National Natural Science Foundation of China(Nos.82473949 and 82273955)Scientific research project of Jiangsu Provincial Health Commission(No.M2022080)+1 种基金Jiangsu Province Capability Improvement Project through Science,Technology and Education(ZDXK202234)Jiangsu Provincial Research Hospital(YJXYY202204),China.
文摘The effective intracellular accumulation of doxorubicin(DOX)is crucial for improving antitumor efficacy,which is severely impeded by limited drug penetration,uncontrollable drug release,and drug resistance.In this study,a thermal-deformative polymer embedding ultrasmall ceria(CeO_(2))was rationally designed for deep tumor drug shuttling and hypoxia reversal to improve chemotherapy.Structurally,the CeO_(2)nanozyme was covalently grafted with a polymer of p(NIPAM-co-AM)that could sharply shrink for DOX loading,which was consolidated with polydopamine(PDA)film encapsulation.Thereafter,a tumor penetration guide of apolipoprotein A-I(apoA-I)conjugated iRGD peptide(apoA-I-iRGD)was further decorated onto the PDA shell via Michael addition for preparing CeO_(2)P/DOX@iAPDA.With the aid of apoA-I-iRGD,CeO_(2)P/DOX@iAPDA penetrated both the tumor spheroids(∼78μm)and the tumors of the mouse model deeply.After internalization by tumor cells and triggering by low pH in lysosomes,rapid DOX release was achieved by peeling off the PDA shell and thermosensitive deformation of p(NIPAM-co-AM).CeO_(2)P/DOX@iAPDA provided 66.4%tumor suppression in 4T1-derived tumor spheroids and 63.2%in 4T1-tumorbearing mice,respectively.Preliminary mechanistic research involving western blotting and immunohistochemistry revealed that CeO_(2)P/DOX@iAPDA reversed resistance through the through HIF-1α-P-gp/lipid axis.Collectively,this study intelligently integrated CeO_(2)nanozymes,temperature-sensitive polymers,and imitated biochemical modifications to improve chemotherapy for breast cancer.
基金Supported by Chongqing Municipal Health Commission Medical Research Project,No.2023WSJK104.
文摘BACKGROUND There is an increased maturation of laparoscopic intracorporeal anastomosis techniques.However,research on its application for small bowel stoma reversal in patients with Crohn's disease(CD)is limited.Therefore,in this study,we compared the perioperative outcomes between laparoscopic intracorporeal ileostomy reversal(LIIR)and open ileostomy reversal(OIR).AIM To compare the safety,feasibility,bowel function recovery,and short-and longterm LIIR and OIR outcomes in patients with CD.METHODS This study included patients who underwent ileal reversal for CD between January 2021 and January 2023 at our institution.The baseline data,postoperative recovery,and complication indicators were retrospectively analyzed.Logistic regression analysis was conducted to explore factors that significantly influenced the development of enteral nutrition intolerance-related symptoms.RESULTS Notably,15 of the 45 patients in this study underwent OIR,and the remaining 30 received LIIR.Notably,no statistically significant differences were found between the two groups regarding clinical baseline characteristics,operation time,intraoperative hemorrhage,anastomotic site,enterolysis range,first postoperative flatus,postoperative complications,reoperation rate,or incidence of postoperative enteral nutrition intolerance.Compared with the OIR group,the LIIR group had a shorter postoperative hospital stay(P=0.045),lower incidence of enteral nutrition intolerance symptoms(P=0.019),and earlier postoperative total enteral nutrition initiation(P=0.033);however,it incurred higher total hospital costs(P=0.038).Furthermore,multivariate logistic regression analysis revealed that the duration of surgery and anastomotic technique were independent risk factors for postoperative symptoms of enteral nutrition intolerance(P<0.05).CONCLUSION Laparoscopic intracorporeal anastomosis for ileostomy reversal is safe and feasible.Patients who underwent this technique demonstrated improved tolerance to postoperative enteral nutrition and quicker resumption of total enteral nutrition.
