Comfort is one of the important indicators evaluation of voice. In order to understand the urban neighborhood public space environment of comfort,this paper is to explore characteristics of consumer society on the pub...Comfort is one of the important indicators evaluation of voice. In order to understand the urban neighborhood public space environment of comfort,this paper is to explore characteristics of consumer society on the public space environment evaluation of the effect,and using the questionnaire survey method,to evaluate the Harbin city neighborhood area public space as the typical case analysis. Based on one of the main sound source in neighborhood public space,environment,business facilities environment as the breakthrough point,it is to consider neighborhood public space environment evaluation and social characteristics.展开更多
1.Introduction Hepatocellular carcinoma(HCC)is the most common primary malignancy of the liver.HCC is the sixth most frequently diagnosed cancer and the third leading cause of cancer-relatedmortality worldwide.[1]Part...1.Introduction Hepatocellular carcinoma(HCC)is the most common primary malignancy of the liver.HCC is the sixth most frequently diagnosed cancer and the third leading cause of cancer-relatedmortality worldwide.[1]Partial hepatectomy is recommended for patients with early stage HCC.[2]A large proportion of patients with HCC inChina are diagnosed in the intermediate to advanced HCC stages,rendering them ineligible for hepatectomy due to aspects such as liver dysfunction,insufficient residual liver volume,or surgical technique.展开更多
Emergency medical services (EMS) are a vital element of the public healthcare system in China,^([1])providing an opportunity to respond to critical medical conditions and save people’s lives.^([2])The accessibility o...Emergency medical services (EMS) are a vital element of the public healthcare system in China,^([1])providing an opportunity to respond to critical medical conditions and save people’s lives.^([2])The accessibility of EMS has received considerable attention in health and transport geography studies.^([3])One of the optimal gauges for evaluating the accessibility of EMS is the response time,which is defined as the time from receiving an emergency call to the arrival of an ambulance.^([4])Beijing has already reduced the response time to approximately12 min,and the next goal is to ensure that the response time across Beijing does not exceed 12 min (the information comes from the Beijing Emergency Medical Center).展开更多
Optogenetics,a technique that employs light for neuromodulation,has revolutionized the study of neural mechanisms and the treatment of neurological disorders due to its high spatiotemporal resolution and cell-type spe...Optogenetics,a technique that employs light for neuromodulation,has revolutionized the study of neural mechanisms and the treatment of neurological disorders due to its high spatiotemporal resolution and cell-type specificity.However,visible light,particularly blue and green light,commonly used in conventional optogenetics,has limited penetration in biological tissue.This limitation necessitates the implantation of optical fibers for light delivery,especially in deep brain regions,leading to tissue damage and experimental constraints.To overcome these challenges,the use of orange-red and infrared light with greater tissue penetration has emerged as a promising approach for tetherless optical neuromodulation.In this review,we provide an overview of the development and applications of tetherless optical neuromodulation methods with long wavelengths.We first discuss the exploration of orange-red wavelength-responsive rhodopsins and their performance in tetherless optical neuromodulation.Then,we summarize two novel tetherless neuromodulation methods using near-infrared light:upconversion nanoparticle-mediated optogenetics and photothermal neuromodulation.In addition,we discuss recent advances in mid-infrared optical neuromodulation.展开更多
Breast cancer brain metastasis(BCBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical...Breast cancer brain metastasis(BCBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical Research investigated the role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BCBrM,highlighting the clinical relevance of alterations in lipid metabolites,such as phosphatidylcholine(PC)and triacylglycerols(TAGs),by RARRES2 through the modulation of phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway.This commentary aims to elaborate on the key findings and their relevance to the field.展开更多
Tazarotene-induced gene 1(TIG1)is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer.TIG1 is widely expressed in various tissues;yet...Tazarotene-induced gene 1(TIG1)is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer.TIG1 is widely expressed in various tissues;yet in many cancer tissues,it is not expressed because of the methylation of its promoter.Additionally,the expression of TIG1 in cancer cells inhibits their growth and invasion,suggesting that TIG1 acts as a tumor suppressor gene.However,in some cancers,poor prognosis is associated with TIG1 expression,indicating its protumor growth characteristics,especially in promoting the invasion of inflammatory breast cancer cells.This review comprehensively summarizes the roles of the TIG1 gene in cancer development and details the mechanisms through which TIG1 regulates cancer development,with the aim of understanding its various roles in cancer development.展开更多
