The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It ha...The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve) and the extent of neural connections acquired through life(neural reserve) set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain's ability to adapt and reo rganize stru cturally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024).展开更多
Located in southern Ningxia Hui Autonomous Region,northwest China,the Liupan Mountain National Nature Reserve covers a total area of 26,783.64 hectares.Established in 1982 and upgraded to national status in 1988,it pr...Located in southern Ningxia Hui Autonomous Region,northwest China,the Liupan Mountain National Nature Reserve covers a total area of 26,783.64 hectares.Established in 1982 and upgraded to national status in 1988,it protects a vital temperate mountainous forest ecosystem on the Loess Plateau.The reserve is centred around the Liupan Mountain range,one of China’s youngest mountain chains,formed by Himalayan tectonic movements.展开更多
Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value ...Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.展开更多
CHINA Wuliangshan National Nature Reserve Spanning a significant altitudinal range from 1,600 to 3,371 metres and encompassing a total area of 31,585 hectares,the Wuliangshan National Nature Reserve protects one of th...CHINA Wuliangshan National Nature Reserve Spanning a significant altitudinal range from 1,600 to 3,371 metres and encompassing a total area of 31,585 hectares,the Wuliangshan National Nature Reserve protects one of the most intact and pristine forest ecosystems in southern Yunnan Province.展开更多
Elk are seen at the Tian’ezhou National Nature Reserve for Elk in Shishou,Hubei Province,on 27 November 2025.The reserve’s elk population has risen from just 64 in the 1990s to more than 4,500 today.
CHINA.Dinghu Mountain National Nature Reserve.Located in Zhaoqing,Guangdong Province,Dinghu Mountain National Nature Reserve is a pristine natural sanctuary spanning 1,133 hectares within the low mountain ranges of th...CHINA.Dinghu Mountain National Nature Reserve.Located in Zhaoqing,Guangdong Province,Dinghu Mountain National Nature Reserve is a pristine natural sanctuary spanning 1,133 hectares within the low mountain ranges of the Dayunwu Mountains.展开更多
In a pivotal moment for global conservation policy,UNESCO’s Man and the Biosphere(MAB)Programme has endorsed the Hangzhou Strategic Action Plan(HSAP)2026–2035(UNESCO,2025),a decade-long roadmap that positions the Wo...In a pivotal moment for global conservation policy,UNESCO’s Man and the Biosphere(MAB)Programme has endorsed the Hangzhou Strategic Action Plan(HSAP)2026–2035(UNESCO,2025),a decade-long roadmap that positions the World Network of Biosphere Reserves(WNBR)as central actors in delivering biodiversity,climate and sustainable-development goals(SDGs).The plan—developed and opened for global consultation in the runup to the 5th World Congress of Biosphere Reserves—articulates strategic directions,measurable action targets and practical instruments to strengthen biosphere reserves as living laboratories for people and nature(Ma,2025).展开更多
The Qinghai-Xizang Plateau,known as the Roof of the World and the Water Tower of Asia,is recognized as the Earth’s Third Pole.It functions as a vital ecological security barrier and a strategic resource reserve for C...The Qinghai-Xizang Plateau,known as the Roof of the World and the Water Tower of Asia,is recognized as the Earth’s Third Pole.It functions as a vital ecological security barrier and a strategic resource reserve for China,while also serving as an important conservation area that reflects the unique culture of the Chinese nation.Conducting the Second Comprehensive Scientific Expedition to the Qinghai-Xizang Plateau is essential for understanding valuable insights into scientific protection of the region.展开更多
Load balancing is vital for the efficient and long-term operation of cloud data centers.With virtualization,post(reactive)migration of virtual machines(VMs)after allocation is the traditional way for load balancing an...Load balancing is vital for the efficient and long-term operation of cloud data centers.With virtualization,post(reactive)migration of virtual machines(VMs)after allocation is the traditional way for load balancing and consolidation.However,it is not easy for reactive migration to obtain predefined load balance objectives and it may interrupt services and bring instability.Therefore,we provide a new approach,called Prepartition,for load balancing.It partitions a VM request into a few sub-requests sequentially with start time,end time and capacity demands,and treats each sub-request as a regular VM request.In this way,it can proactively set a bound for each VM request on each physical machine and makes the scheduler get ready before VM migration to obtain the predefined load balancing goal,which supports the resource allocation in a fine-grained manner.Simulations with real-world trace and synthetic data show that our proposed approach with offline version(PrepartitionOff)scheduling has 10%–20%better performance than the existing load balancing baselines under several metrics,including average utilization,imbalance degree,makespan and Capacity_makespan.We also extend Prepartition to online load balancing.Evaluation results show that our proposed approach also outperforms state-of-the-art online algorithms.展开更多