基金Gansu Provincial Department of Education:Innovation Fund Project for College Teachers:Research on the Governance of Network Public Opinion Reversal Based on Blockchain Technology(NO.2025A-137)Teaching Reform Research at the School Level of Gansu University of Political Science and Law in 2024:Research and Implementation of CSCW Cloud Storage Collective Lesson Preparation System Based on Blockchain Technology(NO.GZJG2024-A04)+1 种基金2024 Gansu University of Political Science and Law“Three in One Education”Research:Project Research and Implementation of CSCW Network Teaching Platform Based on Web in the Direction of Network Education(NO.GZSQYR-37)2024 Lanzhou Philosophy and Social Sciences Planning Project:Research on Cloud Governance of Network Public Opinion for Major Public Events in Lanzhou City(NO.24-B45)。
文摘In recent years,the network public opinion reversal governance events have occurred frequently.Over time,the repeated truth of the matter will not only weaken the rational judgment of the public to a certain extent,so that its negative emotions accumulate,but also have a serious impact on the credibility of the media and the government,and may even further intensify social contradictions.Therefore,in the face of such a complex online public opinion space,accurately identifying the truth behind the incident and how to carry out the reversal of online public opinion governance is particularly critical.And blockchain technology,with its advantages of decentralization and immutable information,provides new technical support for the network public opinion reversal governance.Based on this,this paper gives an overview and analysis of blockchain technology and network public opinion reversal,and on this basis introduces the network public opinion reversal governance mechanism based on blockchain technology,aiming to further optimize the network public opinion reversal governance process,for reference only.
基金Science and Technology Planning Project of Yuzhong District of Chongqing City,No.20210115.
文摘BACKGROUND Previous studies have analyzed the risk factors for complications after ileostomy reversal for rectal cancer(RC),but there were significant differences in the reported risk factors for complications after stoma reversal.No studies have analyzed the risk factors for stoma-related complications and overall postoperative com-plications separately.AIM To analyze the risk factors for overall complications and stoma-related complications after ileostomy reversal for patients with RC.METHODS This was a retrospective study of 439 patients who underwent ileostomy reversal at a clinical center and were followed up between September 2012 and September 2022.Continuous variables are expressed as the mean±SD and were analyzed with independent-sample t tests,while frequency variables are expressed as n(%),and theχ2 test or Fisher’s exact test was used.Univariate and multivariate logistic regression analyses were used to identify predictors of overall complications and stoma-related complications.RESULTS The overall complication rate after ileostomy reversal was 11.4%.Patients with lower preoperative albumin concentration(P<0.01),greater blood loss(P=0.017),and longer operative times(P<0.01)were more likely to experience postoperative complications.The incidence of stoma-related complications was 6.4%.Analysis of the study showed that a higher body mass index(BMI)(P<0.01),preoperative comorbid hypertension(P=0.049),time from primary surgery to ileostomy reversal(P<0.01)and longer operation time(P=0.010)were more likely to result in stomarelated complications postoperatively.Multivariate logistic regression analysis revealed that a lower preoperative albumin level(P<0.01,OR=0.888,95%CI:0.828-0.958)was an independent risk factor for overall complications.Moreover,multivariate analysis revealed that BMI(P<0.01,OR=1.176,95%CI:1.041-1.330)and time from primary surgery to ileostomy reversal(P<0.01,OR=1.140,95%CI:1.038-1.252)were independent risk factors for stoma-related complications after stoma reversal.CONCLUSION The preoperative albumin level was a predictor of overall complications.Preoperative BMI and the time from primary surgery to ileostomy reversal were predictors of stoma-related complications.