The judicial application of digital evidence in criminal cases(criminal digital evidence)is an inevitable trend for the digital transformation of criminal proceedings in the macro context of the digital economy.It is ...The judicial application of digital evidence in criminal cases(criminal digital evidence)is an inevitable trend for the digital transformation of criminal proceedings in the macro context of the digital economy.It is characterized by digitization,diversification,and traceability.The application of criminal digital evidence can be divided into two main scenarios:the vertical scenario involving phases such as filing,prosecution,and trial;the horizontal scenario related to specific types of crimes.Criminal digital evidence is primarily applied to handling non-contact crimes,such as cybercrimes.However,the application of such evidence may infringe upon the basic rights of suspects,including their rights to privacy,rights to know,and rights to defense.Furthermore,the diversified and non-systematic nature of digital evidence may lead to challenges in applying the law,particularly with algorithmic“black boxes,”which can result in judicial discrimination and other drawbacks.Therefore,it is necessary to formulate or improve the regulatory framework for criminal digital evidence to ensure its lawful and standardized application.Additionally,judicial authorities must strengthen collaboration in case handling to ensure smooth coordination in collecting and applying digital evidence,thereby realizing its efficient litigation value.Furthermore,it is essential to check and balance the algorithm-based conviction and sentencing to protect the legitimate rights and interests of the parties involved,achieving high-quality human rights protection.展开更多
BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal cancer.However,the underlying mechanisms remain elusive.AIM To detect the dif...BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal cancer.However,the underlying mechanisms remain elusive.AIM To detect the differential expression profiles of plasma exosomal microRNAs(miRNAs)in poor and good responders and explore the potential mechanisms of chemoresistance.METHODS In this study,the profiles of plasma exosomal miRNAs were compared in two dimensions according to treatment responses(poor/good responders)and treatment courses(pre/post-nCRT)using RNA sequencing.RESULTS Exosome hsa-miR-483-5p was up-regulated in good responders post-nCRT.Bioinformatics analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways,such as the MAPK signaling pathway,EGFR tyrosine kinase inhibitor resistance,Toll-like receptor signaling pathway,VEGF signaling pathway,and mTOR signaling pathway.Further analysis indicated that MAPK3,RAX2,and RNF165 were associated with inferior recurrence-free survival in patients with rectal cancer,and the profiles of MAPK3,TSPYL5,and ZNF-417 were correlated with tumor stage.In addition,the expression profiles of MAPK3,RNF165,and ZNF417 were negatively correlated with inhibitory concentration 50 values.Accordingly,an hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 network was constructed.CONCLUSION This study provides insights into the mechanism of chemoresistance in terms of exosomal miRNAs.However,further research is required within the framework of our established miRNA-mRNA network.展开更多
[Objective]The aim was to study the sensitive response characteristics of the main agronomic traits of somaclonal and the variation of sensitive response of the lines of somaclonal to sowing date. [Method]The RITSD ch...[Objective]The aim was to study the sensitive response characteristics of the main agronomic traits of somaclonal and the variation of sensitive response of the lines of somaclonal to sowing date. [Method]The RITSD changing of agronomic traits was studied by using 24 rice somaclonal and its donor parent under two sowing dates. [Result]The average values of RITSD were higher （over one） for the traits of pant height （PH）,density of spikelets （DS）,filled spikelets per panicle （FSP）,spikelets per panicle （SP） and grain weight per plant （GWP）,but lower for days of sowing to heading （DSH）,effective panicles （EP）,panicle length （PL）,seed setting rate （SS） and 1 000-grain weight （1 000-GW）. These showed that PH,DS,FSP,SP and GWP were easily affected by sowing date and tended to higher with the later sowing; the RITSD of somaclonal changed with the agronomic traits. The frequency of RITSD＇ variation of DSH and PH was higher than that of PL. The RITSD＇ value of EP,PL,DS,FSP,SP and SS became higher,and higher or lower for DSH and GWP in different somaclonal; compared with the donor,20 of 24 was significantly different,and the frequency of RITSD variation was over 83. 3%,however,RITSD of the most lines （75%） changed only for 1-2 characters; cluster analysis showed that the RITSD of agronomic traits belonged to different combinations of somaclonal in rice. [Conclusion]the study had provided a theoretical basis for the screening and using of the somaclonal.展开更多
In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is p...In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system （GPS） data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response.展开更多
In the course of this work which is the impact of zoological garden in schools, the questionnaire interviewed was used in the collection of data. Based on the finding it was observed that people visit zoological garde...In the course of this work which is the impact of zoological garden in schools, the questionnaire interviewed was used in the collection of data. Based on the finding it was observed that people visit zoological gardens for different purposes like educational, recreational, research, economic and cultural values. Also the chi-square (X2) is used in this research to show if there is significant difference or not. Result indicated that people from various works of life visited the zoo. Some recommendations were also made for further studies as well as the opposition of establishment of a zoo. Thus, the objectives of the this work are to identify the conservation areas in which zoos make a contribution, to develop understanding and support of the conservation potentials of zoos, to convince local zoos and conservation agencies that they can make important contributions to conservation, to help zoos formulate conservation priorities and policies and finally, to promote action of individual zoos by participation in the global zoo and other conservation network.展开更多
