In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabdi...In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish, have been established and used widely for many decades. The controllability of environmental conditions, the high reproducibility, the ease of scale and the comparability of results, as well as the ability to use different standards for ethical protocols, all make an animal model the ideal tool for carrying out studies on human diseases and the development of novel pharmaceuticals and new therapies （Xue et al., 2014）. An ideal animal model should reflect the complete spectra of a specific human disease, with similar features on the following key issues： （1） genetic basis; （2） anatomy and physiology; （3） pathological response（s） and underlying mechanism（s）; （4） phenotypic endpoints as clinical studies; （5） responsiveness to known drugs with clinical efficacy; and （6） prediction of clinical efficacy （McGonigle and Ruggeri, 2014）.展开更多
Single SAR image direct positioning is to determine the ground coordinate for each pixel in the SAR image assisted with a reference DEM.During this procedure,an iterative procedure is essentially needed to solve the u...Single SAR image direct positioning is to determine the ground coordinate for each pixel in the SAR image assisted with a reference DEM.During this procedure,an iterative procedure is essentially needed to solve the uncertainty in elevation of each pixel in the SAR image.However,such an iterative procedure may suffer from the problem of divergence in shaded and serious layover areas.To investigate this problem,we performed a theoretical analysis on the convergence conditions that has not been intensively studied till now.The Range-Doppler(RD)model was simplified and then the general surface is degenerated into a planar surface.Mathematical deduction was then carried out to derive the convergence conditions and the impact factors for the convergence speed were evaluated.The theoretical findings were validated by experiments for both simulated and real scenarios.展开更多
文摘In order to understand the fundamental questions of the biology of life and to duplicate the pathogenesis of human diseases, animal models using different experimental animals, such as rodents, Drosophila, Caenorhabditis elegans, and zebrafish, have been established and used widely for many decades. The controllability of environmental conditions, the high reproducibility, the ease of scale and the comparability of results, as well as the ability to use different standards for ethical protocols, all make an animal model the ideal tool for carrying out studies on human diseases and the development of novel pharmaceuticals and new therapies （Xue et al., 2014）. An ideal animal model should reflect the complete spectra of a specific human disease, with similar features on the following key issues： （1） genetic basis; （2） anatomy and physiology; （3） pathological response（s） and underlying mechanism（s）; （4） phenotypic endpoints as clinical studies; （5） responsiveness to known drugs with clinical efficacy; and （6） prediction of clinical efficacy （McGonigle and Ruggeri, 2014）.
基金The authors would like to thank the German Aerospace Center(DLR)for providing the test data-sets via the DLR AO LAN0793 and LAN0634,and Prof.Miaozhong Xu of LIESMARS for providing the photogrammetric DEM with spatial resolution of 3 mThis work was supported by the National Natural Science Foundation of China[grant number 41271457]the Demonstration System of High Resolution Remote Sensing Applications in Urban Fine Management Area[grant number 06-Y30B04–9002-13/15].
文摘Single SAR image direct positioning is to determine the ground coordinate for each pixel in the SAR image assisted with a reference DEM.During this procedure,an iterative procedure is essentially needed to solve the uncertainty in elevation of each pixel in the SAR image.However,such an iterative procedure may suffer from the problem of divergence in shaded and serious layover areas.To investigate this problem,we performed a theoretical analysis on the convergence conditions that has not been intensively studied till now.The Range-Doppler(RD)model was simplified and then the general surface is degenerated into a planar surface.Mathematical deduction was then carried out to derive the convergence conditions and the impact factors for the convergence speed were evaluated.The theoretical findings were validated by experiments for both simulated and real scenarios.
