With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challe...With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challenge of improving the frequency regulation performance of a thermal-storage primary frequency regulation system while reducing its associated losses,this paper proposes a multi-dimensional cooperative optimization strategy for the control parameters of a combined thermal-storage system,considering regulation losses.First,the frequency regulation losses of various components within the thermal power unit are quantified,and a calculation method for energy storage regulation loss is proposed,based on Depth of Discharge(DOD)and C-rate.Second,a thermal-storage cooperative control method based on series compensation is developed to improve the system’s frequency regulation performance.Third,targeting system regulation loss cost and regulation output,and considering constraints on output overshoot and system parameters,an improved Particle Swarm Optimization(PSO)algorithm is employed to tune the parameters of the low-pass filter and the series compensator,thereby reducing regulation losses while enhancing performance.Finally,simulation results demonstrate that the total loss cost of the proposed control strategy is comparable to that of a system with only thermal power participation.However,the thermal power loss cost is reduced by 42.16%compared to the thermal-only case,while simultaneously improving system frequency stability.Thus,the proposed strategy effectively balances system frequency stability and economic efficiency.展开更多
Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathologica...Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.展开更多
Ischemic stroke therapy has long been dominated by strategies aimed at restoring cerebral blood flow. Yet, accumulating evidence suggests that neuronal survival and functional recovery depend not only on reperfusion, ...Ischemic stroke therapy has long been dominated by strategies aimed at restoring cerebral blood flow. Yet, accumulating evidence suggests that neuronal survival and functional recovery depend not only on reperfusion, but also on the resolution of postischemic immune dysregulation. This study(Chen et al., Prog Biochem Biophys, 2026, 53(3): 697-710. DOI:10.3724/j.pibb.2025.0541) a dvances this emerging paradigm by proposing a therapeutic strategy that integrates lesion-specific delivery with active modulation of the inflammatory microenvironment.展开更多
Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2...Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2)O(1)was synthesized as a 2D structure using Coas the metal source,methanol‑water(4∶6,V/V)as the solvent,and specific concentrations of 2,5‑furandicarboxylic acid(H_(2)FDCA)and 1,3,5‑triimidazole benzene(L).Adjusting to pure water and lowering the concentration of L yielded the 1D chain structure of[Co(HL)2(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(2).Using Cu(Ⅱ)as the metal source,methanol/water(9∶1,V/V)as the solvent,and specific concentrations of L and H2FDCA,the 1D chain structure of[Cu(L)(FDCA)(H_(2)O)]·2H_(2)O(3)was synthesized.Upon increasing the concentrations of L and H2FDCA,and switching the solvent to pure water,the 1D chain structure of[Cu(HL)_(2)(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(4)was obtained.This shows that changing the solvent and ligand concentrations can affect the structural changes of CPs.In addition,the solid‑state photoluminescence of CPs 1‑4 at room temperature was studied,and their morphological changes were observed via scanning electron microscopy.Density functional theory calculations revealed that the negative charge concentrates on the O and N atoms of the ligand,facilitating ligand‑metal ion coordination.CCDC:2403934,1;2403935,2;2403936,3;2403938,4.展开更多
Objectives:Glioblastoma multiforme(GBM)is a highly aggressive brain tumor characterized by extensive transcriptional and epigenetic dysregulation.Brother of the Regulator of Imprinted Sites(BORIS/CTCFL)has been implic...Objectives:Glioblastoma multiforme(GBM)is a highly aggressive brain tumor characterized by extensive transcriptional and epigenetic dysregulation.Brother of the Regulator of Imprinted Sites(BORIS/CTCFL)has been implicated in oncogenic transcriptional programs in several cancers,but its role in GBM remains poorly defined.This study aimed to characterize BORIS-associated transcriptional programs in GBM and to assess their functional relevance using integrative computational and experimental approaches.Methods:Transcriptomic data from The Cancer Genome Atlas(TCGA)-GBM and Genotype-Tissue Expression(GTex)brain cortex were analyzed following batch correction,differential expression analysis,and gene ontology enrichment.TCGA-GBM samples were stratified into BORIS-high and BORIS-low expression quartiles to identify BORIS-associated gene signatures.BORIS chromatin occupancy was examined by Chromatin immunoprecipitation combined with sequencing(ChIP-seq)in U87MG cells,followed by functional annotation of BORIS-bound genes.Experimental validation included BORIS overexpression,RT-qPCR,immunoblotting,ChIP-qPCR,and functional assays assessing proliferation,clonogenic survival,and migration.Results:BORIS was significantly upregulated in GBM compared with normal brain tissue and was associated with transcriptional programs related to development,metabolism,and cell signaling.Quartilebased analysis identified BORIS-associated differentially expressed genes,including CD36 and FBN2.ChIP-seq revealed BORIS binding at promoter-proximal regions,with ChIP-qPCR confirming occupancy at CD36 and FBN2 regulatory regions.BORIS overexpression increased CD36 and FBN2 expression and was associated with reduced proliferation,enhanced clonogenic survival,and increased migratory capacity.Conclusion:These findings indicate that BORIS is associated with transcriptional and phenotypic programs linked to GBM aggressiveness and may represent a candidate for further investigation as a biomarker or therapeutic target in GBM.展开更多
Nanofiltration(NF) technology,with its capacity for nanoscale filtration and controllable selectivity,holds significant promise in diverse applications.However,the current upper bound of permeance and selectivity of N...Nanofiltration(NF) technology,with its capacity for nanoscale filtration and controllable selectivity,holds significant promise in diverse applications.However,the current upper bound of permeance and selectivity of NF membranes is intrinsically constrained by the morphology and structure of the polyamide(PA) selective layer.This issue arises because NF membranes typically exhibit relatively smooth nodular structures,which theoretically impede efficient water transport.In this study,we enhanced the formation of nanobubbles by synergistically regulating with surfactant and low temperatures,resulting in the fabrication of PA NF membranes with a crumpled morphology.We observed that lower temperatures promote enhanced gas solubility in the aqueous phase,facilitating increased nanobubble formation through the foaming effect of surfactant sodium dodecylbenzene sulfonate(SDBS).Consequently,this resulted in the creation of PA NF membranes with more crumpled structures and superior performance,with pure water permeance reaching 36.25 ± 0.42 L m^(-2)h^(-1)bar^(-1),representing an improvement of 14.47 L m^(-2)h^(-1)bar^(-1)compared to the control group.Additionally,it maintains a high Na_(2)SO_(4) rejection rate of97.00 % ± 0.58 %.The PA NF membranes produced by eliminating nanobubbles and free interfaces exhibited a smooth structure,whereas introducing nanobubbles(through Na HCO_(3) addition,N_(2) pressurization,and ultrasonication) resulted in the formation of crumpled membranes.This emphasized that the large amount of nanobubbles generated by SDBS and low temperature in the interfacial process played a critical role in shaping crumpled PA NF membranes and enhancing membrane performance.This approach has the potential to provide valuable insights into customizing the structural design of TFC PA NF membranes,contributing to further advancements in this field.展开更多
