Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain’s borders,and recruited macrophages.They are responsible for neural development,maintenance...Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain’s borders,and recruited macrophages.They are responsible for neural development,maintenance of homeostasis,and orchestrating immune responses.With the rapid exploitation and development of new technologies,there is a deeper understanding of macrophages in the brain barrier system.Here we review the origin,development,important molecules,and functions of macrophages,mainly focusing on microglia and border-associated macrophages.We also highlight some advances in single-cell sequencing and significant cell markers.We anticipate that more advanced methods will emerge to study resident and recruited macrophages in the future,opening new horizons for neuroimmunology and related peripheral immune fields.展开更多
As the most critical part of post-graduate education,the Chinese government launched Standard Resident Training in 2013 to solve the regional inequality of medical quality and meet the increasing social requirement fo...As the most critical part of post-graduate education,the Chinese government launched Standard Resident Training in 2013 to solve the regional inequality of medical quality and meet the increasing social requirement for better medical service.We integrated problem-based learning(PBL)and case-based learning(CBL)in the Endodontics Standard Resident Training.By evaluating with objective parameters including theoretical knowledge and clinical practice skill,and subjective parameters including questionnaire,it was found that PBL+CBL played a positive role in endodontic resident training with a significant difference(P<0.05).This combined training model is instructive for China’s resident training,and this result can provide a rudimentary reference to current postgraduate teaching reform.展开更多
As a crucial assessment tool,the Mini Clinical Evaluation Exercise(Mini-CEX)has gradually garnered attention in the clinical skills training of resident physicians.With the ongoing advancement of medical education ref...As a crucial assessment tool,the Mini Clinical Evaluation Exercise(Mini-CEX)has gradually garnered attention in the clinical skills training of resident physicians.With the ongoing advancement of medical education reform,Mini-CEX not only offers a fresh perspective for evaluating the clinical competence of resident physicians but also establishes a foundation for enhancing their overall quality and professional capabilities.Nonetheless,there are still certain constraints in the application of Mini-CEX,including inconsistent assessment criteria,assessor subjectivity,and inadequate feedback mechanisms.This paper will review relevant domestic and international studies,explore the practical application of Mini-CEX in standardized resident physician training,analyze its strengths and weaknesses in assessing clinical ability,and propose recommendations for future development directions.Through a thorough examination of this field,it aims to provide references and guidance for further optimizing the training model for resident physicians.展开更多
In the context of the global“double carbon”goal,this article uses the Analytic Hierarchy Process and Multiple Linear Regression combined with a survey questionnaire to study the issue of carbon literacy among reside...In the context of the global“double carbon”goal,this article uses the Analytic Hierarchy Process and Multiple Linear Regression combined with a survey questionnaire to study the issue of carbon literacy among residents in Chongqing.The weights of each dimension are determined to promote the formation of a good situation of multi-party collaborative promotion and help achieve the“double carbon”goal.The level of carbon literacy reflects the residents’understanding of carbon literacy and has important significance for economic and social operation and environmental protection.The results indicate that the deepening of the concept of carbon inclusiveness and the continuous advancement of technology will lead to a continuous process of improving the carbon inclusiveness literacy of Chongqing residents.Corresponding suggestions are proposed on how to improve the carbon inclusiveness literacy of Chongqing residents,which is of great research significance.展开更多
Objective:To enhance the reading skills of clinical pathology residents,it is essential to establish a well-structured electronic pathology reading library.Methods:In accordance with the Resident Standardization Train...Objective:To enhance the reading skills of clinical pathology residents,it is essential to establish a well-structured electronic pathology reading library.Methods:In accordance with the Resident Standardization Training Content and Standards(2022 Edition),clinical pathology residents are required to master pathological diagnoses across 11 systems:skin,head and neck,mediastinum and respiratory,digestive,urinary and male reproductive,female reproductive and breast,lymphatic and hematopoietic,bone and soft tissue,cardiovascular,central nervous,and endocrine diseases.Senior pathologists specializing in each subspecialty selected classic pathological slides,which were systematically scanned and compiled into an electronic pathology library.Results:A questionnaire survey was conducted to gather feedback on the electronic pathology reading library.Residents generally found it to be convenient,efficient,and conducive to learning.Conclusion:Training in clinical pathology diagnosis is a core component of standardized resident training.The electronic pathology reading library has been well-received and recognized by resident doctors.However,further efforts are needed to explore diverse teaching methods that align with modern educational approaches,ultimately contributing to the development of highly skilled resident doctors.展开更多
