“新威洋”轮第36航次,空载(船舶吃水7.40m/11.40m),接到明确的航次指令后,驶往巴西ANGRA DOS REIS港办理进港手续。港口锚地相关情况ANGRA DOS REIS港是巴西东南部里约热内卢州的一个重要港口,位于大西洋沿岸,里约热内卢西南约80海里,...“新威洋”轮第36航次,空载(船舶吃水7.40m/11.40m),接到明确的航次指令后,驶往巴西ANGRA DOS REIS港办理进港手续。港口锚地相关情况ANGRA DOS REIS港是巴西东南部里约热内卢州的一个重要港口,位于大西洋沿岸,里约热内卢西南约80海里,是巴西能源产业的重要支点。展开更多
突破以Campaign为中心的局限,超越传统代理商的传播视野,这才是创意无极限的真正内涵。作为电通安吉斯集团巴西CEO兼Isobar拉丁美洲CEO,Abel R e i s一直相信科技革命会刺激文化、经济和精神,并改变后者。＂每天,盘点一下那些过时之物...突破以Campaign为中心的局限,超越传统代理商的传播视野,这才是创意无极限的真正内涵。作为电通安吉斯集团巴西CEO兼Isobar拉丁美洲CEO,Abel R e i s一直相信科技革命会刺激文化、经济和精神,并改变后者。＂每天,盘点一下那些过时之物会促使我更好向前,审视熟知的事物,淘汰旧有的才能获取新知。＂正是秉持着这种信念,他一步步走上职业生涯的制高点：从一家公司的副总裁到巴西第一家创新型数字代理公司的创始人,展开更多
Over the last decades,huge amounts of ash residues have been generated worldwide leading to increasing demand for viable recycling technologies.Magnetic separation is considered a promising option for sustainable mana...Over the last decades,huge amounts of ash residues have been generated worldwide leading to increasing demand for viable recycling technologies.Magnetic separation is considered a promising option for sustainable management of these wastes.The present paper aims to review the recent advances in magnetic separation of ash residues to convert these waste materials into valuable commodities,minimizing negative environmental impact and in compliance with the circular economy requirements.Emphasis is placed on single magnetic separation techniques,multi-step separation procedures,and implementation of the magnetic separation in more complex separation schemes(in combination with particle-size fractionation,flotation,electrostatic separation,density(sink-float)separation,etc.)Novel and special approaches are mentioned as well(using organic solvents,selective magnetic coating,separation supported by thermal treatment or chlorination,methods for removal of non-magnetic components,magnetic separation applied on solubilized/precipitated compounds etc.).It discusses the latest literature results on the magnetospheres’morphology,chemical and mineral composition,and elemental leachability.Particular attention is paid to the utilization perspectives of the magnetic fractions and the non-magnetic residues.Based on the existing research status,the paper also provides concluding remarks highlighting the most promising trends.Current limitations indicating suggestions for future research(including insights on how existing approaches could be further improved)are mentioned as well.展开更多
Background:Despite the efficacy of absolute ethanol(EtOH),its radiolucency introduces several risks in interventional therapy for treating vascular malformations.This study aims to develop a novel radiopaque ethanol i...Background:Despite the efficacy of absolute ethanol(EtOH),its radiolucency introduces several risks in interventional therapy for treating vascular malformations.This study aims to develop a novel radiopaque ethanol injection(REI)to address this issue.Methods:Iopromide is mixed with ethanol to achieve radiopacity and improve the physicochemical properties of the solution.Overall,82 male New Zealand white rabbits are selected for in vivo radiopacity testing,peripheral vein sclerosis[animals were divided into the following 5 groups(n=6):negative control(NC,saline,0.250 ml/kg),positive control(EtOH,0.250 ml/kg),low-dose REI(L-D REI,0.125 ml/kg),moderate-dose REI(M-D REI,0.250 ml/kg),and highdose REI(H-D REI 0.375 ml/kg)],pharmacokinetic analyses(the blood sample was harvested before injection,5 min,10 min,20 min,40 min,1 h,2 h,4 h,and 8 h after injection in peripheral vein sclerosis experiment),peripheral artery embolization[animals were divided into the following 5 groups(n=3):NC(saline,0.250 ml/kg),positive control(EtOH,0.250 ml/kg),L-D REI(0.125 ml/kg),M-D REI(0.250 ml/kg),and H-D REI(0.375 ml/kg)],kidney transcatheter arterial embolization[animals were divided into the following 4 groups(n=3):positive control(EtOH,0.250 ml/kg),L-D REI(0.125 ml/kg),M-D REI(0.250 ml/kg),and H-D REI(0.375 ml/kg);each healthy kidney was injected with saline as negative control],and biosafety evaluations[animals were divided into the following 5 groups(n=3):NC(0.250 ml/kg),high-dose EtOH(0.375 ml/kg),L-D REI(0.125 ml/kg),M-D REI(0.250 ml/kg),and H-D REI(0.375 ml/kg)].Then,a prospective cohort study involving 6 patients with peripheral venous malformations(VMs)is performed to explore the clinical safety and effectiveness of REI.From Jun 1,2023 to August 31,2023,6 patients[age:(33.3±17.2)years]with lingual VMs received sclerotherapy of REI and 2-month follow-up.Adverse events and serious adverse events were evaluated,whereas the efficacy of REI was determined by both the traceability of the REI under DSA throughout the entire injection and the therapeutic effect 2 months after a single injection.Results:The REI contains 81.4%ethanol(v/v)and 111.3 mg/ml iodine,which can be traced throughout the injection in the animals and patients.The REI also exerts a similar effect as EtOH on peripheral venous sclerosis,peripheral arterial embolization,and renal embolization.Furthermore,the REI can be metabolized at a similar rate compared to EtOH and Ultravist^(®)and did not cause injury to the animals’heart,liver,spleen,lungs,kidneys and brain.No REIrelated adverse effects have occurred during sclerotherapy of VMs,and 4/6 patients(66.7%)have achieved complete response at follow-up.Conclusion:In conclusion,REI is safe,exerts therapeutic effects,and compensates for the radiolucency of EtOH in treating VMs.Trial registration:The clinical trial was registered as No.ChiCTR2300071751 on May 242023.展开更多
文摘突破以Campaign为中心的局限,超越传统代理商的传播视野,这才是创意无极限的真正内涵。作为电通安吉斯集团巴西CEO兼Isobar拉丁美洲CEO,Abel R e i s一直相信科技革命会刺激文化、经济和精神,并改变后者。＂每天,盘点一下那些过时之物会促使我更好向前,审视熟知的事物,淘汰旧有的才能获取新知。＂正是秉持着这种信念,他一步步走上职业生涯的制高点：从一家公司的副总裁到巴西第一家创新型数字代理公司的创始人,
基金the financial support of the European Union under the REFRESH-Research Excellence for Region Sustainability and High-tech Industries project number CZ.10.03.01/00/22_003/0000048 via the Operational Programme Just Transition and SGS projects 2022/68 and 2023/034.
