Credit rationing has been an objective phenomenon in medium-small enterprises credit market of China. By analyzing the present situation of medium-small enterprises credit market of China, this study gives a new credi...Credit rationing has been an objective phenomenon in medium-small enterprises credit market of China. By analyzing the present situation of medium-small enterprises credit market of China, this study gives a new credit rationing model fitting medium-small enterprises credit market of China well. It has been showed in the empirical study that different factor has each different influence on medium-small enterprises credit market; further more, only the change of chastisement factor can make the medium-small enterprises credit market achieve whole success, but other factors can merely get integrant success even though under the most ideal condition.展开更多
This article models a novel driving-day-based tradable credit scheme (DD-TCS) to alleviate urban traffic congestion. In this model, car-using allowances (in terms of the number of days in a month, termed as "cred...This article models a novel driving-day-based tradable credit scheme (DD-TCS) to alleviate urban traffic congestion. In this model, car-using allowances (in terms of the number of days in a month, termed as "credit") are freely and uniformly allocated to all travellers, who are also allowed to trade them in a market according to his/her travel needs (e.g. driving more or fewer days than the free endowment). As opposed to most studies on TCS, this paper explicitly considers the transaction cost (e.g. infor-mation cost of finding potential traders) in the trading market. To assess the feasibility of DD-TCS, we compare it against the license plate rationing (LPR) scheme, which has been practically implemented in many cities such as Beijing and Chengdu in China. Taking the performance of LPR as a benchmark, we quantify the threshold values of the transaction cost in DD-TCS when the two schemes yield equivalent performance (in terms of the total gener-alized cost). In numerical studies, we also compare the DD-TCS and LPR with the no-action case and the congestion pricing case (representing the theoretical optimum). Results show that both DD-TCS and LPR outperform the no-action case under certain conditions. With small trans-action cost, DD-TCS may achieve a lower system cost that can be very close to the ideal optimum. In addition, parameter analysis shows that DD-TCS performs better than LPR in a wide range of transaction cost, where the threshold values appear to account for a considerable portion of the auto travel time. This implies that DD-TCS will be more appealing than LPR in practice because a transaction cost lower than the extremely large threshold values can be easily achieved for the trading market, e.g. via a mobile platform and modern communication techniques.展开更多
This paper conducts a survey of 237 rural households in Zhangjiagang City,identifies farmers' risk attitude through ELCE method and problem design and empirically studies the relationship between risk attitudes an...This paper conducts a survey of 237 rural households in Zhangjiagang City,identifies farmers' risk attitude through ELCE method and problem design and empirically studies the relationship between risk attitudes and credit rationing by utilizing Probit and Logit model. The results show that farmers' risk attitude and credit rationing are in a significant positive correlation. The stronger farmers' risk aversion is,the more serious the demanded credit rationing becomes. Such risk attitude determines the risk cost and risk premium,thus affecting the credit behavior and credit rationing degree. In addition,distance between farmers' residence far the city and their land amount have a positive significant influence on credit rationing,while farmers' education level,income,family labor force have a negative significant effect on credit rationing. Based on these findings,the paper further analyzes the relationship between farmers' credit using and credit rationing as to farmers with different risk attitudes. Measures to relieve the farmer's credit rationing must be taken from government,financial institutions and farmers,respectively.展开更多
Because of the amalgamation of coal resourcesin Shanxi Province in 2009, coal production centermoved westward in China. The coal outputs of InnerMongolia and Shaanxi got higher. From January
By analyzing the financing difficulties faced by the small and medium-sized firms, the paper built an artificial credit markets with the agent-based computational modeling to simulate the real world credit transaction...By analyzing the financing difficulties faced by the small and medium-sized firms, the paper built an artificial credit markets with the agent-based computational modeling to simulate the real world credit transactions. There are firms, banks, different risk-type projects as well as legal and supervision environments in which debt contracts constitute the financial instruments. The simulation results show that the number of collateral, average success probability of projects, and the prime interest rate have materially impact on bank's average profit, bank's capital, the overall interest rate,the number of borrowing firms, loan size, and the degree of credit rationing. These results in line with those of the classical S-W model in the sense that the relationship between bank profits and interest rates is non-monotonic as well as the relationship between credit rationing and interest rates. And thus there is an adverse selection effect in credit rationing theory.展开更多