Background:Despite self-determination theory’s prominence,few studies examine BPN in China’s ethnic frontier regions.Therefore,this study investigates and analyzes the current situation of community residents with d...Background:Despite self-determination theory’s prominence,few studies examine BPN in China’s ethnic frontier regions.Therefore,this study investigates and analyzes the current situation of community residents with different demographic characteristics in Yanbian in the three basic psychological needs of competency needs,autonomy needs and attribution needs,so as to provide reference for the construction of community service in Yanbian area.Methods:A survey was conducted among 234 residents in four communities in Yanbian from September to October 2024.The equal probability random sampling method was used to collect data by using a general information questionnaire and basic psychological demand scale,and SPSS 28.0 was used for analysis.Through single factor analysis,Pearson correlation analysis and multiple linear regression analysis,the influencing factors and correlation of basic psychological needs of community residents in Yanbian area were discussed.Results:The basic psychological needs of residents were above the middle level;there is a significant positive correlation between economic status and the three dimensions of basic psychological needs(P<0.001).There is a significant positive correlation between the three dimensions of competence demand(β=2.028,P<0.001),autonomy demand(β=2.022,P<0.001),and attribution demand(β=2.693,P<0.001).Conclusion:The satisfaction degree of basic psychological needs of community residents in Yanbian is significantly affected by economic situation,which urges nurses to advocate for economic empowerment programs in community health and provides an empirical basis for the construction of a psychological service system in this area.At the same time,it is proposed that the region can respond by improving social support and improving employment results.展开更多
This empirical study examines the integration of medical and elderly care services in Guangyuan City through stratified random sampling,targeting 283 eligible residents aged 60+from three representative integrated ins...This empirical study examines the integration of medical and elderly care services in Guangyuan City through stratified random sampling,targeting 283 eligible residents aged 60+from three representative integrated institutions.The research employed a self-designed questionnaire titled“Humanistic Care Experience and Demand Influencing Factors”to collect subjective perceptions regarding basic care,psychological support,health education,and social interaction using a Likert five-point scale.Descriptive statistics,one-way ANOVA,and multiple regression modeling were conducted with SPSS 25.0 software.Results indicated that overall humanistic care experience scores were moderately high,with the“caregiving”dimension scoring highest and“psychological/social support”the lowest.Analysis revealed significant correlations between educational attainment,income,self-reported health status,and family support frequency(P<0.001),particularly among seniors with higher education,better health,and stronger family support.While integrated care facilities provide relatively comprehensive basic care,they should focus on addressing gaps in humanistic services,especially providing targeted support for groups with“low education,low income,poor health,and lack of family support.”展开更多
Objective: The health-related quality of life (HRQoL) theory was used to assess the health quality of elderly residents in Southwest China. This was done by using the European Five-Dimensional Health Scale in a compre...Objective: The health-related quality of life (HRQoL) theory was used to assess the health quality of elderly residents in Southwest China. This was done by using the European Five-Dimensional Health Scale in a comprehensive manner and by analysing the factors influencing it. The findings will provide new perspectives and ideas for improving the health-related quality of life of the elderly population and enhancing the precise health management of elderly residents. Methods: The response data of 1892 elderly residents in southwestern China were included in the analysis based on the CLHLS data. The factors influencing the occurrence of problems, EQ-VAS scores and health utility values were analysed by logistic regression, multiple linear regression and Tobit regression, respectively. Results: The primary health concerns among the elderly population in the Southwest region were limited ability to perform daily activities and pain or discomfort. These individuals exhibited an EQ-VAS self-assessment score of 66.51 ± 14.87 and a health utility value of 0.87 (0.70, 1.00). Gender, age, regular medical check-ups, exercise habits and the prevalence of chronic diseases are the main influencing factors. Conclusions: The health quality of elderly people in Southwest China needs to be improved, and a comprehensive management strategy can be adopted in terms of lifestyle management, health needs management and disease management to improve the quality of their healthy lives and promote the development of healthy ageing.展开更多
Summer residential tourism is the future trend in China because of tourists’living quality improvement,heat crisis,rising market demand,and optimization of the destinations’residential environment,transport and acce...Summer residential tourism is the future trend in China because of tourists’living quality improvement,heat crisis,rising market demand,and optimization of the destinations’residential environment,transport and accessibility.Compared with summer tourism and vacation tourism,summer residential tourism had got less attention and lacks in prospective and preventive research.Hence,this study focused on potential assessment,pattern recognition and phase segmentation of 32 residential tourism destinations in China selected from 4 lists.An index system of 16 indicators from 5 dimensions was established as Summer Residence Index(SRI),and Range method,Entropy weight method and Composite index method were chosen as the core methods.Three main conclusions were as follows.(1)Only 2 typical districts’SRI value were near to 0.6,and 4 destinations were below 0.1,about 26 destinations were at medium-level,which indicated that China’s summer residential tourism was not so popular and only few destinations have stepped into a higher level.(2)Seven patterns could be recognized based on the contribution of the 5 dimensions to SRI value,including 3 single-factor driven patterns and 4 compound factors driven patterns.(3)Like tourist area life cycle(TALC),Unconscious stage,Initial stage,Developmental stage and Maturity stage could be segmented for summer residential destinations with the value of below 0.1,0.1-0.3,0.3-0.5,and above 0.5.Four destinations were under Unconscious stage.Twenty-two destinations were at initiate stage.Only 4 destinations have stepped into development stage and 2 at maturity stage.China’summer residential tourism has just started and has a better prospect.This study is just an attempt and needs further consideration,for example,a tracking study of SRI calculation for each year will be carried to justify the effectiveness of SRI and to check the rationality of the empirical results.As time goes on,policies in housing,residential estate and other aspects should be included as a factor in the SRI index.Data availability should be optimized because of better data sources and new technologies.Some other districts or cities in 2 batches of national Comprehensive Tourism Demonstration Zones(CTDZs)pilots and provincial CTDZs will be further selections of summer residential tourism destinations.展开更多