Eukaryotic mRNAs are polyadenylated at their 3’-ends,and the poly(A)tails play critical roles in post-transcriptional gene regulation by influencing mRNA stability and translation.Here,we describe the biological proc...Eukaryotic mRNAs are polyadenylated at their 3’-ends,and the poly(A)tails play critical roles in post-transcriptional gene regulation by influencing mRNA stability and translation.Here,we describe the biological processes and major protein factors that control poly(A)tail synthesis and shortening.We also discuss recent breakthroughs in poly(A)tail sequencing methods that enable high throughput and accurate measurement of poly(A)tail lengths.Finally,we review how poly(A)-tail regulators and poly(A)-tail-mediated post-transcriptional mechanisms affect stem cell fate and early embryonic development.展开更多
Flowering time is a critical agronomic trait with a profound effect on the productivity and adaptabillity of rapeseed(Brassica napus L.).Strategically advancing flowering time can reduce the risk of yield losses due t...Flowering time is a critical agronomic trait with a profound effect on the productivity and adaptabillity of rapeseed(Brassica napus L.).Strategically advancing flowering time can reduce the risk of yield losses due to extreme climatic conditions and facilitate the cultivation of subsequent crops on the same land,thereby enhancing overall agricultural efficiency.In this review,we synthesize current information on flowering time regulation in rapeseed through an integrated analysis of its genetic,hormonal,and environmental dimensions,emphasizing their crosstalk and implications for yield.We consolidate multi-omics evidence from population genetics,functional genomics,and systems biology to create a haplotype-based framework that overcomes the trade-off between flowering time and yield,providing support for the precision breeding of early-maturing cultivars.The insights presented here could inform future research on flowering time regulation and guide strategies for increasing rapeseed productivity.展开更多
BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this ...BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.展开更多
Sleep is a fundamental biological process essential for maintaining brain function,cognitive performance,and overall health.Despite over a century of research,the mechanisms underlying sleep homeostasis-the process by...Sleep is a fundamental biological process essential for maintaining brain function,cognitive performance,and overall health.Despite over a century of research,the mechanisms underlying sleep homeostasis-the process by which the need for sleep accumulates during wakefulness and dissipates during sleep-remain incompletely understood.This article explores the latest advancements in sleep research,focusing on the role of synaptic plasticity in sleep homeostasis,as illuminated by Sawada et al.(2024).展开更多
Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the ad...Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the adsorption layer and the ambiguous mechanisms of action.In this study,a highly stable Vani molecular brush additive was designed.The additive effectively inhibits H_(2) generation by targeting and anchoring H+in the inner Helmholtz layer,and reduces the water activity by constructing an enhanced hydrogen bonding network through the interaction with water molecules,thus inhibiting the parasitic side reactions on the zinc anode.In addition,the dynamic interfacial molecular layer can regulate and buffer the interfacial Zn^(2+)for highly reversible plating/stripping.Experiments show that the symmetric cell cycle life is as long as 3760 h at a Vani content of only 2×10^(-3) g L^(-1) with a current density of5 mA cm^(-2).The cycle life of the Zn‖MnO_(2) and Zn‖Zn_(0.58)V_(2)O_(5) H_(2)O full battery is significantly improved.This study deepens the understanding of the working mechanism of the zinc electrode interface and provides new ideas for non-sacrififcial trace additive design.展开更多
This article utilizes Katherine Mansfield’s short story The Garden Party as the research object to explore the narrative generation conditions of ethical experience in the text. Through a close analysis of the novel...This article utilizes Katherine Mansfield’s short story The Garden Party as the research object to explore the narrative generation conditions of ethical experience in the text. Through a close analysis of the novel’s narrative structure and key scenes, the article argues that ethical discomfort does not evolve into enduring moral judgments within the text;rather, it is continually managed and deferred through the interplay of aesthetic order, familial discourse, and the distribution of social roles. The novel eschews a linear trajectory of ethical awakening, instead crafting a narrative mechanism that keeps ethical experience palpable yet inarticulable. The female subject is given the role of sensing ethical incongruity, but lacks the narrative position from which to articulate it as judgment. Consequently, ethics remains confined to the level of personalization and unimplementability. Far from a narrative of moral growth or awakening, The Garden Party exposes why ethical judgment has become structurally unrealizable in modern narratives.展开更多
The development of robust anode-electrolyte interfaces(AEI)with enhanced compatibility and mechanical strength is critical for regulating zinc-ion nucleation kinetics,suppressing dendrite formation,and advancing zinc-...The development of robust anode-electrolyte interfaces(AEI)with enhanced compatibility and mechanical strength is critical for regulating zinc-ion nucleation kinetics,suppressing dendrite formation,and advancing zinc-ion battery commercialization.To address persistent interface degradation during battery cycling,we propose a novel manufacturing strategy utilizing digital-light-processing(DLP)3D printing.This approach enables programmable regulation of gel-polymer electrolyte(GPE)structures through layer-by-layer photopolymerization,achieving precision regulation of macro-microstructures and interfacial stresses.The DLP-manufactured GPEs feature cross-scale structures combining dense porous networks with smooth surface topography,providing abundant electrochemical active sites and stable interfacial contact.Multiphase-field simulations integrated with in-situ/ex-situ characterizations reveal stress-enhanced zinc deposition mechanisms,where optimized interfacial stress eliminates AEI contact instability,ensuring rapid mass transfer between electrode and electrolyte.Under regulated interface stress,the symmetrical cell demonstrates stability exceeding 2000 hours,and the full cell retains 91.72%capacity after 8000 ultralong cycles,with reliable operation under extreme temperature conditions(-10℃/60℃).The precise regulation of interfacial stresses establishes stable AEI configurations,demonstrating a transformative approach to durable zinc-ion battery design.展开更多
Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditio...Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditions)faces significant challenges,including accelerated electrolyte decomposition,interfacial instability,and potential thermal runaway risks.To address these challenges,we present a solvation-interphase synergistic regulation strategy using 2-fluorobenzenesulfonamide(2-FBS)as a multifunctional electrolyte additive.The 2-FBS molecule effectively modulates the Li^(+)solvation structure by reducing the coordination of ethylene carbonate(EC)solvent.This transformation suppresses EC-induced parasitic reactions while scavenging superoxide radicals,thereby mitigating gas evolution at electrode interfaces.Upon preferential decomposition,2-FBS further promotes the formation of a robust LiF-Li_(3)N-Li_(2)S-rich interphase with exceptional mechanical strength(Young’s modulus:39.4 GPa).This inorganic-rich hybrid interphase simultaneously enables dendrite-free lithium plating and enhances cathode thermal stability.Consequently,2-FBS-modified electrolyte empowers LiCoO_(2)//Li cells to deliver 82.8%capacity retention after 800 cycles at 55°C and sustain 81.2%capacity retention after 1500 cycles at 4 C.Moreover,practical validation through nail penetration tests confirms the effectiveness of the electrolyte in preventing thermal propagation in fully charged pouch cells.This work establishes a paradigm for enabling reliable battery operation under extreme conditions through synergistic solvation and interphase engineering.展开更多
Molecular engineering has demonstrated significant potential in modulating the crystallization and interfacial defect passivation of perovskite films.However,the deprotonation of conventional organic ammonium under li...Molecular engineering has demonstrated significant potential in modulating the crystallization and interfacial defect passivation of perovskite films.However,the deprotonation of conventional organic ammonium under light or thermal stress compromises the long-term operational stability of perovskite solar cells(PSCs).Here,we designed two multifunctional deprotonation-resistant cycloalkyl amidines with different heteroatoms,tetrahydro-2H-pyran-4-carboximidamide hydroiodide(TPCAI)and tetrahydro-2H-t hiopyran-4-carboximidamide hydroiodide(TTCAI),which were used to precisely regulate the crystallization process and interfacial properties of perovskite films.The larger dipole moment and enhanced electronic properties of sulfur-substituted TTCAI than TPCAI strengthen its interaction with the perovskite lattice.This interaction markedly slows down the crystallization rate,promotes preferential growth along the(100)crystal plane,reduces defect density,and effectively suppresses non-radiative recombination.TTCAI meanwhile construction of passivation layers on the surface and grain boundaries of the perovskite film through multiple hydrogen-bond interactions,passivates grain boundary defects,which significantly improves the film's environmental stability.Consequently,the TTCAI-modified device achieved a high efficiency of 25.58%,and the unencapsulated device retained 92%of its initial efficiency after 1200 h of storage at 65℃ under air(RH 30–65%).This study provides new insights into the rational design of multifunctional amidine ligands toward achieving efficient and stable PSCs.展开更多
Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigeneti...Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigenetic modifications have been indicated to significantly influence anthocyanin accumulation and response to various environmental cues.Recently,epigenetic regulation at the population level has become an increasingly important research focus.Here,we briefly describe the recent studies on epigenetic regulation of anthocyanin biosynthesis in horticultural crops,including the repressive role of DNA methylation,the dynamic gene expression control by histone modifications,and gene silencing or regulation mediated by non-coding RNAs.Furthermore,we also discuss recent technological breakthroughs in epigenetic editing and their potential applications in plant breeding.The review aims to provide new,more flexible research perspectives to enhance fruit quality in horticultural crops and to understand the molecular regulation of color formation.展开更多
Diabetes mellitus is an escalating global health issue,with 463 million adults affected in 2019.Without intervention,this number is projected to increase to 578 million by 2030 and 700 million by 2045[1].Diabetic woun...Diabetes mellitus is an escalating global health issue,with 463 million adults affected in 2019.Without intervention,this number is projected to increase to 578 million by 2030 and 700 million by 2045[1].Diabetic wound,a significant complication,is characterized by delayed healing,high disability rates,and elevated mortality[2].The challenges of wound healing in diabetic patients,compounded by their high morbidity and mortality rates,have drawn growing attention in biomedical research.展开更多
NiFe layered double hydroxide(NiFe LDH)has emerged as a promising catalyst for the oxygen evolution reaction(OER);however,its hydrogen evolution reaction(HER)activity remains suboptimal due to unfavorable electronic s...NiFe layered double hydroxide(NiFe LDH)has emerged as a promising catalyst for the oxygen evolution reaction(OER);however,its hydrogen evolution reaction(HER)activity remains suboptimal due to unfavorable electronic structures,particularly the d-electron density of metal sites,which impede water dissociation and lead to poor hydrogen adsorption/desorption capabilities.Herein,we introduce an efficient cooperative d-electron density regulation(CDDR)engineering to comprehensively optimize the delectron density of NiFe LDH by grafting MoO_(x) -modified NiFe LDH nanosheets onto porous nickel particles(PNPs).The PNPs facilitate d-electron density modulation along the edges of the nanosheets,while the MoO_(x) species enable d-electron density modulation across the plane of the nanosheets,thus cooperatively constructing enriched d-electron density in NiFe LDH.Theoretical studies validate the CDDR process and reveal that the enriched d-electron density accelerates water dissociation and optimizes the hydrogen adsorption behavior of NiFe LDH.As a result,the engineered catalyst exhibits significantly improved HER activity,achieving an ultra-low overpotential of 38 mV at 10 mA cm^(-2)in 1 M KOH.Additionally,the CDDR-optimized catalyst also exhibits good OER performance,demonstrating excellent bifunctional performance for overall water splitting in both alkaline freshwater and seawater electrolytes.This work presents a novel CDDR strategy for engineering NiFe LDH into efficient HER catalysts without compromising its OER activity,potentially paving the way for the development of active and robust electrocatalysts for sustainable energy applications.展开更多
