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马缨杜鹃Rd3GT1的克隆及对矮牵牛花色形成的影响 被引量:2
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作者 孙威 张艳 +3 位作者 王聿晗 徐僡 徐小蓉 鞠志刚 《生物技术通报》 CAS CSCD 北大核心 2022年第9期198-206,共9页
类黄酮3-O-糖基转移酶(3GT)是花色素苷生物合成途径末端的酶,负责将糖基供体转移至花青素的3-OH位置,在增加花色素苷的稳定性与水溶性方面发挥重要作用。研究马缨杜鹃3GT在花色素苷生物合成中的功能,为马缨杜鹃花色形成及调控研究奠定... 类黄酮3-O-糖基转移酶(3GT)是花色素苷生物合成途径末端的酶,负责将糖基供体转移至花青素的3-OH位置,在增加花色素苷的稳定性与水溶性方面发挥重要作用。研究马缨杜鹃3GT在花色素苷生物合成中的功能,为马缨杜鹃花色形成及调控研究奠定基础。运用 RT-PCR 技术克隆获得马缨杜鹃3GT基因(Rd3GT1)全长CDS序列,并对其进行生物信息学分析,再利用DNA重组技术完成植物表达载体pBI121-Rd3GT1的构建,利用农杆菌介导法对矮牵牛进行遗传转化,同时对再生植株进行转基因及表型鉴定,并完成基因表达量及花色素苷检测分析。结果表明,Rd3GT1全长CDS序列为1 395 bp,编码464个氨基酸。蛋白多序列比对和系统进化分析表明,Rd3GT1属于3GT家族成员。与野生型相比,转Rd3GT1的矮牵牛植株花色由白色变为粉色,花色素苷与黄酮醇的积累显著增加,同时多个类黄酮合成相关基因表达显著升高。综上,Rd3GT1在花色素苷合成过程中发挥重要功能,可用于其它植物花色改良研究。 展开更多
关键词 马缨杜鹃 克隆 rd3GT1 遗传转化 花色素苷
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铁路客车RD3A1型轮对超声波探伤分析
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作者 王洪涛 《西铁科技》 2017年第4期37-38,共2页
《铁路客车轮轴组装检修及管理规则》中规定客车RD圳型轮对轮座镶入部进行超声波探伤时须使用横波探头:2.5MHz·K1.2;2.5MHz·K1.7;2.5MHz·K1.3。横波探头探伤扫查轮座镶入部区域时,探头移动区域须保证探头主声... 《铁路客车轮轴组装检修及管理规则》中规定客车RD圳型轮对轮座镶入部进行超声波探伤时须使用横波探头:2.5MHz·K1.2;2.5MHz·K1.7;2.5MHz·K1.3。横波探头探伤扫查轮座镶入部区域时,探头移动区域须保证探头主声柬扫查区域之和不小于轮座镶入部全长。但是经过计算,这三种型号的探头实际移动区域却不能满足此要求。应将其中的横波探头型号2.5MHz·K1.7修改为2.5MHz·K1.8,防止出现漏探的区域。 展开更多
关键词 rd3A1型轮对 超声波探伤 漏探
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黄连碱基于NF-κB信号通道的体外抗炎实验研究 被引量:20
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作者 潘晓丽 向晖 +1 位作者 谢运飞 熊永爱 《中国抗生素杂志》 CAS CSCD 北大核心 2013年第12期951-954,959,共5页
目的探讨黄连碱体外抗炎作用及其机制。方法采用LPS诱导RAW264.7巨噬细胞建立细胞炎症反应模型,用黄连碱对其进行干预,实验结束后,Western Blot技术检测RAW264.7巨噬细胞p-ERK1/2、IκBα和iNOS蛋白的表达。结果与LPS组比较,黄连碱可显... 目的探讨黄连碱体外抗炎作用及其机制。方法采用LPS诱导RAW264.7巨噬细胞建立细胞炎症反应模型,用黄连碱对其进行干预,实验结束后,Western Blot技术检测RAW264.7巨噬细胞p-ERK1/2、IκBα和iNOS蛋白的表达。结果与LPS组比较,黄连碱可显著下调LPS所致炎性RAW264.7巨噬细胞中p-ERK1/2和iNOS蛋白表达(P<0.05);显著升高IκBα蛋白的表达(P<0.05)。结论黄连碱抗炎作用机制与其下调LPS诱导的RAW264.7巨噬细胞ERK1/2蛋白磷酸化水平,减少IκB-α蛋白磷酸化降解和抑制iNOS蛋白表达等环节有关。 展开更多
关键词 黄连碱 抗炎模型 NF id3信号通道蛋白
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补体旁路激活产物刺激内皮细胞NF-κB、p38MAPK、JAK2通路活化及抑制剂的干预研究 被引量:12
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作者 李红玲 孙黔云 +1 位作者 李敏 石京山 《中国细胞生物学学报》 CAS CSCD 北大核心 2013年第6期836-841,共6页
研究补体旁路激活产物刺激人微血管内皮细胞NF-κB、p38MAPK、JAK2通路活化的作用及相关抑制剂对其活化的干预作用。采用眼镜蛇毒因子(cobra venom factor,CVF)特异激活血清补体旁路。将旁路活化的血清作用于人微血管内皮细胞,通过ELIS... 研究补体旁路激活产物刺激人微血管内皮细胞NF-κB、p38MAPK、JAK2通路活化的作用及相关抑制剂对其活化的干预作用。采用眼镜蛇毒因子(cobra venom factor,CVF)特异激活血清补体旁路。将旁路活化的血清作用于人微血管内皮细胞,通过ELISA测定NF-κB、p38MAPK及JAK2的活化情况,分别采用上述3个通路的抑制剂PDTC、SB203580、AG490干预其活化及黏附分子ICAM-1的表达。结果显示,补体旁路激活产物能导致人微血管内皮细胞JAK2、p38MAPK、NF-κB通路活化,分别在刺激2,15,30 min后,分别检测到3个通路的活化高峰;PDTC、SB203580、AG490可分别抑制NF-κB、p38MAPK、JAK2的活化。AG490对内皮细胞活化后的ICAM-1蛋白表达有明显的抑制作用,PDTC、SB203580对ICAM-1表达没有明显影响。表明AG490对JAK2通路的抑制可有效下调内皮细胞ICAM-1的表达,提示JAK2通路有可能是补体相关炎症的潜在干预靶点。 展开更多
关键词 补体 补体旁路途径 内皮细胞 核转录因子 丝裂原活化蛋白激酶 JANUS激酶 细胞间黏附分子 眼镜蛇毒因子
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雷帕霉素抑制糖尿病大鼠肾Akt/NF-κB信号通路介导的炎症反应的机制研究 被引量:6
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作者 徐麟皓 张晓明 王征 《中国细胞生物学学报》 CAS CSCD 2015年第9期1263-1270,共8页