Based on the empirical analysis of the income and consumption of rural residents,the present paper discusses the reasons for the weak growth of income and the lagging consumption of rural residents in China.Finally,it...Based on the empirical analysis of the income and consumption of rural residents,the present paper discusses the reasons for the weak growth of income and the lagging consumption of rural residents in China.Finally,it comes up with some recommendations and measures to increase the income of rural residents,promote the consumption of rural residents,and open up the rural market.展开更多
Change trend of Chinese urban residents＇ per capita food-nitrogen annual consumption from 1981 to 2007 was analyzed and predicted by using ARIMA time-series model in order to reveal the change of urban food-nitrogen ...Change trend of Chinese urban residents＇ per capita food-nitrogen annual consumption from 1981 to 2007 was analyzed and predicted by using ARIMA time-series model in order to reveal the change of urban food-nitrogen consumption during the China＇s urbanization process.Results showed that after 1980s,the annual consumption of Chinese urban residents＇ food-nitrogen had a change trend of ＂ increase-decrease-increase＂ and generally presented as a slight increasing trend;With the acceleration of rapid economic development and urbanization process,Chinese urban residents＇ food-nitrogen consumption will still keep a rising trend in future,and also has a large rising space.展开更多
Standardized residency training programs primarily focus on developing clinical diagnostic and treatment skills,often allocating limited time to research activities.However,enhancing research skills is of paramount im...Standardized residency training programs primarily focus on developing clinical diagnostic and treatment skills,often allocating limited time to research activities.However,enhancing research skills is of paramount importance for residents,as it fosters critical thinking,problem-solving abilities,and a deeper understanding of applying scientific principles to clinical practice.This paper explores the necessity and significance of integrating research training into residency programs,emphasizing its role in cultivating well-rounded physicians capable of advancing medical knowledge.This study proposes a competency-based research training model that encompasses research literacy,study design,biostatistics,and scientific writing.Additionally,online asynchronous training modules,robust mentorship,and balanced time management strategies are recommended to enhance residents’research engagement without compromising clinical training.By implementing these measures,residency programs can improve residents’research capabilities,contributing to both individual professional growth and the broader advancement of medical science.展开更多
Colorectal cancer(CRC)is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells.It is increasingly recognized that tumour progression is also regulated by tu...Colorectal cancer(CRC)is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells.It is increasingly recognized that tumour progression is also regulated by tumour microenvironment(TME).The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis.Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors(angiogenic/inflammatory/immune)which contribute to cancer cell proliferation,invasion,neoangiogenesis,evasion of immune surveillance and therapy resistance.Furthermore,adipocytes represent a fuel rich source for increasing energy demand of rapidly proliferating tumour cells.Interestingly,a relationship between obesity and molecular variants in CRC has recently been identified.Whether adipose tissue promotes cancer progression in subsets of molecular phenotypes or whether local tissue adipocytes are involved in inactivation of tumour suppressor genes and/or activation of oncogenes still needs to be explored.This editorial highlights the major findings related to crosstalk between adipocytes and colon cancer cells and how local paracrine interactions may promote cancer progression.Furthermore,we provide future strategies in studying colonic TME which could provide insights in bidirectional cross-talk mechanisms between adipocytes and colonic epithelial cells.This could enable to decipher critical signalling pathways of both early colonic carcinogenesis and cancer progression.展开更多
Traditional village protection has been a hot topic recently. And traditional villages are far from meeting residents＇ demands in infrastructure as economic and social advances. Besides, local residents are not fully...Traditional village protection has been a hot topic recently. And traditional villages are far from meeting residents＇ demands in infrastructure as economic and social advances. Besides, local residents are not fully aware of cultural protection or inheritance, so that many traditional buildings long fallen into disrepair, have been replaced by new ones. In the meantime, the population of migrant workers is in- creasing, making cultural inheritance more difficult and causing decreasing of tradi- tional villages. Now, it is an important and tough job to release the conflict between increasing material needs of the people and historical cultural inheritance. In the re- search, field investigation was made on Dongkeng Village, Le＇an county to seek the optimal strategy for traditional village sustainable development from the perspective of importance on traditional village protection.展开更多
BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the ...BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the potential role of T_(RM) cells in providing immunogenicity in CRC stratified by microsatellite instability(MSI) and BRAF status.METHODS Patients with known MSI and BRAF mutation status were eligible for inclusion in this study. CRC tumour sections stained with haematoxylin and eosin were microscopically reviewed and the images scanned prior to assessment for location of invading edge and core of tumour. Sequential sections were prepared for quantitative multiplex immunohistochemistry(IHC) staining. Opal Multiplex IHC staining was performed with appropriate positive and negative controls and imaged using a standard fluorescent microscope fitted with a spectral scanning camera(Mantra) in conjunction with Mantra snap software. Images were unmixed and annotated in in Form 2.2.0. Statistical analysis was performed using Graphpad Prism Version 7 and Stata Version 15.RESULTS Seventy-two patients with known MSI and BRAF status were included in the study. All patients were assessed for MSI by IHC and high resolution capillary electrophoresis testing and 44 of these patients successfully underwent quantitative multiplex IHC staining. Overall, there was a statistically significant increase in CD8+ T_(RM) cells in the MSI(BRAF mutant and wild type) group over the microsatellite stable(MSS) group. There was a statistically significant difference in CD8+ T_(RM) between high level MSI(MSI-H):BRAF mutant [22.57, 95% confidence interval(CI): 14.31-30.84] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0076 and MSI-H:BRAF wild type [16.18(95%CI: 10.44-21.93)] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0279. There was no statistically significant difference in CD8 T cells(both CD8+CD103-and CD8+CD103+T_(RM)) between MSI-H: BRAF mutant and wild type CRC.CONCLUSION This study has shown that CD8+ T_(RM) are found in greater abundance in MSI-H CRC, both BRAF mutant and MSI-H:BRAF wild type, when compared with their MSS counterpart. CD8+ T_(RM) may play a role in the immunogenicity in MSI-H CRC(BRAF mutant and BRAF wild type). Further studies should focus on the potential immunogenic qualities of T_(RM) cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC.展开更多