Firms employing both offshore outsourcing and nearshore sourcing strategies may face supply disruption,demand uncertainty,and quality risks simultaneously.Sourcing decisions become inevitably important and complicated...Firms employing both offshore outsourcing and nearshore sourcing strategies may face supply disruption,demand uncertainty,and quality risks simultaneously.Sourcing decisions become inevitably important and complicated when both profit and the customer-service level are taken into consideration.In this paper,we model a scenario where a manufacturer who faces stochastic demand procures major modules from an overseas supplier and two local suppliers.The overseas supplier offers quality products while being susceptible to disruption risks;if the local suppliers,who are completely reliable and serve as a backup,offer products that are of inferior quality,it may result in lower market acceptance and a bad experience for the final customers.The manufacturer has to reserve capacity with backup suppliers before urgent orders are placed,when the primary source experiences a shortfall.We explicitly derive the manufacturer’s optimal order quantities and reservation quantities,which are functions of the heterogeneous suppliers’wholesale prices,reservation prices,and other parameters.The impacts of the fill-rate constraint and customer-experience quality constraint on the manufacturer’s purchasing decisions are investigated.Interesting managerial insights on the merits of backup sourcing with capacity reservations for managing demand uncertainties and supply disruption risks are also discussed.展开更多
Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world.However,a century ago,they were considered hazardous environments due to their great dynamic nat...Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world.However,a century ago,they were considered hazardous environments due to their great dynamic nature.As a result,stabilization practices were considered necessary.The systematic introduction of fast-growing exotic trees helped stabilize the sand,making it easier for tourism urbanization to take place,but also leading to erosion processes.This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina.This complex region includes urban resorts,afforestation zones,and protected areas.A GIS-based geospatial analysis was conducted using a large satellite database(>350 images),and the future evolution of the vegetation was modeled.The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover,accompanied by a concurrent reduction in sandy areas.In 1986,the dune area comprised 75%more surface than vegetation,whereas in 2021,it represented 60%less than vegetation.Furthermore,the 2050 scenario suggests a potential 40%reduction of dunes in certain areas.It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance.Long-term management strategies must focus on restoring native plant communities and controlling invasive species,and avoiding new dune fixation initiatives based on the introduction of exotic species.展开更多
Percutaneous coronary intervention(PCI),as an essential treatment for coronary artery disease,has significantly improved the prognosis of patients with large coronary artery lesions.However,some patients continue to e...Percutaneous coronary intervention(PCI),as an essential treatment for coronary artery disease,has significantly improved the prognosis of patients with large coronary artery lesions.However,some patients continue to experience myocar-dial ischemic symptoms post-procedure,largely due to coronary microvascular dysfunction(CMD).The pathophysiological mechanisms of CMD are complex and involve endothelial dysfunction,microvascular remodeling,reperfusion in-jury,and metabolic abnormalities.Moreover,components of metabolic syndrome,including obesity,hyperglycemia,hypertension,and dyslipidemia,exacerbate the occurrence and progression of CMD through multiple pathways.This review systematically summarizes the latest research advan-cements in CMD after PCI,including its pathogenesis,diagnostic techniques,management strategies,and future research directions.For diagnosis,invasive techniques such as coronary flow reserve and the index of microcirculatory resistance,as well as non-invasive imaging modalities(positron emission tomography and cardiac magnetic reso-nance),provide tools for early CMD detection.In terms of management,a multi-level intervention strategy is emphasized,incorporating lifestyle modifications(diet,exercise,and weight control),pharmacotherapy(vasodilators,hypoglycemic agents,statins,and metabolic modulators),traditional Chinese medicine,and specialized treatments(enhanced external counterpulsation,metabolic surgery,and lipoprotein apheresis).However,challenges remain in CMD treatment,including limitations in diagnostic tools and the lack of personalized treatment strategies.Future research should focus on the complex interactions between CMD and metabolic risks,aiming to optimize diagnostic and therapeutic strate-gies to improve the long-term prognosis of patients post-PCI.展开更多