Let X be a closed simply connected rationally elliptic 4-manifold.The rational homotopy type of homotopy fixed point sets X^(hS^(1))is determined,and based on some relations between X^(hS^(1))and X^(S^(1)),the rationa...Let X be a closed simply connected rationally elliptic 4-manifold.The rational homotopy type of homotopy fixed point sets X^(hS^(1))is determined,and based on some relations between X^(hS^(1))and X^(S^(1)),the rational homotopy type of the fixed point set X^(S^(1))is determined.展开更多
This study examines some social consequences of food rationing and economic reforms in Shanghai by considering the notion of ＂Shanghai little men＂ （a broader translation of which is ＂Shanghai less-than-manly men＂...This study examines some social consequences of food rationing and economic reforms in Shanghai by considering the notion of ＂Shanghai little men＂ （a broader translation of which is ＂Shanghai less-than-manly men＂）. Male Shanghainese are notorious for doing household labor and being obedient to their wives, which has earned them the nickname Shanghai little men. This study indicates that their grocery shopping and cooking were first inspired by fundamental changes in food distribution and the power structure during the 1950s and 1960s. It treats Shanghai little men as both a special group and a symbol of certain changes in gender roles at home and the redefining of gender norms in the larger society. It examines the shifting discourse concerning Shanghai little men in the era of economic reforms and analyzes a recent popular discourse about ＂seeking real men＂ and ＂being real women.＂ Finally, it deconstructs the current cultural nostalgia for traditional gender-defined divisions of labor, reflecting a parallel developmen--the ＂transnational business masculinity＂ that one sees in China.展开更多
This research aims to understand the causes of fraud through the approach of the Fraud Triangle Theory,which includes three main factors:pressure,opportunity,rationalization.By using the Systematic Literature Review m...This research aims to understand the causes of fraud through the approach of the Fraud Triangle Theory,which includes three main factors:pressure,opportunity,rationalization.By using the Systematic Literature Review method from various relevant international journals,it analyzed systematically to identify patterns,trends,and theoretical contributions to efforts in detecting and preventing fraud.The results of this study show that the three factors in the Fraud Triangle Theory significantly contribute to the occurrence of fraud.Opportunity as the most dominant factor is caused by weak internal control systems and lack of oversight.In addition,economic pressure,and a permissive organizational environment,as well as the rationalization processes by individuals,also increase the tendency for a person to commit fraud.These findings emphasize the need for a comprehensive approach in fraud prevention strategies,through ethical values,the establishment of an organizational culture with integrity,and the implementation of more effective internal control and oversight.展开更多
In the successive rise of the metaverse and artificial intelligence(AI),rationalism and emotionalism have consistently manifested as symptoms of modernity throughout their developmental trajectories.This paper argues ...In the successive rise of the metaverse and artificial intelligence(AI),rationalism and emotionalism have consistently manifested as symptoms of modernity throughout their developmental trajectories.This paper argues that the achievements and crises of both fields signify the triumph of rationalism in the context of deepening modernity,while simultaneously harboring an intrinsic impetus and possibility for transitioning from rationalism to emotionalism.This dynamic serves as a quintessential representation of modernity’s crises and their transcendence.Centered on embodied cognitive science,AI and the metaverse—rooted in rationalism—now face challenges in shifting toward emotionalism,revealing their inadequacy in addressing this shift.Humanity must explore new modernity-deepening paradigms grounded in emotionalism to confront and transcend the potential crises posed by the metaverse and AI.展开更多
Background:Neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ration(PLR)have been shown to contribute to tumour progression and response to therapy.Methods:We retrospectively counted NLR and PLR in 719 patients ...Background:Neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ration(PLR)have been shown to contribute to tumour progression and response to therapy.Methods:We retrospectively counted NLR and PLR in 719 patients with advanced malignancies receiving chemo-and/or immuno-therapy.Results:Both the pretreatment NLR and PLR were significantly elevated in patients with progressive disease than in those without progressive disease.Compared to low groups,the high NLR and PLR groups showed significantly worse event free survival.Conclusion:We propose that NLR and PLR are not only effective blood markers for predicting therapeutic responses to chemo-and/or immuno-therapy,but also useful in detecting survival in diverse malignancies.展开更多