The standard ordered response model (SORM) is a common disaggregate approach with ordered outcomes in which the effects of various exogenous attributes are assumed constant across ordinal choices. In this study, an in...The standard ordered response model (SORM) is a common disaggregate approach with ordered outcomes in which the effects of various exogenous attributes are assumed constant across ordinal choices. In this study, an innovative latent class based generalized ordered response model (LC-GORM) is formulated and used to assess the effects of various factors on respondents’ choice behavior with respect to congestion charge proposal for Jakarta, Indonesia. The proposed model probabilistically assigns respondents into selfish and altruistic class memberships (latently) based on their knowledge of the proposed scheme and their specific attributes. Aiming to capture observable preference heterogeneity across ordinal choices and allow the thresholds to be varied across observations, we parameterize the thresholds as a linear function of the exogenous variables for each ordinal preference. Using stated preference data collected in Jakarta in December 2013, we incorporate the influence of a comprehensive set of explanatory variables into four categories: charges, latent variables related to respondent’s psychological motivations, mobility attributes and socio-demographic characteristics. Empirical results obviously verify the existence of preference heterogeneity across outcomes. The findings confirm that the altruistic class are more sensitive with respect to acceptance of the scheme, while the selfish class are more sensitive with respect to rejection. The key factors influencing public acceptability include the charge level and respondent variables such as car dependency, awareness of the problem of cars in society, frequency of visits to the city center and frequency of private mode usage.展开更多
A survey on different aspects of Buriganga River encroachment was conducted in a 300 meter long encroached part of the river located in Dhaka, Bangladesh. A total of 100 respondents were surveyed and three Focus Group...A survey on different aspects of Buriganga River encroachment was conducted in a 300 meter long encroached part of the river located in Dhaka, Bangladesh. A total of 100 respondents were surveyed and three Focus Group Discussions (FGDs) were arranged prior to the semi-structured questionnaire survey. It was observed that almost all of the respondents migrated to the study area. The majority of the respondents had better business opportunity (69.23%) as the cause of encroachment. Significant portions of the respondents occupying the encroached area were found to be landless (36.84%), small businessmen (31.58%) and people with political affluence (26.32%). Major portions (23.33%) of the encroached land were used for industrial development as well as housing and developmental projects. Negative health impact (40%) was found to be the main adverse effect of encroachment of the river. Other adverse effects included economic loss through obliteration of fisheries (35.71%), scarcity of clean water (32.14%), reduction of aesthetic value of the surroundings (25%) etc. For the protection of the river, the majority of the respondents opted for relocation of the industries (46.15%) and enforcement of strict rules and regulations (38.46%).展开更多
The article describes and interprets the results of a study aimed at studying public opinion about the activities of national parks. The attitude of the local population to the activities of the State Institution “Na...The article describes and interprets the results of a study aimed at studying public opinion about the activities of national parks. The attitude of the local population to the activities of the State Institution “National Park of Tajikistan” was studied. A total of 40 respondents from local residents were surveyed. Fifteen local residents of Khorog, most of them educated people, students of Khorog University and teachers of the Biological Institute of the Pamirs who are familiar with the Tajik National Park in the vicinity have carried out several scientific studies. Twenty-five respondents of the residents of the Murghab district are directly the population who live in the park. They have less education, and they are more prone to a rural lifestyle, and livestock far more knowledgeable about the Tajik National Park than the residents of Khorog. Interviewed residents of the Murgab and Karakuls villages believe that the activities of the Tajik National Park should be more efficient and lay down ways to improve its activities and form a positive image. In their opinion, the employees of the national park should interact more with the local population, take into account their interests, improve information carrying out activities of the national park. Proceeding from the answers of the respondents, we can conclude that the Tajik national park is already widely known to the circle of researchers and scientific applicants as a place or testing ground for research. For the local populations who live in the park, they use it as a place for animal husbandry and natural resources. During the survey, it turned out that the park is currently being used by all means, but not protected in any way. The results of a public opinion poll conducted in the September of 2021 in the settlements of the Khorug town of the Gorno-Badakhshan Autonomous Oblast GBAO region, belonging to the central ecological zone of the Pamir natural territory, are presented. The attitude of the local population to the activities of the Tajik Nation Park was studied. Interviewed residents believe that the activities of the Tajik National Park should be more efficient and lay down ways to improve its activities and form a positive image.展开更多
The Central Statistical Agency （CSA） of Ethiopia included some questions in its 2005 Demographic and Health Survey （DHS） questionnaire, asking for the opinion of men and women if wives beaten by husbands is justif...The Central Statistical Agency （CSA） of Ethiopia included some questions in its 2005 Demographic and Health Survey （DHS） questionnaire, asking for the opinion of men and women if wives beaten by husbands is justified if wives commit some mistakes while they are undertaking their day to day family responsibilities and other personal functions. The sample size was about 14,000 women in the reproductive and productive ages of 15-49 and about 6,000 men in the age brackets of 15-59. The reasons for wife beating by husbands are examined against some selected independent background variables of the sampled men and women respondents, while the dependent variables are the responses to questions of wife beating. With respect to the analytical model, the author decided to focus on some descriptive statistics, such as frequency distributions tables, proportions, comparative analysis, and application of chi-squares （Xz） techniques to examine the variations in the responses of women and men amongst the independent backgrounds.展开更多