Clarifying the mechanisms through which coal mining affects groundwater storage(GWS)variations is crucial for water resource conservation and sustainable development.The Ordos Mining Region in China,a key energy base ...Clarifying the mechanisms through which coal mining affects groundwater storage(GWS)variations is crucial for water resource conservation and sustainable development.The Ordos Mining Region in China,a key energy base in China with significant strategic importance,has undergone intensive coal mining activities that have substantially disrupted regional groundwater circulation.This study integrated data from the Gravity Recovery and Climate Experiment Satellite(GRACE)and Famine Early Warning Systems Network(FEWS NET)Land Data Assimilation System(FLDAS)models,combined with weighted downscaling methodology and water balance principles,to reconstruct high-resolution(0.01°)terrestrial water storage(TWS)and GWS changes in the Ordos Mining Region,China from April 2002 to December 2021.The accuracy of GWS variations were validated through pumping test measurements.Subsequently,Geodetector analysis was implemented to quantify the contributions of natural and anthropogenic factors to groundwater storage dynamics.Key findings include:1)TWS in the study area showed a fluctuating but overall decreasing trend,with a total reduction of 8901.11 mm during study period.The most significant annual decrease occurred in 2021,reaching 1696.77 mm.2)GWS exhibited an accelerated decline,with an average annual change rate of 44.35 mm/yr,totaling a decrease of 887.05 mm.The lowest annual groundwater storage level was recorded in 2020,reaching 185.69 mm.3)Precipitation(PRE)contributed the most to GWS variation(q=0.52),followed by coal mining water consumption(MWS)(q=0.41).The interaction between PRE and MWS exhibited a nonlinear enhancement effect on GWS changes(0.54).The synergistic effect of natural hydrological factors has a great influence on the change of GWS,but coal mining water consumption will continue to reduce GWS.These findings provide critical references for the management and regulation of groundwater resource in mining regions.展开更多
Objective To evaluate the association of GGN repeat polymorphism of androgen receptor(AR)with ovarian reserve and ovarian response in controlled ovarian stimulation(COS).Methods This genetic association study was cond...Objective To evaluate the association of GGN repeat polymorphism of androgen receptor(AR)with ovarian reserve and ovarian response in controlled ovarian stimulation(COS).Methods This genetic association study was conducted among a total of 361 women aged≤40 years with basal FSH≤12 U/L undergoing the GnRH-agonist long protocol for COS in a university affiliated IVF center.GGN repeat in the AR gene was analyzed with Sanger sequencing.The primary endpoint was the number of antral follicle counts(AFCs),and the secondary endpoints were stimulation days,total dose of gonadotropin(Gn)used,total number of retrieved oocytes,ovarian sensitivity index,and follicular output rate.Results The GGN repeat in exon 1 of the AR gene ranged from 13 to 24,and the median repeat length was 22.Based on the genotypes(S for GGN repeats<22,L for GGN repeats≥22),the patients were divided into 3 groups:SS,SL,and LL.Generalized regression analysis indicated that the number of AFCs in group SS was significantly lower than those in group SL(adjusted β=1.8,95%CI:0.2-3.4,P=0.024)and group LL(adjusted β=1.5,95%CI:0.2-2.7,P=0.021).No significant difference was observed in the number of AFCs between group SL and group LL(P>0.05).Generalized regression analysis indicated no significant differences in ovarian stimulation parameters among the 3 groups,either before or after adjusting for confounding factors(P>0.05).Conclusion GGN repeat length on the AR gene is associated with AFC but not with ovarian response in Chinese women,indicating that AR gene polymorphisms may affect ovarian reserve.展开更多
CHINA Gaoligongshan National Natural Reserve Rising to over 4,000 metres above sea level in western Yunnan Province,Gaoligong Mountain forms part of the southern Hengduan Mountain Range and is renowned for its rich bi...CHINA Gaoligongshan National Natural Reserve Rising to over 4,000 metres above sea level in western Yunnan Province,Gaoligong Mountain forms part of the southern Hengduan Mountain Range and is renowned for its rich biodiversity and vibrant cultural landscape.Encompassing a vast protected area across the Tengchong and Baoshan regions,the Gaoligongshan National Natural Reserve is a secluded ecological treasure trove.In April 2000,the reserve joined the UNESCO World Network of Biosphere Reserves.展开更多
The pioneering work of China’s Zhejiang Province in biosphere preservation and restoration,as well as its green development of residential areas around its nature reserves,made it the ideal location to host the 5th W...The pioneering work of China’s Zhejiang Province in biosphere preservation and restoration,as well as its green development of residential areas around its nature reserves,made it the ideal location to host the 5th World Congress of Biosphere Reserves and share China’s achievements in this field with the world.展开更多
Established in 1958,Xishuangbanna National Nature Reserve is one of China’s first protected areas.Covering about 2,435 square km,it is the country’s largest tropical primeval forest and one of the world’s most biol...Established in 1958,Xishuangbanna National Nature Reserve is one of China’s first protected areas.Covering about 2,435 square km,it is the country’s largest tropical primeval forest and one of the world’s most biologically diverse regions.In 1993,it became part of the UNESCO World Biosphere Reserve Network,reflecting its global ecological significance.展开更多