文摘Over the last decades,huge amounts of ash residues have been generated worldwide leading to increasing demand for viable recycling technologies.Magnetic separation is considered a promising option for sustainable management of these wastes.The present paper aims to review the recent advances in magnetic separation of ash residues to convert these waste materials into valuable commodities,minimizing negative environmental impact and in compliance with the circular economy requirements.Emphasis is placed on single magnetic separation techniques,multi-step separation procedures,and implementation of the magnetic separation in more complex separation schemes(in combination with particle-size fractionation,flotation,electrostatic separation,density(sink-float)separation,etc.)Novel and special approaches are mentioned as well(using organic solvents,selective magnetic coating,separation supported by thermal treatment or chlorination,methods for removal of non-magnetic components,magnetic separation applied on solubilized/precipitated compounds etc.).It discusses the latest literature results on the magnetospheres’morphology,chemical and mineral composition,and elemental leachability.Particular attention is paid to the utilization perspectives of the magnetic fractions and the non-magnetic residues.Based on the existing research status,the paper also provides concluding remarks highlighting the most promising trends.Current limitations indicating suggestions for future research(including insights on how existing approaches could be further improved)are mentioned as well.
基金supported by the Transverse Research Project of Shanghai Ninth People’s Hospital(JYHX2022007)the Clinical Research Program of Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(JYLJ202111).
文摘Background:Despite the efficacy of absolute ethanol(EtOH),its radiolucency introduces several risks in interventional therapy for treating vascular malformations.This study aims to develop a novel radiopaque ethanol injection(REI)to address this issue.Methods:Iopromide is mixed with ethanol to achieve radiopacity and improve the physicochemical properties of the solution.Overall,82 male New Zealand white rabbits are selected for in vivo radiopacity testing,peripheral vein sclerosis[animals were divided into the following 5 groups(n=6):negative control(NC,saline,0.250 ml/kg),positive control(EtOH,0.250 ml/kg),low-dose REI(L-D REI,0.125 ml/kg),moderate-dose REI(M-D REI,0.250 ml/kg),and highdose REI(H-D REI 0.375 ml/kg)],pharmacokinetic analyses(the blood sample was harvested before injection,5 min,10 min,20 min,40 min,1 h,2 h,4 h,and 8 h after injection in peripheral vein sclerosis experiment),peripheral artery embolization[animals were divided into the following 5 groups(n=3):NC(saline,0.250 ml/kg),positive control(EtOH,0.250 ml/kg),L-D REI(0.125 ml/kg),M-D REI(0.250 ml/kg),and H-D REI(0.375 ml/kg)],kidney transcatheter arterial embolization[animals were divided into the following 4 groups(n=3):positive control(EtOH,0.250 ml/kg),L-D REI(0.125 ml/kg),M-D REI(0.250 ml/kg),and H-D REI(0.375 ml/kg);each healthy kidney was injected with saline as negative control],and biosafety evaluations[animals were divided into the following 5 groups(n=3):NC(0.250 ml/kg),high-dose EtOH(0.375 ml/kg),L-D REI(0.125 ml/kg),M-D REI(0.250 ml/kg),and H-D REI(0.375 ml/kg)].Then,a prospective cohort study involving 6 patients with peripheral venous malformations(VMs)is performed to explore the clinical safety and effectiveness of REI.From Jun 1,2023 to August 31,2023,6 patients[age:(33.3±17.2)years]with lingual VMs received sclerotherapy of REI and 2-month follow-up.Adverse events and serious adverse events were evaluated,whereas the efficacy of REI was determined by both the traceability of the REI under DSA throughout the entire injection and the therapeutic effect 2 months after a single injection.Results:The REI contains 81.4%ethanol(v/v)and 111.3 mg/ml iodine,which can be traced throughout the injection in the animals and patients.The REI also exerts a similar effect as EtOH on peripheral venous sclerosis,peripheral arterial embolization,and renal embolization.Furthermore,the REI can be metabolized at a similar rate compared to EtOH and Ultravist^(®)and did not cause injury to the animals’heart,liver,spleen,lungs,kidneys and brain.No REIrelated adverse effects have occurred during sclerotherapy of VMs,and 4/6 patients(66.7%)have achieved complete response at follow-up.Conclusion:In conclusion,REI is safe,exerts therapeutic effects,and compensates for the radiolucency of EtOH in treating VMs.Trial registration:The clinical trial was registered as No.ChiCTR2300071751 on May 242023.
