Rapid and accurate visible-light photopolymerization is essential for advancing bioprinted engineered tissues.In this study,we developed a novel three-component photoinitiator system for visible light-induced crosslin...Rapid and accurate visible-light photopolymerization is essential for advancing bioprinted engineered tissues.In this study,we developed a novel three-component photoinitiator system for visible light-induced crosslinking of gelatin methacryloyl(GelMA)hydrogels,designed to improve polymerization kinetics,mechanical strength,and structural integrity.Incorporation of 2-bromoacetophenone(BAP)considerably accelerated photopolymerization,with reaction rates increasing alongside BAP concentration,enabling the rapid fabrication of stable hydrogel scaffolds.Printing experiments confirmed that BAP promoted fast crosslinking of GelMA bioinks under visible light,reducing printing time while preserving high-resolution structural features.Additionally,the incorporation of BAP induced microscale structural transformations in the hydrogels during hydration,as evidenced by scanning electron microscopy imaging and swelling analyses.This unique property enabled the fabrication of multilayer constructs exhibiting time-dependent deformation,demonstrating four-dimensional(4 D)printing ca pabilities.Moreover,biocompatibility evaluations revealed that cells maintained high viability in BAP-containing hydrogels.Overall,the BAP-based photoinitiator system offers a promising strategy for high-speed,high-resolution bioprinting,combining enhanced mechanical performance,reduced fabrication time,and dynamic structural adaptability-features that make it highly suitable for advanced biofabrication and tissue engineering applications.展开更多
A rapid, one-pot and highly efficient protocol for the synthesis of pharmaceutically interesting functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives has been developed using commercially available Cs...A rapid, one-pot and highly efficient protocol for the synthesis of pharmaceutically interesting functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives has been developed using commercially available Cs F as a catalyst in the reaction of malononitrile and aryl aldehydes or isatins with 1,3-cyclohexanediones. The major advantages of this methodology are excellent yield at ambient temperature, very short reaction time（5–10 min）, and use of an inexpensive catalyst.展开更多
A potential version of the UrQMD （UrQMD/M） transport model and a traditional coalescence model are combined to calculate the production of 3He fragments in central Pb＋Pb collisions at SPS energies 20-80 GeV/nucleon...A potential version of the UrQMD （UrQMD/M） transport model and a traditional coalescence model are combined to calculate the production of 3He fragments in central Pb＋Pb collisions at SPS energies 20-80 GeV/nucleon. It is found that the Lorentz transformation in the afterburner influences visibly the 3He yield and should be considered in calculations. The rapidity distribution of 3He multiplicities （including the concave shape） can be described well with UrQMD/M when it stops during tout=（100＋25） fm/c and the coalescence afterburner with one parameter set of （R0,P0）=（3.8 fm, 0.3 GeV/c） is taken into use afterwards.展开更多
The latest iteration of PaveVision3D Ultra can obtain true 1 mm resolution 3D data at full- lane coverage in all 3 directions at highway speed up to 60 mph. This paper introduces the PaveVision3D Ultra technology for ...The latest iteration of PaveVision3D Ultra can obtain true 1 mm resolution 3D data at full- lane coverage in all 3 directions at highway speed up to 60 mph. This paper introduces the PaveVision3D Ultra technology for rapid network level pavement survey on approximately 1280 center miles of Oklahoma interstate highways. With sophisticated automated distress analyzer （ADA） software interface, the collected 1 mm 3D data provide Oklahoma Department of Transportation （ODOT） with comprehensive solutions for automated eval- uation of pavement surface including longitudinal profile for roughness, transverse profile for rutting, predicted hydroplaning speed for safety analysis, and cracking and various surface defects for distresses. The pruned exact linear time （PELT） method, an optimal partitioning algorithm, is implemented to identify change points and dynamically deter- mine homogeneous segments so as to assist ODOT effectively using the available 1 mm 3D pavement surface condition data for decision-making. The application of 1 mm 3D laser imaging technology for network survey is unprecedented. This innovative technology allows highway agencies to access its options in using the 1 mm 3D system for its design and management purposes, particularly to meet the data needs for pavement management system （PMS）, pavement ME design and highway performance monitoring system （HPMS）.展开更多
基金supported by the Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grant(No.RGPIN-2020-04559)the Canada Foundation for Innovation John R.Evans Leaders Fund(JELF).