Heparin,a glycosaminoglycan,is a stable source of carbon that supports the growth of microorganisms in the human intestine.It is also a commonly used anticoagulant drug in clinical practice,with significant therapeuti...Heparin,a glycosaminoglycan,is a stable source of carbon that supports the growth of microorganisms in the human intestine.It is also a commonly used anticoagulant drug in clinical practice,with significant therapeutic effects.Low molecular weight heparin(LMWH)is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin.LMWH has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients.Simultaneously,as a potential prebiotic,because of its low molecular weight,LMWH can be well degraded by the gut microbiota to maintain intestinal balance.Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWH preparation;however,only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years.The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes.Herein,we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening.Several Bacteroides thetaiotaomicron heparanase I(Bt-HepI)mutants were obtained and screened for high thermal stability.We obtained the Bt-HepI^(D204C/K208C/H189W/Q198R)variant,which features a stabilized protein surface structure,with a 1.3-fold increase in catalytic constant/michaelis-menten constant(k_(cat)/K_(m)),a 2.44-fold increase in thermal stability at 50℃,and a 1.8-fold decrease in the average molecular weight of LMWH produced at 40℃compared with that seen with Bt-HepI^(WT).Our study establishes a strategy to engineer thermostable HepI to underpin its industrial applications.展开更多
Chlorobenzene is a model molecule for researching harmful chlorinated volatile organic compounds.Designing the chemical adsorption site for complex molecules such as chlorobenzene is challenging without a large datase...Chlorobenzene is a model molecule for researching harmful chlorinated volatile organic compounds.Designing the chemical adsorption site for complex molecules such as chlorobenzene is challenging without a large dataset and reasonable descriptors.Here,the adsorption of chlorobenzene on a phosphorylated CeO_(2)catalyst was analyzed using density functional theory calculations.Three different surface phosphate(H_(x)PO_(4))models were constructed and used to adsorb chlorobenzene.An orbital interaction with fully occupied antibonding is found in one of three physical adsorptions.Based on this,the surface sites of a tri-cluster(M_(3))located at the CeO_(2)surface have been suggested to activate chlorobenzene.Three different clusters have been tested,namely Fe_(3),Ru_(3),and B_(3).All these clusters can activate and twist chlorobenzene by donating electrons.Fe_(3)and Ru_(3)form bonds with weak covalent and strong ionic characters,while B3forms strong covalent bonds between boron and carbon.This work not only predicts a class of sites for chlorobenzene activation that may prevent polychlorinated by-products but also gives a template for catalyst rational design according to fundamental catalytic theory.展开更多
Dual-atom catalysts(DACs),a natural extension of single-atom catalysts(SACs),have emerged as a prominent focal point in the field of heterogeneous catalysis,particularly in the context of chemical and energy conversio...Dual-atom catalysts(DACs),a natural extension of single-atom catalysts(SACs),have emerged as a prominent focal point in the field of heterogeneous catalysis,particularly in the context of chemical and energy conversion processes.Despite the fact that the catalytic activity of DACs is significantly modulated by the electronic structure of the catalyst,understanding how electron spin states are affected by variations in topology and geometric structure remains challenging and relatively unexplored.Herein,we propose the rational design of stable DACs composed of two iron atoms anchored on pristine graphdiyne(GDY),Fe_(2)-GDYn.A comprehensive and systematic investigation was carried out to elucidate the electronic configuration and spin states involved in the deliberate convergence towards the magnetic ground state,with the aim of uncovering the structure-spin relationship.Through an in-depth analysis of spin populations,electronic localization/delocalization,and the chemical bonding characteristics of the central metal atoms and the GDY skeleton,it was revealed that the spin coupling between the two iron atoms is preponderantly dictated by adjacent short-range Fe-Fe interactions.Conversely,spin decoupling can be attributed to the long-rangeπ-bond component within the linkage.Moreover,geometric and chemical bonding asymmetries were found to induce orbital and spin splitting in iron atoms possessing an electronic configuration of d8.These findings provide important insights into the relationship between topology and spin,thereby presenting novel strategies for the rational design of spin-manipulated DACs.展开更多
Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery betwe...Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.展开更多
Objective To establish a drug use evaluation(DUE)standard for meropenem in a tertiary medical institution in Beijing,and to analyze the use of meropenem for promoting the rational use of antibiotics.Methods A criteria...Objective To establish a drug use evaluation(DUE)standard for meropenem in a tertiary medical institution in Beijing,and to analyze the use of meropenem for promoting the rational use of antibiotics.Methods A criteria of DUE of meropenem was established based on drug instructions,related guidelines and experts’opinions.Then,120 cases of meropenem use from January to December 2021 were selected to carry out a retrospective study.Results and Conclusion 120 cases of meropenem use involved 8 clinical departments,including 38 cases in the Department of Respiratory Medicine,25 cases in the Department of Tuberculosis,and 20 cases in the Department of Gastroenterology.The detection rate of pathogenic microorganisms before first use was 79.17%,and the clinical treatment effectiveness rate was 81.67%.The irrational use of meropenem included poor grasp of usage indications,excessively high starting points,inappropriate usage and dosage,non-standard treatment courses,and excessive combination medication.Pharmacists should strengthen the monitoring and evaluation of carbapenem drugs such as meropenem,provide timely feedback on relevant situations,and promote rational clinical medication.展开更多
