This special issue of the Asian Journal of Andrology is fully dedicated to the thematic area of non-obstructive azoospermia(NOA),one of the most complex and challenging conditions in the realm of andrology,urology,and...This special issue of the Asian Journal of Andrology is fully dedicated to the thematic area of non-obstructive azoospermia(NOA),one of the most complex and challenging conditions in the realm of andrology,urology,and reproductive medicine.展开更多
Dear Editor,Influenza viruses cause significant mortality and morbidity in humans.Vaccination is currently the most effective way to combat the virus(Perofsky and Nelson,2020).Unfortunately,the influenza virus frequen...Dear Editor,Influenza viruses cause significant mortality and morbidity in humans.Vaccination is currently the most effective way to combat the virus(Perofsky and Nelson,2020).Unfortunately,the influenza virus frequently changes its antigenicity through rapid mutations,leading to decreased vaccine efficacy or even failure.To improve vaccine effectiveness,it is necessary to monitor antigenic variation and update vaccine strains when significant antigenic variation occurs(Perofsky and Nelson,2020;Malik et al.,2024).展开更多
This paper examines the impact of algorithmic recommendations and data-driven marketing on consumer engagement and business performance.By leveraging large volumes of user data,businesses can deliver personalized cont...This paper examines the impact of algorithmic recommendations and data-driven marketing on consumer engagement and business performance.By leveraging large volumes of user data,businesses can deliver personalized content that enhances user experiences and increases conversion rates.However,the growing reliance on these technologies introduces significant risks,including privacy violations,algorithmic bias,and ethical concerns.This paper explores these challenges and provides recommendations for businesses to mitigate associated risks while optimizing marketing strategies.It highlights the importance of transparency,fairness,and user control in ensuring responsible and effective data-driven marketing.展开更多
With the increasing complexity of hotel selection,traditional decision-making models often struggle to account for uncertainty and interrelated criteria.Multi-criteria decision-making(MCDM)techniques,particularly thos...With the increasing complexity of hotel selection,traditional decision-making models often struggle to account for uncertainty and interrelated criteria.Multi-criteria decision-making(MCDM)techniques,particularly those based on fuzzy logic,provide a robust framework for handling such challenges.This paper presents a novel approach to MCDM within the framework of Circular Intuitionistic Fuzzy Sets(C-IFS)by combining three distinct methodologies:Weighted Aggregated Sum Product Assessment(WASPAS),an Alternative Ranking Order Method Accounting for Two-Step Normalization(AROMAN),and the CRITIC method(Criteria Importance Through Inter-criteria Correlation).To address the dynamic nature of traveler preferences in hotel selection,the study employs a comprehensive set of criteria encompassing aspects such as location proximity,amenities,pricing,customer reviews,environmental impact,safety,booking flexibility,and cultural experiences.The CRITIC method is used to determine the importance of each criterion by assessing intercriteria correlations.AROMAN is employed for the systematic evaluation of alternatives,considering their additive relationships and providing a weighted assessment.WASPAS further analyzes the results obtained from AROMAN,incorporating both positive and negative aspects for a comprehensive evaluation.The integration of C-IFS enhances the model’s ability to manage uncertainty and imprecision in the decision-making process.Through a case study,we demonstrate the effectiveness of this integrated approach,offering decision-makers valuable insights for selecting the most suitable hotel option in alignment with the diverse preferences of contemporary travelers.This research contributes to the evolving field of decision science by showcasing the practical applicability of these methodologies within a C-IFS framework for complex decision scenarios.展开更多
A survey conducted on the premature bolting of Huarong large leaf mustard from 2018 to 2024 revealed that Huarong large leaf mustard sown in middle August was associated with a higher propensity for premature bolting....A survey conducted on the premature bolting of Huarong large leaf mustard from 2018 to 2024 revealed that Huarong large leaf mustard sown in middle August was associated with a higher propensity for premature bolting. Furthermore, it was observed that the earlier being sown, the greater the rate of premature bolting when being sown prior to middle August. The rate of premature bolting observed in seedlings sown on August 8 was recorded at 35.6%. It was noted that as the age of the seedlings increased, the rate of premature bolting correspondingly increased. There were notable differences in the tolerance of various cultivars to elevated temperatures and prolonged sunlight exposure. For instance, cultivars such as Zhangjie 1 and Sichuan Shaguodi, which exhibit greater heat resistance, did not demonstrate premature bolting when sown in early August. The prolonged exposure to elevated temperatures, drought conditions, and extended periods of sunlight during the seedling stage of Huarong large leaf mustard, coupled with delayed irrigation and transplantation, contributed to the occurrence of premature bolting. The Huarong large leaf mustard, when been sown from late August to early September and transplanted at the appropriate time, exhibited normal growth and development, with no instances of premature bolting observed. It is advisable to select heat-resistant varieties, such as Zhangjie 1, prior to middle August. Huarong large leaf mustard should be sown in early to middle September. Additionally, it is essential to ensure centralized production and timely release of seeds, prompt transplantation and harvesting, and enhance the management of pests and diseases.展开更多
As legal cases grow in complexity and volume worldwide,integrating machine learning and artificial intelligence into judicial systems has become a pivotal research focus.This study introduces a comprehensive framework...As legal cases grow in complexity and volume worldwide,integrating machine learning and artificial intelligence into judicial systems has become a pivotal research focus.This study introduces a comprehensive framework for verdict recommendation that synergizes rule-based methods with deep learning techniques specifically tailored to the legal domain.The proposed framework comprises three core modules:legal feature extraction,semantic similarity assessment,and verdict recommendation.For legal feature extraction,a rule-based approach leverages Black’s Law Dictionary and WordNet Synsets to construct feature vectors from judicial texts.Semantic similarity between cases is evaluated using a hybrid method that combines rule-based logic with an LSTM model,analyzing the feature vectors of query cases against a legal knowledge base.Verdicts are then recommended through a rule-based retrieval