Background Non-invasive computed tomography angiography(CTA)-based fractional flow reserve(CT-FFR)could become a gatekeeper to invasive coronary angiography.Deep learning(DL)-based CT-FFR has shown promise when compar...Background Non-invasive computed tomography angiography(CTA)-based fractional flow reserve(CT-FFR)could become a gatekeeper to invasive coronary angiography.Deep learning(DL)-based CT-FFR has shown promise when compared to invasive FFR.To evaluate the performance of a DL-based CT-FFR technique,DeepVessel FFR(DVFFR).Methods This retrospective study was designed for iScheMia Assessment based on a Retrospective,single-center Trial of CTFFR(SMART).Patients suspected of stable coronary artery disease(CAD)and undergoing both CTA and invasive FFR examinations were consecutively selected from the Beijing Anzhen Hospital between January 1,2016 to December 30,2018.FFR obtained during invasive coronary angiography was used as the reference standard.DVFFR was calculated blindly using a DL-based CTFFR approach that utilized the complete tree structure of the coronary arteries.Results Three hundred and thirty nine patients(60.5±10.0 years and 209 men)and 414 vessels with direct invasive FFR were included in the analysis.At per-vessel level,sensitivity,specificity,accuracy,positive predictive value(PPV)and negative predictive value(NPV)of DVFFR were 94.7%,88.6%,90.8%,82.7%,and 96.7%,respectively.The area under the receiver operating characteristics curve(AUC)was 0.95 for DVFFR and 0.56 for CTA-based assessment with a significant difference(P<0.0001).At patient level,sensitivity,specificity,accuracy,PPV and NPV of DVFFR were 93.8%,88.0%,90.3%,83.0%,and 95.8%,respectively.The computation for DVFFR was fast with the average time of 22.5±1.9 s.Conclusions The results demonstrate that DVFFR was able to evaluate lesion hemodynamic significance accurately and effectively with improved diagnostic performance over CTA alone.Coronary artery disease(CAD)is a critical disease in which coronary artery luminal narrowing may result in myocardial ischemia.Early and effective assessment of myocardial ischemia is essential for optimal treatment planning so as to improve the quality of life and reduce medical costs.展开更多
The Yangtze finless porpoise(Neophocaena asiaeorientalis asiaeorientalis)is distributed in the main stream of the middle and lower reaches of the Yangtze River,as well as in Dongting and Poyang lakes.Currently,the mos...The Yangtze finless porpoise(Neophocaena asiaeorientalis asiaeorientalis)is distributed in the main stream of the middle and lower reaches of the Yangtze River,as well as in Dongting and Poyang lakes.Currently,the most crucial conservation approach involves the establishment and management of both in-situ and ex-situ nature reserves.Since the 1990s,seven nature reserves have been established in the middle and lower reaches of the Yangtze River,covering nearly one-third of its main stream.Additionally,two nature reserves,one in the Dongting Lake and another in the Poyang Lake,have been set up;and three ex-situ nature reserves have been established in three oxbows respectively in Hunan,Hubei,and Anhui provinces.Through measures such as improving the ecological environment quality within the reserves,regulating human activities,and conducting continuous monitoring,the finless porpoise population showed a slight increase in 2022 for the first time.The ex-situ population has continued to grow,with four individuals being released back into the main stream of the Yangtze River after undergoing reintroduction training in 2023.Based on the population development lasting for over three decades,and predictions of future ecological changes,orderly establishment and scientific management of nature reserves have played a key role in and will remain an important basis for the sustaining growth of the finless porpoise population.展开更多
CHINA Tarim Populus Euphratica National Nature Reserve Located along the northern edge of the Taklimakan Desert in Xinjiang,the Tarim Populus Euphratica National Nature Reserve lies in the middle reaches of the Tarim ...CHINA Tarim Populus Euphratica National Nature Reserve Located along the northern edge of the Taklimakan Desert in Xinjiang,the Tarim Populus Euphratica National Nature Reserve lies in the middle reaches of the Tarim River-the longest inland river in China-within Bayingolin Mongol Autonomous Prefecture.Established in 1983 and upgraded to a national reserve in 2006,it covers an area of about 395,420 hectares,including a core,bu!er,and experimental zone.The reserve features alluvial plains and desert terrain,with elevations ranging from 800 to 940 metres.The landscape consists of river floodplains,ancient riverbeds,and oasis margins,forming a remarkable ecological mosaic shaped by the Tarim River and its tributaries.The region experiences a typical temperate continental desert climate-dry,hot,and windy with scarce rainfall.展开更多
文摘The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve) and the extent of neural connections acquired through life(neural reserve) set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain's ability to adapt and reo rganize stru cturally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024).