Excessive growth of population and urbanization in the developing countries set an increasing demand of mobility services. To meet this demand, public transport plays a significant role by providing an easy and afford...Excessive growth of population and urbanization in the developing countries set an increasing demand of mobility services. To meet this demand, public transport plays a significant role by providing an easy and affordable mobility service. Public transport service is a process evolving over time nevertheless is not always directly responsive to the changing demand of the passengers. Recently in developing countries, the unpleasant experience in public transport services is seen as one of the main reasons behind increased passenger car share, which eventually lead to traffic congestion. However, the situation can be ameliorated if the features of the public transport are improved by addressing the users’ demand. In this study, the primary features desired and demanded by the passengers of a developing country are identified by three phase survey. These identified features are also categorized based on public responses. And finally, the required features in an appropriate public transport mode are prioritized by using a common Multi Criteria Decision Making approach (AHP—Analytic Hierarchy Process). The study suggests that residents of the developing city are not that much concern on the outlook and ambience of the service rather they are concerned about finishing their trips safely in time at an affordable rate. The findings of this research will help planners and decision makers to make the best use of the investment in public transport services and infrastructure to promote these modes over privately owned vehicle.展开更多
Cholera is a disease that Benin has been fighting against for years but which continues to create economic losses for households. The aim of this study is to assess the level of knowledge of the population about this ...Cholera is a disease that Benin has been fighting against for years but which continues to create economic losses for households. The aim of this study is to assess the level of knowledge of the population about this disease and to assess hygiene practices in order to identify the factors responsible for its sustainability. The data were collected through a survey of 720 households in the 12 departments of the country. These data were analyzed with SAS software and three groups of people were identified on the basis of hygiene measures. The majority of respondents know cholera. The main symptoms they mentioned were vomiting (84.83%) and diarrhea (81.04%). Diarrhea was more reported in group 3 (88.96%) than in groups 1 (86.58%) and 2 (83.19%). Low levels of hygiene were the main cause of this disease. In the absence of toilets, the interviewees pass stool in the bush and at the edge of water sources used in households. Some of them have bins (in particular group 1) for household waste but do not subscribe to refuse collection structures. Therefore, they throw garbage in sometimes unofficial landfills. Others, on the other hand, have not garbage cans (mainly group 2) and they empty garbage everywhere (street, gutters and bushes). In addition, hand washing is hardly ever done after using the toilet. Hygiene practices in some households are insufficient, which does not protect the population from cholera.展开更多
It is acknowledged that teachers' instruction and guidance play an important role in students' improvements of schooling. A number of teachers, however, regard effectively responding to students' papers as...It is acknowledged that teachers' instruction and guidance play an important role in students' improvements of schooling. A number of teachers, however, regard effectively responding to students' papers as a touchy issue. In order to address this problem, this essay will review some of the major studies on teachers' response to students' writing in a historical way and, from these studies, some beneficial methods will be suggested, such as a process approach, collaborative ways of writing and motivational techniques.展开更多
Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% ...Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined “no responders”. Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney disease, human immunodeficiency virus infection, chronic liver disease, celiac disease, thalassaemia, type I diabetes mellitus, down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects. To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection. Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route. This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients. A comprehensive review of the literature using PubMed database, with appropriate terms, was undertaken for articles in English published since 1983. The literature search was undertaken in September 2013.展开更多
基金Sponsored by the National Science & Technology Pillar Program during the 12th Five-year Plan Period (Grant No.2013BAJ12B01)
文摘Comfort is one of the important indicators evaluation of voice. In order to understand the urban neighborhood public space environment of comfort,this paper is to explore characteristics of consumer society on the public space environment evaluation of the effect,and using the questionnaire survey method,to evaluate the Harbin city neighborhood area public space as the typical case analysis. Based on one of the main sound source in neighborhood public space,environment,business facilities environment as the breakthrough point,it is to consider neighborhood public space environment evaluation and social characteristics.