Objective:To analyze the effect of pharmacist-led rational drug use management of antibiotics during the perioperative period in gynecology.Methods:Two hundred patients who underwent gynecological surgery between Marc...Objective:To analyze the effect of pharmacist-led rational drug use management of antibiotics during the perioperative period in gynecology.Methods:Two hundred patients who underwent gynecological surgery between March 2023 and December 2023 were selected and randomly divided into two groups.In the experimental group,the pharmacist led the medication management during the perioperative use of antibiotics,while the control group received routine antibiotic management.The management effects were compared between the two groups.Results:The irrational drug use rate,the incidence of adverse drug reactions,the cost of antibiotics,and the incidence of postoperative infection were all lower in the experimental group compared to the control group(P<0.05).Conclusion:Implementing pharmacist-led medication management during the perioperative period of gynecological surgery can prevent irrational drug use,reduce adverse drug reactions,control drug costs,and lower the risk of postoperative infection.展开更多
Objective:To explore the intervention value of the medical institution prescription review mechanism on the rationality of Western medicine use.Methods:A total of 159 patients(with 159 western medicine prescriptions)a...Objective:To explore the intervention value of the medical institution prescription review mechanism on the rationality of Western medicine use.Methods:A total of 159 patients(with 159 western medicine prescriptions)admitted to the hospital from January 2023 to December 2024 were selected and divided into an observation group(n=80,adopting the medical institution prescription review mechanism)and a control group(n=79,without prescription review)based on the random number table method.A comparative analysis was conducted on the work quality of medical personnel,irrational prescription drug use,and prescription drug dispensing situations.Results:The work quality of medical personnel in the observation group was significantly better than that in the control group(P<0.05).The incidence of irrational prescription drug use in the observation group(22.50%)was significantly higher than that in the control group(7.59%)(P<0.05).The observation group had fewer types of prescribed drugs,lower usage rates of injections and antibiotics,and a significantly higher usage rate of national essential drugs compared to the control group(P<0.05).Conclusion:The prescription review mechanism can significantly improve the work quality of medical personnel,increase the detection rate of irrational drug use,reduce the types of prescription drugs and the use of injections and antibiotics,and promote the standardized application of national essential drugs,which has important intervention value.展开更多
This paper examines the classic Chinese novel Journey to the West through the lens of rational choice theory,with a particular focus on the logic of cultivation and behavioral decision-making.By incorporating the noti...This paper examines the classic Chinese novel Journey to the West through the lens of rational choice theory,with a particular focus on the logic of cultivation and behavioral decision-making.By incorporating the notion of“inner cultivation”(xin xing xiulian)into the analytical framework,we introduce the concept of the“cultivating economic agent,”aiming to explore how rationality is generated,evolved,and transcended throughout the spiritual journey.The study argues that,in the context of Eastern culture,rationality is not merely an innate or static faculty but one that can be cultivated and transformed.Through textual analysis of the behavioral trajectories of Sun Wukong,Zhu Bajie,and Tang Sanzang,we uncover a structured behavioral logic of“goal orientation–institutional discipline–purification of the mind.”The findings suggest that although cultivation behaviors are not utilitarian decisions per se,they exhibit rational characteristics such as goal stability,autonomous will,and embedded incentives.展开更多
文摘Credit rationing has been an objective phenomenon in medium-small enterprises credit market of China. By analyzing the present situation of medium-small enterprises credit market of China, this study gives a new credit rationing model fitting medium-small enterprises credit market of China well. It has been showed in the empirical study that different factor has each different influence on medium-small enterprises credit market; further more, only the change of chastisement factor can make the medium-small enterprises credit market achieve whole success, but other factors can merely get integrant success even though under the most ideal condition.