该文探讨了雷帕霉素在抑制糖尿病大鼠肾脏中炎症反应的分子机制。30只SD大鼠随机分为三组:对照组、糖尿病组、雷帕霉素治疗组(1 mg/kg/d)。采用一次腹腔注射链脲佐菌素(streptozotocin,STZ,65 mg/kg)制备糖尿病模型。注射STZ 2 d后,雷... 该文探讨了雷帕霉素在抑制糖尿病大鼠肾脏中炎症反应的分子机制。30只SD大鼠随机分为三组:对照组、糖尿病组、雷帕霉素治疗组(1 mg/kg/d)。采用一次腹腔注射链脲佐菌素(streptozotocin,STZ,65 mg/kg)制备糖尿病模型。注射STZ 2 d后,雷帕霉素治疗组于皮下注射雷帕霉素,对照组和糖尿病组注射等量的生理盐水。实验结果表明,造模6周后,糖尿病组大鼠血清中肌酐和尿素氮含量增高,而雷帕霉素能够明显降低肌酐和尿素氮的表达水平(P<0.05)。苏木精–伊红染色显示,糖尿病大鼠中肾小囊变狭,基底膜完整性受损,肾小管上皮细胞肥大。同时,在糖尿病大鼠中,肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-6(interleukin-6,IL-6)、磷酸化蛋白激酶B(phosphorylated protein kinase B,p-Akt)及核转录因子-κB p65(nuclear transcription factor-κB p65,NF-κB p65)的表达均上升。而雷帕霉素能够改善肾病理结构,并降低TNF-α、IL-1β、IL-6、p-Akt和NF-κB p65的表达。雷帕霉素能够缓解糖尿病大鼠肾功能的损伤,而这与抑制Akt/NF-κB信号通路介导的炎症反应有关。 展开更多
关键词 雷帕霉素 糖尿病肾病 蛋白激酶B 核转录因子-ΚB P65
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UPLC法用于参麦注射液及其中间体的皂苷含量研究 被引量:7
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作者 曹树萍 聂黎行 +1 位作者 王钢力 林瑞超 《药物分析杂志》 CAS CSCD 北大核心 2014年第7期1264-1268,共5页
目的:建立超高效液相色谱法(UPLC)同时测定参麦注射液及其中间体中9个人参皂苷含量。方法:采用WATERS ACQUITY UPLC HSS T3色谱柱(100 mm×2.1 mm,1.8μm),流动相为乙腈(A)-水(B),梯度洗脱(0~8 min,2%A→10%A;8~16 min... 目的:建立超高效液相色谱法(UPLC)同时测定参麦注射液及其中间体中9个人参皂苷含量。方法:采用WATERS ACQUITY UPLC HSS T3色谱柱(100 mm×2.1 mm,1.8μm),流动相为乙腈(A)-水(B),梯度洗脱(0~8 min,2%A→10%A;8~16 min,10%A→22%A;16~18 min,22%A→22%A;18~30 min,22%A→46%A;30~36 min,46%A→60%A),流速为0.4 mL·min^-1,检测波长203 nm。结果:本法可在36 min内完成一次色谱分析,9个主要成分(Rg1、Re、Rf、Rb1、Rc、Rb2、Rb3、Rd和Rg3)色谱峰之间具有较好的分离度,回收率在95%~105%之间。结论:本法能同时测定参麦注射液及5个中间体中9个人参皂苷成分,可检测参麦注射液及中间体的质量,并可为生产企业改善工艺提供参考。 展开更多
关键词 参麦注射液 中间体 人参皂苷Rg1、Re、Rf、Rb1、Rc、Rb2、Rb3、Rd和Rg3 超高效液相色谱(UPLC) 质量控制
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Key Points in the Supervision of Road Landscaping Project——A Case Study of the South 3^(rd) Ring Road in Yanta District of Xi'an City,China 被引量:1
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作者 弓弼 魏代谋 《Journal of Landscape Research》 2011年第6期71-74,共4页
Characteristics of road landscaping were analyzed,as a kind of "linear" landscaping,it could be classified into urban street landscaping,urban ring road and expressway landscaping.Differences between road la... Characteristics of road landscaping were analyzed,as a kind of "linear" landscaping,it could be classified into urban street landscaping,urban ring road and expressway landscaping.Differences between road landscaping projects and other garden landscaping projects or construction projects were analyzed.Landscaping project for the South 3rd Ring Road of Xi'an City(in Yanta District)was taken for an example to summarize construction experience,discuss present conditions and features of garden landscaping supervision in China.The artistic and physiological properties of garden landscaping,as well as the supervision during maintenance period were stressed,but it was also pointed out that garden landscaping supervision in China was actually not given sufficient attention.On this basis,key points in the supervision of road landscaping project were proposed:understanding design ideas,selection of landscape plants,quality control of concealed works,prevention and control of diseases and insects,construction safety management and overall image;only by effectively implementing these key points,a high-quality road landscaping project could be realized to improve the image of a city and beautify its environment. 展开更多