文摘1.Introduction Hepatocellular carcinoma(HCC)is the most common primary malignancy of the liver.HCC is the sixth most frequently diagnosed cancer and the third leading cause of cancer-relatedmortality worldwide.[1]Partial hepatectomy is recommended for patients with early stage HCC.[2]A large proportion of patients with HCC inChina are diagnosed in the intermediate to advanced HCC stages,rendering them ineligible for hepatectomy due to aspects such as liver dysfunction,insufficient residual liver volume,or surgical technique.
基金supported by National Key Research & Development Program of China (2022YFC3006201)。
文摘Emergency medical services (EMS) are a vital element of the public healthcare system in China,^([1])providing an opportunity to respond to critical medical conditions and save people’s lives.^([2])The accessibility of EMS has received considerable attention in health and transport geography studies.^([3])One of the optimal gauges for evaluating the accessibility of EMS is the response time,which is defined as the time from receiving an emergency call to the arrival of an ambulance.^([4])Beijing has already reduced the response time to approximately12 min,and the next goal is to ensure that the response time across Beijing does not exceed 12 min (the information comes from the Beijing Emergency Medical Center).
基金supported by China Postdoctoral Science Foundation(2022M723356),"From 0 to 1"Original Innovation Project of the Basic Frontier Scientific Research Program of the Chinese Academy of Sciences(29J20-015-Ⅲ)Chinese Academy of Sciences 100 Talents Project:Research on Task oriented Functional Brain Development of Infants(29J20-052-Ⅲ)Natural Science Basic Research Plan in Shaanxi Province of China(2022JQ544).
文摘Optogenetics,a technique that employs light for neuromodulation,has revolutionized the study of neural mechanisms and the treatment of neurological disorders due to its high spatiotemporal resolution and cell-type specificity.However,visible light,particularly blue and green light,commonly used in conventional optogenetics,has limited penetration in biological tissue.This limitation necessitates the implantation of optical fibers for light delivery,especially in deep brain regions,leading to tissue damage and experimental constraints.To overcome these challenges,the use of orange-red and infrared light with greater tissue penetration has emerged as a promising approach for tetherless optical neuromodulation.In this review,we provide an overview of the development and applications of tetherless optical neuromodulation methods with long wavelengths.We first discuss the exploration of orange-red wavelength-responsive rhodopsins and their performance in tetherless optical neuromodulation.Then,we summarize two novel tetherless neuromodulation methods using near-infrared light:upconversion nanoparticle-mediated optogenetics and photothermal neuromodulation.In addition,we discuss recent advances in mid-infrared optical neuromodulation.
文摘Breast cancer brain metastasis(BCBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical Research investigated the role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BCBrM,highlighting the clinical relevance of alterations in lipid metabolites,such as phosphatidylcholine(PC)and triacylglycerols(TAGs),by RARRES2 through the modulation of phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway.This commentary aims to elaborate on the key findings and their relevance to the field.
基金supported by the Taipei Tzu Chi Hospital through grants from the Buddhist Tzu Chi Medical Foundation under the Numbers TCRD-TPE-111-23(2/3)and TCRD-TPE-113-20,Taipei,Taiwan.
文摘Tazarotene-induced gene 1(TIG1)is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer.TIG1 is widely expressed in various tissues;yet in many cancer tissues,it is not expressed because of the methylation of its promoter.Additionally,the expression of TIG1 in cancer cells inhibits their growth and invasion,suggesting that TIG1 acts as a tumor suppressor gene.However,in some cancers,poor prognosis is associated with TIG1 expression,indicating its protumor growth characteristics,especially in promoting the invasion of inflammatory breast cancer cells.This review comprehensively summarizes the roles of the TIG1 gene in cancer development and details the mechanisms through which TIG1 regulates cancer development,with the aim of understanding its various roles in cancer development.