基金supported by the National Natural Science Foundation of China (Project No.51608455)
文摘This article models a novel driving-day-based tradable credit scheme (DD-TCS) to alleviate urban traffic congestion. In this model, car-using allowances (in terms of the number of days in a month, termed as "credit") are freely and uniformly allocated to all travellers, who are also allowed to trade them in a market according to his/her travel needs (e.g. driving more or fewer days than the free endowment). As opposed to most studies on TCS, this paper explicitly considers the transaction cost (e.g. infor-mation cost of finding potential traders) in the trading market. To assess the feasibility of DD-TCS, we compare it against the license plate rationing (LPR) scheme, which has been practically implemented in many cities such as Beijing and Chengdu in China. Taking the performance of LPR as a benchmark, we quantify the threshold values of the transaction cost in DD-TCS when the two schemes yield equivalent performance (in terms of the total gener-alized cost). In numerical studies, we also compare the DD-TCS and LPR with the no-action case and the congestion pricing case (representing the theoretical optimum). Results show that both DD-TCS and LPR outperform the no-action case under certain conditions. With small trans-action cost, DD-TCS may achieve a lower system cost that can be very close to the ideal optimum. In addition, parameter analysis shows that DD-TCS performs better than LPR in a wide range of transaction cost, where the threshold values appear to account for a considerable portion of the auto travel time. This implies that DD-TCS will be more appealing than LPR in practice because a transaction cost lower than the extremely large threshold values can be easily achieved for the trading market, e.g. via a mobile platform and modern communication techniques.
基金Supported by Humanities and Social Sciences Project for Western and Frontier Areas,the Ministry of Education(11XJC790007)Fundamental Research Fund for Central Universities,Southwest University(SWU1309229)+1 种基金Science and Technology Innovation Fund of Shizhu Base,Southwest University(Sz201108)Business Management Cultivation Discipline Project,Southwest University Rongchang Campus(Rcqg207001)
文摘This paper conducts a survey of 237 rural households in Zhangjiagang City,identifies farmers' risk attitude through ELCE method and problem design and empirically studies the relationship between risk attitudes and credit rationing by utilizing Probit and Logit model. The results show that farmers' risk attitude and credit rationing are in a significant positive correlation. The stronger farmers' risk aversion is,the more serious the demanded credit rationing becomes. Such risk attitude determines the risk cost and risk premium,thus affecting the credit behavior and credit rationing degree. In addition,distance between farmers' residence far the city and their land amount have a positive significant influence on credit rationing,while farmers' education level,income,family labor force have a negative significant effect on credit rationing. Based on these findings,the paper further analyzes the relationship between farmers' credit using and credit rationing as to farmers with different risk attitudes. Measures to relieve the farmer's credit rationing must be taken from government,financial institutions and farmers,respectively.
文摘Because of the amalgamation of coal resourcesin Shanxi Province in 2009, coal production centermoved westward in China. The coal outputs of InnerMongolia and Shaanxi got higher. From January
基金supported by the National Natural Science Foundation of China under Grant Nos.71532009,71320107003 and 71271145Core Projects in Tianjin Education Bureaus Social Science Program under Grant Nos.2012JWZD11 and 2014ZD13Specialized Research Fund for the Doctoral Program of Higher Education of China under Grant No.20110032110031
文摘By analyzing the financing difficulties faced by the small and medium-sized firms, the paper built an artificial credit markets with the agent-based computational modeling to simulate the real world credit transactions. There are firms, banks, different risk-type projects as well as legal and supervision environments in which debt contracts constitute the financial instruments. The simulation results show that the number of collateral, average success probability of projects, and the prime interest rate have materially impact on bank's average profit, bank's capital, the overall interest rate,the number of borrowing firms, loan size, and the degree of credit rationing. These results in line with those of the classical S-W model in the sense that the relationship between bank profits and interest rates is non-monotonic as well as the relationship between credit rationing and interest rates. And thus there is an adverse selection effect in credit rationing theory.