关键词 ROAD LANDSCAPING project Construction SUPERVISION The SOUTH 3rd RING ROAD of Xi’an
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RD_(3A1)车轴卸荷槽部位腐蚀裂纹的失效分析 被引量:2
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作者 姜建东 秦世亮 《铁道车辆》 北大核心 2007年第1期38-39,共2页
在现场调研的基础上,对典型失效样品进行了失效分析,对表面腐蚀坑、裂纹进行了宏观和微观分析,表明裂纹是从表面腐蚀坑处萌生,沿着大体垂直于表面的方向向内穿晶扩展。结合RD3A1车轴卸荷槽部位的结构特点,阐述了车轴轴颈卸荷槽部位裂纹... 在现场调研的基础上,对典型失效样品进行了失效分析,对表面腐蚀坑、裂纹进行了宏观和微观分析,表明裂纹是从表面腐蚀坑处萌生,沿着大体垂直于表面的方向向内穿晶扩展。结合RD3A1车轴卸荷槽部位的结构特点,阐述了车轴轴颈卸荷槽部位裂纹产生的机理,为制定有效的预防措施提供了可靠的依据。 展开更多
关键词 rd3A1车轴 卸荷槽 腐蚀裂纹 失效
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RP-HPLC法测定西洋参茎叶中二醇皂苷5种成分含量 被引量:3
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作者 尹尚军 吴鸿雁 +1 位作者 徐芳菲 尹笠佥 《第三军医大学学报》 CAS CSCD 北大核心 2010年第7期658-660,共3页
目的建立反相高效液相色谱法(RP-HPLC)同时测定西洋参茎叶二醇皂苷中5个成分(人参皂苷Rb1、Rc、Rb2、Rb3、Rd)含量测定方法。方法采用高效液相色谱法。色谱柱AgilentTC-C18(4.6mm×250mm,5μm);乙腈-0.2%磷酸水溶液为流动相梯度洗脱... 目的建立反相高效液相色谱法(RP-HPLC)同时测定西洋参茎叶二醇皂苷中5个成分(人参皂苷Rb1、Rc、Rb2、Rb3、Rd)含量测定方法。方法采用高效液相色谱法。色谱柱AgilentTC-C18(4.6mm×250mm,5μm);乙腈-0.2%磷酸水溶液为流动相梯度洗脱;检测波长203nm;体积流量1.0ml/min;柱温40℃。结果5种成分均达到基线分离,线性良好。人参皂苷Rb1、Rc、Rb2、Rb3、Rd平均回收率分别为98.39%、97.36%、98.02%、97.70%、97.01%。结论该方法能快速、准确地测定西洋叁茎叶二醇皂苷5种成分的含量,而且重复性好。 展开更多
关键词 西洋参茎叶二醇皂苷 人参皂苷Rb1、Rc、Rb2、Rb3、Rd 高效液相色谱法
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卡介苗与结核菌野毒株的基因差异的研究进展
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作者 刘东旭 时坤 +1 位作者 李健明 杜锐 《吉林畜牧兽医》 2011年第4期7-10,共4页
人类结核已经存在数千年之久,无一个国家能幸免于难,尤其是第三国家。人们在感染结核病的同时也能感染艾滋病,这给人类的健康带来了巨大的挑战。现阶段,预防结核病的唯一方法就是接种BCG-减毒牛型结核分枝杆菌活疫苗。该疫苗是在1908年,... 人类结核已经存在数千年之久,无一个国家能幸免于难,尤其是第三国家。人们在感染结核病的同时也能感染艾滋病,这给人类的健康带来了巨大的挑战。现阶段,预防结核病的唯一方法就是接种BCG-减毒牛型结核分枝杆菌活疫苗。该疫苗是在1908年,由Leon Calmette和Camile Guerin将一株牛型结核分枝杆菌强毒株经历13年230次传代培养,使其毒力发生变异,成为对人无致病性,而保持了良好的免疫原性的菌株。本文主要是探讨结核分枝杆菌,牛型结核分枝杆菌和卡介苗之间的基因的差异。为卡介苗的改良和结核病的检测提供有益借鉴。 展开更多
关键词 卡介苗 结核分枝杆菌 牛型结核分枝杆菌 基因差异 RD1RD2rd3
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黄河三角洲盐碱土壤来源真菌Penicillium terrigenum RD 4-3次级代谢产物及其抗炎抗肿瘤活性
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作者 张臻 苗双 +3 位作者 齐世洲 武艳 蔡国伟 宫凯凯 《山东大学学报(医学版)》 CAS 北大核心 2024年第3期28-38,共11页
目的研究黄河三角洲盐碱土壤中真菌Penicillium terrigenum RD 4-3的次级代谢产物及其生物活性。方法采用多种色谱分离技术对真菌液态发酵次级代谢产物进行分离纯化,并根据化合物的理化性质及波谱数据进行结构鉴定,同时进行细胞毒活性... 目的研究黄河三角洲盐碱土壤中真菌Penicillium terrigenum RD 4-3的次级代谢产物及其生物活性。方法采用多种色谱分离技术对真菌液态发酵次级代谢产物进行分离纯化,并根据化合物的理化性质及波谱数据进行结构鉴定,同时进行细胞毒活性和NO检测,探究其抗肿瘤与抗炎活性。结果最终从Penicillium terrigenum RD 4-3发酵产物中分离鉴定14个单体化合物,分别为倍半萜类14-hydroxypetasol(1)、6-dehydropetasol(2)、isopetasol(3)、acremeremophilane G(4)、phomenone(6)、7-hydroxypetasol(7)、sporogen-AO1(9)、petasol(10)、JBIR-28(11)、JBIR-27(12)、3-acetyl-13-deoxyphome(13)、penicilleremophilane A(14),以及苯的衍生物3-chloro-4-hydroxypheylacetamide(5)、phenols(8),其中化合物1(14-hydroxypetasol)为新化合物。活性结果显示,化合物6(phomenone)和9(sporogen-AO1)对非小细胞肺癌细胞A549和H1299均具有显著的抗肿瘤活性,IC_(50)值均在10μmol/L以下。在浓度为50μmol/L时,化合物6(phomenone)、10(petasol)、11(JBIR-28)在LPS诱导的炎症模型中表现出一定的抗炎活性。初步的构效关系研究发现,6,7位的氧环结构可以显著提高化合物的抗肿瘤及抗炎活性。结论真菌Penicillium terrigenum RD 4-3的次级代谢产物中的倍半萜类在抗肿瘤抗炎先导化合物发现方面具有巨大研发潜力。 展开更多