The unique two-stage "Chinese path" of China’s ru-ral-urban migration, which cannot be fully explained by classical theories of economic development, makes us to give peasant workers’ transformation to urb...The unique two-stage "Chinese path" of China’s ru-ral-urban migration, which cannot be fully explained by classical theories of economic development, makes us to give peasant workers’ transformation to urban residents a top priority. On the basis of fully explaining peasant workers’ transformation to urban residents, a method for measuring its process has been advanced and then confirmed with the data of March in 2005 from surveys to peasant workers in Wuhan. Finally, the suggestions of acceler-ating peasant workers’ transformation to urban residents to pro-mote the construction of a harmonious society have been drawn from the analysis.展开更多
The development status of rural resident tourism market is introduced in this study,and its potential influencing factors are analyzed.With coastal areas as the study case,the future development trend of rural residen...The development status of rural resident tourism market is introduced in this study,and its potential influencing factors are analyzed.With coastal areas as the study case,the future development trend of rural resident tourism market in China is predicted from the aspects of market scale,consumption pattern,tourism level and tourism season,moreover,countermeasures are put forward for the healthy and sustainable development of rural resident tourism market.展开更多
It is a fact that in U.S. the immigration between rural areas and city areas is free, but in China this type of immigration is restricted by HUKOU system (Hukou, namely the household registration system, was designed ...It is a fact that in U.S. the immigration between rural areas and city areas is free, but in China this type of immigration is restricted by HUKOU system (Hukou, namely the household registration system, was designed to control rural-urban in China). All of those national policies in city areas are much better than those in rural areas, so those corresponding differences bring about great discrepancy of the economic status (mainly including GDP per person and income per resident) between rural and city areas in the same urban region, especially in different urban re- gions because the percentage of urban residents in those urban regions is in-equable. The present paper mainly researches the topic of relationship between the percentage of urban residents and the economic status in an urban region in China, including the relationship between the economic and the political functions of a settlement in China during the process of urbanization.展开更多
Based on the relevant data of the actual income and consumption of rural residents in Hebei Province from 1983 to 2007,the relationship between actual income and consumption of rural residents was tested by applying t...Based on the relevant data of the actual income and consumption of rural residents in Hebei Province from 1983 to 2007,the relationship between actual income and consumption of rural residents was tested by applying the co-integration theory and Granger causality test.The result shows that there is long-term stable equilibrium relationship between the net Income per capita and consumption expenditure per capita of rural residents in Hebei Province from 1983 to 2007;the result of Granger causality test shows that the actual Income of rural residents in Hebei Province has significant impact on the actual consumption,but the impact is weakened gradually;in short term,the impact of the actual consumption on the actual income is not so significant,but the impact will become significant gradually as time goes on.During the process of the mutual impact and function of the actual income and consumption of rural residents in Hebei Province,the impact of the actual income of rural residents on the actual consumption is mainly represented in short term;in middle term,the interactions between the actual Income and actual consumption are significant;in long term,the impact of the actual consumption on the actual income is mainly displayed.According to the result,in short term the government in Hebei Province can expand consumption through increasing the income of rural residents,while in long term the government can drive the economic growth by expanding domestic demands.展开更多
People's livelihood improvement is the prerequisite of social harmony.Food,clothing shelter and transportation are the direct manifestation of the people's livelihood.In China's vast rural areas,the most s...People's livelihood improvement is the prerequisite of social harmony.Food,clothing shelter and transportation are the direct manifestation of the people's livelihood.In China's vast rural areas,the most significant manifestation of people's livelihood improvement is the improvement of living conditions.Based on the data on two censuses,this paper analyzes the degree of improvement of rural residents'living conditions from the changes in the rural residents'residential structure.Finally this paper puts forth the following recommendations for improving the rural residents'residential structure:continuing to put farmers in the first place;taking truly improving the residential structure as a starting point,and prohibiting the"vanity project";taking preferential policies for the improvement of living conditions.展开更多
基金supported by Ministry of Science and Technology China Brain Initiative Grant,No.2022ZD0204702(to ZY)the National Natural Science Foundation of China,No.82371357(to LC)+2 种基金Foundation for Military Medicine,No.16QNP085(to ZY)Navy Medical University Basic Medical College“Yi Zhang”Basic Medical Talent Development and Support Program,Nos.JCYZRC-D-022(to TC)and JCYZRC-D-024(to HD)Science and Technology Innovation Special Fund of Shanghai Baoshan District,No.2023-E-05(to YW).