system,enhanced by predefined legal statutes and regulations.By merging rule-based methodologies with deep learning,this framework addresses the interpretability challenges often associated with contemporary AImodels,thereby enhancing both transparency and generalizability across diverse legal contexts.The system was rigorously tested using a legal corpus of 43,000 case laws across six categories:Criminal,Revenue,Service,Corporate,Constitutional,and Civil law,ensuring its adaptability across a wide range of judicial scenarios.Performance evaluation showed that the feature extraction module achieved an average accuracy of 91.6%with an F-Score of 95%.The semantic similarity module,tested using Manhattan,Euclidean,and Cosine distance metrics,achieved 88%accuracy and a 93%F-Score for short queries(Manhattan),89%accuracy and a 93.7%F-Score for medium-length queries(Euclidean),and 87%accuracy with a 92.5%F-Score for longer queries(Cosine).The verdict recommendation module outperformed existing methods,achieving 90%accuracy and a 93.75%F-Score.This study highlights the potential of hybrid AI frameworks to improve judicial decision-making and streamline legal processes,offering a robust,interpretable,and adaptable solution for the evolving demands of modern legal systems.展开更多
In sub-Saharan Africa(SSA),63%of new human immunodeficiency virus(HIV)infections in 2021 were among women,particularly adolescent girls,and young women.There is a high incidence of HIV among pregnant and lactating wom...In sub-Saharan Africa(SSA),63%of new human immunodeficiency virus(HIV)infections in 2021 were among women,particularly adolescent girls,and young women.There is a high incidence of HIV among pregnant and lactating women(PLW)in SSA.It is estimated that the risk of HIV-acquisition during pregnancy and the postpartum period more than doubles.In this article,we discuss the safety and effectiveness of drugs used for oral HIV pre-exposure prophylaxis(PrEP),considerations for initiating PrEP in PLW,the barriers to initiating and adhering to PrEP among them and suggest recommendations to address these barriers.Tenofovir/emtricitabine,the most widely used combination in SSA,is safe,clinically effective,and cost-effective among PLW.Any PLW who requests PrEP and has no medical contraindications should receive it.PrEP users who are pregnant or lactating may experience barriers to starting and adhering for a variety of reasons,including personal,pill-related,and healthcare facility-related issues.To address the barriers,we recommend an increased provision of information on PrEP to the women and the communities,increasing and/or facilitating access to PrEP among the PLW,and developing strategies to increase adherence.展开更多
Solid organ transplant recipients face unique challenges in managing their im-munosuppressed status,making vaccination a critical consideration.This review aimed to comprehensively analyze current recommendations,eval...Solid organ transplant recipients face unique challenges in managing their im-munosuppressed status,making vaccination a critical consideration.This review aimed to comprehensively analyze current recommendations,evaluate the effi-cacy of vaccinations in this population,and assess safety concerns.We explored the latest evidence on vaccine types,timing,and potential benefits for transplant patients,highlighting the importance of individualized approaches for routinely used vaccines as well as coronavirus disease 2019 vaccines.By synthesizing avai-lable data,this review underscored the pressing need to optimize vaccination strategies,ensuring that transplant recipients can obtain the full protection against many pathogens while minimizing risks associated with their post-transplant immunosuppression.展开更多
Introduction: Chest radiography is the most frequently prescribed imaging test in general practice in France. We aimed to assess the extent to which general practitioners follow the recommendations of the French Natio...Introduction: Chest radiography is the most frequently prescribed imaging test in general practice in France. We aimed to assess the extent to which general practitioners follow the recommendations of the French National Authority for Health in prescribing chest radiography. Methodology: We conducted a retrospective analysis study, in two radiology centers belonging to the same group in Saint-Omer and Aire-sur-la-Lys, of requests for chest radiography sent by general practitioners over the winter period between December 22, 2013, and March 21, 2014, for patients aged over 18 years. Results: One hundred and seventy-seven requests for chest X-rays were analyzed, 71.75% of which complied with recommendations. The most frequent reason was the search for bronchopulmonary infection, accounting for 70.08% of prescriptions, followed by 11.2% for requests to rule out pulmonary neoplasia, whereas the latter reason did not comply with recommendations. Chest X-rays contributed to a positive diagnosis in 28.81% of cases. The positive diagnosis was given by 36.22% of the recommended chest X-rays, versus 10% for those not recommended. Conclusion: In most cases, general practitioners follow HAS recommendations for prescribing chest X-rays. Non-recommended chest X-rays do not appear to make a major contribution to diagnosis or patient management, confirming the value of following the recommendations of the French National Authority for Health.展开更多
A Recommender System(RS)is a crucial part of several firms,particularly those involved in e-commerce.In conventional RS,a user may only offer a single rating for an item-that is insufficient to perceive consumer prefe...A Recommender System(RS)is a crucial part of several firms,particularly those involved in e-commerce.In conventional RS,a user may only offer a single rating for an item-that is insufficient to perceive consumer preferences.Nowadays,businesses in industries like e-learning and tourism enable customers to rate a product using a variety of factors to comprehend customers’preferences.On the other hand,the collaborative filtering(CF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested items.However,the cost of these computations increases nonlinearly as the number of items and users increases.To triumph over the issues,a novel expanded stacked autoencoder(ESAE)with Kernel Fuzzy C-Means Clustering(KFCM)technique is proposed with two phases.In the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the ESAE approach and users are clustered using the KFCM approach.In the next phase of online,the top-N recommendation prediction is made by the ESAE approach involving only the most similar user from multiple clusters.Hence the ESAE_KFCM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation time.An experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the ESAE_KFCM model constantly outperforms conventional RS algorithms on a variety of assessment measures.展开更多