文摘Let X be a closed simply connected rationally elliptic 4-manifold.The rational homotopy type of homotopy fixed point sets X^(hS^(1))is determined,and based on some relations between X^(hS^(1))and X^(S^(1)),the rational homotopy type of the fixed point set X^(S^(1))is determined.
文摘This study examines some social consequences of food rationing and economic reforms in Shanghai by considering the notion of ＂Shanghai little men＂ （a broader translation of which is ＂Shanghai less-than-manly men＂）. Male Shanghainese are notorious for doing household labor and being obedient to their wives, which has earned them the nickname Shanghai little men. This study indicates that their grocery shopping and cooking were first inspired by fundamental changes in food distribution and the power structure during the 1950s and 1960s. It treats Shanghai little men as both a special group and a symbol of certain changes in gender roles at home and the redefining of gender norms in the larger society. It examines the shifting discourse concerning Shanghai little men in the era of economic reforms and analyzes a recent popular discourse about ＂seeking real men＂ and ＂being real women.＂ Finally, it deconstructs the current cultural nostalgia for traditional gender-defined divisions of labor, reflecting a parallel developmen--the ＂transnational business masculinity＂ that one sees in China.
文摘This research aims to understand the causes of fraud through the approach of the Fraud Triangle Theory,which includes three main factors:pressure,opportunity,rationalization.By using the Systematic Literature Review method from various relevant international journals,it analyzed systematically to identify patterns,trends,and theoretical contributions to efforts in detecting and preventing fraud.The results of this study show that the three factors in the Fraud Triangle Theory significantly contribute to the occurrence of fraud.Opportunity as the most dominant factor is caused by weak internal control systems and lack of oversight.In addition,economic pressure,and a permissive organizational environment,as well as the rationalization processes by individuals,also increase the tendency for a person to commit fraud.These findings emphasize the need for a comprehensive approach in fraud prevention strategies,through ethical values,the establishment of an organizational culture with integrity,and the implementation of more effective internal control and oversight.
基金supported by the China Metaverse and Digital Talent Development Initiative and the general project of the National Social Science Foundation of China titled“Theoretical Interpretation of Advertising Messaging and the Development of a Typical Case Database”(19BXW085).
文摘In the successive rise of the metaverse and artificial intelligence(AI),rationalism and emotionalism have consistently manifested as symptoms of modernity throughout their developmental trajectories.This paper argues that the achievements and crises of both fields signify the triumph of rationalism in the context of deepening modernity,while simultaneously harboring an intrinsic impetus and possibility for transitioning from rationalism to emotionalism.This dynamic serves as a quintessential representation of modernity’s crises and their transcendence.Centered on embodied cognitive science,AI and the metaverse—rooted in rationalism—now face challenges in shifting toward emotionalism,revealing their inadequacy in addressing this shift.Humanity must explore new modernity-deepening paradigms grounded in emotionalism to confront and transcend the potential crises posed by the metaverse and AI.
基金supported by the project of Young Technical Talents of Tianjin Medical University General Hospital(GG-2021-08).
文摘Background:Neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ration(PLR)have been shown to contribute to tumour progression and response to therapy.Methods:We retrospectively counted NLR and PLR in 719 patients with advanced malignancies receiving chemo-and/or immuno-therapy.Results:Both the pretreatment NLR and PLR were significantly elevated in patients with progressive disease than in those without progressive disease.Compared to low groups,the high NLR and PLR groups showed significantly worse event free survival.Conclusion:We propose that NLR and PLR are not only effective blood markers for predicting therapeutic responses to chemo-and/or immuno-therapy,but also useful in detecting survival in diverse malignancies.