关键词 黄河三角洲 真菌 Penicillium terrigenum RD 4-3 次级代谢产物 抗肿瘤活性 抗炎活性
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MT01/PEN复合物对人成骨样细胞MG63表达骨保护蛋白和核因子κB受体活化因子配体的影响 被引量:1
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作者 崔野 郑义 +3 位作者 申玉芹 侯旭 娄译心 孙新华 《华西口腔医学杂志》 CAS CSCD 北大核心 2016年第1期32-36,共5页
目的应用聚乙烯亚胺阳离子聚合物(PEN)载体装载寡脱氧核苷酸MT01,制备MT01/PEN复合物,检测该复合物对人成骨样细胞MG63表达骨保护蛋白(OPG)和核因子κB受体活化因子配体(RANKL)的影响。方法制备3种不同配比的MT01/PEN(质量比分别为1∶2... 目的应用聚乙烯亚胺阳离子聚合物(PEN)载体装载寡脱氧核苷酸MT01,制备MT01/PEN复合物,检测该复合物对人成骨样细胞MG63表达骨保护蛋白(OPG)和核因子κB受体活化因子配体(RANKL)的影响。方法制备3种不同配比的MT01/PEN(质量比分别为1∶2、1∶4、1∶6)复合物,以全硫代化修饰MT01(MT01-s)和未修饰的MT01作阳性对照,分别转染MG63细胞。采用酶联免疫吸附测定法和real-time聚合酶链反应法分别检测培养24、48、72 h时各组上清液及细胞内OPG和RANKL的表达水平。结果经MT01/PEN复合物转染后,上清液及细胞内OPG表达水平均升高(P<0.05);多数组中RANKL表达水平降低,而OPG/RANKL比值呈升高趋势(P<0.05);不同质量配比的MT01/PEN均对MG63细胞的成骨具有影响,其中质量比为1∶6时作用最明显。结论应用PEN作为基因载体装载MT01可增强MT01对MG63细胞的促成骨作用。 展开更多
关键词 人成骨样细胞MG63 寡脱氧核苷酸MT01 聚乙烯亚胺阳离子聚合物 骨保护蛋白 核因子κB受体 活化因子配体
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3G与物联网的融合概述
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作者 张晓蓉 《科技信息》 2013年第15期91-91,共1页
3G和物联网都是近些年出现的新的技术名词,广泛应用于日常生活中的各个方面。本文分别对其进行简要介绍,对日常生活中能见到的3G与物联网的融合的方式进行阐述和分析,并对二者融合的应用前景进行了展望。
关键词 3rd—generation 物联网 融合
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The 3rd Symposium on Animal Models of Primates——The Application of Non-Human Primates to Basic Research and Translational Medicine 被引量:4
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作者 Yong-Gang Yao Yong-Bin Chen Bin Liang 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2015年第6期339-341,共3页
In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabdi... In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish, have been established and used widely for many decades. The controllability of environmental conditions, the high reproducibility, the ease of scale and the comparability of results, as well as the ability to use different standards for ethical protocols, all make an animal model the ideal tool for carrying out studies on human diseases and the development of novel pharmaceuticals and new therapies (Xue et al., 2014). An ideal animal model should reflect the complete spectra of a specific human disease, with similar features on the following key issues: (1) genetic basis; (2) anatomy and physiology; (3) pathological response(s) and underlying mechanism(s); (4) phenotypic endpoints as clinical studies; (5) responsiveness to known drugs with clinical efficacy; and (6) prediction of clinical efficacy (McGonigle and Ruggeri, 2014). 展开更多
关键词 The 3rd Symposium on Animal Models of Primates The Application of Non-Human Primates to Basic Research and Translational Medicine
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Effects of bifenthrin on Daphnia magna during chronic toxicity test and the recovery test 被引量:2