文摘Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain’s borders,and recruited macrophages.They are responsible for neural development,maintenance of homeostasis,and orchestrating immune responses.With the rapid exploitation and development of new technologies,there is a deeper understanding of macrophages in the brain barrier system.Here we review the origin,development,important molecules,and functions of macrophages,mainly focusing on microglia and border-associated macrophages.We also highlight some advances in single-cell sequencing and significant cell markers.We anticipate that more advanced methods will emerge to study resident and recruited macrophages in the future,opening new horizons for neuroimmunology and related peripheral immune fields.
基金supported by the Teaching Reform Project of Stomatology College of Chongqing Medical University(KQJ202215,KQJ202204)the Teaching Reform Project of Chongqing Medical University(JY20220317).
文摘As the most critical part of post-graduate education,the Chinese government launched Standard Resident Training in 2013 to solve the regional inequality of medical quality and meet the increasing social requirement for better medical service.We integrated problem-based learning(PBL)and case-based learning(CBL)in the Endodontics Standard Resident Training.By evaluating with objective parameters including theoretical knowledge and clinical practice skill,and subjective parameters including questionnaire,it was found that PBL+CBL played a positive role in endodontic resident training with a significant difference(P<0.05).This combined training model is instructive for China’s resident training,and this result can provide a rudimentary reference to current postgraduate teaching reform.
基金Scientific Research Fund Project of China Three Gorges University(Project No.:2022kj008)Special Scientific Research Fund Project of China Three Gorges University(Project No.:2023kjzx001)。
文摘As a crucial assessment tool,the Mini Clinical Evaluation Exercise(Mini-CEX)has gradually garnered attention in the clinical skills training of resident physicians.With the ongoing advancement of medical education reform,Mini-CEX not only offers a fresh perspective for evaluating the clinical competence of resident physicians but also establishes a foundation for enhancing their overall quality and professional capabilities.Nonetheless,there are still certain constraints in the application of Mini-CEX,including inconsistent assessment criteria,assessor subjectivity,and inadequate feedback mechanisms.This paper will review relevant domestic and international studies,explore the practical application of Mini-CEX in standardized resident physician training,analyze its strengths and weaknesses in assessing clinical ability,and propose recommendations for future development directions.Through a thorough examination of this field,it aims to provide references and guidance for further optimizing the training model for resident physicians.
基金Research on the Measurement and Influencing Factors of Carbon Inclusive Literacy of Chongqing Residents under the“ Dual Carbon”Goal(S2024115001011)。
文摘In the context of the global“double carbon”goal,this article uses the Analytic Hierarchy Process and Multiple Linear Regression combined with a survey questionnaire to study the issue of carbon literacy among residents in Chongqing.The weights of each dimension are determined to promote the formation of a good situation of multi-party collaborative promotion and help achieve the“double carbon”goal.The level of carbon literacy reflects the residents’understanding of carbon literacy and has important significance for economic and social operation and environmental protection.The results indicate that the deepening of the concept of carbon inclusiveness and the continuous advancement of technology will lead to a continuous process of improving the carbon inclusiveness literacy of Chongqing residents.Corresponding suggestions are proposed on how to improve the carbon inclusiveness literacy of Chongqing residents,which is of great research significance.
文摘Objective:To enhance the reading skills of clinical pathology residents,it is essential to establish a well-structured electronic pathology reading library.Methods:In accordance with the Resident Standardization Training Content and Standards(2022 Edition),clinical pathology residents are required to master pathological diagnoses across 11 systems:skin,head and neck,mediastinum and respiratory,digestive,urinary and male reproductive,female reproductive and breast,lymphatic and hematopoietic,bone and soft tissue,cardiovascular,central nervous,and endocrine diseases.Senior pathologists specializing in each subspecialty selected classic pathological slides,which were systematically scanned and compiled into an electronic pathology library.Results:A questionnaire survey was conducted to gather feedback on the electronic pathology reading library.Residents generally found it to be convenient,efficient,and conducive to learning.Conclusion:Training in clinical pathology diagnosis is a core component of standardized resident training.The electronic pathology reading library has been well-received and recognized by resident doctors.However,further efforts are needed to explore diverse teaching methods that align with modern educational approaches,ultimately contributing to the development of highly skilled resident doctors.
基金supported in part by the 2025 Yanbian University College Students’Innovation and Entrepreneurship Training Program.