文摘BACKGROUND Cognitive-behavioral therapy(CBT)and habit reversal training(HRT)have shown application potential in addressing tic symptoms and comorbid psychiatric conditions.Despite their theoretical potential,empirical evidence on their combined efficacy remains limited.AIM To evaluate the efficacy of CBT combined with HRT on anxiety disorders in children with Tourette’s syndrome(TS).METHODS Clinical data of children with TS admitted to our hospital from January 2022 to June 2023 were collected,and the patients were grouped into the conventional therapy(control)group and the CBT combined with HRT group.Baseline charac-teristics,anxiety scores,tic severity scores,treatment adherence,and parental satisfaction were assessed.Statistical analysis was performed using t-tests,chi-square tests,and correlation analysis.RESULTS A total of 136 patients,including 65 patients in the control group and 71 patients in the CBT combined with HRT group,were included.The CBT combined with HRT group showed remarkable improvements compared with the control group.Post-intervention assessment revealed a decrease in anxiety scores from 63.52±1.81 to 40.53±1.64(t=2.022,P=0.045),and the Yale Global Tic Severity Scale total score decreased from 22.14±5.67 to 16.28±4.91(t=2.288,P=0.024).Treatment adherence was significantly higher in the CBT combined with HRT group(85.47±7.62%)compared with the control group(82.32±6.54%;t=2.596,P=0.010).Parental satisfaction scores were also higher in the CBT combined with HRT group(8.69±1.77)compared with the control group(7.87±1.92;t=2.592,P=0.011).CONCLUSION This study demonstrates that CBT combined with HRT significantly reduces anxiety symptoms and tic severity in children with TS,with higher treatment adherence and parental satisfaction.These findings support the potential application of this comprehensive therapeutic approach for TS treatment.
基金supported by National Natural Science Foundation of China (No. 12075276)partly by the Comprehensive Research Facility for Fusion Technology Program of China (No. 2018000052-73-01-001228)。
文摘In recent decades, tokamak discharges with zero total toroidal current have been reported in tokamak experiments, and this is one of the key problems in alternating current(AC) operations.An efficient free-boundary equilibrium code is developed to investigate such advanced tokamak discharges with current reversal equilibrium configuration. The calculation results show that the reversal current equilibrium can maintain finite pressure and also has considerable effects on the position of the X-point and the magnetic separatrix shape, and hence also on the position of the strike point on the divertor plates, which is extremely useful for magnetic design, MHD stability analysis, and experimental data analysis etc. for the AC plasma current operation on tokamaks.
基金Project supported by Indian Institute of Engineering Science and Technology, Shibpur, India
文摘We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is known to Alice while the two-qubit state which is a non-maximally entangled Bell state is known to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describe the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describe the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown by numerical computation in specific examples of the states to be created. Finally, we show that it is possible to maintain the label of fidelity to some extent and hence to decrease the effect of noise by the application of weak and reversal measurements. We also present a scheme for the generation of the five-qubit entangled resource which we require as a quantum channel. The generation scheme is run on the IBMQ platform.
基金funding for this project was provided by the National Natural Science Foundation of China (No.41976049)。
文摘In the sedimentary strata dating of estuarial coastal areas,it is often found that there is phenomenon of time-reversal in strata.The seabed sediments could be liquefied under storm waves.A laboratory wave flume experiment demonstrated that storm-induced liquefaction deposits are formed by the oscillations of liquefied sediments.In this paper,the particle size distribution and ^(210)Pb_(ex) specific activity of the sediment samples from the liquefaction disturbed zone and adjacent stable zone of the Yellow River Delta were tested.The stratigraphic divisions based on storm liquefaction deposit sequence can effectively explain the vertical changes in particle size and ^(210)Pb_(ex) specific activity.Due to the differentiation of particles during the storm induced liquefaction,coarse and fine particles regrouped,which could explain the phenomenon of time-reversal in dating data.