Layered oxides have attracted significant attention as cathodes for sodium-ion batteries(SIBs)due to their compositional versatility and tuneable electrochemical performance.However,these materials still face challeng...Layered oxides have attracted significant attention as cathodes for sodium-ion batteries(SIBs)due to their compositional versatility and tuneable electrochemical performance.However,these materials still face challenges such as structural phase transitions,Na^(+)/vacancy ordering,and Jahn–Teller distortion effect,resulting in severe capacity decay and sluggish ion kinetics.We develop a novel Cu/Y dual-doping strategy that leads to the formation of"Na–Y"interlayer aggregates,which act as structural pillars within alkali metal layers,enhancing structural stability and disrupting the ordered arrangement of Na^(+)/vacancies.This disruption leads to a unique coexistence of ordered and disordered Na^(+)/vacancy states with near-zero strain,which significantly improves Na^(+)diffusion kinetics.This structural innovation not only mitigates the unfavorable P2–O2 phase transition but also facilitates rapid ion transport.As a result,the doped material demonstrates exceptional electrochemical performance,including an ultra-long cycle life of 3000 cycles at 10 C and an outstanding high-rate capability of~70 mAh g^(−1)at 50 C.The discovery of this novel interlayer pillar,along with its role in modulating Na^(+)/vacancy arrangements,provides a fresh perspective on engineering layered oxides.It opens up promising new pathways for the structural design of advanced cathode materials toward efficient,stable,and high-rate SIBs.展开更多
Nekemias megalophylla is a popular folk tea consumed by people in the Western Hubei(China)of which ampelopsin(AMP)is the main active ingredient.In this study,we investigated the effect of AMP on cervical cancer and ex...Nekemias megalophylla is a popular folk tea consumed by people in the Western Hubei(China)of which ampelopsin(AMP)is the main active ingredient.In this study,we investigated the effect of AMP on cervical cancer and explored its mechanism of action,focusing on apoptosis and autophagy.Firstly,we verified that AMP strongly inhibited the growth of C-33A cells and observed apoptosis and autophagy phenomenon in vivo,and found that AMP induces C-33A cell apoptosis via death receptor or mitochondrial pathways.The results also indicated that AMP-induced autophagy occurs via the PI3K/Akt/m TOR pathway.Secondly,when autophagy was inhibited,the AMP-induced apoptosis of C-33A cells was strengthened,when apoptosis was inhibited,the AMP-induced autophagy of C-33A cells was strengthened.PI3K/Akt/m TOR pathway activation enhances AMP-induced apoptosis in C-33A cells,while its inhibition strengthens AMP-induced autophagy.Finally,we confirmed that AMP inhibited cell growth and induced apoptosis and autophagy of C-33A cells in an in vivo nude mouse model of C-33A tumor xenografts.These results elucidate that AMP bidirectionally regulates apoptosis and autophagy in human cervical cancer C-33A cells by mediating the PI3K/Akt/m TOR pathway.展开更多
基金supported by the Science and Technology Development Project of Jilin Province(Project No.YDZJ202301ZYTS284).
文摘With the increasing penetration of renewable energy,the coordination of energy storage with thermal power for frequency regulation has become an effective means to enhance grid frequency security.Addressing the challenge of improving the frequency regulation performance of a thermal-storage primary frequency regulation system while reducing its associated losses,this paper proposes a multi-dimensional cooperative optimization strategy for the control parameters of a combined thermal-storage system,considering regulation losses.First,the frequency regulation losses of various components within the thermal power unit are quantified,and a calculation method for energy storage regulation loss is proposed,based on Depth of Discharge(DOD)and C-rate.Second,a thermal-storage cooperative control method based on series compensation is developed to improve the system’s frequency regulation performance.Third,targeting system regulation loss cost and regulation output,and considering constraints on output overshoot and system parameters,an improved Particle Swarm Optimization(PSO)algorithm is employed to tune the parameters of the low-pass filter and the series compensator,thereby reducing regulation losses while enhancing performance.Finally,simulation results demonstrate that the total loss cost of the proposed control strategy is comparable to that of a system with only thermal power participation.However,the thermal power loss cost is reduced by 42.16%compared to the thermal-only case,while simultaneously improving system frequency stability.Thus,the proposed strategy effectively balances system frequency stability and economic efficiency.
文摘Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological characteristics and molecular pathways associated with its progression.Advances in scientific research have increasingly highlighted the crucial role of non-coding RNAs in the progression of Alzheimer's disease.These non-coding RNAs regulate several biological processes critical to the advancement of the disease,offering promising potential as therapeutic targets and diagnostic biomarkers.Therefore,this review aims to investigate the underlying mechanisms of Alzheimer's disease onset,with a particular focus on microRNAs,long non-coding RNAs,and circular RNAs associated with the disease.The review elucidates the potential pathogenic processes of Alzheimer's disease and provides a detailed description of the synthesis mechanisms of the three aforementioned non-coding RNAs.It comprehensively summarizes the various non-coding RNAs that have been identified to play key regulatory roles in Alzheimer's disease,as well as how these noncoding RNAs influence the disease's progression by regulating gene expression and protein functions.For example,miR-9 targets the UBE4B gene,promoting autophagy-mediated degradation of Tau protein,thereby reducing Tau accumulation and delaying Alzheimer's disease progression.Conversely,the long non-coding RNA BACE1-AS stabilizes BACE1 mRNA,promoting the generation of amyloid-βand accelerating Alzheimer's disease development.Additionally,circular RNAs play significant roles in regulating neuroinflammatory responses.By integrating insights from these regulatory mechanisms,there is potential to discover new therapeutic targets and potential biomarkers for early detection and management of Alzheimer's disease.This review aims to enhance the understanding of the relationship between Alzheimer's disease and non-coding RNAs,potentially paving the way for early detection and novel treatment strategies.
文摘Ischemic stroke therapy has long been dominated by strategies aimed at restoring cerebral blood flow. Yet, accumulating evidence suggests that neuronal survival and functional recovery depend not only on reperfusion, but also on the resolution of postischemic immune dysregulation. This study(Chen et al., Prog Biochem Biophys, 2026, 53(3): 697-710. DOI:10.3724/j.pibb.2025.0541) a dvances this emerging paradigm by proposing a therapeutic strategy that integrates lesion-specific delivery with active modulation of the inflammatory microenvironment.