文摘The judicial application of digital evidence in criminal cases(criminal digital evidence)is an inevitable trend for the digital transformation of criminal proceedings in the macro context of the digital economy.It is characterized by digitization,diversification,and traceability.The application of criminal digital evidence can be divided into two main scenarios:the vertical scenario involving phases such as filing,prosecution,and trial;the horizontal scenario related to specific types of crimes.Criminal digital evidence is primarily applied to handling non-contact crimes,such as cybercrimes.However,the application of such evidence may infringe upon the basic rights of suspects,including their rights to privacy,rights to know,and rights to defense.Furthermore,the diversified and non-systematic nature of digital evidence may lead to challenges in applying the law,particularly with algorithmic“black boxes,”which can result in judicial discrimination and other drawbacks.Therefore,it is necessary to formulate or improve the regulatory framework for criminal digital evidence to ensure its lawful and standardized application.Additionally,judicial authorities must strengthen collaboration in case handling to ensure smooth coordination in collecting and applying digital evidence,thereby realizing its efficient litigation value.Furthermore,it is essential to check and balance the algorithm-based conviction and sentencing to protect the legitimate rights and interests of the parties involved,achieving high-quality human rights protection.
基金Supported by the National High Level Hospital Clinical Research Funding,No.2022-PUMCH-C-005.
文摘BACKGROUND Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy(nCRT)for rectal cancer.However,the underlying mechanisms remain elusive.AIM To detect the differential expression profiles of plasma exosomal microRNAs(miRNAs)in poor and good responders and explore the potential mechanisms of chemoresistance.METHODS In this study,the profiles of plasma exosomal miRNAs were compared in two dimensions according to treatment responses(poor/good responders)and treatment courses(pre/post-nCRT)using RNA sequencing.RESULTS Exosome hsa-miR-483-5p was up-regulated in good responders post-nCRT.Bioinformatics analysis revealed that the target genes of hsa-miR-483-5p were mainly enriched in tumor-specific pathways,such as the MAPK signaling pathway,EGFR tyrosine kinase inhibitor resistance,Toll-like receptor signaling pathway,VEGF signaling pathway,and mTOR signaling pathway.Further analysis indicated that MAPK3,RAX2,and RNF165 were associated with inferior recurrence-free survival in patients with rectal cancer,and the profiles of MAPK3,TSPYL5,and ZNF-417 were correlated with tumor stage.In addition,the expression profiles of MAPK3,RNF165,and ZNF417 were negatively correlated with inhibitory concentration 50 values.Accordingly,an hsa-miR-483-5p/MAPK3/RNF 165/ZNF417 network was constructed.CONCLUSION This study provides insights into the mechanism of chemoresistance in terms of exosomal miRNAs.However,further research is required within the framework of our established miRNA-mRNA network.
基金Supported by Chongqing Major Research Project "Innovation in Hybrid Rice Breeding and New Materials" ( CSTC, 2007, AA1019 )Sichuan Province Breeding Research Project (06yzgg-01)~~
文摘[Objective]The aim was to study the sensitive response characteristics of the main agronomic traits of somaclonal and the variation of sensitive response of the lines of somaclonal to sowing date. [Method]The RITSD changing of agronomic traits was studied by using 24 rice somaclonal and its donor parent under two sowing dates. [Result]The average values of RITSD were higher （over one） for the traits of pant height （PH）,density of spikelets （DS）,filled spikelets per panicle （FSP）,spikelets per panicle （SP） and grain weight per plant （GWP）,but lower for days of sowing to heading （DSH）,effective panicles （EP）,panicle length （PL）,seed setting rate （SS） and 1 000-grain weight （1 000-GW）. These showed that PH,DS,FSP,SP and GWP were easily affected by sowing date and tended to higher with the later sowing; the RITSD of somaclonal changed with the agronomic traits. The frequency of RITSD＇ variation of DSH and PH was higher than that of PL. The RITSD＇ value of EP,PL,DS,FSP,SP and SS became higher,and higher or lower for DSH and GWP in different somaclonal; compared with the donor,20 of 24 was significantly different,and the frequency of RITSD variation was over 83. 3%,however,RITSD of the most lines （75%） changed only for 1-2 characters; cluster analysis showed that the RITSD of agronomic traits belonged to different combinations of somaclonal in rice. [Conclusion]the study had provided a theoretical basis for the screening and using of the somaclonal.
基金The Special Project of the Ministry of Construction ofChina (No.20060909).