Recommendations for probiotics are available in several regions.This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region.Epidemiology and clinical patterns o...Recommendations for probiotics are available in several regions.This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region.Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed.Evidence-based recommendations and randomized controlled trials in the region were revised.Cultural aspects,health management issues and economic factors were also considered.Final recommendations were approved by applying the Likert scale and rated using the GRADE system.Saccharomyces boulardii CNCM I-745(Sb)and Lactobacillus rhamnosus GG(LGG)were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis.Lactobacillus reuteri could also be considered.Probiotics may be considered for prevention of(with the indicated strains):antibiotic-associated diarrhea(LGG or Sb);Clostridium difficile-induced diarrhea(Sb);nosocomial diarrhea(LGG);infantile colic(L reuteri)and as adjunct treatment of Helicobacter pylori(Sb and others).Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis.There is insufficient evidence for recommendations in other conditions.Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries.These need to be validated with local randomized-controlled trials.展开更多
BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with azathioprine.Second-line treatments are needed for patients who have refractory disease.However,h...BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with azathioprine.Second-line treatments are needed for patients who have refractory disease.However,high-quality data on the alternative management of AIH are scarce.AIM To evaluate the efficacy and safety of tacrolimus and mycophenolate mofetil(MMF)and the quality of evidence by using the Grading of Recommendations Assessment,Development and Evaluation approach(GRADE).METHODS A systematic review and meta-analysis of the available data were performed.We calculated pooled event rates for three outcome measures:Biochemical remission,adverse events,and mortality,with their corresponding 95%confidence intervals(CI).RESULTS The pooled biochemical remission rate was 68.9%(95%CI:60.4-76.2)for tacrolimus,and 59.6%(95%CI:54.8-64.2)for MMF,and rates of adverse events were 25.5%(95%CI:12.4-45.3)for tacrolimus and 24.1%(95%CI:15.4-35.7)for MMF.The pooled mortality rate was estimated at 11.5%(95%CI:7.1-18.1)for tacrolimus and 9.01%(95%CI:6.2-12.8)for MMF.Pooled biochemical remission rates for tacrolimus and MMF in patients with intolerance to standard therapy were 56.6%(CI:43.4-56.6)vs 73.5%(CI:58.1-84.7),and among non-responders were 59.1%(CI:48.7-68.8)vs 40.8%(CI:32.3-50.0),respectively.Moreover,the overall quality assessments using GRADE proved to be very low for all our outcomes in both treatment groups.CONCLUSION Tacrolimus and MMF are in practice considered effective for patients with AIH who are non-responders or intolerant to first-line treatment,but we found no high-quality evidence to support this statement.展开更多
This opinion review considers the prevailing question of whether to screen or notto screen for adolescent idiopathic scoliosis. New and improved standards ofpeople-oriented care and person-centredness, as well as impr...This opinion review considers the prevailing question of whether to screen or notto screen for adolescent idiopathic scoliosis. New and improved standards ofpeople-oriented care and person-centredness, as well as improved principles ofpreventive screening and guideline development, have been postulated andimplemented in health care systems and cultures. Recommendations addressingscreening for scoliosis differ substantially, in terms of their content, standards ofdevelopment and screening principles. Some countries have discontinued issuingrecommendations. In the last decade, a number of updated and newrecommendations and statements have been released. Systematically developedguidelines and recommendations are confronted by consensus and opinion-basedstatements. The dilemmas and discrepancies prevail. The arguments concentrateon the issues of the need for early detection through screening in terms of theeffectiveness of early treatment, on costs and cost-effectiveness issues, scientificand epidemiologic value of screenings, and the credibility of the sources ofevidence. The problem matter is of global scale and applies to millions of people.It regards clinical and methodological dilemmas, but also the matter of vulnerableand fragile time of adolescence and, more generally, children’s rights. Thedecisions need to integrate people’s values and preferences – screening tests needto be acceptable to the population, and treatments need to be acceptable forpatients. Therefore we present one more crucial, but underrepresented in thediscussion, issue of understanding and implementation of the contemporaryprinciples of person-centred care, standards of preventive screening, andguideline development, in the context of screening for scoliosis.展开更多
This paper first analyzes the important role of Nanfan Base in China: " accelerator" for breeding new varieties of crops; " unallocated store" to ensure the varieties for agricultural production; &...This paper first analyzes the important role of Nanfan Base in China: " accelerator" for breeding new varieties of crops; " unallocated store" to ensure the varieties for agricultural production; " lightning rod" to ensure the quality and safety of seeds; " big stage" for variety and technical exchanges and cooperation; " big school" for cultivating seed industry technology talents; " booster" for promoting local economic development. Then it points out the main problems about Nanfan Base and finally sets forth the relevant recommendations.展开更多
Background: Based on the transtheoretical model, the current study investigated whether awareness of physical activity(PA) recommendations had an impact on the stages of PA behavior change and levels of PA among Chine...Background: Based on the transtheoretical model, the current study investigated whether awareness of physical activity(PA) recommendations had an impact on the stages of PA behavior change and levels of PA among Chinese college students.Methods: In Study 1, with a cross-sectional study design, 9826 students were recruited, and their knowledge of international PA recommendations,PA stage distribution, and self-reported PA level were surveyed. Pearson's χ2 test was used to test whether those participants who were aware and not aware of PA guidelines were equally distributed across the stages of PA behavior, and independent t test was conducted to test the group difference in the actual levels of PA. In Study 2, 279 students who were not aware of the PA recommendations were randomly allocated to either an intervention group or a control group, and only those in the intervention group were presented with international PA guidelines. In both groups,students' PA stages and PA level were examined before the test and then 4 months post-test. Mc Nemar's test for correlated proportions and repeated-measures analysis of variance were conducted to examine the changes in PA stage membership and PA level after the intervention.Results: Study 1 results revealed that only 4.4% of the surveyed students had correct knowledge of PA recommendations. Those who were aware of the recommendations were in later stages of PA behavior(χ~2(4) = 167.19, p < 0.001). They were also significantly more physically active than those who were not aware of the recommendations(t(443.71) = 9.00, p < 0.001, Cohen's d = 0.53). Study 2 results demonstrated that the intervention group participants who were at the precontemplation and contemplation stages at the pre-test each progressed further in the PA stages in the post-test(χ~2(1) = 112.06, p < 0.001; χ~2(1) = 118.76, p = 0.03, respectively), although no significant change in PA level was observed(t(139) < 1, p = 0.89).Conclusion: The results showed that awareness of the PA recommendations was associated with higher stages and levels of PA behavior, and a brief educational exposure to PA recommendations led to improved stages of PA behavior but no change in the levels of PA among Chinese college students. More effective public health campaign strategies are needed to promote the dissemination of the PA recommendations and to raise the awareness of the Chinese student population.展开更多