文摘Located in southern Ningxia Hui Autonomous Region,northwest China,the Liupan Mountain National Nature Reserve covers a total area of 26,783.64 hectares.Established in 1982 and upgraded to national status in 1988,it protects a vital temperate mountainous forest ecosystem on the Loess Plateau.The reserve is centred around the Liupan Mountain range,one of China’s youngest mountain chains,formed by Himalayan tectonic movements.
文摘Background There is still limited data on predictive value of coronary computed tomography angiography(CCTA)–derived fractional flow reserve(CT-FFR) for long term outcomes. We examined the long-term prognostic value of CT-FFR combined with CCTA–defined atherosclerotic extent in diabetic patients with coronary artery disease(CAD).Methods A retrospective pooled analysis of individual patient data was performed. Deep-learning-based vessel-specific CTFFR was calculated. All patients enrolled were followed-up for at least 5 years. Predictive abilities for major adverse cardiac events(MACE) were compared among three models(model 1), constructed using clinical variables;model 2, model 1+CCTA–derived atherosclerotic extent(Leiden risk score);and model 3, model 2+CT-FFR.Results A total of 480 diabetic patients [median age, 61(55–66) years;52.9% men] were included. During a median follow-up time of 2197(2126–2355) days, 55 patients(11.5%) experienced MACE. In multivariate-adjusted Cox models, Leiden risk score(HR: 1.06;95% CI: 1.01–1.11;P = 0.013) and CT-FFR ≤ 0.80(HR: 6.54;95% CI: 3.18–13.45;P < 0.001) were the independent predictors. The discriminant ability was higher in model 2 than in model 1(C-index, 0.75 vs. 0.63;P < 0.001) and was further promoted by adding CT-FFR to model 3(C-index, 0.81 vs. 0.75;P = 0.002). Net reclassification improvement(NRI) was 0.19(P = 0.009) for model 2 beyond model 1. Of note, adding CT-FFR to model 3 also exhibited significantly improved reclassification compared with model 2(NRI = 0.14;P = 0.011).Conclusion In diabetic patients with CAD, CT-FFR provides robust and incremental prognostic information for predicting longterm outcomes. The combined model exhibits improved prediction abilities, which is beneficial for risk stratification.
文摘CHINA Wuliangshan National Nature Reserve Spanning a significant altitudinal range from 1,600 to 3,371 metres and encompassing a total area of 31,585 hectares,the Wuliangshan National Nature Reserve protects one of the most intact and pristine forest ecosystems in southern Yunnan Province.
文摘Elk are seen at the Tian’ezhou National Nature Reserve for Elk in Shishou,Hubei Province,on 27 November 2025.The reserve’s elk population has risen from just 64 in the 1990s to more than 4,500 today.
文摘CHINA.Dinghu Mountain National Nature Reserve.Located in Zhaoqing,Guangdong Province,Dinghu Mountain National Nature Reserve is a pristine natural sanctuary spanning 1,133 hectares within the low mountain ranges of the Dayunwu Mountains.
基金supported by the National Key Research and Development Program of China,China(2022YFE0209400).
文摘In a pivotal moment for global conservation policy,UNESCO’s Man and the Biosphere(MAB)Programme has endorsed the Hangzhou Strategic Action Plan(HSAP)2026–2035(UNESCO,2025),a decade-long roadmap that positions the World Network of Biosphere Reserves(WNBR)as central actors in delivering biodiversity,climate and sustainable-development goals(SDGs).The plan—developed and opened for global consultation in the runup to the 5th World Congress of Biosphere Reserves—articulates strategic directions,measurable action targets and practical instruments to strengthen biosphere reserves as living laboratories for people and nature(Ma,2025).
文摘The Qinghai-Xizang Plateau,known as the Roof of the World and the Water Tower of Asia,is recognized as the Earth’s Third Pole.It functions as a vital ecological security barrier and a strategic resource reserve for China,while also serving as an important conservation area that reflects the unique culture of the Chinese nation.Conducting the Second Comprehensive Scientific Expedition to the Qinghai-Xizang Plateau is essential for understanding valuable insights into scientific protection of the region.
基金supported by Shenzhen Industrial Application Projects of undertaking the National Key Research and Development Program of China under Grant No.CJGJZD20210408091600002the National Natural Science Foundation of China under Grant No.62102408Shenzhen Science and Technology Program under Grant No.RCBS20210609104609044.