文摘In order to establish the relationship between the measured dynamic response and the health status of long-span bridges, a double-layer model updating method for steel-concrete composite beam cable-stayed bridges is proposed. Measured frequencies are selected as the first-layer reference data, and the mass of the bridge deck, the grid density, the modulus of concrete and the ballast on the side span are modified by using a manual tuning technique. Measured global positioning system （GPS） data is selected as the second-layer reference data, and the degradation of the integral structure stiffness EI of the whole bridge is taken into account for the second-layer model updating by using the finite element iteration algorithm. The Nanpu Bridge in Shanghai is taken as a case to verify the applicability of the proposed model updating method. After the first-layer model updating, the standard deviation of modal frequencies is smaller than 7%. After the second-layer model updating, the error of the deflection of the mid-span is smaller than 10%. The integral structure stiffness of the whole bridge decreases about 20%. The research results show a good agreement between the calculated response and the measured response.
文摘In the course of this work which is the impact of zoological garden in schools, the questionnaire interviewed was used in the collection of data. Based on the finding it was observed that people visit zoological gardens for different purposes like educational, recreational, research, economic and cultural values. Also the chi-square (X2) is used in this research to show if there is significant difference or not. Result indicated that people from various works of life visited the zoo. Some recommendations were also made for further studies as well as the opposition of establishment of a zoo. Thus, the objectives of the this work are to identify the conservation areas in which zoos make a contribution, to develop understanding and support of the conservation potentials of zoos, to convince local zoos and conservation agencies that they can make important contributions to conservation, to help zoos formulate conservation priorities and policies and finally, to promote action of individual zoos by participation in the global zoo and other conservation network.
文摘The standard ordered response model (SORM) is a common disaggregate approach with ordered outcomes in which the effects of various exogenous attributes are assumed constant across ordinal choices. In this study, an innovative latent class based generalized ordered response model (LC-GORM) is formulated and used to assess the effects of various factors on respondents’ choice behavior with respect to congestion charge proposal for Jakarta, Indonesia. The proposed model probabilistically assigns respondents into selfish and altruistic class memberships (latently) based on their knowledge of the proposed scheme and their specific attributes. Aiming to capture observable preference heterogeneity across ordinal choices and allow the thresholds to be varied across observations, we parameterize the thresholds as a linear function of the exogenous variables for each ordinal preference. Using stated preference data collected in Jakarta in December 2013, we incorporate the influence of a comprehensive set of explanatory variables into four categories: charges, latent variables related to respondent’s psychological motivations, mobility attributes and socio-demographic characteristics. Empirical results obviously verify the existence of preference heterogeneity across outcomes. The findings confirm that the altruistic class are more sensitive with respect to acceptance of the scheme, while the selfish class are more sensitive with respect to rejection. The key factors influencing public acceptability include the charge level and respondent variables such as car dependency, awareness of the problem of cars in society, frequency of visits to the city center and frequency of private mode usage.
文摘A survey on different aspects of Buriganga River encroachment was conducted in a 300 meter long encroached part of the river located in Dhaka, Bangladesh. A total of 100 respondents were surveyed and three Focus Group Discussions (FGDs) were arranged prior to the semi-structured questionnaire survey. It was observed that almost all of the respondents migrated to the study area. The majority of the respondents had better business opportunity (69.23%) as the cause of encroachment. Significant portions of the respondents occupying the encroached area were found to be landless (36.84%), small businessmen (31.58%) and people with political affluence (26.32%). Major portions (23.33%) of the encroached land were used for industrial development as well as housing and developmental projects. Negative health impact (40%) was found to be the main adverse effect of encroachment of the river. Other adverse effects included economic loss through obliteration of fisheries (35.71%), scarcity of clean water (32.14%), reduction of aesthetic value of the surroundings (25%) etc. For the protection of the river, the majority of the respondents opted for relocation of the industries (46.15%) and enforcement of strict rules and regulations (38.46%).