文摘Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2)O(1)was synthesized as a 2D structure using Coas the metal source,methanol‑water(4∶6,V/V)as the solvent,and specific concentrations of 2,5‑furandicarboxylic acid(H_(2)FDCA)and 1,3,5‑triimidazole benzene(L).Adjusting to pure water and lowering the concentration of L yielded the 1D chain structure of[Co(HL)2(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(2).Using Cu(Ⅱ)as the metal source,methanol/water(9∶1,V/V)as the solvent,and specific concentrations of L and H2FDCA,the 1D chain structure of[Cu(L)(FDCA)(H_(2)O)]·2H_(2)O(3)was synthesized.Upon increasing the concentrations of L and H2FDCA,and switching the solvent to pure water,the 1D chain structure of[Cu(HL)_(2)(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(4)was obtained.This shows that changing the solvent and ligand concentrations can affect the structural changes of CPs.In addition,the solid‑state photoluminescence of CPs 1‑4 at room temperature was studied,and their morphological changes were observed via scanning electron microscopy.Density functional theory calculations revealed that the negative charge concentrates on the O and N atoms of the ligand,facilitating ligand‑metal ion coordination.CCDC:2403934,1;2403935,2;2403936,3;2403938,4.
基金supported by the Secretaría de Ciencia,Humanidades,Tecnología e Innovación(SECIHTI),Fondo Ciencia Básica y de Frontera 2025(CBF-2025-G-97)to E.Soto-Reyes and PRODEP(511/2023-3066-1599)SECIHTI,Fondo de Ciencia de Frontera 2023(CF-2023-G398)to C.Sámano+2 种基金supported by the Departamen to de Ciencias Naturales(DCN),División de Ciencias Naturales e Ingeniería(DCNI),UAM,Unidad Cuajimalpa,through Divisional Project Number 101S243-23 to E.Soto-Reyes and 123 S289-25 to C.Sámanoa master student from Programa de Maestría y Doctorado en Ciencias Bio-químicas,Universidad Nacional Autónoma deMéxico(UNAM)and received a fellowship(CVU number 1184475)fromSecretaría de Ciencia,Humanidades,Tecnología e Innovación(SECIHTI),Mexicoa postdoctoral fellow at the Universidad Autónoma Metropolitana-Cuajimalpa(UAM-C)and received a fellowship(CVU number 588333)from SECIHTI,Mexico.
文摘Objectives:Glioblastoma multiforme(GBM)is a highly aggressive brain tumor characterized by extensive transcriptional and epigenetic dysregulation.Brother of the Regulator of Imprinted Sites(BORIS/CTCFL)has been implicated in oncogenic transcriptional programs in several cancers,but its role in GBM remains poorly defined.This study aimed to characterize BORIS-associated transcriptional programs in GBM and to assess their functional relevance using integrative computational and experimental approaches.Methods:Transcriptomic data from The Cancer Genome Atlas(TCGA)-GBM and Genotype-Tissue Expression(GTex)brain cortex were analyzed following batch correction,differential expression analysis,and gene ontology enrichment.TCGA-GBM samples were stratified into BORIS-high and BORIS-low expression quartiles to identify BORIS-associated gene signatures.BORIS chromatin occupancy was examined by Chromatin immunoprecipitation combined with sequencing(ChIP-seq)in U87MG cells,followed by functional annotation of BORIS-bound genes.Experimental validation included BORIS overexpression,RT-qPCR,immunoblotting,ChIP-qPCR,and functional assays assessing proliferation,clonogenic survival,and migration.Results:BORIS was significantly upregulated in GBM compared with normal brain tissue and was associated with transcriptional programs related to development,metabolism,and cell signaling.Quartilebased analysis identified BORIS-associated differentially expressed genes,including CD36 and FBN2.ChIP-seq revealed BORIS binding at promoter-proximal regions,with ChIP-qPCR confirming occupancy at CD36 and FBN2 regulatory regions.BORIS overexpression increased CD36 and FBN2 expression and was associated with reduced proliferation,enhanced clonogenic survival,and increased migratory capacity.Conclusion:These findings indicate that BORIS is associated with transcriptional and phenotypic programs linked to GBM aggressiveness and may represent a candidate for further investigation as a biomarker or therapeutic target in GBM.
基金the National Natural Science Foundation of China (Nos.52430001,52470091,52200108) for the financial support。
文摘Nanofiltration(NF) technology,with its capacity for nanoscale filtration and controllable selectivity,holds significant promise in diverse applications.However,the current upper bound of permeance and selectivity of NF membranes is intrinsically constrained by the morphology and structure of the polyamide(PA) selective layer.This issue arises because NF membranes typically exhibit relatively smooth nodular structures,which theoretically impede efficient water transport.In this study,we enhanced the formation of nanobubbles by synergistically regulating with surfactant and low temperatures,resulting in the fabrication of PA NF membranes with a crumpled morphology.We observed that lower temperatures promote enhanced gas solubility in the aqueous phase,facilitating increased nanobubble formation through the foaming effect of surfactant sodium dodecylbenzene sulfonate(SDBS).Consequently,this resulted in the creation of PA NF membranes with more crumpled structures and superior performance,with pure water permeance reaching 36.25 ± 0.42 L m^(-2)h^(-1)bar^(-1),representing an improvement of 14.47 L m^(-2)h^(-1)bar^(-1)compared to the control group.Additionally,it maintains a high Na_(2)SO_(4) rejection rate of97.00 % ± 0.58 %.The PA NF membranes produced by eliminating nanobubbles and free interfaces exhibited a smooth structure,whereas introducing nanobubbles(through Na HCO_(3) addition,N_(2) pressurization,and ultrasonication) resulted in the formation of crumpled membranes.This emphasized that the large amount of nanobubbles generated by SDBS and low temperature in the interfacial process played a critical role in shaping crumpled PA NF membranes and enhancing membrane performance.This approach has the potential to provide valuable insights into customizing the structural design of TFC PA NF membranes,contributing to further advancements in this field.
基金supported in part by the National Institute of Environmental Health Sciences(Z01ES102745 to GH).
文摘Eukaryotic mRNAs are polyadenylated at their 3’-ends,and the poly(A)tails play critical roles in post-transcriptional gene regulation by influencing mRNA stability and translation.Here,we describe the biological processes and major protein factors that control poly(A)tail synthesis and shortening.We also discuss recent breakthroughs in poly(A)tail sequencing methods that enable high throughput and accurate measurement of poly(A)tail lengths.Finally,we review how poly(A)-tail regulators and poly(A)-tail-mediated post-transcriptional mechanisms affect stem cell fate and early embryonic development.
