为提高风电的接纳能力,减少碳排放,提出了风电与蓄热电采暖REH(regenerative electric heating)的联合运行模式。首先,以系统总煤耗最小为目标,以风电出力、火电出力以及REH的功率为决策变量,建立了发电侧与REH侧的联合优化模型。以优...为提高风电的接纳能力,减少碳排放,提出了风电与蓄热电采暖REH(regenerative electric heating)的联合运行模式。首先,以系统总煤耗最小为目标,以风电出力、火电出力以及REH的功率为决策变量,建立了发电侧与REH侧的联合优化模型。以优化结果为基础,对风电侧、系统侧、需求侧和环境侧的效益变化进行了量化分析。最后从技术、经济和环境的角度构建了该联合模式的评价指标体系,以综合评估其效果与意义。算例分析表明,REH的应用促进了风电的接纳,降低了系统煤耗率,并且增加了综合效益。展开更多
Objective:To explore the mechanism of drug resistance in acute lymphoblastic leukemia and the anti-tumor effect of combination therapy of dehydroabietic acid and vincristine against acute lymphoblastic leukemia cells....Objective:To explore the mechanism of drug resistance in acute lymphoblastic leukemia and the anti-tumor effect of combination therapy of dehydroabietic acid and vincristine against acute lymphoblastic leukemia cells.Methods:Acute lymphoblastic leukemia cells REH and CCRFCEM were employed to detect the anti-tumor effect of vincristine and doxorubicin on proliferation and apoptosis using EdU assay,human active caspase-3 Quantikine ELISA kit,and flow cytometry.Vincristine-resistant REH cells(REH-R),survivin knockdown and overexpressing REH cells were established to verify the role of survivin in drug resistance.Additionally,in vitro and in vivo assays were performed to determine the effect of dehydroabietic acid on the cytotoxicity of vincristine.Results:Vincristine and doxorubicin markedly suppressed proliferation and induced apoptosis of REH and CCRF-CEM cells.Survivin expression was upregulated in REH-R cells compared with REH cells.Knockdown of survivin expression obviously restored the sensitivity of REH-R cells to vincristine.Akt phosphorylation was also increased in REH-R cells compared to REH cells.In addition,LY294002,a PI3k/Akt pathway blocker,inhibited survivin expression and enhanced cytotoxicity of vincristine to REH-R cells.Dehydroabietic acid effectively reduced survivin expression in REH-R cells,thereby enhancing the therapeutic effect of vincristine on drug-resistant cells.Survivin overexpression markedly reduced the effect of dehydroabietic acid on enhancing the anti-proliferation and inducing apoptosis effect of vincristine.Moreover,the combination of dehydroabietic acid with vincristine significantly extended the survival rate in a mouse xenograft model of acute lymphoblastic leukemia,compared with vincristine treatment alone.Conclusions:Dehydroabietic acid may be used as a potential candidate for the treatment of acute lymphoblastic leukemia in combination with vincristine.展开更多
This study questions the importance of public debt in stable growth between 1980 and 2018,specifically,the Ricardian equivalence hypothesis and Keynesian view are questioned.This study used data obtained from the Nort...This study questions the importance of public debt in stable growth between 1980 and 2018,specifically,the Ricardian equivalence hypothesis and Keynesian view are questioned.This study used data obtained from the Northern Cyprus State Planning Office.A restricted vector autoregressive model is used to test the causal relationships between this model and public debt,government expenditure,total capital,consumption,investment,employment,net exports,exchange rate,and gross domestic product growth rate.To ensure financial stability,the variables that trigger economic growth through increased interactions were evaluated.Accordingly,unlike other studies,the Wald test results reveal that public debt does not have a direct effect on the gross national product but indirectly affects total capital,consumption,investment,and public expenditure,all of which influence real gross domestic product(RGDP).It has been observed that employment affects RGDP,consumption,government spending,and investment.There is also bidirectional causality between consumption,government spending,and RGDP.The estimates of the Ricardian equivalent hypothesis are important.However,today’s changing economic policies,declining real incomes,and consumer behavior in the face of ever-increasing inflation require that the theory be redesigned.Therefore,contrary to theoretical predictions,consumers are concerned about maintaining their standard of living rather than directing tax deductions to savings.Contrary to the claims of Keynesian researchers,no causal relationship is observed between public debt and growth in this study.However,public debt directly affects total capital,consumption,government spending,and investment,which are important for sustainable economic policy.展开更多
综合能源系统为多能源互补利用提供有效载体,而楼宇级的综合能源系统由于容易受到外界环境以及用户用能规律的影响,存在着大量的不确定性因素。基于一个由冷热电联产系统、储热装置以及插电式混合动力汽车等组成的居民能源集线器(reside...综合能源系统为多能源互补利用提供有效载体,而楼宇级的综合能源系统由于容易受到外界环境以及用户用能规律的影响,存在着大量的不确定性因素。基于一个由冷热电联产系统、储热装置以及插电式混合动力汽车等组成的居民能源集线器(residential energy hub,REH),研究了在不确定性因素下楼宇级综合能源系统经济运行问题。建立了基于机会约束规划的REH经济调度模型,该模型以最小运行成本为目标,冷热电联产系统备用出力以及备用市场购电为机会约束,在python环境中进行建模,利用Gurobipy求解器进行求解。讨论了关于插电式混合动力汽车运行状态的几种典型场景、不同置信水平下REH调度方案及运行成本,以期为平衡经济性和可靠性的REH运行调度提供参考。展开更多