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作者 YEWei-hong WENYue-zhong +1 位作者 LIUWei-ping WANGZhong-qiang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2004年第5期843-846,共4页
The acute and chronic toxic effects of bifenthrin on Daphnia magna were studied. The results showed that 24 h-EC 50 , 48 h-LC 50 and 96 h-LC 50 of bifenthrin on D. magna were 3.24, 12.40 and 1.40 μg/L r... The acute and chronic toxic effects of bifenthrin on Daphnia magna were studied. The results showed that 24 h-EC 50 , 48 h-LC 50 and 96 h-LC 50 of bifenthrin on D. magna were 3.24, 12.40 and 1.40 μg/L respectively. And the LOEC and NOEC of bifenthrin were 0.02 and 0.004 μg/L respectively. The recovery test of bifenthrin on Daphnia magna was presented. Daphnia magna(F 0 generation) were exposed during 21 d to different bifenthrin concentrations. Offspring(animals from the first and third brood: F 1(1st) and F 1(3rd), respectively) were transferred to a free pesticide medium during a 21 d recovery period. In this recovery study, survival, growth, reproduction(mean total young per female, onset of reproduction and number broods per female) and the intrinsic rate of natural increase (r) were assessed as parameters. Reproduction such as number of young per female as well as length was still reduced in F 1(1st) generation daphnids from parentals(F 0) exposed to the bifenthrin. However F 1(3rd) individuals from parentals exposed to pesticide concentrations were able to restore reproduction when a recovery period of 21 d was allowed, but the length of F 1(3rd) from parentals exposed to the 0.5 and 0.75 μg/L bifenthrin concentration was still significantly effected(P<0.05). 展开更多
关键词 BIFENTHRIN Daphnia magna parental generation(F 0) F 1(1st) and F 1(3rd) recovery test toxic test
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跨欧亚大陆交流的响应——新石器至青铜时代中国北方农业区、牧业区和农牧交错带生业模式演变过程及影响因素 被引量:1
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作者 董广辉 梁欢 +1 位作者 芦永秀 王佳 《Journal of Geographical Sciences》 SCIE CSCD 2024年第4期681-698,共18页
Significant spatiotemporal variation in human livelihood patterns and its relationship to trans-Eurasian exchange and climate change in north China during the late Neolithic and Bronze Age, has been intensively studie... Significant spatiotemporal variation in human livelihood patterns and its relationship to trans-Eurasian exchange and climate change in north China during the late Neolithic and Bronze Age, has been intensively studied in recent years, but the comprehensive influence of natural and social factors on this variation is not well understood. Therefore, we analyze archaeobotanical, zooarchaeological and carbon isotopic data from late Neolithic and Bronze Age sites in agricultural, pastoral, and agro-pastoral regions of north China. Our results demonstrate human subsistence strategies transformed at different speeds in these three geographic areas after wheat, barley, and sheep, goats, and cattle were introduced into north China. Introduced crops and