In the presented short clinical case of depression, the constructs of Research Domain Criteria (RDoC) of loss (negative valence systems) and cognitive control (cognitive systems) have been operationalized. It has been...In the presented short clinical case of depression, the constructs of Research Domain Criteria (RDoC) of loss (negative valence systems) and cognitive control (cognitive systems) have been operationalized. It has been concluded that a normal cognitive control of emotion, requiring the functional and structural integrity of prefrontal cortex (PFC) and orbitofrontal cortex (OFC), is lacking in depression, but its amelioration can be achieved through the implementation of cognitive remediation/rehabilitation programs. A mini-review on neural and cognitive markers and regulation of emotion in depression is previously presented.展开更多
We analyze certain mental automatisms appearing in the consciousness with phenomenological features of simple partial seizures (SPSs). We propose to include all these phenomena into a cognitive function to which we te...We analyze certain mental automatisms appearing in the consciousness with phenomenological features of simple partial seizures (SPSs). We propose to include all these phenomena into a cognitive function to which we term hyperia. In this paper, we analyze the similarities between the nature of this cognitive function and the mechanisms used by our brain to elicit neuronal plasticity.展开更多
With pharmaceutical companies’ repeated failures at finding effective interventions for Alzheimer’s disease, together with an increasing reliance on the growing Federal funding for research, there is an emergent opp...With pharmaceutical companies’ repeated failures at finding effective interventions for Alzheimer’s disease, together with an increasing reliance on the growing Federal funding for research, there is an emergent opportunity for financing alternate research through crowdfunding. Crowdfundingwhere funding is obtained from small donations from a large group of peoplehas become a new source of funding for medical research. By understanding how the research community has evolved to study Alzheimer’s disease the pitfalls of this strategy can be highlighted. Alzheimer’s disease research is complex. From its inception in the early 1900s, Alzheimer’s disease has been at the center of movement within psychiatry to define the disease on the basis of its biology. Recent emphasisthrough the DSM (Diagnostic and Statistical Manual of Mental Disorders), RDoC (Research Diagnostic Criteria), RDoC (Research Domain Criteria) as well as the more recent Framework from the U.S. National Institute on Aginghave supported an exclusive emphasis on biology. But by excluding other aspects of the disease, such as its clinical expression, this research approach will be shown to be faulty and contradictory. So far this approach has resulted in 100% failures. By examining the historical and financial circumstances of the industry centered on Alzheimer’s disease a strong warning is given to the public to mistrust crowdfunding Alzheimer’s disease research. A broader and more inclusive approach is likely to generate a better understanding of the disease and therefore hold better promise for understanding the disease in the long term. Such a nuance approach competes badly with the more binary search for a cure and is less receptive to public support through crowdfunding.展开更多
文摘In the presented short clinical case of depression, the constructs of Research Domain Criteria (RDoC) of loss (negative valence systems) and cognitive control (cognitive systems) have been operationalized. It has been concluded that a normal cognitive control of emotion, requiring the functional and structural integrity of prefrontal cortex (PFC) and orbitofrontal cortex (OFC), is lacking in depression, but its amelioration can be achieved through the implementation of cognitive remediation/rehabilitation programs. A mini-review on neural and cognitive markers and regulation of emotion in depression is previously presented.
文摘We analyze certain mental automatisms appearing in the consciousness with phenomenological features of simple partial seizures (SPSs). We propose to include all these phenomena into a cognitive function to which we term hyperia. In this paper, we analyze the similarities between the nature of this cognitive function and the mechanisms used by our brain to elicit neuronal plasticity.
文摘With pharmaceutical companies’ repeated failures at finding effective interventions for Alzheimer’s disease, together with an increasing reliance on the growing Federal funding for research, there is an emergent opportunity for financing alternate research through crowdfunding. Crowdfundingwhere funding is obtained from small donations from a large group of peoplehas become a new source of funding for medical research. By understanding how the research community has evolved to study Alzheimer’s disease the pitfalls of this strategy can be highlighted. Alzheimer’s disease research is complex. From its inception in the early 1900s, Alzheimer’s disease has been at the center of movement within psychiatry to define the disease on the basis of its biology. Recent emphasisthrough the DSM (Diagnostic and Statistical Manual of Mental Disorders), RDoC (Research Diagnostic Criteria), RDoC (Research Domain Criteria) as well as the more recent Framework from the U.S. National Institute on Aginghave supported an exclusive emphasis on biology. But by excluding other aspects of the disease, such as its clinical expression, this research approach will be shown to be faulty and contradictory. So far this approach has resulted in 100% failures. By examining the historical and financial circumstances of the industry centered on Alzheimer’s disease a strong warning is given to the public to mistrust crowdfunding Alzheimer’s disease research. A broader and more inclusive approach is likely to generate a better understanding of the disease and therefore hold better promise for understanding the disease in the long term. Such a nuance approach competes badly with the more binary search for a cure and is less receptive to public support through crowdfunding.