文摘Background:Despite self-determination theory’s prominence,few studies examine BPN in China’s ethnic frontier regions.Therefore,this study investigates and analyzes the current situation of community residents with different demographic characteristics in Yanbian in the three basic psychological needs of competency needs,autonomy needs and attribution needs,so as to provide reference for the construction of community service in Yanbian area.Methods:A survey was conducted among 234 residents in four communities in Yanbian from September to October 2024.The equal probability random sampling method was used to collect data by using a general information questionnaire and basic psychological demand scale,and SPSS 28.0 was used for analysis.Through single factor analysis,Pearson correlation analysis and multiple linear regression analysis,the influencing factors and correlation of basic psychological needs of community residents in Yanbian area were discussed.Results:The basic psychological needs of residents were above the middle level;there is a significant positive correlation between economic status and the three dimensions of basic psychological needs(P<0.001).There is a significant positive correlation between the three dimensions of competence demand(β=2.028,P<0.001),autonomy demand(β=2.022,P<0.001),and attribution demand(β=2.693,P<0.001).Conclusion:The satisfaction degree of basic psychological needs of community residents in Yanbian is significantly affected by economic situation,which urges nurses to advocate for economic empowerment programs in community health and provides an empirical basis for the construction of a psychological service system in this area.At the same time,it is proposed that the region can respond by improving social support and improving employment results.
基金Survey and Analysis on Humanistic Care Experience and Influencing Factors of Elderly Residents in 3 Integrated Medical and Nursing Institutions in Guangyuan City(Project No.:24SCLN055)。
文摘This empirical study examines the integration of medical and elderly care services in Guangyuan City through stratified random sampling,targeting 283 eligible residents aged 60+from three representative integrated institutions.The research employed a self-designed questionnaire titled“Humanistic Care Experience and Demand Influencing Factors”to collect subjective perceptions regarding basic care,psychological support,health education,and social interaction using a Likert five-point scale.Descriptive statistics,one-way ANOVA,and multiple regression modeling were conducted with SPSS 25.0 software.Results indicated that overall humanistic care experience scores were moderately high,with the“caregiving”dimension scoring highest and“psychological/social support”the lowest.Analysis revealed significant correlations between educational attainment,income,self-reported health status,and family support frequency(P<0.001),particularly among seniors with higher education,better health,and stronger family support.While integrated care facilities provide relatively comprehensive basic care,they should focus on addressing gaps in humanistic services,especially providing targeted support for groups with“low education,low income,poor health,and lack of family support.”
文摘Objective: The health-related quality of life (HRQoL) theory was used to assess the health quality of elderly residents in Southwest China. This was done by using the European Five-Dimensional Health Scale in a comprehensive manner and by analysing the factors influencing it. The findings will provide new perspectives and ideas for improving the health-related quality of life of the elderly population and enhancing the precise health management of elderly residents. Methods: The response data of 1892 elderly residents in southwestern China were included in the analysis based on the CLHLS data. The factors influencing the occurrence of problems, EQ-VAS scores and health utility values were analysed by logistic regression, multiple linear regression and Tobit regression, respectively. Results: The primary health concerns among the elderly population in the Southwest region were limited ability to perform daily activities and pain or discomfort. These individuals exhibited an EQ-VAS self-assessment score of 66.51 ± 14.87 and a health utility value of 0.87 (0.70, 1.00). Gender, age, regular medical check-ups, exercise habits and the prevalence of chronic diseases are the main influencing factors. Conclusions: The health quality of elderly people in Southwest China needs to be improved, and a comprehensive management strategy can be adopted in terms of lifestyle management, health needs management and disease management to improve the quality of their healthy lives and promote the development of healthy ageing.
基金Supported by Ningxia Natural Science Foundation(2024AAC03100).
文摘Summer residential tourism is the future trend in China because of tourists’living quality improvement,heat crisis,rising market demand,and optimization of the destinations’residential environment,transport and accessibility.Compared with summer tourism and vacation tourism,summer residential tourism had got less attention and lacks in prospective and preventive research.Hence,this study focused on potential assessment,pattern recognition and phase segmentation of 32 residential tourism destinations in China selected from 4 lists.An index system of 16 indicators from 5 dimensions was established as Summer Residence Index(SRI),and Range method,Entropy weight method and Composite index method were chosen as the core methods.Three main conclusions were as follows.(1)Only 2 typical districts’SRI value were near to 0.6,and 4 destinations were below 0.1,about 26 destinations were at medium-level,which indicated that China’s summer residential tourism was not so popular and only few destinations have stepped into a higher level.(2)Seven patterns could be recognized based on the contribution of the 5 dimensions to SRI value,including 3 single-factor driven patterns and 4 compound factors driven patterns.(3)Like tourist area life cycle(TALC),Unconscious stage,Initial stage,Developmental stage and Maturity stage could be segmented for summer residential destinations with the value of below 0.1,0.1-0.3,0.3-0.5,and above 0.5.Four destinations were under Unconscious stage.Twenty-two destinations were at initiate stage.Only 4 destinations have stepped into development stage and 2 at maturity stage.China’summer residential tourism has just started and has a better prospect.This study is just an attempt and needs further consideration,for example,a tracking study of SRI calculation for each year will be carried to justify the effectiveness of SRI and to check the rationality of the empirical results.As time goes on,policies in housing,residential estate and other aspects should be included as a factor in the SRI index.Data availability should be optimized because of better data sources and new technologies.Some other districts or cities in 2 batches of national Comprehensive Tourism Demonstration Zones(CTDZs)pilots and provincial CTDZs will be further selections of summer residential tourism destinations.