文摘The knowledge of the pathogenesis of type 1 diabetes mellitus(T1DM)continues to rapidly evolve.The natural course of the disease can be described in four clinical stages based on the autoimmune markers and glycemic status.Not all individuals of T1DM progress in that specific sequence.We hereby present a case of T1DM with a classical third phase(honeymoon phase)and discuss the intri-cacies of this interesting phase along with a possible future promise of“cure”with the use of immunotherapies.We now know that the course of T1DM may not be in only one direction towards further progression;rather the disease may have a waxing and waning course with even reversal of type 1 diabetes concept being discussed.The third phase popularly called the“honeymoon phase”,is of special interest as this phase is complex in its pathogenesis.The honeymoon phase of T1DM seems to provide the best window of opportunity for using targeted therapies using various immunomodulatory agents leading to the possibility of achieving the elusive“diabetes reversal”in T1DM.Identifying this phase is therefore the key,with a lot of varying criteria having been proposed.
基金Supported by Weifang Health and Family Planning Commission Research Project,No.WFWSJK-2021-212.
文摘BACKGROUND Refractory secondary hyperparathyroidism(SHPT)is a common complication observed in patients with end-stage renal disease and can result in ectopic calcification.Metastatic calcification involving the heart valves and the conduction system can easily lead to arrhythmias,including atrioventricular block.This case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block(CAVB),which was eventually reversed to a first-degree atrioventricular block.CASE SUMMARY We present the case of a 31-year-old Asian female who was receiving maintenance hemodialysis because of lupus nephropathy.She developed SHPT,and an electrocardiogram revealed a first-degree atrioventricular block.Then,she underwent parathyroidectomy(PTX)with autotransplantation.Unfortunately,a few years later,she developed SHPT again,and an electrocardiogram revealed a CAVB.A few years after the second PTX surgery,the calcification of the left atrium and left ventricle improved,and her CAVB was reversed.CONCLUSION This case revealed that metastatic cardiac calcification can result in complete atrioventricular blockage.Following parathyroid surgery,calcification of the cardiac conduction system improved,leading to reversal of the atrioventricular block.It is important for dialysis patients to optimize intact parathyroid hormone therapy and pay attention to calcification metastasis.
文摘This study was conducted to determine the effective dose of 17α-methyltestosterone(MT)that produces all-male fry of black-chinned tilapia,Sarotherodon melanotheron.Five concentrations:0,30,60,90 and 120 mg 17α-methyltestosterone(17α-MT)per kilogram feed were prepared using the ethanol evaporation method,and administered orally to black-chinned tilapia fry for 28 days in triplicate aquarium glass tanks.After the treatment period,triplicates of 60 fry from each treatment were stocked in hapas and further cultured in freshwater ponds.They were fed with commercial fish feed ad libitum.The sex ratio,growth performance and survival were evaluated after 60 and 180 days.At the end of the 60-day period,the sex ratio of 30 fish from each treatment was determined by using the gonadal squash method.The remaining 30 fish from each treatment were grown further for 180 days and their sex ratio determined using the genital papillae.The results demonstrated that 17α-methyltestosterone was effective in producing phenotypic male in S.melanotheron.However,in both 60-day and 180-day experiments,no treatment gave 100%male population.The 90 mg/kg MT yielded the highest all-male fish of 84.13%,highest survival of 70%and highest final mean body weight of 103.99±7.92 g.
文摘Financial performance analysis is of vital importance those involved in a business(e.g.,shareholders,creditors,partners,and company managers).An accurate and appropriate performance measurement is critical for decision-makers to achieve efficient results.Integrated performance measurement,by its nature,consists of multiple criteria with different levels of importance.Multiple Criteria Decision Analysis(MCDA)methods have become increasingly popular for solving complex problems,especially over the last two decades.There are different evaluation methodologies in the literature for selecting the most appropriate one among over 200 MCDA methods.This study comprehensively analyzed 41 companies traded on the Borsa Istanbul Corporate Governance Index for 10 quarters using SWARA,CRITIC,and SD integrated with eight different MCDA method algorithms to determine the position of Turkey's most transparent companies in terms of financial performance.In this study,we propose"stock returns"as a benchmark in comparing and evaluating MCDA methods.Moreover,we calculate the"rank reversal performance of MCDA methods".Finally,we performed a"standard deviation"analysis to identify the objective and characteristic trends for each method.Interestingly,all these innovative comparison procedures suggest that PROMETHEE II(preference ranking organization method for enrichment of evaluations II)and FUCA(Faire Un Choix Adéquat)are the most suitable MCDA methods.In other words,these methods produce a higher correlation with share price;they have fewer rank reversal problems,the distribution of scores they produce is wider,and the amount of information is higher.Thus,it can be said that these advantages make them preferable.The results show that this innovative methodological procedure based on'knowledge discovery'is verifiable,robust and efficient when choosing the MCDA method.