livestock dominated human livelihoods in pastoral regions and became important subsistence in areas above ~1500 m a.s.l. in agro-pastoral regions after ~3600 BP. In agricultural regions, indigenous millet crops were the most important subsistence throughout 6000– 2200 BP, but wheat use increased significantly around 2700 BP. Our study suggests that the introduction of new crops and herbivorous livestock related to the prehistoric trans-Eurasian exchange, and their adaptive advantage in high-cold environments might have rapidly facilitated human adaptability and social development in pastoral regions and northwest margin of agro-pastoral regions during the Bronze Age. 展开更多
关键词 subsistence strategy 6th–3rd Millennium BP north China human-land relation long-distance exchange
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Review of the treatment of metastatic non small cell lung carcinoma:A practical approach 被引量:1
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作者 Vera Hirsh 《World Journal of Clinical Oncology》 CAS 2011年第6期262-271,共10页
In recent years,as we have a better knowledge and understanding of the biology of non small cell lung carcinoma(NSCLC),which leads us to targeting biomarkers driving the NSCLC carcinogenesis and metastatic potential,w... In recent years,as we have a better knowledge and understanding of the biology of non small cell lung carcinoma(NSCLC),which leads us to targeting biomarkers driving the NSCLC carcinogenesis and metastatic potential,we now have an increased number of options to offer our patients with NSCLC.We also realize the importance of distinguishing squamous and non squamous histology to guide our treatment decisions of NSCLC.The palliative care concomitant with therapies from the very start of the treatment also showed an impact on survival.This review examines the treatment options in all lines of therapy for metastatic NSCLC that have been approved in Canada,the United States,or Europe. 展开更多
关键词 METASTATIC Non small cell LUNG CARCINOMA 1st LINE 2nd LINE 3rd LINE TREATMENT
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3rd Definition of SHRM: HR Systems Approach 被引量:1
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作者 Gurhan Uysal 《Management Studies》 2019年第5期496-501,共6页
First definition of SHRM is made by Devanna, Tichy and Fonbrum (1981, 1984). It is Michigan model. 1st definition relates HRM with strategic management. i.e., HRM affects firm-level strategies. Second definition is ma... First definition of SHRM is made by Devanna, Tichy and Fonbrum (1981, 1984). It is Michigan model. 1st definition relates HRM with strategic management. i.e., HRM affects firm-level strategies. Second definition is made by Wright and McMahan (1992). It relates HRM with performance. There exists direct relations between HRM and firm performance. Innovation capability of human resources provides of linear relation between HR and performance. HR make innovations, and it increases firm performance. This is linear relations in American HRM (HR (innovation)→ performance). This study makes 3rd definition in SHRM. It relates performance with HR systems. Accordingly, HR applies HR systems in organizations that increases employee’s individual performance. and individual performance has impact on firm performance. In 3rd definition there is relation between HR system and performance through individual performance. Moderator is individual performance. 展开更多