Rural e-commerce and logistics development is of great significance to promote rural economic development and increase farmers' income. This paper analyzed existing problems in development of rural e-commerce and ...Rural e-commerce and logistics development is of great significance to promote rural economic development and increase farmers' income. This paper analyzed existing problems in development of rural e-commerce and logistics in China,mainly including objective restriction of rural e-commerce and logistics by economic level,relatively backward capital construction facilities,lack of logistics information service platform,and insufficient professional personnel,and shortage of rural logistics professional personnel,and weak financial support of government. On the basis of these problems,it came up with pertinent recommendations from government,enterprises,and rural areas.展开更多
The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific region.Emerging evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in p...The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific region.Emerging evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in patients with cardiovascular risk,and pre-existing mild-to-moderate DR.Fenofibrate has also been found to reduce maculopathy,and the need for laser treatment in these patients.Considering these benefits of fenofibrate,a group of experts from the fields of endocrinology and ophthalmology convened in May 2017,to discuss on the the mechanism of action,and clinical efficacy of fenofibrate in DR.The findings from key clinical studies on fenofibrate in DR were reviewed by the experts,and consensus statements were derived to define the role of fenofibrate in the prevention and treatment of DR.The statements were rated based on the GRADE criteria.An algorithm was also developed for the screening and treatment of DR in patients with type 2 diabetes(T2D),and the place of fenofibrate was defined in the algorithm.The expert recommendations,and the algorithm provided in this review will serve as a guide to the clinicians to reconsider the adjunctive use of fenofibrate for preventing the progression of DR in selected T2D patients.展开更多
Sampling studies in North Dakota conducted from 1994 to 2003 showed that variable-rate N application could be practically directed with zone soil sampling. Results from variable-rate N studies using zone soil sampling...Sampling studies in North Dakota conducted from 1994 to 2003 showed that variable-rate N application could be practically directed with zone soil sampling. Results from variable-rate N studies using zone soil sampling were often less than rewarding due in part to the use of a whole-field predicted yield-based formula for developing the N recommendation in each zone. Nitrogen rate studies on spring wheat and durum were established in 2005 through 2009 with the objective to reexamine N recommendations and construct a new system if necessary. The results of the study and archived wheat N response data showed that the state should be divided into three separate N response regions. Within each region historic yields from low to high productivity were defined. The gross N rate was determined using the return-to-N concept developed in the US corn-belt states but with additional consideration for wheat protein value The gross N rate is then modified by credits for previous crop, soil test N from zone soil sampling, tillage systems, excessive straw from the previous year, relative susceptibility to nitrate leaching or denitrification. Finally, the user is encouraged to use common sense and consider whether particular fields have characteristics that require more or less N fertilizer than suggested by the recommendation formulas.展开更多
Although substantial advances have been made in treating ischemic heart disease and subsequent heart failure, the overall morbidity and mortality from these conditions remain high. Stem cell-based therapy has emerged ...Although substantial advances have been made in treating ischemic heart disease and subsequent heart failure, the overall morbidity and mortality from these conditions remain high. Stem cell-based therapy has emerged as a promising approach for prompting cardiac rejuvenation. Various cell types have been tested in the clinical arena, proving consistent safety results. As for efficiency outcomes, contradictory findings have been reported, partly due to inconsistency in study protocols but also due to poor survival, engraftment and differentiation of transplanted cells in the hostile milieu of the ischemic host tissue. Studies have varied in terms of route of delivery, type and dose of implanted stem cells, patient selection and randomization, and assessment of therapeutic effect. Founded on the main achievements and challenges within almost 20 years of research, a number of official documents have been published by leading experts in the field. Core recommendations have focused on developing and optimizing effective strategies to enrich cell retention and their regenerative potential. Issued consensus and position papers have stemmed from an unmet need to provide a harmonized framework for future research, resulting in improved therapeutic application of cell-based therapies for cardiac regeneration and repair.展开更多
The development of information technology has changed people's learning methods. Fragmented learning,as an informal learning method,has become an important way to accept new knowledge and learn new technologies. T...The development of information technology has changed people's learning methods. Fragmented learning,as an informal learning method,has become an important way to accept new knowledge and learn new technologies. Through analyzing the connotation,characteristics,and advantages and disadvantages of fragmented learning,this paper came up with reasonable recommendations for fragmented learning. To truly become systematic and holistic knowledge,fragmented knowledge must be explored,understood,integrated and internalized. This paper is expected to play an important guiding role in building a lifelong learning society.展开更多
文摘This special issue of the Asian Journal of Andrology is fully dedicated to the thematic area of non-obstructive azoospermia(NOA),one of the most complex and challenging conditions in the realm of andrology,urology,and reproductive medicine.