基金supported by the National Key Research and Development Program of China(2022YFD1200400)the National Natural Science Foundation of China(32272111)+4 种基金Special fund for youth team of the Southwest Universities(SWU-XJPY202306)Chongqing Natural Science Foundation(CSTB2024NSCQLZX0012)Modern Agro-industry Technology Research System(CARS-12)Chongqing Modern Agricultural Industry Technology System(COMAITS202504)Biological Breeding-National Science and Technology Major Project(2022ZD04008).We sincerely appreciate the Plant Editors team for English language editing of the manuscript,which significantly improved its clarity and overall quality.
文摘Flowering time is a critical agronomic trait with a profound effect on the productivity and adaptabillity of rapeseed(Brassica napus L.).Strategically advancing flowering time can reduce the risk of yield losses due to extreme climatic conditions and facilitate the cultivation of subsequent crops on the same land,thereby enhancing overall agricultural efficiency.In this review,we synthesize current information on flowering time regulation in rapeseed through an integrated analysis of its genetic,hormonal,and environmental dimensions,emphasizing their crosstalk and implications for yield.We consolidate multi-omics evidence from population genetics,functional genomics,and systems biology to create a haplotype-based framework that overcomes the trade-off between flowering time and yield,providing support for the precision breeding of early-maturing cultivars.The insights presented here could inform future research on flowering time regulation and guide strategies for increasing rapeseed productivity.
文摘BACKGROUND The prevalence of negative emotional states,such as anxiety and depression,has increased annually.Although personal habits are known to influence emotional regulation,the precise mechanisms underlying this relationship remain unclear.AIM To investigate emotion regulation habits impact on students negative emotions during lockdown,using the coronavirus disease 2019 pandemic as a case example.METHODS During the coronavirus disease 2019 lockdown,an online cross-sectional survey was conducted at a Chinese university.Emotional states were assessed using the Depression,Anxiety,and Stress Scale-21(DASS-21),while demographic data and emotion regulation habits were collected concurrently.Data analysis was performed using SPSS version 27.0 and includedχ^(2)-tests for intergroup comparisons,Spearman’s rank-order correlation coefficient analysis to examine associations,and stepwise linear regression modeling to explore the relationships between emotion regulation habits and emotional states.Statistical significance was set atα=0.05.RESULTS Among the 494 valid questionnaires analyzed,the prevalence rates of negative emotional states were as follows:Depression(65.0%),anxiety(69.4%),and stress(50.8%).DASS-21 scores(mean±SD)demonstrated significant symptomatology:Total(48.77±34.88),depression(16.21±12.18),anxiety(14.90±11.91),and stress(17.64±12.07).Significant positive intercorrelations were observed among all DASS-21 subscales(P<0.01).Regression analysis identified key predictors of negative emotions(P<0.05):Risk factors included late-night frequency and academic pressure,while protective factors were the frequency of parental contact and the number of same-gender friends.Additionally,compensatory spending and binge eating positively predicted all negative emotion scores(β>0,P<0.01),whereas appropriate recreational activities negatively predicted these scores(β<0,P<0.01).CONCLUSION High negative emotion prevalence occurred among confined students.Recreational activities were protective,while compensatory spending and binge eating were risk factors,necessitating guided emotion regulation.
基金supported by Japan Society forthe Promotion of Science(JSPS)Grants-in-Aidfor Scientific Research(KAKENHI)(20H05894,20H05903,21K15136,22K21351,23H02518A,23H02663,and 23K18147 to SS),JST-CREST(JPMJCR24T4 to SS),the World PremierInternational Research Center Initiative(WPI)fromthe Ministry of Education,Culture,Sports,Scienceand Technology(MEXT)to SS(WPI-IIIS),the TopRunners in Strategy of Transborder AdvancedResearches(TRiSTAR)by the MEXT to SSJapanAgency for Medical Research and Development(AMED)(JP21zf0127005 to SS),Cell ScienceResearch Foundation Grant to YI,38th Brain ScienceFoundation Research Grant to YI,Research Granton Biogenic Amines and Neurological Diseases(Sumitomo pharma)to YI.
文摘Sleep is a fundamental biological process essential for maintaining brain function,cognitive performance,and overall health.Despite over a century of research,the mechanisms underlying sleep homeostasis-the process by which the need for sleep accumulates during wakefulness and dissipates during sleep-remain incompletely understood.This article explores the latest advancements in sleep research,focusing on the role of synaptic plasticity in sleep homeostasis,as illuminated by Sawada et al.(2024).
基金supported by the Heilongjiang Province“Double First Class”Discipline Collaborative Innovation Project(LJGXCG2023-061)。
文摘Currently,zinc anodes are facing problems such as the growth of zinc dendrites and the frequent occurrence of side reactions,while existing additive strategies are still challenging due to the poor stability of the adsorption layer and the ambiguous mechanisms of action.In this study,a highly stable Vani molecular brush additive was designed.The additive effectively inhibits H_(2) generation by targeting and anchoring H+in the inner Helmholtz layer,and reduces the water activity by constructing an enhanced hydrogen bonding network through the interaction with water molecules,thus inhibiting the parasitic side reactions on the zinc anode.In addition,the dynamic interfacial molecular layer can regulate and buffer the interfacial Zn^(2+)for highly reversible plating/stripping.Experiments show that the symmetric cell cycle life is as long as 3760 h at a Vani content of only 2×10^(-3) g L^(-1) with a current density of5 mA cm^(-2).The cycle life of the Zn‖MnO_(2) and Zn‖Zn_(0.58)V_(2)O_(5) H_(2)O full battery is significantly improved.This study deepens the understanding of the working mechanism of the zinc electrode interface and provides new ideas for non-sacrififcial trace additive design.