文摘Rapid and accurate visible-light photopolymerization is essential for advancing bioprinted engineered tissues.In this study,we developed a novel three-component photoinitiator system for visible light-induced crosslinking of gelatin methacryloyl(GelMA)hydrogels,designed to improve polymerization kinetics,mechanical strength,and structural integrity.Incorporation of 2-bromoacetophenone(BAP)considerably accelerated photopolymerization,with reaction rates increasing alongside BAP concentration,enabling the rapid fabrication of stable hydrogel scaffolds.Printing experiments confirmed that BAP promoted fast crosslinking of GelMA bioinks under visible light,reducing printing time while preserving high-resolution structural features.Additionally,the incorporation of BAP induced microscale structural transformations in the hydrogels during hydration,as evidenced by scanning electron microscopy imaging and swelling analyses.This unique property enabled the fabrication of multilayer constructs exhibiting time-dependent deformation,demonstrating four-dimensional(4 D)printing ca pabilities.Moreover,biocompatibility evaluations revealed that cells maintained high viability in BAP-containing hydrogels.Overall,the BAP-based photoinitiator system offers a promising strategy for high-speed,high-resolution bioprinting,combining enhanced mechanical performance,reduced fabrication time,and dynamic structural adaptability-features that make it highly suitable for advanced biofabrication and tissue engineering applications.
基金SAIF Panjab University for providing analytical facilities for characterization of compounds
文摘A rapid, one-pot and highly efficient protocol for the synthesis of pharmaceutically interesting functionalized 2-amino-3-cyano-4H-pyran and spirooxindole derivatives has been developed using commercially available Cs F as a catalyst in the reaction of malononitrile and aryl aldehydes or isatins with 1,3-cyclohexanediones. The major advantages of this methodology are excellent yield at ambient temperature, very short reaction time（5–10 min）, and use of an inexpensive catalyst.
基金the National Natural Science Foundation of China(Grant Nos.11375062,11275068,11505056,and 11505057)the project sponsored by SRF for ROCS,SEM,the Education Bureau of Zhejiang Province(Grant No.Y201533176)the Doctoral Scientific ResearchFoundation(Grant No.11447109)
文摘A potential version of the UrQMD （UrQMD/M） transport model and a traditional coalescence model are combined to calculate the production of 3He fragments in central Pb＋Pb collisions at SPS energies 20-80 GeV/nucleon. It is found that the Lorentz transformation in the afterburner influences visibly the 3He yield and should be considered in calculations. The rapidity distribution of 3He multiplicities （including the concave shape） can be described well with UrQMD/M when it stops during tout=（100＋25） fm/c and the coalescence afterburner with one parameter set of （R0,P0）=（3.8 fm, 0.3 GeV/c） is taken into use afterwards.
基金partially sponsored by the Oklahoma Department of Transportation(ODOT)
文摘The latest iteration of PaveVision3D Ultra can obtain true 1 mm resolution 3D data at full- lane coverage in all 3 directions at highway speed up to 60 mph. This paper introduces the PaveVision3D Ultra technology for rapid network level pavement survey on approximately 1280 center miles of Oklahoma interstate highways. With sophisticated automated distress analyzer （ADA） software interface, the collected 1 mm 3D data provide Oklahoma Department of Transportation （ODOT） with comprehensive solutions for automated eval- uation of pavement surface including longitudinal profile for roughness, transverse profile for rutting, predicted hydroplaning speed for safety analysis, and cracking and various surface defects for distresses. The pruned exact linear time （PELT） method, an optimal partitioning algorithm, is implemented to identify change points and dynamically deter- mine homogeneous segments so as to assist ODOT effectively using the available 1 mm 3D pavement surface condition data for decision-making. The application of 1 mm 3D laser imaging technology for network survey is unprecedented. This innovative technology allows highway agencies to access its options in using the 1 mm 3D system for its design and management purposes, particularly to meet the data needs for pavement management system （PMS）, pavement ME design and highway performance monitoring system （HPMS）.