9上颌骨切除游离皮瓣修复重建术后的气道治疗
Airway management after maxillectomy with free flap reconstruction. Brickman DS, Reh DD, Schneider DS, et al. Head Neck, 2012 Aug 21. [Epub ahead of print]
文摘为提高风电的接纳能力,减少碳排放,提出了风电与蓄热电采暖REH(regenerative electric heating)的联合运行模式。首先,以系统总煤耗最小为目标,以风电出力、火电出力以及REH的功率为决策变量,建立了发电侧与REH侧的联合优化模型。以优化结果为基础,对风电侧、系统侧、需求侧和环境侧的效益变化进行了量化分析。最后从技术、经济和环境的角度构建了该联合模式的评价指标体系,以综合评估其效果与意义。算例分析表明,REH的应用促进了风电的接纳,降低了系统煤耗率,并且增加了综合效益。
基金supported by Suzhou Science and Technology Development Plan (SKJYD2021047)the Fundation of Suzhou Kowloon Hospital (SZJL202111 and SZJL202104)
文摘Objective:To explore the mechanism of drug resistance in acute lymphoblastic leukemia and the anti-tumor effect of combination therapy of dehydroabietic acid and vincristine against acute lymphoblastic leukemia cells.Methods:Acute lymphoblastic leukemia cells REH and CCRFCEM were employed to detect the anti-tumor effect of vincristine and doxorubicin on proliferation and apoptosis using EdU assay,human active caspase-3 Quantikine ELISA kit,and flow cytometry.Vincristine-resistant REH cells(REH-R),survivin knockdown and overexpressing REH cells were established to verify the role of survivin in drug resistance.Additionally,in vitro and in vivo assays were performed to determine the effect of dehydroabietic acid on the cytotoxicity of vincristine.Results:Vincristine and doxorubicin markedly suppressed proliferation and induced apoptosis of REH and CCRF-CEM cells.Survivin expression was upregulated in REH-R cells compared with REH cells.Knockdown of survivin expression obviously restored the sensitivity of REH-R cells to vincristine.Akt phosphorylation was also increased in REH-R cells compared to REH cells.In addition,LY294002,a PI3k/Akt pathway blocker,inhibited survivin expression and enhanced cytotoxicity of vincristine to REH-R cells.Dehydroabietic acid effectively reduced survivin expression in REH-R cells,thereby enhancing the therapeutic effect of vincristine on drug-resistant cells.Survivin overexpression markedly reduced the effect of dehydroabietic acid on enhancing the anti-proliferation and inducing apoptosis effect of vincristine.Moreover,the combination of dehydroabietic acid with vincristine significantly extended the survival rate in a mouse xenograft model of acute lymphoblastic leukemia,compared with vincristine treatment alone.Conclusions:Dehydroabietic acid may be used as a potential candidate for the treatment of acute lymphoblastic leukemia in combination with vincristine.
文摘This study questions the importance of public debt in stable growth between 1980 and 2018,specifically,the Ricardian equivalence hypothesis and Keynesian view are questioned.This study used data obtained from the Northern Cyprus State Planning Office.A restricted vector autoregressive model is used to test the causal relationships between this model and public debt,government expenditure,total capital,consumption,investment,employment,net exports,exchange rate,and gross domestic product growth rate.To ensure financial stability,the variables that trigger economic growth through increased interactions were evaluated.Accordingly,unlike other studies,the Wald test results reveal that public debt does not have a direct effect on the gross national product but indirectly affects total capital,consumption,investment,and public expenditure,all of which influence real gross domestic product(RGDP).It has been observed that employment affects RGDP,consumption,government spending,and investment.There is also bidirectional causality between consumption,government spending,and RGDP.The estimates of the Ricardian equivalent hypothesis are important.However,today’s changing economic policies,declining real incomes,and consumer behavior in the face of ever-increasing inflation require that the theory be redesigned.Therefore,contrary to theoretical predictions,consumers are concerned about maintaining their standard of living rather than directing tax deductions to savings.Contrary to the claims of Keynesian researchers,no causal relationship is observed between public debt and growth in this study.However,public debt directly affects total capital,consumption,government spending,and investment,which are important for sustainable economic policy.
文摘综合能源系统为多能源互补利用提供有效载体,而楼宇级的综合能源系统由于容易受到外界环境以及用户用能规律的影响,存在着大量的不确定性因素。基于一个由冷热电联产系统、储热装置以及插电式混合动力汽车等组成的居民能源集线器(residential energy hub,REH),研究了在不确定性因素下楼宇级综合能源系统经济运行问题。建立了基于机会约束规划的REH经济调度模型,该模型以最小运行成本为目标,冷热电联产系统备用出力以及备用市场购电为机会约束,在python环境中进行建模,利用Gurobipy求解器进行求解。讨论了关于插电式混合动力汽车运行状态的几种典型场景、不同置信水平下REH调度方案及运行成本,以期为平衡经济性和可靠性的REH运行调度提供参考。
文摘9上颌骨切除游离皮瓣修复重建术后的气道治疗
Airway management after maxillectomy with free flap reconstruction. Brickman DS, Reh DD, Schneider DS, et al. Head Neck, 2012 Aug 21. [Epub ahead of print]