文摘The article describes and interprets the results of a study aimed at studying public opinion about the activities of national parks. The attitude of the local population to the activities of the State Institution “National Park of Tajikistan” was studied. A total of 40 respondents from local residents were surveyed. Fifteen local residents of Khorog, most of them educated people, students of Khorog University and teachers of the Biological Institute of the Pamirs who are familiar with the Tajik National Park in the vicinity have carried out several scientific studies. Twenty-five respondents of the residents of the Murghab district are directly the population who live in the park. They have less education, and they are more prone to a rural lifestyle, and livestock far more knowledgeable about the Tajik National Park than the residents of Khorog. Interviewed residents of the Murgab and Karakuls villages believe that the activities of the Tajik National Park should be more efficient and lay down ways to improve its activities and form a positive image. In their opinion, the employees of the national park should interact more with the local population, take into account their interests, improve information carrying out activities of the national park. Proceeding from the answers of the respondents, we can conclude that the Tajik national park is already widely known to the circle of researchers and scientific applicants as a place or testing ground for research. For the local populations who live in the park, they use it as a place for animal husbandry and natural resources. During the survey, it turned out that the park is currently being used by all means, but not protected in any way. The results of a public opinion poll conducted in the September of 2021 in the settlements of the Khorug town of the Gorno-Badakhshan Autonomous Oblast GBAO region, belonging to the central ecological zone of the Pamir natural territory, are presented. The attitude of the local population to the activities of the Tajik Nation Park was studied. Interviewed residents believe that the activities of the Tajik National Park should be more efficient and lay down ways to improve its activities and form a positive image.
文摘The Central Statistical Agency （CSA） of Ethiopia included some questions in its 2005 Demographic and Health Survey （DHS） questionnaire, asking for the opinion of men and women if wives beaten by husbands is justified if wives commit some mistakes while they are undertaking their day to day family responsibilities and other personal functions. The sample size was about 14,000 women in the reproductive and productive ages of 15-49 and about 6,000 men in the age brackets of 15-59. The reasons for wife beating by husbands are examined against some selected independent background variables of the sampled men and women respondents, while the dependent variables are the responses to questions of wife beating. With respect to the analytical model, the author decided to focus on some descriptive statistics, such as frequency distributions tables, proportions, comparative analysis, and application of chi-squares （Xz） techniques to examine the variations in the responses of women and men amongst the independent backgrounds.
文摘Excessive growth of population and urbanization in the developing countries set an increasing demand of mobility services. To meet this demand, public transport plays a significant role by providing an easy and affordable mobility service. Public transport service is a process evolving over time nevertheless is not always directly responsive to the changing demand of the passengers. Recently in developing countries, the unpleasant experience in public transport services is seen as one of the main reasons behind increased passenger car share, which eventually lead to traffic congestion. However, the situation can be ameliorated if the features of the public transport are improved by addressing the users’ demand. In this study, the primary features desired and demanded by the passengers of a developing country are identified by three phase survey. These identified features are also categorized based on public responses. And finally, the required features in an appropriate public transport mode are prioritized by using a common Multi Criteria Decision Making approach (AHP—Analytic Hierarchy Process). The study suggests that residents of the developing city are not that much concern on the outlook and ambience of the service rather they are concerned about finishing their trips safely in time at an affordable rate. The findings of this research will help planners and decision makers to make the best use of the investment in public transport services and infrastructure to promote these modes over privately owned vehicle.
文摘Cholera is a disease that Benin has been fighting against for years but which continues to create economic losses for households. The aim of this study is to assess the level of knowledge of the population about this disease and to assess hygiene practices in order to identify the factors responsible for its sustainability. The data were collected through a survey of 720 households in the 12 departments of the country. These data were analyzed with SAS software and three groups of people were identified on the basis of hygiene measures. The majority of respondents know cholera. The main symptoms they mentioned were vomiting (84.83%) and diarrhea (81.04%). Diarrhea was more reported in group 3 (88.96%) than in groups 1 (86.58%) and 2 (83.19%). Low levels of hygiene were the main cause of this disease. In the absence of toilets, the interviewees pass stool in the bush and at the edge of water sources used in households. Some of them have bins (in particular group 1) for household waste but do not subscribe to refuse collection structures. Therefore, they throw garbage in sometimes unofficial landfills. Others, on the other hand, have not garbage cans (mainly group 2) and they empty garbage everywhere (street, gutters and bushes). In addition, hand washing is hardly ever done after using the toilet. Hygiene practices in some households are insufficient, which does not protect the population from cholera.
文摘It is acknowledged that teachers' instruction and guidance play an important role in students' improvements of schooling. A number of teachers, however, regard effectively responding to students' papers as a touchy issue. In order to address this problem, this essay will review some of the major studies on teachers' response to students' writing in a historical way and, from these studies, some beneficial methods will be suggested, such as a process approach, collaborative ways of writing and motivational techniques.
文摘Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined “no responders”. Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney disease, human immunodeficiency virus infection, chronic liver disease, celiac disease, thalassaemia, type I diabetes mellitus, down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects. To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection. Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route. This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients. A comprehensive review of the literature using PubMed database, with appropriate terms, was undertaken for articles in English published since 1983. The literature search was undertaken in September 2013.