关键词 SHRM 3rd DEFINITION HR SYSTEMS INDIVIDUAL PERFORMANCE FIRM PERFORMANCE
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Advanced endoscopic imaging to improve adenoma detection 被引量:1
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作者 Helmut Neumann Andreas Ngel Andrea Buda 《World Journal of Gastrointestinal Endoscopy》 CAS 2015年第3期224-229,共6页
Advanced endoscopic imaging is revolutionizing our way on how to diagnose and treat colorectal lesions. Within recent years a variety of modern endoscopic imaging techniques was introduced to improve adenoma detection... Advanced endoscopic imaging is revolutionizing our way on how to diagnose and treat colorectal lesions. Within recent years a variety of modern endoscopic imaging techniques was introduced to improve adenoma detection rates. Those include high-definition imaging, dye-less chromoendoscopy techniques and novel, highly flexible endoscopes, some of themequipped with balloons or multiple lenses in order to improve adenoma detection rates. In this review we will focus on the newest developments in the field of colonoscopic imaging to improve adenoma detection rates. Described techniques include high-definition imaging, optical chromoendoscopy techniques, virtual chromoendoscopy techniques, the Third Eye Retroscope and other retroviewing devices, the G-EYE endoscope and the Full Spectrum Endoscopy-system. 展开更多
关键词 ADVANCED endoscopic IMAGING G-Eye Full Spectrum Endoscopy-system CHROMOENDOSCOPY I-scan Narrow band IMAGING Fujinon Intelligent ColorEnhancement 3rd Eye POLYPS COLORECTAL cancer
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Decoding the Information of Life 被引量:1
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作者 ShantilalG. Goradia 《Journal of Physical Science and Application》 2015年第3期191-195,共5页
We link nuclear force with gravity. We use statistical entropy to link fine-structure constant (ct) and cosmological constant, showing mystical number 137 (as reciprocal of increasing entropy of the universe) as n... We link nuclear force with gravity. We use statistical entropy to link fine-structure constant (ct) and cosmological constant, showing mystical number 137 (as reciprocal of increasing entropy of the universe) as negative entropy needed for life to exist. If our computational route applies to the physical universe, it should apply to life. Molecular biology is searching for the fundamental source of information that would link to the information in DNA. 展开更多
关键词 3rd law of thermodynamics fine-structure constant cosmological constant strong coupling information.
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