基金upported by the Major Project of Guangzhou National Laboratory(GZNL2024A01002)National Key Plan for Scientific Research and Development of China(2022YFC2303802)+1 种基金National Natural Science Foundation of China(32170651&32370700)Hunan Provincial Natural Science Foundation of China(2024JJ2015).
文摘Dear Editor,Influenza viruses cause significant mortality and morbidity in humans.Vaccination is currently the most effective way to combat the virus(Perofsky and Nelson,2020).Unfortunately,the influenza virus frequently changes its antigenicity through rapid mutations,leading to decreased vaccine efficacy or even failure.To improve vaccine effectiveness,it is necessary to monitor antigenic variation and update vaccine strains when significant antigenic variation occurs(Perofsky and Nelson,2020;Malik et al.,2024).
文摘This paper examines the impact of algorithmic recommendations and data-driven marketing on consumer engagement and business performance.By leveraging large volumes of user data,businesses can deliver personalized content that enhances user experiences and increases conversion rates.However,the growing reliance on these technologies introduces significant risks,including privacy violations,algorithmic bias,and ethical concerns.This paper explores these challenges and provides recommendations for businesses to mitigate associated risks while optimizing marketing strategies.It highlights the importance of transparency,fairness,and user control in ensuring responsible and effective data-driven marketing.
基金supported by the Princess Nourah bint Abdulrahman University Researchers Supporting Project Number(PNURSP2025R259)Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia+1 种基金supported by the Researchers Supporting Project Number(UM-DSR-IG-2023-07)Almaarefa University,Riyadh,Saudi Arabia.
文摘With the increasing complexity of hotel selection,traditional decision-making models often struggle to account for uncertainty and interrelated criteria.Multi-criteria decision-making(MCDM)techniques,particularly those based on fuzzy logic,provide a robust framework for handling such challenges.This paper presents a novel approach to MCDM within the framework of Circular Intuitionistic Fuzzy Sets(C-IFS)by combining three distinct methodologies:Weighted Aggregated Sum Product Assessment(WASPAS),an Alternative Ranking Order Method Accounting for Two-Step Normalization(AROMAN),and the CRITIC method(Criteria Importance Through Inter-criteria Correlation).To address the dynamic nature of traveler preferences in hotel selection,the study employs a comprehensive set of criteria encompassing aspects such as location proximity,amenities,pricing,customer reviews,environmental impact,safety,booking flexibility,and cultural experiences.The CRITIC method is used to determine the importance of each criterion by assessing intercriteria correlations.AROMAN is employed for the systematic evaluation of alternatives,considering their additive relationships and providing a weighted assessment.WASPAS further analyzes the results obtained from AROMAN,incorporating both positive and negative aspects for a comprehensive evaluation.The integration of C-IFS enhances the model’s ability to manage uncertainty and imprecision in the decision-making process.Through a case study,we demonstrate the effectiveness of this integrated approach,offering decision-makers valuable insights for selecting the most suitable hotel option in alignment with the diverse preferences of contemporary travelers.This research contributes to the evolving field of decision science by showcasing the practical applicability of these methodologies within a C-IFS framework for complex decision scenarios.
基金Supported by Key R&D Projects of Hunan Provincial Department of Science and Technology"Study on Key Modern Processing Techniques and Product Development of Huarong Mustard"(2023NK2039).
文摘A survey conducted on the premature bolting of Huarong large leaf mustard from 2018 to 2024 revealed that Huarong large leaf mustard sown in middle August was associated with a higher propensity for premature bolting. Furthermore, it was observed that the earlier being sown, the greater the rate of premature bolting when being sown prior to middle August. The rate of premature bolting observed in seedlings sown on August 8 was recorded at 35.6%. It was noted that as the age of the seedlings increased, the rate of premature bolting correspondingly increased. There were notable differences in the tolerance of various cultivars to elevated temperatures and prolonged sunlight exposure. For instance, cultivars such as Zhangjie 1 and Sichuan Shaguodi, which exhibit greater heat resistance, did not demonstrate premature bolting when sown in early August. The prolonged exposure to elevated temperatures, drought conditions, and extended periods of sunlight during the seedling stage of Huarong large leaf mustard, coupled with delayed irrigation and transplantation, contributed to the occurrence of premature bolting. The Huarong large leaf mustard, when been sown from late August to early September and transplanted at the appropriate time, exhibited normal growth and development, with no instances of premature bolting observed. It is advisable to select heat-resistant varieties, such as Zhangjie 1, prior to middle August. Huarong large leaf mustard should be sown in early to middle September. Additionally, it is essential to ensure centralized production and timely release of seeds, prompt transplantation and harvesting, and enhance the management of pests and diseases.
