Objective:To assess inter-and intraobserver reproducibility for measuring perfusion CT derived cerebral blood volume (CBV) and relative cerebral blood volume (rCBV) with different slice thickness in patients with brai...Objective:To assess inter-and intraobserver reproducibility for measuring perfusion CT derived cerebral blood volume (CBV) and relative cerebral blood volume (rCBV) with different slice thickness in patients with brain neoplasms. Meth- ods: Three independent observers who were blinded to the histopathologic diagnosis performed perfusion derived CBV and rCBV measurements with 5 mm and 10 mm slice thickness in 52 patients with various cerebral neoplasms. The results of the measurements with different slice thickness were compared. Calculation of coefficient of variation (CV), and relative paired difference of the measurements were used to determine the levels of inter- and intraobserver reproducibility. Results: The differences of CBV and rCBV measurements between different slice thickness groups were statistically significant (P < 0.05) respectively in observer 2, and were not significant in the other two observers (P > 0.05). For the same slice thickness, both the difference of CBV and rCBV measurements among the three observers were not statistically significant. Interobserver CV and relative paired difference of the measurements with 10 mm slice thickness group were slightly lower than those of 5 mm slice thickness group. Interobserver CV and relative paired difference of CBV group were slightly lower than those of rCBV group. The intraobserver differences of CBV and rCBV in 10 mm slice thickness group were statistically significant for observer 2 respectively. No other intraobserver differences of measurements were statistically significant. CV and relative paired difference of intraobserver CBV and rCBV measurements for observer 2 were significantly higher than for the other two observers. Conclusion: High reproducibility of CBV and rCBV measurements was acquired with the two different slice thickness. Suitable training may be helpful to maintain a high level of consistency for measurements.展开更多
目的探讨脑血疏口服液联合甘油果糖治疗脑出血的临床疗效。方法选取2017年2月—2018年1月在洛阳市第一人民医院进行治疗的76例脑出血患者为研究对象,根据用药的差别分为对照组和治疗组,每组各38例。对照组静脉滴注甘油果糖氯化钠注射液5...目的探讨脑血疏口服液联合甘油果糖治疗脑出血的临床疗效。方法选取2017年2月—2018年1月在洛阳市第一人民医院进行治疗的76例脑出血患者为研究对象,根据用药的差别分为对照组和治疗组,每组各38例。对照组静脉滴注甘油果糖氯化钠注射液500 m L/次,每次1~1.5 h,2次/d;治疗组在对照组治疗基础上口服脑血疏口服液,10 m L/次,3次/d。两组均经过4周治疗后进行效果比较。观察两组的临床疗效,比较两组治疗前后NIHSS评分、血肿量、周围水肿量、相关临床指标、脑灌注参数、血清学指标的变化情况。结果治疗后,对照组和治疗组的总有效率分别为81.58%、97.37%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分、血肿量、周围水肿量、平均通过时间(MTT)较治疗前均明显降低,脑血流量(rCBF)、相对脑血容量(rCBV)显著升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组NIHSS评分、血肿量、周围水肿量、MTT均明显小于对照组,rCBF、rCBV显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)、白细胞介素-1β(IL-1β)水平均降低,而胰岛素样生长因子-1(IGF-1)水平均增高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,hs-CRP、MMP-9、IL-1β水平低于对照组,IGF-1水平高于对照组,两组比较差异具有统计学意义(P<0.05)。结论脑血疏口服液联合甘油果糖治疗脑出血具有较好的临床疗效,可有效改善患者神经功能,有利于减轻血肿周围组织低灌注损伤,促进血肿吸收,改善机体炎症反应,具有一定的临床推广应用价值。展开更多
文摘Objective:To assess inter-and intraobserver reproducibility for measuring perfusion CT derived cerebral blood volume (CBV) and relative cerebral blood volume (rCBV) with different slice thickness in patients with brain neoplasms. Meth- ods: Three independent observers who were blinded to the histopathologic diagnosis performed perfusion derived CBV and rCBV measurements with 5 mm and 10 mm slice thickness in 52 patients with various cerebral neoplasms. The results of the measurements with different slice thickness were compared. Calculation of coefficient of variation (CV), and relative paired difference of the measurements were used to determine the levels of inter- and intraobserver reproducibility. Results: The differences of CBV and rCBV measurements between different slice thickness groups were statistically significant (P < 0.05) respectively in observer 2, and were not significant in the other two observers (P > 0.05). For the same slice thickness, both the difference of CBV and rCBV measurements among the three observers were not statistically significant. Interobserver CV and relative paired difference of the measurements with 10 mm slice thickness group were slightly lower than those of 5 mm slice thickness group. Interobserver CV and relative paired difference of CBV group were slightly lower than those of rCBV group. The intraobserver differences of CBV and rCBV in 10 mm slice thickness group were statistically significant for observer 2 respectively. No other intraobserver differences of measurements were statistically significant. CV and relative paired difference of intraobserver CBV and rCBV measurements for observer 2 were significantly higher than for the other two observers. Conclusion: High reproducibility of CBV and rCBV measurements was acquired with the two different slice thickness. Suitable training may be helpful to maintain a high level of consistency for measurements.
文摘目的探讨脑血疏口服液联合甘油果糖治疗脑出血的临床疗效。方法选取2017年2月—2018年1月在洛阳市第一人民医院进行治疗的76例脑出血患者为研究对象,根据用药的差别分为对照组和治疗组,每组各38例。对照组静脉滴注甘油果糖氯化钠注射液500 m L/次,每次1~1.5 h,2次/d;治疗组在对照组治疗基础上口服脑血疏口服液,10 m L/次,3次/d。两组均经过4周治疗后进行效果比较。观察两组的临床疗效,比较两组治疗前后NIHSS评分、血肿量、周围水肿量、相关临床指标、脑灌注参数、血清学指标的变化情况。结果治疗后,对照组和治疗组的总有效率分别为81.58%、97.37%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分、血肿量、周围水肿量、平均通过时间(MTT)较治疗前均明显降低,脑血流量(rCBF)、相对脑血容量(rCBV)显著升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组NIHSS评分、血肿量、周围水肿量、MTT均明显小于对照组,rCBF、rCBV显著高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)、白细胞介素-1β(IL-1β)水平均降低,而胰岛素样生长因子-1(IGF-1)水平均增高,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,hs-CRP、MMP-9、IL-1β水平低于对照组,IGF-1水平高于对照组,两组比较差异具有统计学意义(P<0.05)。结论脑血疏口服液联合甘油果糖治疗脑出血具有较好的临床疗效,可有效改善患者神经功能,有利于减轻血肿周围组织低灌注损伤,促进血肿吸收,改善机体炎症反应,具有一定的临床推广应用价值。