基金General Project of Philosophy and Social Science Research in Jiangsu Universities"Research on the Long-term Mechanism for Expanding Consumption Demand of Rural Residents in Jiangsu Province during the Historical Convergence Period of the Two Centenary Goals"(2022SJYB0493).
文摘Based on the empirical analysis of the income and consumption of rural residents,the present paper discusses the reasons for the weak growth of income and the lagging consumption of rural residents in China.Finally,it comes up with some recommendations and measures to increase the income of rural residents,promote the consumption of rural residents,and open up the rural market.
基金Supported by State Council Special Fund for Pollution Sources Survey (WPXC2007C200)~~
文摘Change trend of Chinese urban residents＇ per capita food-nitrogen annual consumption from 1981 to 2007 was analyzed and predicted by using ARIMA time-series model in order to reveal the change of urban food-nitrogen consumption during the China＇s urbanization process.Results showed that after 1980s,the annual consumption of Chinese urban residents＇ food-nitrogen had a change trend of ＂ increase-decrease-increase＂ and generally presented as a slight increasing trend;With the acceleration of rapid economic development and urbanization process,Chinese urban residents＇ food-nitrogen consumption will still keep a rising trend in future,and also has a large rising space.
基金Research on the Construction of a Course Ideological and Political Education System and Evaluation Framework for the“Traditional Chinese Medicine Internal Medicine”Course(Project No.:2025J0459)Open Research Fund Program of Yunnan Key Laboratory of Integrated Traditional Chinese(Project No.:CWCD2023-002,CWCD2023-003&CWCD2023-009)+2 种基金Western Medicine for Chronic Disease in Prevention and TreatmentYunnan 047 Key Laboratory of Yi Dai Medicine and Yi Medicine(Project No.:2024SS24047)Yunnan 025 Key Laboratory of Yi Dai Medicine and Yi Medicine(Project No.:2024SS24025)。
文摘Standardized residency training programs primarily focus on developing clinical diagnostic and treatment skills,often allocating limited time to research activities.However,enhancing research skills is of paramount importance for residents,as it fosters critical thinking,problem-solving abilities,and a deeper understanding of applying scientific principles to clinical practice.This paper explores the necessity and significance of integrating research training into residency programs,emphasizing its role in cultivating well-rounded physicians capable of advancing medical knowledge.This study proposes a competency-based research training model that encompasses research literacy,study design,biostatistics,and scientific writing.Additionally,online asynchronous training modules,robust mentorship,and balanced time management strategies are recommended to enhance residents’research engagement without compromising clinical training.By implementing these measures,residency programs can improve residents’research capabilities,contributing to both individual professional growth and the broader advancement of medical science.
文摘Colorectal cancer(CRC)is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells.It is increasingly recognized that tumour progression is also regulated by tumour microenvironment(TME).The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis.Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors(angiogenic/inflammatory/immune)which contribute to cancer cell proliferation,invasion,neoangiogenesis,evasion of immune surveillance and therapy resistance.Furthermore,adipocytes represent a fuel rich source for increasing energy demand of rapidly proliferating tumour cells.Interestingly,a relationship between obesity and molecular variants in CRC has recently been identified.Whether adipose tissue promotes cancer progression in subsets of molecular phenotypes or whether local tissue adipocytes are involved in inactivation of tumour suppressor genes and/or activation of oncogenes still needs to be explored.This editorial highlights the major findings related to crosstalk between adipocytes and colon cancer cells and how local paracrine interactions may promote cancer progression.Furthermore,we provide future strategies in studying colonic TME which could provide insights in bidirectional cross-talk mechanisms between adipocytes and colonic epithelial cells.This could enable to decipher critical signalling pathways of both early colonic carcinogenesis and cancer progression.
文摘Traditional village protection has been a hot topic recently. And traditional villages are far from meeting residents＇ demands in infrastructure as economic and social advances. Besides, local residents are not fully aware of cultural protection or inheritance, so that many traditional buildings long fallen into disrepair, have been replaced by new ones. In the meantime, the population of migrant workers is in- creasing, making cultural inheritance more difficult and causing decreasing of tradi- tional villages. Now, it is an important and tough job to release the conflict between increasing material needs of the people and historical cultural inheritance. In the re- search, field investigation was made on Dongkeng Village, Le＇an county to seek the optimal strategy for traditional village sustainable development from the perspective of importance on traditional village protection.