基金funded by the Deanship of Scientific Research at Jouf University under Grant number DSR-2022-RG-0101。
文摘As legal cases grow in complexity and volume worldwide,integrating machine learning and artificial intelligence into judicial systems has become a pivotal research focus.This study introduces a comprehensive framework for verdict recommendation that synergizes rule-based methods with deep learning techniques specifically tailored to the legal domain.The proposed framework comprises three core modules:legal feature extraction,semantic similarity assessment,and verdict recommendation.For legal feature extraction,a rule-based approach leverages Black’s Law Dictionary and WordNet Synsets to construct feature vectors from judicial texts.Semantic similarity between cases is evaluated using a hybrid method that combines rule-based logic with an LSTM model,analyzing the feature vectors of query cases against a legal knowledge base.Verdicts are then recommended through a rule-based retrieval system,enhanced by predefined legal statutes and regulations.By merging rule-based methodologies with deep learning,this framework addresses the interpretability challenges often associated with contemporary AImodels,thereby enhancing both transparency and generalizability across diverse legal contexts.The system was rigorously tested using a legal corpus of 43,000 case laws across six categories:Criminal,Revenue,Service,Corporate,Constitutional,and Civil law,ensuring its adaptability across a wide range of judicial scenarios.Performance evaluation showed that the feature extraction module achieved an average accuracy of 91.6%with an F-Score of 95%.The semantic similarity module,tested using Manhattan,Euclidean,and Cosine distance metrics,achieved 88%accuracy and a 93%F-Score for short queries(Manhattan),89%accuracy and a 93.7%F-Score for medium-length queries(Euclidean),and 87%accuracy with a 92.5%F-Score for longer queries(Cosine).The verdict recommendation module outperformed existing methods,achieving 90%accuracy and a 93.75%F-Score.This study highlights the potential of hybrid AI frameworks to improve judicial decision-making and streamline legal processes,offering a robust,interpretable,and adaptable solution for the evolving demands of modern legal systems.
文摘In sub-Saharan Africa(SSA),63%of new human immunodeficiency virus(HIV)infections in 2021 were among women,particularly adolescent girls,and young women.There is a high incidence of HIV among pregnant and lactating women(PLW)in SSA.It is estimated that the risk of HIV-acquisition during pregnancy and the postpartum period more than doubles.In this article,we discuss the safety and effectiveness of drugs used for oral HIV pre-exposure prophylaxis(PrEP),considerations for initiating PrEP in PLW,the barriers to initiating and adhering to PrEP among them and suggest recommendations to address these barriers.Tenofovir/emtricitabine,the most widely used combination in SSA,is safe,clinically effective,and cost-effective among PLW.Any PLW who requests PrEP and has no medical contraindications should receive it.PrEP users who are pregnant or lactating may experience barriers to starting and adhering for a variety of reasons,including personal,pill-related,and healthcare facility-related issues.To address the barriers,we recommend an increased provision of information on PrEP to the women and the communities,increasing and/or facilitating access to PrEP among the PLW,and developing strategies to increase adherence.
基金the European Union-Next Generation EU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,No.BG-RRP-2.004-0008.
文摘Solid organ transplant recipients face unique challenges in managing their im-munosuppressed status,making vaccination a critical consideration.This review aimed to comprehensively analyze current recommendations,evaluate the effi-cacy of vaccinations in this population,and assess safety concerns.We explored the latest evidence on vaccine types,timing,and potential benefits for transplant patients,highlighting the importance of individualized approaches for routinely used vaccines as well as coronavirus disease 2019 vaccines.By synthesizing avai-lable data,this review underscored the pressing need to optimize vaccination strategies,ensuring that transplant recipients can obtain the full protection against many pathogens while minimizing risks associated with their post-transplant immunosuppression.
文摘Introduction: Chest radiography is the most frequently prescribed imaging test in general practice in France. We aimed to assess the extent to which general practitioners follow the recommendations of the French National Authority for Health in prescribing chest radiography. Methodology: We conducted a retrospective analysis study, in two radiology centers belonging to the same group in Saint-Omer and Aire-sur-la-Lys, of requests for chest radiography sent by general practitioners over the winter period between December 22, 2013, and March 21, 2014, for patients aged over 18 years. Results: One hundred and seventy-seven requests for chest X-rays were analyzed, 71.75% of which complied with recommendations. The most frequent reason was the search for bronchopulmonary infection, accounting for 70.08% of prescriptions, followed by 11.2% for requests to rule out pulmonary neoplasia, whereas the latter reason did not comply with recommendations. Chest X-rays contributed to a positive diagnosis in 28.81% of cases. The positive diagnosis was given by 36.22% of the recommended chest X-rays, versus 10% for those not recommended. Conclusion: In most cases, general practitioners follow HAS recommendations for prescribing chest X-rays. Non-recommended chest X-rays do not appear to make a major contribution to diagnosis or patient management, confirming the value of following the recommendations of the French National Authority for Health.
文摘A Recommender System(RS)is a crucial part of several firms,particularly those involved in e-commerce.In conventional RS,a user may only offer a single rating for an item-that is insufficient to perceive consumer preferences.Nowadays,businesses in industries like e-learning and tourism enable customers to rate a product using a variety of factors to comprehend customers’preferences.On the other hand,the collaborative filtering(CF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested items.However,the cost of these computations increases nonlinearly as the number of items and users increases.To triumph over the issues,a novel expanded stacked autoencoder(ESAE)with Kernel Fuzzy C-Means Clustering(KFCM)technique is proposed with two phases.In the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the ESAE approach and users are clustered using the KFCM approach.In the next phase of online,the top-N recommendation prediction is made by the ESAE approach involving only the most similar user from multiple clusters.Hence the ESAE_KFCM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation time.An experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the ESAE_KFCM model constantly outperforms conventional RS algorithms on a variety of assessment measures.