文摘Load balancing is vital for the efficient and long-term operation of cloud data centers.With virtualization,post(reactive)migration of virtual machines(VMs)after allocation is the traditional way for load balancing and consolidation.However,it is not easy for reactive migration to obtain predefined load balance objectives and it may interrupt services and bring instability.Therefore,we provide a new approach,called Prepartition,for load balancing.It partitions a VM request into a few sub-requests sequentially with start time,end time and capacity demands,and treats each sub-request as a regular VM request.In this way,it can proactively set a bound for each VM request on each physical machine and makes the scheduler get ready before VM migration to obtain the predefined load balancing goal,which supports the resource allocation in a fine-grained manner.Simulations with real-world trace and synthetic data show that our proposed approach with offline version(PrepartitionOff)scheduling has 10%–20%better performance than the existing load balancing baselines under several metrics,including average utilization,imbalance degree,makespan and Capacity_makespan.We also extend Prepartition to online load balancing.Evaluation results show that our proposed approach also outperforms state-of-the-art online algorithms.
基金supported by the National Natural Science Foundation of China(No.71201047,No.71433003,No.71601069)the Humanities and Social Sciences Foundation of the Ministry of Education in China(No.12YJC630058)the Fundamental Research Funds for the Central Universities(No.2016B09314).
文摘Firms employing both offshore outsourcing and nearshore sourcing strategies may face supply disruption,demand uncertainty,and quality risks simultaneously.Sourcing decisions become inevitably important and complicated when both profit and the customer-service level are taken into consideration.In this paper,we model a scenario where a manufacturer who faces stochastic demand procures major modules from an overseas supplier and two local suppliers.The overseas supplier offers quality products while being susceptible to disruption risks;if the local suppliers,who are completely reliable and serve as a backup,offer products that are of inferior quality,it may result in lower market acceptance and a bad experience for the final customers.The manufacturer has to reserve capacity with backup suppliers before urgent orders are placed,when the primary source experiences a shortfall.We explicitly derive the manufacturer’s optimal order quantities and reservation quantities,which are functions of the heterogeneous suppliers’wholesale prices,reservation prices,and other parameters.The impacts of the fill-rate constraint and customer-experience quality constraint on the manufacturer’s purchasing decisions are investigated.Interesting managerial insights on the merits of backup sourcing with capacity reservations for managing demand uncertainties and supply disruption risks are also discussed.
基金supported by the Ministry of Science,Technology and Innovation of Argentina trough the project“Topografía,escurrimiento superficial y monitoreo de playas en el Partido de Villa Gesell,provincia de Buenos Aires”(Impact.AR N°106-RESOL-2022-224-APN-SACT#MCT)by the Nacional Council of Scientific and Technical Research(CONICET)through the project“Impactos de la reversión del nivel del mar en Buenos Aires,Argentina”(PIP 21/2311220200100041CO-RESOL-2021-1639-APN-DIR#CONICET)。
文摘Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world.However,a century ago,they were considered hazardous environments due to their great dynamic nature.As a result,stabilization practices were considered necessary.The systematic introduction of fast-growing exotic trees helped stabilize the sand,making it easier for tourism urbanization to take place,but also leading to erosion processes.This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina.This complex region includes urban resorts,afforestation zones,and protected areas.A GIS-based geospatial analysis was conducted using a large satellite database(>350 images),and the future evolution of the vegetation was modeled.The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover,accompanied by a concurrent reduction in sandy areas.In 1986,the dune area comprised 75%more surface than vegetation,whereas in 2021,it represented 60%less than vegetation.Furthermore,the 2050 scenario suggests a potential 40%reduction of dunes in certain areas.It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance.Long-term management strategies must focus on restoring native plant communities and controlling invasive species,and avoiding new dune fixation initiatives based on the introduction of exotic species.
文摘Percutaneous coronary intervention(PCI),as an essential treatment for coronary artery disease,has significantly improved the prognosis of patients with large coronary artery lesions.However,some patients continue to experience myocar-dial ischemic symptoms post-procedure,largely due to coronary microvascular dysfunction(CMD).The pathophysiological mechanisms of CMD are complex and involve endothelial dysfunction,microvascular remodeling,reperfusion in-jury,and metabolic abnormalities.Moreover,components of metabolic syndrome,including obesity,hyperglycemia,hypertension,and dyslipidemia,exacerbate the occurrence and progression of CMD through multiple pathways.This review systematically summarizes the latest research advan-cements in CMD after PCI,including its pathogenesis,diagnostic techniques,management strategies,and future research directions.For diagnosis,invasive techniques such as coronary flow reserve and the index of microcirculatory resistance,as well as non-invasive imaging modalities(positron emission tomography and cardiac magnetic reso-nance),provide tools for early CMD detection.In terms of management,a multi-level intervention strategy is emphasized,incorporating lifestyle modifications(diet,exercise,and weight control),pharmacotherapy(vasodilators,hypoglycemic agents,statins,and metabolic modulators),traditional Chinese medicine,and specialized treatments(enhanced external counterpulsation,metabolic surgery,and lipoprotein apheresis).However,challenges remain in CMD treatment,including limitations in diagnostic tools and the lack of personalized treatment strategies.Future research should focus on the complex interactions between CMD and metabolic risks,aiming to optimize diagnostic and therapeutic strate-gies to improve the long-term prognosis of patients post-PCI.
