[Objective] The study aimed at predicting the T cell epitopes from proteins encoded by the specific RD1 region of Mycobacterium tuberculosis.[Method] By using bioinformatics software NetMHC Server,all possible peptide...[Objective] The study aimed at predicting the T cell epitopes from proteins encoded by the specific RD1 region of Mycobacterium tuberculosis.[Method] By using bioinformatics software NetMHC Server,all possible peptides sequences from RD1 region of M.tuberculosis were analyzed in silico for the ability to bind to 34 alleles of HLA I and 9 alleles of HLA II.[Result] 1 580 peptides binding to 9 alleles of HLA II and 336 peptides binding to 34 alleles of HLA I were obtained by predication.[Conclusion] Identification of T cell epitopes from the proteins encoded by RD1 region may serve to define candidate antigens with potentials in specific diagnosis and development of new vaccines against TB.展开更多
基金Supported by National Science and Technology Major Project(2008ZX10301)~~
文摘[Objective] The study aimed at predicting the T cell epitopes from proteins encoded by the specific RD1 region of Mycobacterium tuberculosis.[Method] By using bioinformatics software NetMHC Server,all possible peptides sequences from RD1 region of M.tuberculosis were analyzed in silico for the ability to bind to 34 alleles of HLA I and 9 alleles of HLA II.[Result] 1 580 peptides binding to 9 alleles of HLA II and 336 peptides binding to 34 alleles of HLA I were obtained by predication.[Conclusion] Identification of T cell epitopes from the proteins encoded by RD1 region may serve to define candidate antigens with potentials in specific diagnosis and development of new vaccines against TB.