基金supported by the Natural Science Foundation of Jiangsu Province(BE2021623,BK20220155)Natural Science Foundation of Jiangsu Province(BE2021623)+4 种基金National Natural Science Foundation of China(32001665,U1903205,32021005)the National Key Research and Development Program of China(2017YF0400303)the Key Scientific and Technological Research Projects in the Key Areas of the Xinjiang Production and Construction Corps(2018AB010)the Key Research and Development 303 Program of Ningxia(2020BFG02012)Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。
文摘Heparin,a glycosaminoglycan,is a stable source of carbon that supports the growth of microorganisms in the human intestine.It is also a commonly used anticoagulant drug in clinical practice,with significant therapeutic effects.Low molecular weight heparin(LMWH)is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin.LMWH has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients.Simultaneously,as a potential prebiotic,because of its low molecular weight,LMWH can be well degraded by the gut microbiota to maintain intestinal balance.Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWH preparation;however,only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years.The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes.Herein,we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening.Several Bacteroides thetaiotaomicron heparanase I(Bt-HepI)mutants were obtained and screened for high thermal stability.We obtained the Bt-HepI^(D204C/K208C/H189W/Q198R)variant,which features a stabilized protein surface structure,with a 1.3-fold increase in catalytic constant/michaelis-menten constant(k_(cat)/K_(m)),a 2.44-fold increase in thermal stability at 50℃,and a 1.8-fold decrease in the average molecular weight of LMWH produced at 40℃compared with that seen with Bt-HepI^(WT).Our study establishes a strategy to engineer thermostable HepI to underpin its industrial applications.
基金the support from the National Key Research and Development Program of China(No.2023YFA1508500)the National Natural Science Foundation of China(No.22276120)。
文摘Chlorobenzene is a model molecule for researching harmful chlorinated volatile organic compounds.Designing the chemical adsorption site for complex molecules such as chlorobenzene is challenging without a large dataset and reasonable descriptors.Here,the adsorption of chlorobenzene on a phosphorylated CeO_(2)catalyst was analyzed using density functional theory calculations.Three different surface phosphate(H_(x)PO_(4))models were constructed and used to adsorb chlorobenzene.An orbital interaction with fully occupied antibonding is found in one of three physical adsorptions.Based on this,the surface sites of a tri-cluster(M_(3))located at the CeO_(2)surface have been suggested to activate chlorobenzene.Three different clusters have been tested,namely Fe_(3),Ru_(3),and B_(3).All these clusters can activate and twist chlorobenzene by donating electrons.Fe_(3)and Ru_(3)form bonds with weak covalent and strong ionic characters,while B3forms strong covalent bonds between boron and carbon.This work not only predicts a class of sites for chlorobenzene activation that may prevent polychlorinated by-products but also gives a template for catalyst rational design according to fundamental catalytic theory.
文摘Dual-atom catalysts(DACs),a natural extension of single-atom catalysts(SACs),have emerged as a prominent focal point in the field of heterogeneous catalysis,particularly in the context of chemical and energy conversion processes.Despite the fact that the catalytic activity of DACs is significantly modulated by the electronic structure of the catalyst,understanding how electron spin states are affected by variations in topology and geometric structure remains challenging and relatively unexplored.Herein,we propose the rational design of stable DACs composed of two iron atoms anchored on pristine graphdiyne(GDY),Fe_(2)-GDYn.A comprehensive and systematic investigation was carried out to elucidate the electronic configuration and spin states involved in the deliberate convergence towards the magnetic ground state,with the aim of uncovering the structure-spin relationship.Through an in-depth analysis of spin populations,electronic localization/delocalization,and the chemical bonding characteristics of the central metal atoms and the GDY skeleton,it was revealed that the spin coupling between the two iron atoms is preponderantly dictated by adjacent short-range Fe-Fe interactions.Conversely,spin decoupling can be attributed to the long-rangeπ-bond component within the linkage.Moreover,geometric and chemical bonding asymmetries were found to induce orbital and spin splitting in iron atoms possessing an electronic configuration of d8.These findings provide important insights into the relationship between topology and spin,thereby presenting novel strategies for the rational design of spin-manipulated DACs.