文摘Aim To analyze the transient speciality of nonlinear, anisotropic, AC+DC coupling electric field, and to compare the withstand voltage strength of different insulation structures. Methods The transient process of polarity reversal is analyzed, considering the anisotropic property of oil immersed press board, a new finite element model based on Galerkin method is presented and verified. The model developed is applied to calculate the electric field distribution in four typical winding end structures of the converter transformer. Results\ The whole ring structure possesses the best insulation characteristics. Conclusion\ By introducing reasonable insulation components, insulation strength with the same surrounding sizes can be improved more than 30%.
基金supported by Zhejiang Provincial Natural Science Foundation of China(No.LGC20E010004)the Science Foundation for Distinguished Young Scholars of Zhejiang Province(No.LR15E010001)+2 种基金the National Natural Science Foundation of China(No.51871205)the Key R&D Program of Zhejiang Province of China(No.2017C01004)the National Key Research and Development Project(No.2019YFF0217205)。
文摘In the present work,the magnetization reversal behavior for the melt spinning(Nd_(0.8)Ce_(0.2))_(2)Fe_(12)Co_(2-x)Zr_(x)B(x=0,0.5)permanent alloys with high coercivity was investigated by analyzing the hysteresis curves and the recoil loops.Compared to the Zr-free alloy,the Zr-doped sample obtains higher magnetic properties:coercivity of H_(cj)=650.5 kA·m^(-1),squareness of H_(k)/H_(cj)=0.76 and maximum energy product of(BH)_(max)=131.0 kJ·m^(-3).The first-order reversal curves(FORCs)analysis was taken to identify optimal conditions of exchange coupling for the Zr-free and Zr-doped alloys.The coercivity mechanism of theα-Fe/Nd_(2)Fe_(14)B nanocomposite alloys was analyzed by the angular dependence of the coercive field as measured for the Zr-doped sample.The results show that the magnetic reverse process of the Zr-doped sample can be explained by the pinning model.
基金Project supported by the National Natural Science Foundation of China (Nos. 60702022 and 60772094)the National Basic Re-search Program (973) of China (No. 5132103ZZT21B)
文摘This paper presents a detailed analysis of the effects of noise (reverberation) on the focusing performance of de-composition of the time reversal operator (DORT) in a noise-limited case and in a reverberation-limited case, respectively. Quantitative results obtained from simulations and experiments are presented. The results show the DORT method can be effi-ciently applied to target detection with enough source level to yield significant backscatter. For a target placed on the bottom, the influence of the reverberation on the focusing performance is slight. However, distinguishing between a target and constant backscattering returning from strong local clutter on the bottom (false alarms) needs further research.
基金supported by the National Natural Science Foundation of China(6130127161331007)+2 种基金the Specialized Research Fund for the Doctoral Program of Higher Education of China(2011018512000820120185130001)the Fundamental Research Funds for Central Universities(ZYGX2012J043)
文摘An efficient hybrid time reversal（TR） imaging method based on signal subspace and noise subspace is proposed for electromagnetic superresolution detecting and imaging. First, the locations of targets are estimated by the transmitting-mode decomposition of the TR operator（DORT） method employing the signal subspace. Then, the TR multiple signal classification（TR-MUSIC）method employing the noise subspace is used in the estimated target area to get the superresolution imaging of targets. Two examples with homogeneous and inhomogeneous background mediums are considered, respectively. The results show that the proposed hybrid method has advantages in CPU time and memory cost because of the combination of rough and fine imaging.