文摘This article utilizes Katherine Mansfield’s short story The Garden Party as the research object to explore the narrative generation conditions of ethical experience in the text. Through a close analysis of the novel’s narrative structure and key scenes, the article argues that ethical discomfort does not evolve into enduring moral judgments within the text;rather, it is continually managed and deferred through the interplay of aesthetic order, familial discourse, and the distribution of social roles. The novel eschews a linear trajectory of ethical awakening, instead crafting a narrative mechanism that keeps ethical experience palpable yet inarticulable. The female subject is given the role of sensing ethical incongruity, but lacks the narrative position from which to articulate it as judgment. Consequently, ethics remains confined to the level of personalization and unimplementability. Far from a narrative of moral growth or awakening, The Garden Party exposes why ethical judgment has become structurally unrealizable in modern narratives.
基金supported by National Natural Science Foundation of China(U22A20193)National Key Research and Development Program of China(2024YFB3409000)+1 种基金TCL science and technology innovation fund(20231751)Fundamental Research Funds for the Central Universities(No.2024ZYGXZR066)。
文摘The development of robust anode-electrolyte interfaces(AEI)with enhanced compatibility and mechanical strength is critical for regulating zinc-ion nucleation kinetics,suppressing dendrite formation,and advancing zinc-ion battery commercialization.To address persistent interface degradation during battery cycling,we propose a novel manufacturing strategy utilizing digital-light-processing(DLP)3D printing.This approach enables programmable regulation of gel-polymer electrolyte(GPE)structures through layer-by-layer photopolymerization,achieving precision regulation of macro-microstructures and interfacial stresses.The DLP-manufactured GPEs feature cross-scale structures combining dense porous networks with smooth surface topography,providing abundant electrochemical active sites and stable interfacial contact.Multiphase-field simulations integrated with in-situ/ex-situ characterizations reveal stress-enhanced zinc deposition mechanisms,where optimized interfacial stress eliminates AEI contact instability,ensuring rapid mass transfer between electrode and electrolyte.Under regulated interface stress,the symmetrical cell demonstrates stability exceeding 2000 hours,and the full cell retains 91.72%capacity after 8000 ultralong cycles,with reliable operation under extreme temperature conditions(-10℃/60℃).The precise regulation of interfacial stresses establishes stable AEI configurations,demonstrating a transformative approach to durable zinc-ion battery design.
基金supported by the Key Laboratory of Sichuan Province for Lithium Resources Comprehensive Utilization and New Lithium Based Materials for Advanced Battery Technology(LRMKF202405)the National Natural Science Foundation of China(52402226)the Sichuan Provincial Natural Science Foundation (2024NSFSC1016)
文摘Lithium metal batteries(LMBs)have emerged as pivotal energy storage solutions for electric vehicles and portable electronics.However,their operation under extreme conditions(high-temperature and fast-charging conditions)faces significant challenges,including accelerated electrolyte decomposition,interfacial instability,and potential thermal runaway risks.To address these challenges,we present a solvation-interphase synergistic regulation strategy using 2-fluorobenzenesulfonamide(2-FBS)as a multifunctional electrolyte additive.The 2-FBS molecule effectively modulates the Li^(+)solvation structure by reducing the coordination of ethylene carbonate(EC)solvent.This transformation suppresses EC-induced parasitic reactions while scavenging superoxide radicals,thereby mitigating gas evolution at electrode interfaces.Upon preferential decomposition,2-FBS further promotes the formation of a robust LiF-Li_(3)N-Li_(2)S-rich interphase with exceptional mechanical strength(Young’s modulus:39.4 GPa).This inorganic-rich hybrid interphase simultaneously enables dendrite-free lithium plating and enhances cathode thermal stability.Consequently,2-FBS-modified electrolyte empowers LiCoO_(2)//Li cells to deliver 82.8%capacity retention after 800 cycles at 55°C and sustain 81.2%capacity retention after 1500 cycles at 4 C.Moreover,practical validation through nail penetration tests confirms the effectiveness of the electrolyte in preventing thermal propagation in fully charged pouch cells.This work establishes a paradigm for enabling reliable battery operation under extreme conditions through synergistic solvation and interphase engineering.
基金supported by the National Natural Science Foundation of China(22471218)Shaanxi Fundamental Science Research Project for Chemistry&Biology(22JHQ002)+3 种基金Program for Young Talents of Shaanxi Province(5113190023)the Natural Science Foundation of Shaanxi Province(2025JC-YBMS-147 and2024JC-ZDXM-08)the Natural Science Foundation of Zhejiang Province(LY24B010002)the Natural Science Foundation of Guangdong Province(2025A1515012305)。
文摘Molecular engineering has demonstrated significant potential in modulating the crystallization and interfacial defect passivation of perovskite films.However,the deprotonation of conventional organic ammonium under light or thermal stress compromises the long-term operational stability of perovskite solar cells(PSCs).Here,we designed two multifunctional deprotonation-resistant cycloalkyl amidines with different heteroatoms,tetrahydro-2H-pyran-4-carboximidamide hydroiodide(TPCAI)and tetrahydro-2H-t hiopyran-4-carboximidamide hydroiodide(TTCAI),which were used to precisely regulate the crystallization process and interfacial properties of perovskite films.The larger dipole moment and enhanced electronic properties of sulfur-substituted TTCAI than TPCAI strengthen its interaction with the perovskite lattice.This interaction markedly slows down the crystallization rate,promotes preferential growth along the(100)crystal plane,reduces defect density,and effectively suppresses non-radiative recombination.TTCAI meanwhile construction of passivation layers on the surface and grain boundaries of the perovskite film through multiple hydrogen-bond interactions,passivates grain boundary defects,which significantly improves the film's environmental stability.Consequently,the TTCAI-modified device achieved a high efficiency of 25.58%,and the unencapsulated device retained 92%of its initial efficiency after 1200 h of storage at 65℃ under air(RH 30–65%).This study provides new insights into the rational design of multifunctional amidine ligands toward achieving efficient and stable PSCs.
基金funded by grants from the sub-project of Liaoning Province Germplasm Innovation Grain Storage and Technology Special Program(Grant No.2023JH1/10200003)National Natural Science Foundation of China(Grant Nos.32102350,32130092)+1 种基金Liaoning Provincial Department of Education Project(Grant No.LJKZ0635)funded by Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Vegetables),Ministry of Agriculture and Rural Affairs.