文摘Objective:To analyze the positive impact of pharmaceutical care in the ophthalmology perioperative period on the rational use of antibiotics.Methods:A total of 115 patients who underwent ophthalmological surgery between March and June 2023 were selected as the control group,receiving routine medication management.Another 115 patients who underwent ophthalmological surgery between July and October 2023 were selected as the observation group,receiving pharmaceutical care.The rationality of medication use,mastery of medication knowledge,medication compliance,and adverse reaction rates were compared between the two groups.Results:The observation group had higher rationality of medication use,higher scores for mastery of medication knowledge,higher medication compliance,and a lower adverse reaction rate compared to the control group(P<0.05).Conclusion:The combination of antibiotic therapy and pharmaceutical care in the ophthalmology perioperative period can improve the rationality of medication use,enhance patients’mastery of medication knowledge,increase their medication compliance,and prevent adverse reactions to antibiotics.
文摘Objective To establish a drug use evaluation(DUE)standard for meropenem in a tertiary medical institution in Beijing,and to analyze the use of meropenem for promoting the rational use of antibiotics.Methods A criteria of DUE of meropenem was established based on drug instructions,related guidelines and experts’opinions.Then,120 cases of meropenem use from January to December 2021 were selected to carry out a retrospective study.Results and Conclusion 120 cases of meropenem use involved 8 clinical departments,including 38 cases in the Department of Respiratory Medicine,25 cases in the Department of Tuberculosis,and 20 cases in the Department of Gastroenterology.The detection rate of pathogenic microorganisms before first use was 79.17%,and the clinical treatment effectiveness rate was 81.67%.The irrational use of meropenem included poor grasp of usage indications,excessively high starting points,inappropriate usage and dosage,non-standard treatment courses,and excessive combination medication.Pharmacists should strengthen the monitoring and evaluation of carbapenem drugs such as meropenem,provide timely feedback on relevant situations,and promote rational clinical medication.
文摘Objective:To analyze the effect of pharmacist-led rational drug use management of antibiotics during the perioperative period in gynecology.Methods:Two hundred patients who underwent gynecological surgery between March 2023 and December 2023 were selected and randomly divided into two groups.In the experimental group,the pharmacist led the medication management during the perioperative use of antibiotics,while the control group received routine antibiotic management.The management effects were compared between the two groups.Results:The irrational drug use rate,the incidence of adverse drug reactions,the cost of antibiotics,and the incidence of postoperative infection were all lower in the experimental group compared to the control group(P<0.05).Conclusion:Implementing pharmacist-led medication management during the perioperative period of gynecological surgery can prevent irrational drug use,reduce adverse drug reactions,control drug costs,and lower the risk of postoperative infection.
文摘Objective:To explore the intervention value of the medical institution prescription review mechanism on the rationality of Western medicine use.Methods:A total of 159 patients(with 159 western medicine prescriptions)admitted to the hospital from January 2023 to December 2024 were selected and divided into an observation group(n=80,adopting the medical institution prescription review mechanism)and a control group(n=79,without prescription review)based on the random number table method.A comparative analysis was conducted on the work quality of medical personnel,irrational prescription drug use,and prescription drug dispensing situations.Results:The work quality of medical personnel in the observation group was significantly better than that in the control group(P<0.05).The incidence of irrational prescription drug use in the observation group(22.50%)was significantly higher than that in the control group(7.59%)(P<0.05).The observation group had fewer types of prescribed drugs,lower usage rates of injections and antibiotics,and a significantly higher usage rate of national essential drugs compared to the control group(P<0.05).Conclusion:The prescription review mechanism can significantly improve the work quality of medical personnel,increase the detection rate of irrational drug use,reduce the types of prescription drugs and the use of injections and antibiotics,and promote the standardized application of national essential drugs,which has important intervention value.
文摘This paper examines the classic Chinese novel Journey to the West through the lens of rational choice theory,with a particular focus on the logic of cultivation and behavioral decision-making.By incorporating the notion of“inner cultivation”(xin xing xiulian)into the analytical framework,we introduce the concept of the“cultivating economic agent,”aiming to explore how rationality is generated,evolved,and transcended throughout the spiritual journey.The study argues that,in the context of Eastern culture,rationality is not merely an innate or static faculty but one that can be cultivated and transformed.Through textual analysis of the behavioral trajectories of Sun Wukong,Zhu Bajie,and Tang Sanzang,we uncover a structured behavioral logic of“goal orientation–institutional discipline–purification of the mind.”The findings suggest that although cultivation behaviors are not utilitarian decisions per se,they exhibit rational characteristics such as goal stability,autonomous will,and embedded incentives.