基金Under the National Key R&D Program Key Project(No.2021YFC3201201)National Natural Science Foundation of China(No.52360032)+2 种基金Basic Scientific Research Business Fee Project of Colleges And Universities Directly Under the Inner Mongolia Autonomous Region(No.JBYYWF2022001)Development Plan of Innovation Team of Colleges And Universities in Inner Mongolia Autonomous Region(No.NMGIRT2313)the Innovation Team of‘Grassland Talents’。
文摘Clarifying the mechanisms through which coal mining affects groundwater storage(GWS)variations is crucial for water resource conservation and sustainable development.The Ordos Mining Region in China,a key energy base in China with significant strategic importance,has undergone intensive coal mining activities that have substantially disrupted regional groundwater circulation.This study integrated data from the Gravity Recovery and Climate Experiment Satellite(GRACE)and Famine Early Warning Systems Network(FEWS NET)Land Data Assimilation System(FLDAS)models,combined with weighted downscaling methodology and water balance principles,to reconstruct high-resolution(0.01°)terrestrial water storage(TWS)and GWS changes in the Ordos Mining Region,China from April 2002 to December 2021.The accuracy of GWS variations were validated through pumping test measurements.Subsequently,Geodetector analysis was implemented to quantify the contributions of natural and anthropogenic factors to groundwater storage dynamics.Key findings include:1)TWS in the study area showed a fluctuating but overall decreasing trend,with a total reduction of 8901.11 mm during study period.The most significant annual decrease occurred in 2021,reaching 1696.77 mm.2)GWS exhibited an accelerated decline,with an average annual change rate of 44.35 mm/yr,totaling a decrease of 887.05 mm.The lowest annual groundwater storage level was recorded in 2020,reaching 185.69 mm.3)Precipitation(PRE)contributed the most to GWS variation(q=0.52),followed by coal mining water consumption(MWS)(q=0.41).The interaction between PRE and MWS exhibited a nonlinear enhancement effect on GWS changes(0.54).The synergistic effect of natural hydrological factors has a great influence on the change of GWS,but coal mining water consumption will continue to reduce GWS.These findings provide critical references for the management and regulation of groundwater resource in mining regions.
文摘Objective To evaluate the association of GGN repeat polymorphism of androgen receptor(AR)with ovarian reserve and ovarian response in controlled ovarian stimulation(COS).Methods This genetic association study was conducted among a total of 361 women aged≤40 years with basal FSH≤12 U/L undergoing the GnRH-agonist long protocol for COS in a university affiliated IVF center.GGN repeat in the AR gene was analyzed with Sanger sequencing.The primary endpoint was the number of antral follicle counts(AFCs),and the secondary endpoints were stimulation days,total dose of gonadotropin(Gn)used,total number of retrieved oocytes,ovarian sensitivity index,and follicular output rate.Results The GGN repeat in exon 1 of the AR gene ranged from 13 to 24,and the median repeat length was 22.Based on the genotypes(S for GGN repeats<22,L for GGN repeats≥22),the patients were divided into 3 groups:SS,SL,and LL.Generalized regression analysis indicated that the number of AFCs in group SS was significantly lower than those in group SL(adjusted β=1.8,95%CI:0.2-3.4,P=0.024)and group LL(adjusted β=1.5,95%CI:0.2-2.7,P=0.021).No significant difference was observed in the number of AFCs between group SL and group LL(P>0.05).Generalized regression analysis indicated no significant differences in ovarian stimulation parameters among the 3 groups,either before or after adjusting for confounding factors(P>0.05).Conclusion GGN repeat length on the AR gene is associated with AFC but not with ovarian response in Chinese women,indicating that AR gene polymorphisms may affect ovarian reserve.
文摘CHINA Gaoligongshan National Natural Reserve Rising to over 4,000 metres above sea level in western Yunnan Province,Gaoligong Mountain forms part of the southern Hengduan Mountain Range and is renowned for its rich biodiversity and vibrant cultural landscape.Encompassing a vast protected area across the Tengchong and Baoshan regions,the Gaoligongshan National Natural Reserve is a secluded ecological treasure trove.In April 2000,the reserve joined the UNESCO World Network of Biosphere Reserves.