文摘Anthocyanins,a major water-soluble pigment in plants,endow horticultural plants with colors and nutritional value,and serve as a key factor in shaping fruit quality and commercial value.Over the past decades,epigenetic modifications have been indicated to significantly influence anthocyanin accumulation and response to various environmental cues.Recently,epigenetic regulation at the population level has become an increasingly important research focus.Here,we briefly describe the recent studies on epigenetic regulation of anthocyanin biosynthesis in horticultural crops,including the repressive role of DNA methylation,the dynamic gene expression control by histone modifications,and gene silencing or regulation mediated by non-coding RNAs.Furthermore,we also discuss recent technological breakthroughs in epigenetic editing and their potential applications in plant breeding.The review aims to provide new,more flexible research perspectives to enhance fruit quality in horticultural crops and to understand the molecular regulation of color formation.
基金supported by a grant from General Scientific Research Project of Zhejiang Provincial Department of Education(No.Y202455614).
文摘Diabetes mellitus is an escalating global health issue,with 463 million adults affected in 2019.Without intervention,this number is projected to increase to 578 million by 2030 and 700 million by 2045[1].Diabetic wound,a significant complication,is characterized by delayed healing,high disability rates,and elevated mortality[2].The challenges of wound healing in diabetic patients,compounded by their high morbidity and mortality rates,have drawn growing attention in biomedical research.
基金financially supported from the National Key Research and Development Program of China(2022YFB3803600)the National Natural Science Foundation of China(52301272,22309168,12564025,and 52472205)+7 种基金the Fundamental Research Funds for the Central Universities(CCNU25ZH006)the National College Student Innovation and Entrepreneurship Training Project(202510513082)the Research Program of HBNU(2025X082 and2025Y145)the Foundation of Hubei Key Laboratory of Photoelectric Materials and Devices(PMD202404)the General Program of Open Project of the State Key Laboratory of Precision Welding and Joining of Materials Structures(MSWJ-25M-18)the Key Research Project of Hubei Provincial Department of Education(No.D20252503)the Key Project of Hubei Provincial Natural Science Foundation of China(2025AFD002)the Foundation of National Laboratory of Solid State Microstructures(M37087)。
文摘NiFe layered double hydroxide(NiFe LDH)has emerged as a promising catalyst for the oxygen evolution reaction(OER);however,its hydrogen evolution reaction(HER)activity remains suboptimal due to unfavorable electronic structures,particularly the d-electron density of metal sites,which impede water dissociation and lead to poor hydrogen adsorption/desorption capabilities.Herein,we introduce an efficient cooperative d-electron density regulation(CDDR)engineering to comprehensively optimize the delectron density of NiFe LDH by grafting MoO_(x) -modified NiFe LDH nanosheets onto porous nickel particles(PNPs).The PNPs facilitate d-electron density modulation along the edges of the nanosheets,while the MoO_(x) species enable d-electron density modulation across the plane of the nanosheets,thus cooperatively constructing enriched d-electron density in NiFe LDH.Theoretical studies validate the CDDR process and reveal that the enriched d-electron density accelerates water dissociation and optimizes the hydrogen adsorption behavior of NiFe LDH.As a result,the engineered catalyst exhibits significantly improved HER activity,achieving an ultra-low overpotential of 38 mV at 10 mA cm^(-2)in 1 M KOH.Additionally,the CDDR-optimized catalyst also exhibits good OER performance,demonstrating excellent bifunctional performance for overall water splitting in both alkaline freshwater and seawater electrolytes.This work presents a novel CDDR strategy for engineering NiFe LDH into efficient HER catalysts without compromising its OER activity,potentially paving the way for the development of active and robust electrocatalysts for sustainable energy applications.
基金supported by the “Pioneer” and “Leading Goose” R&D Program of Zhejiang Province of China (No. 2024C01056)the support from London South Bank University
文摘Layered oxides have attracted significant attention as cathodes for sodium-ion batteries(SIBs)due to their compositional versatility and tuneable electrochemical performance.However,these materials still face challenges such as structural phase transitions,Na^(+)/vacancy ordering,and Jahn–Teller distortion effect,resulting in severe capacity decay and sluggish ion kinetics.We develop a novel Cu/Y dual-doping strategy that leads to the formation of"Na–Y"interlayer aggregates,which act as structural pillars within alkali metal layers,enhancing structural stability and disrupting the ordered arrangement of Na^(+)/vacancies.This disruption leads to a unique coexistence of ordered and disordered Na^(+)/vacancy states with near-zero strain,which significantly improves Na^(+)diffusion kinetics.This structural innovation not only mitigates the unfavorable P2–O2 phase transition but also facilitates rapid ion transport.As a result,the doped material demonstrates exceptional electrochemical performance,including an ultra-long cycle life of 3000 cycles at 10 C and an outstanding high-rate capability of~70 mAh g^(−1)at 50 C.The discovery of this novel interlayer pillar,along with its role in modulating Na^(+)/vacancy arrangements,provides a fresh perspective on engineering layered oxides.It opens up promising new pathways for the structural design of advanced cathode materials toward efficient,stable,and high-rate SIBs.
基金supported by the Major Science and Technology Project of Hubei Province(2020ACA007)the Scientific and Technological Bureau of Wuhan(2018060401011308).
文摘Nekemias megalophylla is a popular folk tea consumed by people in the Western Hubei(China)of which ampelopsin(AMP)is the main active ingredient.In this study,we investigated the effect of AMP on cervical cancer and explored its mechanism of action,focusing on apoptosis and autophagy.Firstly,we verified that AMP strongly inhibited the growth of C-33A cells and observed apoptosis and autophagy phenomenon in vivo,and found that AMP induces C-33A cell apoptosis via death receptor or mitochondrial pathways.The results also indicated that AMP-induced autophagy occurs via the PI3K/Akt/m TOR pathway.Secondly,when autophagy was inhibited,the AMP-induced apoptosis of C-33A cells was strengthened,when apoptosis was inhibited,the AMP-induced autophagy of C-33A cells was strengthened.PI3K/Akt/m TOR pathway activation enhances AMP-induced apoptosis in C-33A cells,while its inhibition strengthens AMP-induced autophagy.Finally,we confirmed that AMP inhibited cell growth and induced apoptosis and autophagy of C-33A cells in an in vivo nude mouse model of C-33A tumor xenografts.These results elucidate that AMP bidirectionally regulates apoptosis and autophagy in human cervical cancer C-33A cells by mediating the PI3K/Akt/m TOR pathway.