基金Supported by a medical educational grant from Biocodex,France
文摘Recommendations for probiotics are available in several regions.This paper proposes recommendations for probiotics in pediatric gastrointestinal diseases in the Asia-Pacific region.Epidemiology and clinical patterns of intestinal diseases in Asia-Pacific countries were discussed.Evidence-based recommendations and randomized controlled trials in the region were revised.Cultural aspects,health management issues and economic factors were also considered.Final recommendations were approved by applying the Likert scale and rated using the GRADE system.Saccharomyces boulardii CNCM I-745(Sb)and Lactobacillus rhamnosus GG(LGG)were strongly recommended as adjunct treatment to oral rehydration therapy for gastroenteritis.Lactobacillus reuteri could also be considered.Probiotics may be considered for prevention of(with the indicated strains):antibiotic-associated diarrhea(LGG or Sb);Clostridium difficile-induced diarrhea(Sb);nosocomial diarrhea(LGG);infantile colic(L reuteri)and as adjunct treatment of Helicobacter pylori(Sb and others).Specific probiotics with a history of safe use in preterm and term infants may be considered in infants for prevention of necrotizing enterocolitis.There is insufficient evidence for recommendations in other conditions.Despite a diversity of epidemiological,socioeconomical and health system conditions,similar recommendations apply well to Asia pacific countries.These need to be validated with local randomized-controlled trials.
文摘BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with azathioprine.Second-line treatments are needed for patients who have refractory disease.However,high-quality data on the alternative management of AIH are scarce.AIM To evaluate the efficacy and safety of tacrolimus and mycophenolate mofetil(MMF)and the quality of evidence by using the Grading of Recommendations Assessment,Development and Evaluation approach(GRADE).METHODS A systematic review and meta-analysis of the available data were performed.We calculated pooled event rates for three outcome measures:Biochemical remission,adverse events,and mortality,with their corresponding 95%confidence intervals(CI).RESULTS The pooled biochemical remission rate was 68.9%(95%CI:60.4-76.2)for tacrolimus,and 59.6%(95%CI:54.8-64.2)for MMF,and rates of adverse events were 25.5%(95%CI:12.4-45.3)for tacrolimus and 24.1%(95%CI:15.4-35.7)for MMF.The pooled mortality rate was estimated at 11.5%(95%CI:7.1-18.1)for tacrolimus and 9.01%(95%CI:6.2-12.8)for MMF.Pooled biochemical remission rates for tacrolimus and MMF in patients with intolerance to standard therapy were 56.6%(CI:43.4-56.6)vs 73.5%(CI:58.1-84.7),and among non-responders were 59.1%(CI:48.7-68.8)vs 40.8%(CI:32.3-50.0),respectively.Moreover,the overall quality assessments using GRADE proved to be very low for all our outcomes in both treatment groups.CONCLUSION Tacrolimus and MMF are in practice considered effective for patients with AIH who are non-responders or intolerant to first-line treatment,but we found no high-quality evidence to support this statement.
基金We wish to deeply thank and,at the same time,dedicate this work to our Dear colleague and co-author,Professor Ejgil Jespersen,who sadly fell seriously ill.He has always been an advocate for the humanistic and personal way of treating every person,even when he or she happens to be in a role of a patient.We are grateful for his expertise,inspiration,and friendship.
文摘This opinion review considers the prevailing question of whether to screen or notto screen for adolescent idiopathic scoliosis. New and improved standards ofpeople-oriented care and person-centredness, as well as improved principles ofpreventive screening and guideline development, have been postulated andimplemented in health care systems and cultures. Recommendations addressingscreening for scoliosis differ substantially, in terms of their content, standards ofdevelopment and screening principles. Some countries have discontinued issuingrecommendations. In the last decade, a number of updated and newrecommendations and statements have been released. Systematically developedguidelines and recommendations are confronted by consensus and opinion-basedstatements. The dilemmas and discrepancies prevail. The arguments concentrateon the issues of the need for early detection through screening in terms of theeffectiveness of early treatment, on costs and cost-effectiveness issues, scientificand epidemiologic value of screenings, and the credibility of the sources ofevidence. The problem matter is of global scale and applies to millions of people.It regards clinical and methodological dilemmas, but also the matter of vulnerableand fragile time of adolescence and, more generally, children’s rights. Thedecisions need to integrate people’s values and preferences – screening tests needto be acceptable to the population, and treatments need to be acceptable forpatients. Therefore we present one more crucial, but underrepresented in thediscussion, issue of understanding and implementation of the contemporaryprinciples of person-centred care, standards of preventive screening, andguideline development, in the context of screening for scoliosis.
基金Supported by Fund Project of Hubei Agricultural Science and Technology Innovation Center(2007-620-003-03-05)
文摘This paper first analyzes the important role of Nanfan Base in China: " accelerator" for breeding new varieties of crops; " unallocated store" to ensure the varieties for agricultural production; " lightning rod" to ensure the quality and safety of seeds; " big stage" for variety and technical exchanges and cooperation; " big school" for cultivating seed industry technology talents; " booster" for promoting local economic development. Then it points out the main problems about Nanfan Base and finally sets forth the relevant recommendations.
