Enhancing the sensitivity of nuclear magnetic resonance(NMR)technology has been the focus of NMR research for decades,which offers the potential to significantly expand its applications in chemistry,biology,and medica...Enhancing the sensitivity of nuclear magnetic resonance(NMR)technology has been the focus of NMR research for decades,which offers the potential to significantly expand its applications in chemistry,biology,and medical imaging.Parahydrogen-induced polarization(PHIP)emerges as a cost-effective approach to substantially enhance the sensitivity of NMR.Nevertheless,the amplification of the ^(1)H signal in PHIP is susceptible to interference from the thermal polarization state ^(1)H NMR signal.Employing RASER(radiofrequency amplification by stimulated emission of radiation)proves effective in mitigating such interference,which can reduce the linewidth and increase the sensitivity at the same time.In this work,we utilized PHIP and RASER to enhance the signal-to-noise ratio(SNR)of a series of biocompatible alkynyl organic acid molecules.The alkynyl acid with the highest enhancement factor was first identified through PASADENA(parahydrogen and synthesis allow dramatically enhanced nuclear alignment)experiments.Subsequently,RASER experiments were carried out through hyperpolarization of 5-hexynoic acid,exploring its signal characteristics under varying flow rates and pressures.The SNR of proton signals of 5-hexynoic acid surpassed 150,000,an 18.62-fold improvement compared with traditional hyperpolarized signals in PASADENA,and a markedly narrowed linewidth of 0.06 Hz.展开更多
Nine Inch Nails:美国工业噪音乐队,简称NIN,最早于上世纪八十年代末的美国俄亥俄州成立,执迷于工业噪音的制造,并不断揣摩重型音乐与流行音乐的最佳契合点,这一特质使得乐队始终游离于主流与非主流音乐的交界处。早期的Nine Inch Nail...Nine Inch Nails:美国工业噪音乐队,简称NIN,最早于上世纪八十年代末的美国俄亥俄州成立,执迷于工业噪音的制造,并不断揣摩重型音乐与流行音乐的最佳契合点,这一特质使得乐队始终游离于主流与非主流音乐的交界处。早期的Nine Inch Nails曾欣然将电子舞曲元素融入工业音乐当中,处女专辑《Pretry Hate Machine》当中的"Head Like A Hole"和"Sin"展开更多
基金supported by the National Natural Science Foundation of China(grant number:22274050)the Shanghai Science and Technology Commission(contract number:23J21900300)the Fundamental Research Funds for the Central Universities.
文摘Enhancing the sensitivity of nuclear magnetic resonance(NMR)technology has been the focus of NMR research for decades,which offers the potential to significantly expand its applications in chemistry,biology,and medical imaging.Parahydrogen-induced polarization(PHIP)emerges as a cost-effective approach to substantially enhance the sensitivity of NMR.Nevertheless,the amplification of the ^(1)H signal in PHIP is susceptible to interference from the thermal polarization state ^(1)H NMR signal.Employing RASER(radiofrequency amplification by stimulated emission of radiation)proves effective in mitigating such interference,which can reduce the linewidth and increase the sensitivity at the same time.In this work,we utilized PHIP and RASER to enhance the signal-to-noise ratio(SNR)of a series of biocompatible alkynyl organic acid molecules.The alkynyl acid with the highest enhancement factor was first identified through PASADENA(parahydrogen and synthesis allow dramatically enhanced nuclear alignment)experiments.Subsequently,RASER experiments were carried out through hyperpolarization of 5-hexynoic acid,exploring its signal characteristics under varying flow rates and pressures.The SNR of proton signals of 5-hexynoic acid surpassed 150,000,an 18.62-fold improvement compared with traditional hyperpolarized signals in PASADENA,and a markedly narrowed linewidth of 0.06 Hz.
文摘Nine Inch Nails:美国工业噪音乐队,简称NIN,最早于上世纪八十年代末的美国俄亥俄州成立,执迷于工业噪音的制造,并不断揣摩重型音乐与流行音乐的最佳契合点,这一特质使得乐队始终游离于主流与非主流音乐的交界处。早期的Nine Inch Nails曾欣然将电子舞曲元素融入工业音乐当中,处女专辑《Pretry Hate Machine》当中的"Head Like A Hole"和"Sin"