文摘BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the potential role of T_(RM) cells in providing immunogenicity in CRC stratified by microsatellite instability(MSI) and BRAF status.METHODS Patients with known MSI and BRAF mutation status were eligible for inclusion in this study. CRC tumour sections stained with haematoxylin and eosin were microscopically reviewed and the images scanned prior to assessment for location of invading edge and core of tumour. Sequential sections were prepared for quantitative multiplex immunohistochemistry(IHC) staining. Opal Multiplex IHC staining was performed with appropriate positive and negative controls and imaged using a standard fluorescent microscope fitted with a spectral scanning camera(Mantra) in conjunction with Mantra snap software. Images were unmixed and annotated in in Form 2.2.0. Statistical analysis was performed using Graphpad Prism Version 7 and Stata Version 15.RESULTS Seventy-two patients with known MSI and BRAF status were included in the study. All patients were assessed for MSI by IHC and high resolution capillary electrophoresis testing and 44 of these patients successfully underwent quantitative multiplex IHC staining. Overall, there was a statistically significant increase in CD8+ T_(RM) cells in the MSI(BRAF mutant and wild type) group over the microsatellite stable(MSS) group. There was a statistically significant difference in CD8+ T_(RM) between high level MSI(MSI-H):BRAF mutant [22.57, 95% confidence interval(CI): 14.31-30.84] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0076 and MSI-H:BRAF wild type [16.18(95%CI: 10.44-21.93)] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0279. There was no statistically significant difference in CD8 T cells(both CD8+CD103-and CD8+CD103+T_(RM)) between MSI-H: BRAF mutant and wild type CRC.CONCLUSION This study has shown that CD8+ T_(RM) are found in greater abundance in MSI-H CRC, both BRAF mutant and MSI-H:BRAF wild type, when compared with their MSS counterpart. CD8+ T_(RM) may play a role in the immunogenicity in MSI-H CRC(BRAF mutant and BRAF wild type). Further studies should focus on the potential immunogenic qualities of T_(RM) cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC.
文摘The unique two-stage "Chinese path" of China’s ru-ral-urban migration, which cannot be fully explained by classical theories of economic development, makes us to give peasant workers’ transformation to urban residents a top priority. On the basis of fully explaining peasant workers’ transformation to urban residents, a method for measuring its process has been advanced and then confirmed with the data of March in 2005 from surveys to peasant workers in Wuhan. Finally, the suggestions of acceler-ating peasant workers’ transformation to urban residents to pro-mote the construction of a harmonious society have been drawn from the analysis.
文摘The development status of rural resident tourism market is introduced in this study,and its potential influencing factors are analyzed.With coastal areas as the study case,the future development trend of rural resident tourism market in China is predicted from the aspects of market scale,consumption pattern,tourism level and tourism season,moreover,countermeasures are put forward for the healthy and sustainable development of rural resident tourism market.
文摘It is a fact that in U.S. the immigration between rural areas and city areas is free, but in China this type of immigration is restricted by HUKOU system (Hukou, namely the household registration system, was designed to control rural-urban in China). All of those national policies in city areas are much better than those in rural areas, so those corresponding differences bring about great discrepancy of the economic status (mainly including GDP per person and income per resident) between rural and city areas in the same urban region, especially in different urban re- gions because the percentage of urban residents in those urban regions is in-equable. The present paper mainly researches the topic of relationship between the percentage of urban residents and the economic status in an urban region in China, including the relationship between the economic and the political functions of a settlement in China during the process of urbanization.
基金Supported by the Hebei Social Science Fund Project(HB08BTJ001)
文摘Based on the relevant data of the actual income and consumption of rural residents in Hebei Province from 1983 to 2007,the relationship between actual income and consumption of rural residents was tested by applying the co-integration theory and Granger causality test.The result shows that there is long-term stable equilibrium relationship between the net Income per capita and consumption expenditure per capita of rural residents in Hebei Province from 1983 to 2007;the result of Granger causality test shows that the actual Income of rural residents in Hebei Province has significant impact on the actual consumption,but the impact is weakened gradually;in short term,the impact of the actual consumption on the actual income is not so significant,but the impact will become significant gradually as time goes on.During the process of the mutual impact and function of the actual income and consumption of rural residents in Hebei Province,the impact of the actual income of rural residents on the actual consumption is mainly represented in short term;in middle term,the interactions between the actual Income and actual consumption are significant;in long term,the impact of the actual consumption on the actual income is mainly displayed.According to the result,in short term the government in Hebei Province can expand consumption through increasing the income of rural residents,while in long term the government can drive the economic growth by expanding domestic demands.
基金Supported by Project of Hebei Provincial Federation of Humanities & Social Sciences(201201081)
文摘People's livelihood improvement is the prerequisite of social harmony.Food,clothing shelter and transportation are the direct manifestation of the people's livelihood.In China's vast rural areas,the most significant manifestation of people's livelihood improvement is the improvement of living conditions.Based on the data on two censuses,this paper analyzes the degree of improvement of rural residents'living conditions from the changes in the rural residents'residential structure.Finally this paper puts forth the following recommendations for improving the rural residents'residential structure:continuing to put farmers in the first place;taking truly improving the residential structure as a starting point,and prohibiting the"vanity project";taking preferential policies for the improvement of living conditions.