基金partly supported by the China Scholarship Council (No. 201406010330)
文摘Background: Based on the transtheoretical model, the current study investigated whether awareness of physical activity(PA) recommendations had an impact on the stages of PA behavior change and levels of PA among Chinese college students.Methods: In Study 1, with a cross-sectional study design, 9826 students were recruited, and their knowledge of international PA recommendations,PA stage distribution, and self-reported PA level were surveyed. Pearson's χ2 test was used to test whether those participants who were aware and not aware of PA guidelines were equally distributed across the stages of PA behavior, and independent t test was conducted to test the group difference in the actual levels of PA. In Study 2, 279 students who were not aware of the PA recommendations were randomly allocated to either an intervention group or a control group, and only those in the intervention group were presented with international PA guidelines. In both groups,students' PA stages and PA level were examined before the test and then 4 months post-test. Mc Nemar's test for correlated proportions and repeated-measures analysis of variance were conducted to examine the changes in PA stage membership and PA level after the intervention.Results: Study 1 results revealed that only 4.4% of the surveyed students had correct knowledge of PA recommendations. Those who were aware of the recommendations were in later stages of PA behavior(χ~2(4) = 167.19, p < 0.001). They were also significantly more physically active than those who were not aware of the recommendations(t(443.71) = 9.00, p < 0.001, Cohen's d = 0.53). Study 2 results demonstrated that the intervention group participants who were at the precontemplation and contemplation stages at the pre-test each progressed further in the PA stages in the post-test(χ~2(1) = 112.06, p < 0.001; χ~2(1) = 118.76, p = 0.03, respectively), although no significant change in PA level was observed(t(139) < 1, p = 0.89).Conclusion: The results showed that awareness of the PA recommendations was associated with higher stages and levels of PA behavior, and a brief educational exposure to PA recommendations led to improved stages of PA behavior but no change in the levels of PA among Chinese college students. More effective public health campaign strategies are needed to promote the dissemination of the PA recommendations and to raise the awareness of the Chinese student population.
文摘Rural e-commerce and logistics development is of great significance to promote rural economic development and increase farmers' income. This paper analyzed existing problems in development of rural e-commerce and logistics in China,mainly including objective restriction of rural e-commerce and logistics by economic level,relatively backward capital construction facilities,lack of logistics information service platform,and insufficient professional personnel,and shortage of rural logistics professional personnel,and weak financial support of government. On the basis of these problems,it came up with pertinent recommendations from government,enterprises,and rural areas.
文摘The prevalence of diabetic retinopathy(DR),and associated morbidity is high in the Asia-Pacific region.Emerging evidence suggests a potential role for fenofibrate in the prevention of progression of DR,especially in patients with cardiovascular risk,and pre-existing mild-to-moderate DR.Fenofibrate has also been found to reduce maculopathy,and the need for laser treatment in these patients.Considering these benefits of fenofibrate,a group of experts from the fields of endocrinology and ophthalmology convened in May 2017,to discuss on the the mechanism of action,and clinical efficacy of fenofibrate in DR.The findings from key clinical studies on fenofibrate in DR were reviewed by the experts,and consensus statements were derived to define the role of fenofibrate in the prevention and treatment of DR.The statements were rated based on the GRADE criteria.An algorithm was also developed for the screening and treatment of DR in patients with type 2 diabetes(T2D),and the place of fenofibrate was defined in the algorithm.The expert recommendations,and the algorithm provided in this review will serve as a guide to the clinicians to reconsider the adjunctive use of fenofibrate for preventing the progression of DR in selected T2D patients.
文摘Sampling studies in North Dakota conducted from 1994 to 2003 showed that variable-rate N application could be practically directed with zone soil sampling. Results from variable-rate N studies using zone soil sampling were often less than rewarding due in part to the use of a whole-field predicted yield-based formula for developing the N recommendation in each zone. Nitrogen rate studies on spring wheat and durum were established in 2005 through 2009 with the objective to reexamine N recommendations and construct a new system if necessary. The results of the study and archived wheat N response data showed that the state should be divided into three separate N response regions. Within each region historic yields from low to high productivity were defined. The gross N rate was determined using the return-to-N concept developed in the US corn-belt states but with additional consideration for wheat protein value The gross N rate is then modified by credits for previous crop, soil test N from zone soil sampling, tillage systems, excessive straw from the previous year, relative susceptibility to nitrate leaching or denitrification. Finally, the user is encouraged to use common sense and consider whether particular fields have characteristics that require more or less N fertilizer than suggested by the recommendation formulas.
文摘Although substantial advances have been made in treating ischemic heart disease and subsequent heart failure, the overall morbidity and mortality from these conditions remain high. Stem cell-based therapy has emerged as a promising approach for prompting cardiac rejuvenation. Various cell types have been tested in the clinical arena, proving consistent safety results. As for efficiency outcomes, contradictory findings have been reported, partly due to inconsistency in study protocols but also due to poor survival, engraftment and differentiation of transplanted cells in the hostile milieu of the ischemic host tissue. Studies have varied in terms of route of delivery, type and dose of implanted stem cells, patient selection and randomization, and assessment of therapeutic effect. Founded on the main achievements and challenges within almost 20 years of research, a number of official documents have been published by leading experts in the field. Core recommendations have focused on developing and optimizing effective strategies to enrich cell retention and their regenerative potential. Issued consensus and position papers have stemmed from an unmet need to provide a harmonized framework for future research, resulting in improved therapeutic application of cell-based therapies for cardiac regeneration and repair.
基金Supported by Research Project on Education and Teaching Reform of Higher Education Institutions in Hainan Province(Hnjg2016-12)Education and Teaching Reform Research Project of Hainan University(hdjy1604)
文摘The development of information technology has changed people's learning methods. Fragmented learning,as an informal learning method,has become an important way to accept new knowledge and learn new technologies. Through analyzing the connotation,characteristics,and advantages and disadvantages of fragmented learning,this paper came up with reasonable recommendations for fragmented learning. To truly become systematic and holistic knowledge,fragmented knowledge must be explored,understood,integrated and internalized. This paper is expected to play an important guiding role in building a lifelong learning society.