文摘The pioneering work of China’s Zhejiang Province in biosphere preservation and restoration,as well as its green development of residential areas around its nature reserves,made it the ideal location to host the 5th World Congress of Biosphere Reserves and share China’s achievements in this field with the world.
文摘Established in 1958,Xishuangbanna National Nature Reserve is one of China’s first protected areas.Covering about 2,435 square km,it is the country’s largest tropical primeval forest and one of the world’s most biologically diverse regions.In 1993,it became part of the UNESCO World Biosphere Reserve Network,reflecting its global ecological significance.
文摘Background Non-invasive computed tomography angiography(CTA)-based fractional flow reserve(CT-FFR)could become a gatekeeper to invasive coronary angiography.Deep learning(DL)-based CT-FFR has shown promise when compared to invasive FFR.To evaluate the performance of a DL-based CT-FFR technique,DeepVessel FFR(DVFFR).Methods This retrospective study was designed for iScheMia Assessment based on a Retrospective,single-center Trial of CTFFR(SMART).Patients suspected of stable coronary artery disease(CAD)and undergoing both CTA and invasive FFR examinations were consecutively selected from the Beijing Anzhen Hospital between January 1,2016 to December 30,2018.FFR obtained during invasive coronary angiography was used as the reference standard.DVFFR was calculated blindly using a DL-based CTFFR approach that utilized the complete tree structure of the coronary arteries.Results Three hundred and thirty nine patients(60.5±10.0 years and 209 men)and 414 vessels with direct invasive FFR were included in the analysis.At per-vessel level,sensitivity,specificity,accuracy,positive predictive value(PPV)and negative predictive value(NPV)of DVFFR were 94.7%,88.6%,90.8%,82.7%,and 96.7%,respectively.The area under the receiver operating characteristics curve(AUC)was 0.95 for DVFFR and 0.56 for CTA-based assessment with a significant difference(P<0.0001).At patient level,sensitivity,specificity,accuracy,PPV and NPV of DVFFR were 93.8%,88.0%,90.3%,83.0%,and 95.8%,respectively.The computation for DVFFR was fast with the average time of 22.5±1.9 s.Conclusions The results demonstrate that DVFFR was able to evaluate lesion hemodynamic significance accurately and effectively with improved diagnostic performance over CTA alone.Coronary artery disease(CAD)is a critical disease in which coronary artery luminal narrowing may result in myocardial ischemia.Early and effective assessment of myocardial ischemia is essential for optimal treatment planning so as to improve the quality of life and reduce medical costs.
基金supported by the National Natural Science Foundation of China(42225604,31500456,31430080)the 2023 Strategic Consultation Project of the Chinese National Committee for Man and the Biosphere,the National Key Programme of Research and Development of Ministry of Science and Technology of China(2022YFF1301603)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA23040403).
文摘The Yangtze finless porpoise(Neophocaena asiaeorientalis asiaeorientalis)is distributed in the main stream of the middle and lower reaches of the Yangtze River,as well as in Dongting and Poyang lakes.Currently,the most crucial conservation approach involves the establishment and management of both in-situ and ex-situ nature reserves.Since the 1990s,seven nature reserves have been established in the middle and lower reaches of the Yangtze River,covering nearly one-third of its main stream.Additionally,two nature reserves,one in the Dongting Lake and another in the Poyang Lake,have been set up;and three ex-situ nature reserves have been established in three oxbows respectively in Hunan,Hubei,and Anhui provinces.Through measures such as improving the ecological environment quality within the reserves,regulating human activities,and conducting continuous monitoring,the finless porpoise population showed a slight increase in 2022 for the first time.The ex-situ population has continued to grow,with four individuals being released back into the main stream of the Yangtze River after undergoing reintroduction training in 2023.Based on the population development lasting for over three decades,and predictions of future ecological changes,orderly establishment and scientific management of nature reserves have played a key role in and will remain an important basis for the sustaining growth of the finless porpoise population.
文摘CHINA Tarim Populus Euphratica National Nature Reserve Located along the northern edge of the Taklimakan Desert in Xinjiang,the Tarim Populus Euphratica National Nature Reserve lies in the middle reaches of the Tarim River-the longest inland river in China-within Bayingolin Mongol Autonomous Prefecture.Established in 1983 and upgraded to a national reserve in 2006,it covers an area of about 395,420 hectares,including a core,bu!er,and experimental zone.The reserve features alluvial plains and desert terrain,with elevations ranging from 800 to 940 metres.The landscape consists of river floodplains,ancient riverbeds,and oasis margins,forming a remarkable ecological mosaic shaped by the Tarim River and its tributaries.The region experiences a typical temperate continental desert climate-dry,hot,and windy with scarce rainfall.
